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All Journal Prosiding Seminar Biologi Science and Technology Indonesia Jurnal Pengabdian Magister Pendidikan IPA Jurnal Medika Malahayati Jurnal Review Pendidikan dan Pengajaran (JRPP) Al-Syakhsiyyah : Journal of Law and Family Studies JURALIANSI (Jurnal Lingkup Anak Usia Dini) Jurnal Kesehatan Tambusai Jurnal Tika Education Enthusiast : Jurnal Pendidikan dan Keguruan Jurnal Publik: Jurnal Ilmiah Bidang Ilmu Administrasi Negara Prosiding Temu Ilmiah Nasional Guru Abdi Masyarakat UIKA Nak-Kanak: Journal of Child Research Pedagogy: Journal of Multidisciplinary Education EduImpact: Jurnal Pengabdian dan Inovasi Masyarakat Cindoku: Jurnal Keperawatan dan Ilmu Kesehatan JURALIANSI (JURNAL LINGKUP ANAK USIA DINI) International Journal of Public Administration and Policy
Uswatul Hasanah, Uswatul
Jurusan Biologi, Fakultas Sains dan Teknologi, UIN Alauddin Makassar
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Journal : Science and Technology Indonesia

 1 
Enhancing the Solubility and Dissolution Rate of Tenoxicam through Co-Amorphous Formation with Meglumine by a Solvent Dropped Grinding Method Fitriani, Lili; Arif, Zhafira; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.131-138

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID), one of the oxicam group. It is categorized as Biopharmaceutical Classification System class II, as its low solubility and high permeability. The aims of this research were to enhance the solubility and dissolution rate of tenoxicam by its modification into a co-amorphous phase with meglumine at a molar 1:1 ratio. The co amorphous form of tenoxicam-meglumine was prepared by a solvent drop grinding method, and characterized by thermal analysis using differential scanning calorimetry (DSC), solid phase by powder X-ray diffraction (PXRD), identification of functional group by Fourier-transform infrared (FT-IR) spectroscopy, and morphology by polarized light microscopy (PLM) and scanning electron microscopy (SEM). The solubility test was conducted in water, whereas the dissolution test was performed in 0.1 N HCl solution and water. The DSC thermogram demonstrated a decrease in the endothermic peak of the co-amorphous tenoxicam-meglumine. The PXRD diffractogram revealed a reduction in the peak intensity of the X-ray diffraction, which formed a halo pattern. The FT-IR spectroscopy analysis indicated the formation of the co-amorphous system. The co-amorphous of tenoxicam-meglumine solubility’s increased by 42.71-fold as compared to intact tenoxicam. The co-amorphous tenoxicam meglumine exhibited a dissolution rate of 92.71% and 100% in 0.1 N HCl and distilled water, respectively, after 60 minutes, and resulting in separate increases in dissolution efficiency by 3.05 and 9.12-times in 0.1 N HCl and distilled water. In summary, the formation of the co-amorphous phase of tenoxicam and meglumine successfully enhanced the solubility and dissolution of tenoxicam.
Ticagrelor Solubility and Dissolution Rate Enhancement Using Mesoporous Silica SBA-15 Hasanah, Uswatul; Rizky, Fattihatul; Mohd Amin, Mohd Cairul Iqbal; Zaini, Erizal
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.598-604

Abstract

Ticagrelor is a triazolopyrimidine antiplatelet agent with poor water solubility. Ticagrelor was incorporated into mesoporous silica SBA15 in this study to evaluate its physical stability and improve its solubility and dissolution rate. TEOS was employed as a silica precursor and Pluronic P123 as a template to synthesize SBA-15. Ticagrelor was loaded into SBA-15 at a mass ratio of 1:1. Physicochemical characterization was conducted using nitrogen adsorption-desorption isotherm analysis, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Ticagrelor solubility and dissolution were tested using distilled water as the medium. To evaluate the physical stability, Ticagrelor-SBA-15 was stored in a climatic chamber at 75% RH and 40°C for a month and analyzed using PXRD. Physicochemical characterization indicated efficient adsorption of ticagrelor into the SBA-15 pores, resulting in an amorphous form of solid material. Meanwhile, solubility and dissolution rate testing showed respective increases of 1.33 times and 1.74 times with significant differences (p<0.05) while maintaining its physical stability after storage for one month. Based on this study, it can be concluded that the incorporation of  mesoporous SBA-15 significantly enhances ticagrelor’s solubility and dissolution rate while maintaining stability.
Amine-Functionalized Mesoporous Silica SBA-15 for Enhanced Solubility and Release Rate of Gliclazide Sayyidina, Fasqina; Gumala, Azhoma; Zaini, Erizal; Hanifa, Dini; Hasanah, Uswatul
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.963-971

Abstract

Gliclazide (GLI), a sulfonylurea-class antidiabetic drug, exhibits poor aqueous solubility, limiting its bioavailability. This study aimed to enhance gliclazide’s solubility and dissolution rate by adsorbing it into mesoporous silica SBA-15 and amine-functionalized SBA-15 (SBA-15-A). SBA-15 was synthesized using Pluronic® P123 as a template and tetraethyl orthosilicate (TEOS) as the silica precursor, while 3-aminopropyltriethoxysilane (APTES) was used to introduce amine functional groups. Gliclazide was loaded into SBA-15 and SBA-15-A at a 1:3 mass ratio. The materials (GLI, SBA-15, SBA-15-A, GLI-SBA, and GLI-SBA-A) were characterized using nitrogen adsorption-desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (PXRD). Characterization revealed that the pore diameters of SBA-15 and SBA-15-A were 6.079 nm and 5.483 nm, respectively. FT-IR confirmed the interaction between gliclazide and the mesoporous carriers. SEM and TEM analysis showed crystalline gliclazide and rod-shaped morphologies for the mesopores samples. DSC and PXRD results indicated that most of the gliclazide had been converted to an amorphous form. Solubility testing over 24 hours showed that GLI-SBA and GLI-SBA-A improved gliclazide solubility by 1.375- and 2.334-fold, respectively, compared to pure gliclazide. Dissolution testing in distilled water revealed a 6.033-fold and 3.887-fold increase in the release rate at 5 minutes for GLI-SBA and GLI-SBA-A, respectively. Both solubility and release rate improvements were statistically significant (p <0.05). These findings suggest that amine functionalization of SBA-15 effectively enhances the solubility and dissolution rate of gliclazide.
Enhanced Piperine Solubility and Dissolution Rate in Piperine-Nicotinamide Multicomponent Crystal Adsorbed in Mesoporous Silica SBA-15 Fitriani, Lili; Fauziah, Gusrina; Hasanah, Uswatul; Agustin, Rini; Zaini, Erizal
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.109-120

Abstract

Piperine, classified as a Class II substance in the Biopharmaceutics Classification System (BCS), has poor solubility in water but high permeability. This research aims to improve the solubility and dissolution rate of piperine by adsorbing a multicomponent crystal (MCC) of piperine-nicotinamide onto mesoporous silica SBA-15. Tetraethyl orthosilicate (TEOS) was used as a silica precursor and Pluronic P123 as a pore-formation template to create SBA-15. Adsorption of the MCC was carried out by solvent evaporation with MCC:SBA-15 mass ratio (1:1). Solid state characterization was carried out by nitrogen adsorption-desorption isotherm, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, and scanning electron microscopy (SEM). Solubility tests were carried out for 24 hours and the dissolution rate profile was conducted for 60 minutes in distilled water. Dissolved piperine was determined using high performance liquid chromatography (HPLC) with methanol and distilled water as the mobile phase (75:25). The physical stability of MCC:SBA-15 was evaluated at various high relative humidities. The solid-state characterization results showed successful adsorption of the MCC in SBA-15 with a decrease in surface area, pore volume, and intensity of the X-ray diffraction peaks. The FT-IR spectrum of MCC:SBA-15 resembled that of SBA-15. The solubility test results showed 2.47-fold and 3.07-fold increases in solubility and dissolution rate compared to pure piperine, respectively. MCC:SBA-15 demonstrated high stability at 75% and 85% RH at 40◦C. In conclusion, adsorption of the MCC piperine-nicotinamide crystal in mesoporous silica SBA-15 can enhance the solubility and dissolution rate of piperine.
Co-Authors Agustin, Yunita Ahmadi, Dela Andika Alvionita, Elsti Amnamuchlisah, Dira Andhi Nur Rahmadi, Andhi Nur Anggita, Dwi Anjarwati, Ani Annisa, Rifa Arif, Zhafira Azhoma Gumala Barokah, Wuni Caesar Rahmawati Khoirina, Riila Dewi, Sentia DINI HANIFA, DINI Erizal Zaini Fakhrur Rozi, Fakhrur Fauziah, Gusrina Fitriana, Arum Hajijah, Sri Hannari, Marysha Ikmaniar Hariyanto, Budi Hasmiati Hasmiati Hermanto Hermanto Hermawan, Dessy Ita Purnama, Ita Kamila, Fi’isatil Khoidar Amirus Korompis, Ferry Lourens S. Lili Fitriani Lusiana Maharani, Aulia Martha Eri Safira Mashuri Masri Melani, Alisyia Putri Moely, Cut Mulyana Mohd Amin, Mohd Cairul Iqbal MUFIDAH, LAILATUL Munira, Widia Mutasar Nadilah Nasirruddin, Muhammad Niesa, Chaeroen Ningsih, Diarti Andra Nuraliza, Vadhea Nurhasanah Puspita, Devi Putri, Siti Julaiha Ananda Rapotan Hasibuan Refiana, Revail Rika Wulandari Rini Agustin Rizky, Fattihatul Rizqi, Puan Maulida Syifa Rohmah, Nurlaili Izzatur Roihanah, Rifah Rusny Rusny Santoso, Fazila Septiani Sayyidina, Fasqina Seda, Faradhillah La Seda, Faradilla La Shafira, Ananda Dwi Suraya, Rani Suryana, Nina Syarif, Edy Witriani, Eca Yunus, Eko Yudianto Zahira, Sayyidati