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All Journal Jurnal Kesehatan Masyarakat Indonesia Indonesian Journal of Urology Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Universa Medicina Paediatrica Indonesiana Health Notions Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Science Midwifery Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Asian Journal of Health Research MEDICINUS
Mia Ratwita Andarsini
Departemen Ilmu Kesehatan Anak, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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ANALYSIS OF DL--TOCOPHEROL AS ANTIOXIDANT ON MALONDIALDEHYDE LEVEL IN PEDIATRIC PATIENTS WITH -THALASSEMIA MAJOR Rismayanti, Levana; Yulistiani, Yulistiani; Andarsini, Mia Ratwita; Qibtiyah, Mariyatul
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.274 KB) | DOI: 10.20473/fmi.v53i1.5490

Abstract

Thalassemia is a hereditary form of anemia that affects the synthesis of hemoglobin. The management of therapy in patients with b-thalassemia major which patients should receive continuous blood transfusions and increased iron absorption from the digestive tract causes excess iron in the body. This will lead to an increase of free iron level that triggers Radical Oxygen Species (ROS). Increased level of ROS can initiate lipid peroxidation which used as an indicator of oxidative stress in cells and tissues and produce reactive carbonyl, mainly malondialdehyde (MDA). Thus, MDA measurement is widely used as an indicator of lipid peroxidation. On the other hand, the risk of oxidative damage can be reduced by antioxidant, one of them is Vitamin E that is a fat-soluble vitamin with high potential antioxidant. The objective of this study was to analyze the effect of the dl-a-tocopherol (Vitamin E) administration on decrease of MDA serum level on pediatric patients with b-thalassemia major. This was a longitudinal observational study design for one group without comparison was conducted to examine the use of vitamin E to decreased MDA serum level on children patients with b-thalassemia major. The inclusion criteria were patients who rely on blood transfusions, patients who received only one type of iron chelating agents during the study period, the clinical condition is stable, agrees, and has completed the informed consent. In the course of the study of 21 patients there were variations in patient compliance in taking vitamin E tablet dosage 200 IU once-daily for one month: only 11 out of 21 patients consumed 30 tablets of vitamin E 200 IU (total dose of 6000 IU) in the 1-month study, and only data from those 11 samples will be analysed further. MDA serum level was measured pre- and post-administration of vitamin E and patient's characteristics of subjects was obtained for additional information. Pre-administration of vitamin E, serum level of MDA was 1239.4 ± 502.55 ng/mL with a range of 216.95 to 2297.3 ng/mL, whereas in the group post administration of vitamin E, MDA serum level was 786.49 ± 704.88 ng/mL with a range of 6.5380 to 1958.6 ng/mL. In conclusion, there was no significant difference in MDA serum level in the group pre- and post- administration of vitamin E (p = 0.15).
Anemia Profile in Pediatric Patients at Pediatric Intensive Care Unit (PICU) of Dr. Soetomo General Academic Hospital Larasati, Sarah Ayu; Setyaningtyas, Arina; Hanindito, Elizeus; Andarsini, Mia Ratwita
Indonesian Journal of Anesthesiology and Reanimation Vol. 4 No. 2 (2022): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V4I22022.80-86

Abstract

Introduction: Anemia often occurs in critically ill children and is associated with increased morbidity and mortality in women and children and impaired cognitive and behavioral development in children. Objective: This study aims to understand the profile and characteristics of anemia patients in the critical care population. Methods: This is a retrospective, descriptive study of the patient's medical records. Data were collected by the total sampling technique. Results: Among 203 patients, 52% were anemic at admission to the Pediatric Intensive Care Unit (PICU), while 45% were anemic at discharge. Anemia tends to be more common in older age and male individuals with their chief complaints being respiratory symptoms, higher mean Red Cell Distribution Width (RDW) levels, and poorer nutritional status. There were 84 patients (41%) who received Packed Red-Cells (PRC) transfusions, among them there were 54 patients (51%) who were anemic at PICU admission. Of the 84 patients who received PRC transfusions during their PICU stay and 43 patients (47%) were anemic on PICU discharge. Conclusion: Anemia is quite common in critically ill children and is dominated by male patients aged under 5 years. Anemia also mostly happens in patients with higher organ dysfunction scores and poorer nutritional status than nonanemic patients. Half of the patients with anemia at the PICU also received PRC blood transfusion.
Maternal compliance with complete basic immunization: The role of knowledge, family support, and anxiety Faradila, Putri; Andarsini, Mia Ratwita; Farizi, Sofia Al; Sulistiawati, Sulistiawati
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2164

Abstract

Complete basic immunization plays a crucial role in public health efforts to protect infants from infectious diseases and to decrease child morbidity and mortality. Despite its importance, the coverage of complete basic immunization in the Socah Community Health Center area remained low at 44.7%, which did not meet the national standard. This situation reflects inadequate maternal adherence in providing immunizations for their children. The present study aimed to examine the association between maternal knowledge, family support, and anxiety levels with their adherence to complete basic immunization. An analytic observational design with a cross-sectional approach was utilized. Eighty-three mothers with children aged 12–24 months were chosen through proportionate cluster random sampling. Data collection was conducted using structured questionnaires and immunization record reviews, and analyzed through the Chi-square test at a significance level of 0.05. Findings revealed significant associations between knowledge (p = 0.005), family support (p = 0.039), and anxiety (p = 0.007) and maternal adherence to immunization. Mothers possessing better knowledge, stronger family backing, and lower anxiety levels tended to follow the immunization schedule more consistently. The study suggests strengthening educational interventions and psychological support programs for mothers and families to enhance complete basic immunization coverage in the community.
Co-Authors -, Regina Rania Cahya Kusumaningrum AGUNG PRANOTO Andi Cahyadi Andi Cahyadi Andi Cahyadi Andy Cahyadi Angela Dinaria Kemala Swary Annette d’Arqom, Annette Arifoel Hajat Arina Setyaningtyas Asmara, Almeir Pradhipta Andras Bambang Permono Bintoro, Siprianus Ugroseno Yudho Dewa Gede Ugrasena Diah Kusuma Arumsari Elizeus Hanindito Endang Retnowati Esthy Poespitaningtyas Faradila, Putri Farizi, Sofia Al Glazydia Juwita Rachma Grawira Drana Putra Respati Hartono, Audylia I Dewa Gede Ugrasena IDG Ugrasena Indiastuti, Danti Nur Jihan Nur Fauziah Joko Susanto Kittidumrongsuk, Prasong Larasati, Maria Christina Shanty Larasati, Sarah Ayu Lazuwardi, Rasya Azka Mangihut Rumiris Maria Christina Shanty Larasati Maria Christina Shanty Larasati Maria Christina Shanty Larasati Mariyatul Qibtiyah Martono Tri Utomo Muhammad Faizi Muhammad Faizi Muhammad Robiul Fuadi Nengcy Erlina Tasik Rerung Novira Widajanti, Novira Nur Rochmah Patoomwan, Autchareeya Peter Asa Pookboonmee, Renu Primadita Syahbani Priscilla Putri Harmany Rahmi Rusanti Risky Vitria Prasetyo Rismayanti, Levana Romadhon, Pradana Zaky Shanty, Maria Christina Sherly Yuniarchan, Sherly Siti Arifah Sulistiawati Sulistiawati Tutwuri Handayani Ugroseno Yudho Bintoro Yetti Hernaningsih Yulistiani Yulistiani, Yulistiani