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All Journal PROSIDING SEMINAR NASIONAL Jurnal Riset Kesehatan Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Mitra Kesehatan Pharmaqueous Jurnal Pengabdian Pancasila (JPP) Innovative: Journal Of Social Science Research Indonesian Journal of Innovation Multidisipliner Research Jurnal Laboratorium Khatulistiwa Jurnal Kesehatan Journal of Community Empowerment Indonesian Journal of Innovation Multidisipliner Research
Dini Puspodewi
Universitas Al-Irsyad Cilacap
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Socialization of Prevention of Escherichia coli Bacterial Contamination in Well Water in Sidanegara Village as a Stunting Countermeasure Imam Agus Faizal; Dini Puspodewi; Frisca Dewi Yunadi; Ira Pangesti; Mika Tri Kumala Swandari
Jurnal Pengabdian Pancasila (JPP) Vol. 3 No. 2 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/jpp.v3i2.9967

Abstract

Human health can be directly affected by water quality if E. Coli bacteria are found. Most residents of Cilacap Regency get their drinking water from wells, cooking, washing household appliances, and poor sanitation behavior. This method of community service in health counseling is divided into several stages of implementation. These stages include pre-service surveys and counseling. The results of the pre-test with the theme Identification of E. coli Bacteria Contamination as a Stunting Response were obtained with an average cadre knowledge score of 86. Meanwhile, the average score of the post-test questionnaire was 93. The conclusion of the results of this service is the results of the pre-test and post-test of the cadres which have experienced a significant increase in cadre knowledge.
Hepatotoxic Test Of Burdock Roots (Arctium Lappa L) On Histopathology Hepar Of Male White Rats (Rattus Norvegicus Wigati, Atika Nur; Faizal, Imam Agus; Puspodewi, Dini
Jurnal Riset Kesehatan Vol 13 No 2 (2024): NOVEMBER 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i2.11903

Abstract

Burdock (Arctium lappa L) is a homologous medical plant that is considered having with many advantages as a traditional medicine. Burdock root contains several substances such as inulin, essential oils, tannins, quercetin,iron, and arctigenin. This study was conducted to determine investigates effect of burdock root extract on the hepar histopathology of male white rats. This study used an experimental method with 20 rats and was divided into 4 groups. The positive control group was given gentamicin induction intramuscularly. The negative control group was given distilled water. The 150 mg/kgBW dose group and the 450 mg/kgBW dose group were given burdock root extract with treatment for 14 days and surgery was performed oin the 15th day to take hepatic organs to make histopathology preparations. The results of the this study were are interpreted by scoring and tabulated, the analysis was is done carried out descriptively with the results, in positive control group found mild damage, the negative group found no damage, in the extract dose group 150mg/kgBW found necrosis, bleeding and vacuolization, and in the extract dose group 450mg/kgBW found degeneration, necrosis, bleeding and vacuolization. The conclusion of this study is the hepatoprotective potential of burdock root extract (Arctium lappa L.) and its related effects on liver tissue in an experimental model. On the other hand, parasitic worms Taenia taeniaeformis were found in the liver which interfered with the interpretation of the results.
Pengaruh Pemberian Ekstrak Buah Pala terhadap Kadar Eritrosit (RBC) dan Granulosit pada Tikus Putih (Rattus norvegicus) dengan Anemia Hasanah, Uswatun; Pangesti, Ira; Puspodewi, Dini
Jurnal Laboratorium Khatulistiwa Vol 9, No 1 (2025): November 2025
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v9i1.2106

Abstract

Anemia is a condition characterized by a decreased number of erythrocytes and an increased number of leukocytes. According to the 2023 Indonesian Health Survey, the prevalence of anemia across all age groups is 16.2%, with a higher rate in women (18%) compared to men (14.4%). Nutmeg (Myristica fragrans Houtt) contains bioactive compounds such as saponins, flavonoids, alkaloids, and essential fatty acids that may contribute to increasing red blood cell counts and modulating leukocyte levels. This study aimed to determine the effect of nutmeg fruit extract on increasing RBC and reducing granulocyte levels in anemic white rats. A total of 25 male rats (200–350 g) were divided into five treatment groups. Anemia was induced using NaNO₂ at a dose of 1.5 mg/kg BW orally. Nutmeg extract was administered at doses of 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW. There were no significant differences (p > 0.05) between the positive control and treatment groups, nor between pre- and post-extract administration. At doses of 200 and 300 mg/kg BW, RBC percentage reached 20.7%. For granulocytes, the 300 mg/kg BW dose produced a higher percentage (27.6%) compared to the 200 and 400 mg/kg BW doses. These findings suggest that nutmeg fruit extract has the potential to support erythrocyte balance in anemia conditions, although further research with larger samples and controlled dosing is needed.%.
CORRELATION OF HBA1C LEVELS TO LDL, HDL AND TRIGLYCERIDE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN KESUGIHAN II PUBLIC HEALTH CENTER, CILACAP DISTRICT Lestari, Tika; Puspodewi, Dini; Farabi, Meka Faizal
Jurnal Mitra Kesehatan Vol. 8 No. 1 (2025): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v8i1.421

Abstract

Introduction: Diabetes mellitus or DM is a disease characterized by hyperglycemia due to abnormalities in insulin secretion, insulin action, or both. To avoid complications, patients with type 2 DM with uncontrolled blood glucose levels require comprehensive treatment. Poor glycemic control results in changes in lipid profiles in type 2 DM patients. The purpose of this study was to prove the correlation of HbA1c levels with LDL, HDL, and Triglyceride levels in Type 2 DM patients at the Kesugihan II Cilacap Health Center. Methods: This study design was cross-sectional. Examination of HbA1c, LDL, HDL, and Triglyceride without comorbidities of Heart, Hypertension, and Stroke. The sample was Prolanis Type 2 DM patients who met the inclusion and exclusion criteria. The analysis used for the normality test was the Shapiro-Wilk test and the nonparametric test used the Spearman test. Results: The Spearman test results between HbA1c levels and LDL levels showed a p value = 0.216, between HbA1c levels and HDL levels showed a p value = 0.123, between HbA1c levels and triglyceride levels showed a p value = 0.326. This shows that the probability is more than 0.05. The conclusion of this study is that there is no correlation between HbA1c levels with LDL, HDL and triglyceride levels in Prolanis DM Type 2 patients at the Kesugihan II Cilacap Health Center.
PENINGKATAN VALUASI EKONOMI ATSIRI PALA GUNA MENDUKUNG SDGS, PENGENTASAN KEMISKINAN DAN MITIGASI BENCANA LONGSOR DI KUTABIMA Puspodewi, Dini; Yusuf, Dede; Fauzy, Yuhansyah Nur; Pancasakti, Hermin; Zainuri, Muhammad; Hersugondo, Hersugondo
Journal of Community Empowerment Vol 4, No 3 (2025): Desember
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jce.v4i3.36530

Abstract

ABSTRAKDesa Kutabima memiliki potensi besar pada komoditas pala, namun pemanfaatannya masih terbatas akibat minimnya teknologi pengolahan, kapasitas sumber daya manusia, serta akses pasar. Pengabdian ini bertujuan meningkatkan valuasi ekonomi produk atsiri pala sekaligus mendukung pengentasan kemiskinan dan mitigasi bencana longsor. Metode pelaksanaan meliputi sosialisasi, pelatihan produksi (manisan pala, sirup pala, dan minyak atsiri daun pala), workshop manajemen usaha dan pemasaran digital, serta reboisasi lahan kritis. Mitra kegiatan adalah Kelompok Tani Sri Cikawung Jaya dan BUMDes Bima Barokah Sejahtera dengan total peserta 30 orang. Evaluasi dilakukan melalui pretest–posttest, observasi keterampilan, dan monitoring usaha. Hasil menunjukkan peningkatan pemahaman teknis peserta sebesar 80%, peningkatan kemampuan manajemen usaha sebesar 75%, serta terbentuknya tiga produk turunan pala dengan identitas branding dan legalitas usaha (NIB dan PIRT). Reboisasi menghasilkan penanaman 300 bibit pala dengan tingkat hidup 82%. Aktivitas pemasaran digital meningkat dengan kenaikan jangkauan hingga 320% dalam satu bulan. Program ini terbukti meningkatkan kapasitas produksi, memperluas peluang ekonomi lokal, dan memperkuat mitigasi bencana berbasis agroforestri. Kata kunci: pala; minyak atsiri; pemberdayaan masyarakat; UMKM; mitigasi bencana ABSTRACTKutabima Village has significant potential in nutmeg commodities; however, its utilization remains limited due to the lack of processing technology, limited human resource capacity, and restricted market access. This community service program aims to enhance the economic value of nutmeg essential oil products while supporting poverty alleviation and landslide disaster mitigation through skills improvement and institutional capacity strengthening. The implementation methods included socialization, training on the production of nutmeg preserves, nutmeg syrup, and nutmeg leaf essential oil, workshops on business management and digital marketing, as well as reforestation of critical land. The program partners were the Sri Cikawung Jaya Farmer Group and Bima Barokah Sejahtera Village-Owned Enterprise (BUMDes), involving 30 participants. Evaluation was conducted through pretest–posttest, skills observation, and business monitoring. The results showed an 80% increase in participants’ technical understanding and a 75% improvement in business management skills. Additionally, three nutmeg-derived products were successfully developed, complete with branding identity and business legality (NIB and PIRT). Reforestation activities resulted in the planting of 300 nutmeg seedlings with an 82% survival rate. Digital marketing activity increased by 320% within one month. This program effectively improved production capacity, expanded local economic opportunities, and strengthened disaster mitigation efforts through an agroforestry-based approach. Keywords: nutmeg; essential oils; community empowerment; MSMEs; disaster mitigation.
Toxicity Test Of Burdock (Arctium lappa L) Root Extract On Renal Histopathological Profile And Granulocyte Response In Wistar Rats : Uji Toksisitas Ekstrak Akar Burdock (Arctium lappa L) Terhadap Profil Histopatologi Ginjal Dan Respon Granulosit Tikus Wistar Nisa, Dwi Faizatun; Faizal, Imam Agus; Puspodewi, Dini
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1790

Abstract

Burdock (Arctium lappa L) is a medicinal plant widely used in traditional therapy due to its active compounds, including arctigen, and phenolic acids, which possess antioxidant and anti inflammatory pro penties. The study aims to investigate the histopatholohical profile of the kidneys and granulocyte levels in wistar rats after administration of burdock root extract. This study employed an experimental method using 8 male and female wistar rats divided into four groups, an negative control group and treatment groups whith doses 0f 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB. The extract was orally for 28 days. Was performed using Periodic Acid Schiff (PAS) sataining, and granulocyte counts were using a hematology analyzer. The results of kidney tissue examination showed no significant histopatological damage in all treatment groups, some sampeles showed the presence of adipocytes, but without indication of kidey damage. PAS staining showed no glycogen or mucopolysaccharides, which indicate tissue damage. Granulocyte levels in the treatment groups showed varying changes, depending on dose and gender, whit a significant increase in high doses in females. It can be mucopolysaccharides indicating tissue damage. Granulocyte counts in the treatment groups showed varying changes depending on dose and gender, whit a significant increase at high doses in famales. It can be concluded that burdock root extrack dose not cause histopathological kidey tissue damage and is relativeky safe use at low to high doses, but it affects granulocyte counts in a dose and sex dependent manner. 
PERBANDINGAN HASIL HITUNG JUMLAH ERITROSIT MENGGUNAKAN TABUNG VACUTAINER EDTA BERDASARKAN SEBELUM DAN SESUDAH KADALUARSA 6 BULAN DAN 12 BULAN Endra Topan; Pangesti, Ira; Puspodewi, Dini
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 7 No. 1 (2025): Volume 7, Nomor 1, Mei 2025
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v7i1.620

Abstract

Erythrocytes or red blood cells are one of the components of blood that are dense shaped like a disc and do not have a nucleus with a size of 7-8 μm that is immobile, reddish-yellow and chewy so that it can change shape according to the blood vessels that are passed. If the blood collection vacutainer tube containing the anticoagulant is used past the expiration date, it is likely that the vacuum does not draw the required amount of blood, so the anticoagulant does not work effectively and does not prevent the blood from clotting it. Based on this background, the purpose of this study is to determine the comparison of the results of calculating the number of erythrocytes using edta vacutainer tubes based on before and after the expiration of 6 months and 12 months. The type of study is a descriptive analytical study by looking at whether there is a comparison of the results of calculating the number of erythrocytes using EDTA vacutainer tubes based on before and after the expiration of 6 months and 12 months with univariate and bivariate data collection and analysis techniques. Based on the results of statistical analysis, it can be seen that the average score of participants decreased from before the ED intervention (M = 4.559; SD = 0.310) to 4.453 (SD = 0.379) at 6 months after ED, and decreased again to 4.437 (SD = 0.438) at 12 months after ED. Despite this downward trend in mean values, the results of the Repeated Measures ANOVA test showed that this difference was not statistically significant (F(1.216) = 2.871; p = 0.086), although p was close to the significance threshold value (p < 0.05). This means that there was no significant change in the score between measurement times, either before or after the ED in the 6 and 12-month periods. Although statistical tests say there is no significant difference, checking the number of erythrocytes using vacutainer EDTA tubes before expiration is still recommended because descriptively there is an increase and decrease in the number of erythrocytes.
KORELASI KADAR ALBUMIN, AST (ASPARTATE TRANSAMINASE) DAN ALT (ALANINE TRANSAMINASE) PADA PASIEN TUBERKULOSIS DI RSU SANTA MARIA CILACAP Sari, Windia Arta; Puspodewi, Dini; Farabi, Meka Faizal
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 7 No. 1 (2025): Volume 7, Nomor 1, Mei 2025
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v7i1.628

Abstract

Tuberkulosis (TBC) adalah penyakit menular yang disebabkan oleh spesies Mycobacterium. Mycobacterium Tuberculosis, sejenis kuman berbentuk batang. Sebagian besar dinding kuman terdiri atas asam lemak (lipid), peptidoglikan dan arabinomanan yang menyebabkan kuman ini lebih tahan terhadap asam sehingga disebut bakteri tahan asam (BTA). Tujuan dari penelitian ini untuk mengetahui korelasi kadar Albumin, AST dan ALT pada pasien Tuberculosis di RSU Santa Maria Cilacap. Metode penelitian ini menggunakan studi analitik observasional dengan pendekatan cross-sectional untuk mengetahui korelasi kadar albumin, AST, dan ALT pada pasien TBC di RSU Santa Maria Cilacap ,pengambilan data menggunakan data sekunder dari Sistem Informasi Manajemen Rumah Sakit (SIM RS) pada periode September 2022 sampai dengan September 2023. Berdasarkan perhitungan rumus slovin, besar sampel yang dibutuhkan sebanyak 46 sampel. Sampel yang diambil berdasarkan teknik probability sampling tipe random sampling. Hasil penelitian menunjukkan bahwa rata-rata nilai Albumin (ALB) adalah 3.387 g/dL dengan rentang 2.110–4.690 g/dL. Rata-rata AST menunjukkan nilai yang sangat tinggi, yaitu 78.109 U/L dengan deviasi standar yang besar (158.941), yang mengindikasikan adanya pencilan atau distribusi data yang tidak normal. Demikian pula, ALT memiliki sebaran luas dari 5 hingga 605 U/L, dengan rata-rata 58.891 U/L. Hasil yang telah di uji tidak terdapat korelasi antara kadar albumin dengan AST maupun ALT, namun AST dan ALT memiliki hubungan yang signifikan dan sangat kuat (p-value < 0,001)
Co-Authors Ajeng Puspo Aji Dede Yusuf, Dede Endang Triwahyuni Maharani Endra Topan Farabi, Meka Faizal Fauzy, Yuhansyah Nur Frisca Dewi Yunadi Hersugondo Hersugondo Ira Pangesti Kusumawati, Dhiah Dwi Lestari, Tika Meka Faizal Farabi Mika Tri Kumala Swandari Mubarok, Akhmad Muhammad Zainuri Nisa, Dwi Faizatun Nugraheni, Fajarita Eky Nugroho, Yusuf Eko Pancasakti, Hermin Pangesti, Ira Retno Retno Saputri, Ratna Dwi Sari, Windia Arta Sri Darmawati Uswatun Hasanah Wigati, Atika Nur Yasinta Aritonang