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All Journal Jurnal Bios Logos BULETIN OSEANOGRAFI MARINA Protobiont: Jurnal Elektronik Biologi SEMIRATA 2015 Majalah Obat Tradisional Jurnal Sains & Teknologi Lingkungan BIOMA Jurnal Bioteknologi & Biosains Indonesia (JBBI) JFMR (Journal of Fisheries and Marine Research) JURNAL PENGABDI Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Jurnal Labora Medika Jurnal Iktiologi Indonesia (Indonesian Journal of Ichthyology) Jurnal Entomologi Indonesia Jurnal Riset Biologi dan Aplikasinya Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Borneo Akcaya : Jurnal Penelitian dan Pengembangan Pelayanan Publik Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Perikanan Indonesia
Diah Wulandari Rousdy
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Tanjungpura, Pontianak, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : BIOMA

 1 
Aktivitas larvasida fraksi metanol dan etil asetat buah lakum (Cayratia trifolia (L.) Domin.) terhadap larva nyamuk Aedes aegypti Diah Wulandari Rousdy; Elvi Rusmiyanto Pancaning Wardoyo; Siti Ifadatin
Bioma : Jurnal Ilmiah Biologi Vol. 10 No. 1: April 2021
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v10i1.5595

Abstract

ABSTRAKAedes aegypti merupakan serangga vektor dari virus Dengue penyebab Demam Berdarah Dengue (DBD). Kandungan senyawa dalam tumbuhan lakum berpotensi sebagai larvasida. Buah lakum dimaserasi dengan pelarut methanol kemudian difraksinasi menggunakan etil asetat. Fraksi diteliti kandungan senyawanya menggunakan analisis fitokimia. Uji larvasida diamati selama 48 jam terdiri dari tujuh konsentrasi berseri yaitu kontrol; 0,04; 0,12; 0,2; 0,6; 1; 3% (b/v). Setiap konsentrasi diulang 3 kali dan setiap ulangan terdiri dari 10 ekor larva nyamuk Ae. aegypti. Data mortalitas dianalisis menggunakan analisis probit untuk menentukan nilai LC50. Fraksi metanol buah lakum  berpotensi sebagai larvasida dengan nilai LC50 6 jam sebesar 1,125%. Fraksi etil asetat  buah lakum  berpotensi sebagai larvasida dengan nilai LC50 6 jam sebesar 1,102%. Buah lakum mengandung senyawa: polifenol, kuinon, flavonoid, alkaloid dan terpenoid. Kata kunci: Aedes aegypti; Cayratia trifolia (L.) Domin; larvasida; LC50  ABSTRACTLarvacidal activity of methanol and ethyl acetate fraction of lakum fruits (Cayratia trifolia (L.) Domin.) against Aedes aegypti larvae. Aedes aegypti is a vector from the Dengue virus which causes Dengue Hemorrhagic Fever (DHF). The compounds of lakum plants has the potential larvicide. The fruit of C. trifolia was macerated with methanol then fractionated using ethyl acetate as a solvent. The fraction was examined for its compound using phytochemical analysis. Larvacide test was observed for 48 hours consisting of seven concentration of 0 (control); 0.04; 0.12; 0.2; 0.6; 1; 3% (w/v). Each concentration was repeated 3 times and each repetition consisted of 10 larvae of Ae. aegypti. Mortality data were analyzed using probit analysis to determine the LC50 of the fraction of methanol and ethyl acetate from lakum fruit. The methanol fraction has the potential larvicide with a six hour LC50 value 1.125%. The ethyl acetate fraction has the potential larvicide with a six hour LC50 value 1.102%. The C. trifolia fruits contains polyphenols, quinones, flavonoids, alkaloids and terpenoids. Keywords: Aedes aegypti; Cayratia trifolia (L.) Domin.; larvacide, LC50
Liver Histopathology of Mice Induced by Paracetamol on Administration of Methanol Extract of Laban Tree Bark (Vitex pubescens Vahl.) Wiwit Anggraini; Diah Wulandari Rousdy; Elvi Rusmiyanto Pancaning Wardoyo
Bioma : Jurnal Ilmiah Biologi Vol 12, No 1: April 2023
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v12i1.11664

Abstract

Paracetamol metabolism takes place in the liver mediated by CYP450 enzymes and generates NAPQI radicals. The NAPQI radical is highly electrophilic to hepatocyte biomolecules and is therefore capable of inducing liver damage. Laban tree bark (V. pubescens) methanol extract is known to contain antioxidant compounds of flavonoids, saponins, and tannins with an IC50 value of 19.83 g/ml. This study aims to determine the optimal dose of extract that can improve the liver microanatomy of mice induced by toxic dose of paracetamol (TDP). This study used 30 male Swiss strain mice with a body weight of 20-30 g. The treatments given consisted of negative control (paracetamol 105 mg kg-1), positive control (vitamin E 46.8 mg kg-1), and laban extract at a dose of 75; 150; 300; 600 mg kg-1 BW. Liver microanatomy parameters measured included hepatocyte diameter (19.50±0.21 µm), sinusoids (4.39±0.23 µm), and central vein (36.84 ± 1.79 µm). Data were analyzed using one-way ANOVA and Duncan's Multiple Range Test further test was then presented in the form of mean ± standard deviation. The results showed that extract at a dose of 600 mg kg-1 had hepatocyte, sinusoid, and central vein diameters that were not significantly different (p>0.05) with vitamin E.
Co-Authors Afriza, Hanafi Anggraini, Wiwit Ari Hepi Yanti Ari Hepi Yanti Ari Hepi Yanti Aswandi Aswandi, Aswandi Catur Wulandari Cesaria Anggun Kinanty Dwi Gusmalawati Edi Kurniadi Edi Kurniadi Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Filda Rahmawati Firman Saputra Firman Saputra Hanafi Afriza Harfan, Donatus Tia Holyness Nurdin Singadimedja Ikha Safitri Irwan Lovadi Junardi Junardi Junardi Junardi Kesha Purwaning Sari Kustiati Kustiati Kustiati Mega Sari Juane Sofiana Mukarlina -, Mukarlina Mukarlina Mukarlina Mukarlina, Mukarlina Nastiti Wijayanti Nora Idiawati Nurul Huda Prianti Prianti Prianti, Prianti Priyandono, Hendro Putri, Winda Eka Rafdinal Rafdinal Rahmawati Rahmawati Rahmawati Rahmawati Rahmawati, Rahmawai Rahmawati, Rahmawati Rikhsan Kurniatuhadi, Rikhsan Rivaldy, Marsianus Marthin Riyandi Riyandi Riza Linda Rizki Perdana Putri Rusliandi Rusliandi Sangau, Paulus Sirait, Evi Marina Siti Anikha Idzni Siti Ifadatin Turnip, Masnur Warsidah, Warsidah Wiwit Anggraini Yuniar, Helenda Ferni Asri Zulfa Zakiah