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GRANUL EFFERVESCENT KOMBINASI BUNGA TELANG (Clitoria ternatea) DAN JERUK KALAMANSI (Citrus microcarpa) SEBAGAI ALTERNATIF MINUMAN KESEHATAN Putri, Nurwigya Mohamad; Slamet, Nangsih Sulastri; Wicita, Prisca Safriani; Imran, Arlan K
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): Februari, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.196

Bunga telang (Clitoria ternatea) adalah tanaman yang memiliki potensi farmakologis sebagai antioksidan, antimikroba, antiparasit, anti-inflamasi, antikanker, antihistamin. Jeruk kalamansi (Citrus microcarpa) merupakan tanaman yang sangat kaya akan mineral dan vitamin C sehingga sangat baik digunakan untuk bahan baku minuman kesehatan. Sediaan granul effervescent adalah hasil dari gabungan senyawa asam dan basa yang bila ditambahkan dengan air (H2O) akan bereaksi melepaskan karbon dioksida (CO2), sehingga efek ini akan menghasilkan buih pada sediaan. Tujuan dari penelitian ini adalah untuk memanfaatkan bunga telang dan jeruk kalamansiÂ sebagai bahan aktif dan untuk menghasilkan sediaan granul effervescent sebagai alternatif minuman kesehatan. Ekstrak bunga telang diperoleh dari metode ekstraksi sederhana dengan cara diblender menggunakan air (1:3). Sari jeruk kalamansi diperoleh dari perasan buahjeruk kalamansi. Hasil penelitian menunjukkan bahwa sediaan granul effervescent kombinasi bunga telang dan jeruk kalamansi ini memiliki warna granul putih keunguan dan larutan biru muda bening serta memiliki bau dan rasa kombinasi bunga telang dan jeruk kalamansi, waktu dispersi yang memenuhi persyaratan waktu larut yakni 1 menit 4 detik dan indeks kompresibilitas 13,3%. Berdasarkan penilaian panelis dari parameter tekstur, warna, aroma dan rasa menunjukkan rata-rata 4,3 denganÂ kategori suka.Kata Kunci : Bunga telang, Jeruk kalamansi, Granul effervescent

AMILUM JAGUNG PULO (Zea mays ceratina) SEBAGAI ALTERNATIF ZAT PENGIKAT TABLET YANG EKONOMIS Imran, Arlan K.; Mohamad, Fihrina; Kisman, Deyanti; Maku, Zahra Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): Februari, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.197

Provinsi Gorontalo merupakan salah satu daerah penghasil jagung, dimana Gorontalo merupakan penghasil jagung terbesar dibandingkan dengan daerah lain di Indonesia. Salah satu jenis jagung yang banyak diproduksi adalah jagung pulo (Zea mays ceratina). Sebagian besar atau seluruh pati jagung pulo adalah amilopektin. Kandungan amilopektin yang tinggi menyebabkan jagung menjadi lengket dan pulen seperti ketan, sehingga dapat digunakan sebagai bahan perekat. Artikel ini bertujuan untuk mendeskripsikan potensi jagung pulo sebagai bahan pengikat dalam pembuatan sediaan tablet. Artikel ini dilaksanakan dengan mengumpulkan data-data potensial yang mendukung dan menunjukkan potensi Pulo Jagung (Zea mays certina) untuk digunakan sebagai bahan pengikat pada sediaan tablet melalui tinjauan literatur yang tersedia.Hasil tinjauan pustaka menunjukkan bahwa jagung pulo memiliki kandungan amilopektin yang sangat tinggi dibandingkan dengan jenis jagung lainnya, yaitu 70 persen. Dalam pembuatannya sebagai bahan pengikat tablet, pati jagung pulo (Zea mays certina) harus dibuat dalam bentuk musilago dengan kisaran konsentrasi 5-10%. Cara pembuatannya adalah dengan mensuspensikan pati dengan air. Dalam hal ini, kadar air yang digunakan adalah 11-14%, yang akan menyebabkan tablet berintegrasi dengan cepat. Pembuatannya juga harus hati-hati agar diperoleh musilago yang baik dan tidak terhidrolisis. Dengan hadirnya tepung jagung pulo (Zea mays certina), alternatif pengikat tablet yang lebih ekonomis dan mudah didapat.Kata Kunci:Â Amilum, Jangung Pulo, Pengikat, Penyiapan TabletÂ

Empowerment of Gorontalo Local Natural Ingredients to Become Functional Food at Dasa Wisma, South Toto Village, Kabila District, Towards A Resilient Village in The Middle of COVID-19 Hartati Hartati; Nangsih Sulastri Slamet; Arlan K. Imran; Salman Salman
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2022): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

COVID-19 is a global health problem, including in Indonesia. In addition to health problems, the increase in the number of cases of COVID-19 also has an impact on the global economy which affects stability in Indonesia. Based on the latest situation data on the development of COVID-19 cases released by the Task Force for the Acceleration of Handling COVID-19, Bone Bolango Regency, Gorontalo Province until December 31, 2020, Kabila District had the highest number of incidents, which had 122 positive confirmed cases of COVID-19. One of the 12 villages within the Kabila sub-district, South Toto Village had the highest incidence which had 38 cases. This community service aims to apply the results of research related to the use of natural materials such us Water Gourds(Lagenaria siceraria) which has antioxidant activity, so it can be used as an immunomodulator that can strengthen the body's resistance during the COVID-19 pandemic. The methods used were the distribution of Water Gourd juice syrup and training of cadres/community groups regarding the procedures for making Water Gourd juice syrup (Lagenaria siceraria). This is to increase the level of health and skills of the Gorontalo community in general and the awareness of cadres/community groups in the location where community service is carried out in particular. The parameters that can be measured in this community service are data from the pretest and posttest results which include questions related to public knowledge about COVID-19, Gorontalo local natural ingredients that are nutritious, knowledge in making functional drinks, as well as the rules and procedures for managing p-IRT for food processing businesses. Based on the results of data analysis, it was found that the average level of public knowledge increased from 58% to 72.4%.

DETERMINATION OF TOTAL FLAVONOID LEVELS OF KAFFIR LIME (Citrus hystrix) LEAF EXTRACT USING SOXHLETATION METHOD USING UV-VIS SPECTROPHOTOMETER Arlan K. Imran
International Interdisciplinary Conference on Sustainable Development Goals Vol 3 No 2 (2020): Proceedings of International Interdisciplinary Conference on Sustainable Developm
Publisher : LP2M Universitas Bina Mandiri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.385 KB)

Kaffir lime (Citrus histrix) is one of the plants with abundant flavonoid content in the leaves. The characteristic flavonoids with the two benzene ring groups cause the process of finding an appropriate extraction technique. This study aims to determine the total flavonoid levels of kaffir lime leaf extract obtained from the soxhletation extraction method. This research was carried out by extracting simplicia kaffir lime leaves by the soxhletation method using 96% ethanol solvent. Comparison between the simplicia and the solvent used is 1: 5, then the extract obtained was carried out with initial qualitative identification of flavonoids and total flavonoid levels were determined using UV-Vis spectrophotometer. The results showed that the extract of kaffir lime leaves obtained by soxhletation extraction in qualitative and quantitative tests contained flavonoid compounds with a total content of 5.62%

UJI AKTIVITAS ANTIBAKTERI SEDIAAN PEEL OFF MASK EKSTRAK ETANOL DAUN KELOR Pratiwi Ishak; Fihrina Mohamad; Prisca Safriani Wicita; Nangsih Sulastri Slamet; Arlan K. Imran
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Propionibacterium acnes is one of the bacteria that trigger acne. A popular face mask preparation today for acne skin care is the peel off Mask. The purpose of this study was to formulate ethanol extract of moringa leaves (Moringa oleifera L.) become a Peel Off mask preparation and see the antibacterial activity of the preparation against Propionibacterium acnes. This research method is quasi experimental, formulated Peel Off Mask preparation with variation of ethanol extract of moringa leaves F1 (10%), F2 (15%) and F3 (20%), then physical test (organoleptic test with hedonic scale 1-5, pH test, irritation test, spreadability test, dry time test) and antibacterial activity test with diffusion method. Data analysis of antibacterial activity test results using one way ANOVA test. The results showed organoleptic test, pH test, irritation test and drying time test F1-F3 all meet the standard. Antibacterial activity test has the greatest power is F1 17.17 mm. The result of one way anova test between F3 treatment with positive control 2 (peel Off mask Brand x®) obtained significance value (0.01) <(0.05), which means F3 has a significant difference to KP2. Conclusion; preparation peel Off Mask ethanol extract of Moringa leaves F3 is the best formula physically and has the greatest antibacterial activity of 17.17 mm (strong) against Propionibacterium acnes.

PENINGKATAN KELARUTAN SIMVASTATIN MELALUI PENAMBAHAN BAHAN PENGOMPLEKS SULFANILAMID Arlan Imran; Prisca Safriani Wicita; Zulfiayu Sapiun
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Simvastatin is a drug used to lower cholesterol levels in the blood. The mechanism of action of simvastatin is by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which competitively inhibits the cholesterol biosynthesis process in the body. Simvastatin is included in the class II BCS (Biopharmaceutics Classification System) drug, which has low water solubility and high permeability. The low solubility of simvastatin in water will affect its bioavailability in the body, which result in a therapeutic effect that is not achieved. Drug complexation is a method used to determine the solubility of a compound by adding a complexing agent. Complexing materials that are often used in other research are materials that do not have therapeutic activity such as cyclodextrin, but ini this study used complexing material from anti-microbial drug class by utilizing the reaction of glucoronide formation in the glucoronic acid structure of sulfanilamide. This research is a quantitative research with a laboratory experimental trial method which aims to see the effect of adding sulfanilamide complexing agents at various concentrations (25 ppm, 50 ppm, 75 ppm, and 100 ppm) on the solubility level of simvastatin using the acid-base titration method. The dissolved simvastatin concentration values for F1, F2, F3, F4, and F5 were 0.261 ± 0.087, respectively; 0.348 ± 0.151; 0.416 ± 0.195; 0.444 ± 0.163; 0.539 ± 0.118. The results obtained showed that the higher concentration of the sulfanilamide complexing agent added, the greater solubility of simvastatin.

Utilization Of Butterfly Pea Instant Powder as an Antihypertension Health Drink in Dungaliyo Village, Gorontalo District Prisca Safriani Wicita; Arlan K. Imran; Fitriah Ayu Magfirah Yunus
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 3 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i3.3464

Hypertension is a state of systolic blood pressure ≥140 mmHg and diastolic ≥90 mmHg. This non-communicable disease has become a problem in the world because of its increasing prevalence and its association with cardiovascular disease, stroke and kidney disease. Gorontalo Regency is a district with the highest number of hypertension sufferers and based on research data, one of the survey data for hypertension sufferers is in the Dungaliyo Village area. This community service aims to apply research results related to the use of natural ingredients in the form of butterfly pea flower (Clitoria ternatea L.) which has many benefits, one of which is antihypertensive activity. The application was realized in the form of distribution of butterfly pea flower instant powder and training for cadres/community groups related to the procedure for making butterfly pea flower instant powder. This is to increase the level of health and skills of the people of Gorontalo in general as well as the awareness of cadres/community groups where the community service is carried out in particular. This community service activity has been carried out in accordance with the objectives and methods planned in 3 (three) stages. Stage 1; Coordination with the Head of Dungaliyo village, Stage 2; Pretest understanding of hypertension and butterfly pea flowers, measurement of blood pressure and dissemination of the use of butterfly pea powder as an antihypertensive health drink, Stage 3; Socialization of butterfly pea flower cultivation, distribution of seeds, measurement of blood pressure and Posttest. This community service activity obtained the results of an evaluation of community understanding which increased from 50% to 90% and a decrease in blood pressure with the percentage of people with high blood pressure from 25% to 20 %.

Granul Effervescent Kombinasi Bunga Telang (Clitoria ternatea) dan Jeruk Kalamansi (Citrus microcarpa) Sebagai Alternatif Minuman Kesehatan Putri, Nurwigya Mohamad; Slamet, Nangsih Sulastri; Wicita, Prisca Safriani; Imran, Arlan K
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): February, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.196

Bunga telang (Clitoria ternatea) adalah tanaman yang memiliki potensi farmakologis sebagai antioksidan, antimikroba, antiparasit, anti-inflamasi, antikanker, antihistamin. Jeruk kalamansi (Citrus microcarpa) merupakan tanaman yang sangat kaya akan mineral dan vitamin C sehingga sangat baik digunakan untuk bahan baku minuman kesehatan. Sediaan granul effervescent adalah hasil dari gabungan senyawa asam dan basa yang bila ditambahkan dengan air (H2O) akan bereaksi melepaskan karbon dioksida (CO2), sehingga efek ini akan menghasilkan buih pada sediaan. Tujuan dari penelitian ini adalah untuk memanfaatkan bunga telang dan jeruk kalamansi sebagai bahan aktif dan untuk menghasilkan sediaan granul effervescent sebagai alternatif minuman kesehatan. Ekstrak bunga telang diperoleh dari metode ekstraksi sederhana dengan cara diblender menggunakan air (1:3). Sari jeruk kalamansi diperoleh dari perasan buahjeruk kalamansi. Hasil penelitian menunjukkan bahwa sediaan granul effervescent kombinasi bunga telang dan jeruk kalamansi ini memiliki warna granul putih keunguan dan larutan biru muda bening serta memiliki bau dan rasa kombinasi bunga telang dan jeruk kalamansi, waktu dispersi yang memenuhi persyaratan waktu larut yakni 1 menit 4 detik dan indeks kompresibilitas 13,3%. Berdasarkan penilaian panelis dari parameter tekstur, warna, aroma dan rasa menunjukkan rata-rata 4,3 dengan kategori suka. Telang flower (Clitoria ternatea) is a plant that has the potential pharmacologically as antioxidant, antimicrobial, antiparasitic, anti-inflammatory, anticancer, antihistamine. Kalamansi (Citrus microcarpa) is a plant that is very rich in minerals and vitamin C so it is very good for use as raw material for health drinks. Granule preparation effervescent is the result of a combination of acid and base compounds which when added with water (H2O) will react to release carbon dioxide (CO2), so this effect will produce foam on the preparation. The purpose of this research is to utilize the telang flower and calamansi as an active ingredient and to produce granules effervescent as an alternative to health drinks. Pea flower extract obtained from a simple extraction method by means of a blender use water (1:3). Calamansi juice is obtained from the juice calamansi. The results showed that the granule preparations This effervescent combination of telang flower and calamansi has purplish white granule color and clear light blue solution and has the smell and taste of a combination of telang flower and calamansi, time dispersion that meets the requirements for dissolving time of 1 minute 4 seconds and a compressibility index of 13.3%. Based on the panelist's assessment of texture, color, aroma and taste parameters showed an average of 4.3 with likes category.

Amilum Jagung Pulo (Zea mays ceratina) Sebagai Alternatif Zat Pengikat Tablet yang Ekonomis Imran, Arlan K.; Mohamad, Fihrina; Kisman, Deyanti; Maku, Zahra Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): February, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.197

Provinsi Gorontalo merupakan salah satu daerah penghasil jagung, dimana Gorontalo merupakan penghasil jagung terbesar dibandingkan dengan daerah lain di Indonesia. Salah satu jenis jagung yang banyak diproduksi adalah jagung pulo (Zea mays ceratina). Sebagian besar atau seluruh pati jagung pulo adalah amilopektin. Kandungan amilopektin yang tinggi menyebabkan jagung menjadi lengket dan pulen seperti ketan, sehingga dapat digunakan sebagai bahan perekat. Artikel ini bertujuan untuk mendeskripsikan potensi jagung pulo sebagai bahan pengikat dalam pembuatan sediaan tablet. Artikel ini dilaksanakan dengan mengumpulkan data-data potensial yang mendukung dan menunjukkan potensi Pulo Jagung (Zea mays certina) untuk digunakan sebagai bahan pengikat pada sediaan tablet melalui tinjauan literatur yang tersedia.Hasil tinjauan pustaka menunjukkan bahwa jagung pulo memiliki kandungan amilopektin yang sangat tinggi dibandingkan dengan jenis jagung lainnya, yaitu 70 persen. Dalam pembuatannya sebagai bahan pengikat tablet, pati jagung pulo (Zea mays certina) harus dibuat dalam bentuk musilago dengan kisaran konsentrasi 5-10%. Cara pembuatannya adalah dengan mensuspensikan pati dengan air. Dalam hal ini, kadar air yang digunakan adalah 11-14%, yang akan menyebabkan tablet berintegrasi dengan cepat. Pembuatannya juga harus hati-hati agar diperoleh musilago yang baik dan tidak terhidrolisis. Dengan hadirnya tepung jagung pulo (Zea mays certina), alternatif pengikat tablet yang lebih ekonomis dan mudah didapat.Gorontalo Province is one of the corn producing areas, where Gorontalo is the largest corn producer compared to with other regions in Indonesia. One of the many types of corn produced is corn pulo (Zea mays ceratina). Most or all Pulo corn starch is amylopectin. Amylopectin content which causes the corn to become sticky and fluffier like sticky rice, so it can be used as an adhesive. This article aims to describe the potential of Pulo corn as a binder in tablet preparation. This article was carried out with collect potential data that supports and shows the potential of Pulo Corn (Zea mays certina) to be used as an ingredient binders in tablet preparations through a review of the available literature. Result literature review shows that Pulo corn contains very high amylopectin compared to other types of corn, that is 70%. In its manufacture as a tablet binder, starch Pulo corn (Zea mays certina) must be made in the form of a musilago with concentration range of 5-10%. The way to make it is by suspend starch with water. In this case, the water content used is 11-14%, which will cause the tablet to integrate quickly. The manufacture must also be careful in order to obtain a good and beautiful musilago not hydrolyzed. With the presence of Pulo corn flour (Zea mays certina), alternative to tablet binders that are more economical and easy to obtain.

Skrining Fitokimia dari Ekstrak Metanol Akar Kelor (Moringa oleifera L.) Basri, Insyira Fadliana; Mohamad, Fihrina; Slamet, Nangsih Sulastri; Imran, Arlan K.; Daud, Rizka Puji Astuti; Yunus, Fitriah Ayu Magfirah; Wicita, Prisca Safriani; Basri, Rakhmadhana Fitraeni
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 2 (2022): August 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i2.345

Tanaman kelor tumbuh di daerah tropis dan telah dikenal oleh masyarakat sebagai sayur dan berkhasiat sebagai obat tradisional. Sangat jarang ditemukan penelitian yang mengidentifikasi senyawa metabolit sekunder pada bagian akar kelor. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi senyawa metabolit sekunder yang terkandung dalam akar kelor (Moringa oleifera L.) yang berasal dari Desa Talulobutu, Kabupaten Bone Bolango. Metode penelitian ini menggunakan reagen Mayer dan reagen Dragendorff untuk mengidentifikasi senyawa alkaloid, reagen NaOH 4% untuk mengidentifikasi senyawa tanin, reagen Pb(C2H3O2)2 10% untuk megidentifikasi senyawa flavonoid, dan uji buih menggunakan aquadest panas untuk megidentifikasi senyawa saponin.Moringa plant grows in the tropics and has been known by the public as a vegetable and efficacious as traditional medicine. It is very rare to find studies that identify secondary metabolites in the roots of Moringa. Therefore, this study aims to identify secondary metabolites contained in Moringa root ( Moringa oleifera L.) originating from Talulobutu Village, Bone Bolango Regency. This research method uses Mayer's reagent and Dragendorff's reagent to identify alkaloid compounds, 4% NaOH reagent to identify tannin compounds, Pb(C2H3O2)2 10% reagent to identify flavonoid compounds, and foam test using hot aquadest to identify saponins compounds.

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