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All Journal Jurnal Penelitian Kesehatan Suara Forikes Majalah Kedokteran Andalas Jurnal Health Sains Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kesehatan Komunitas Indonesia Jurnal Riset Ilmiah Jurnal Penelitian dan Pengkajian Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Noza Hilbertina
Andalas University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Epidermal Growth Factor Receptor Expression and Mutations as Diagnostic and Predictive Biomarkers in Lung Cancer: A Literature Review Sri Melati Munir; Wirsma Arief Harahap; Masrul Basyar; Noza Hilbertina
Jurnal Kesehatan Komunitas Indonesia Vol 6 No 1: April 2026
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jkki.v6i1.712

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, with diagnostic challenges due to nonspecific symptoms and limitations in tissue sampling. Molecular biomarkers, particularly Epidermal Growth Factor Receptor (EGFR), have gained attention for improving diagnostic accuracy and understanding tumor biology. EGFR plays a critical role in regulating cell proliferation, differentiation, and survival through multiple signaling pathways. This study aims to analyze the role of EGFR expression as a diagnostic biomarker in lung cancer by reviewing its biological function, molecular mechanisms, and clinical relevance. This study used a literature review approach by collecting relevant articles from databases such as PubMed, Scopus, and Google Scholar. Keywords including “EGFR,” “lung cancer,” and “biomarker” were used to identify studies discussing EGFR expression and its diagnostic value. EGFR overexpression and mutations are frequently found in lung cancer, especially non-small cell lung cancer. Activation of EGFR triggers signaling pathways such as MAPK, PI3K, and STAT, promoting tumor proliferation and survival. Detection methods, including immunohistochemistry, PCR, and FISH, are widely used. EGFR expression has shown potential as a diagnostic biomarker and provides important information for targeted therapy. EGFR expression plays a significant role in lung cancer diagnosis and offers potential as a diagnostic biomarker. However, variations across populations and tumor subtypes require careful interpretation in clinical applications.
Clinicopathological Characteristics of Hepatocellular Carcinoma at a Tertiary Hospital: A Retrospective Study Rum Affida Rasfa; Noza Hilbertina; Aswiyanti Asri; Yenita -; Loli Devianti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202637-44

Abstract

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and shows significant regional variations in clinicopathological characteristics. Limited data exist on HCC patterns in Indonesia, particularly in West Sumatra. This study aimed to characterize the clinicopathological features of HCC at Dr. M. Djamil Hospital, Padang, from 2021to2024.Methods: A descriptive retrospective study was conducted using medical records and histopathological re-evaluation of 46 HCC cases. Specimens were examined for demographic data, tumor characteristics, histopathological subtypes according to the WHO 2019 classification, differentiation grade, lymphovascular invasion, and background liver pathology.Results: The median age was 56 years, with male predominance (60.9%). Most specimens were resection specimens (60.9%) with tumor size ≥4 cm in 47.8% of cases and single nodules in 52.1%. Clear cell (39.1%) and macrotrabecular massive (37.0%) were the predominant subtypes, contrasting with global data showing NOS predominance. Most tumors were moderately differentiated (63.0%), with lymphovascular invasion present in 65.2% and cirrhotic background in 58.7% of casesConclusion: HCC in West Sumatra demonstrates distinct histopathological patterns, with a predominance of clear cell and macrotrabecular massive subtypes and high rates of lymphovascular invasion. These finding suggest histopathological features associated with aggressive tumor behavior (particularly macrotrabecular massive subtype and lymphovascular invasion), although no clinical outcome or survival analysis was performed.
CLINICOPATHOLOGICAL CHARACTERISTICS OF PROSTATE CANCER AT THE ANATOMICAL PATHOLOGY LABORATORY OF RSUP DR. M. DJAMIL PADANG 2018–2022 Iklil Latifah; Yenita Yenita; Ida Rahmah Burhan; Noza Hilbertina; Yevri Zulfiqar; Mutia Lailani
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 3 (2026): SINERGI : Jurnal Riset Ilmiah, Maret 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i3.2455

Abstract

Prostate cancer is one of the most common and deadliest cancers among men, both worldwide and in Indonesia. Prostate cancer is a malignant disease characterized by abnormal cellular proliferation within the prostate tissue. Age is the most common risk factor for prostate cancer, with the risk increasing markedly in men aged 50 years and older. The most frequently identified subtype of prostate cancer is adenocarcinoma. This study was a descriptive observational study using medical record data of patients diagnosed with prostate cancer based on histopathological findings at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital, Padang, during the period 2018–2022. Total sampling was employed. The variables analyzed included age, clinical manifestations, prostate-specific antigen (PSA) levels, histopathological cell type, and the degree of cellular differentiation of prostate cancer. The results showed that a total of 41 prostate cancer patients met the inclusion criteria. The most common age group was 55–70 years (63.4%). Local clinical manifestations were observed in 92.7% of patients, serum PSA levels >20 ng/mL in 82.9%, adenocarcinoma as the histopathological type in 100%, and poorly differentiated tumors in 82.9% of cases. The predominant histopathological type of prostate cancer was adenocarcinoma. Most patients were aged 55–70 years, commonly presented with local clinical symptoms, had serum PSA levels >20 ng/mL, and most frequently exhibited a poorly differentiated degree of tumor differentiation.
Co-Authors Artes Putri Melayu Aswiyanti Asri Daan Khambri Dessy Arisanty Devianti, Loli Dewi Safnita Endrinaldi Henny Mulyani Hera Novianti Husna Yetti Ida Rahmah Burhan Iklil Latifah Intan Putri Syamtoni Intan, Shinta Ayu Loli Devianti Loli Devianti Masrul Basyar Meta Zulyati O ktora Meta Zulyati Oktora Miftah Irramah Mutia Lailani Nadya Mirenda Putri Nelzima, Maisyah Nice Rachmawati Pamelia Mayorita Rahmi Ramadhani Rini Purnama Sari Rita Hamdani Rum Affida Rasfa Rum Affida Rasfa Sri Melati Munir Tofrizal Tofrizal Tofrizal, Alimuddin Wirsma Arief Harahap Yenita Yenita Yenita - Yenita Afriyeni Yessy Setiawati Yevri Zulfiqar Yuliza Ariani Zurayya Fadila