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All Journal Majalah Kedokteran Bandung Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Chimica et Natura Acta Indonesian Journal of Chemistry
Shabarni Gaffar -, Shabarni Gaffar
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jl. Raya Bandung-Sumedang Km 21, Jatinangor, Sumedang 45363, East Java
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Dysobinol from Chisocheton macrophyllus Selectively Induces G1 Cell Cycle Arrest in MCF-7 Breast Cancer Cells Gaffar, Shabarni; Tambunan, Ghina Uli Felicia; Hafiz, Ersanda; Herlina, Tati; Wiraswati, Hesti Lina; Nurlelasari, Nurlelasari; Ma'ruf, Ilma Fauziah
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100479

Abstract

Chisocheton macrophyllus is a medicinal plant that contains sesquiterpenoids, triterpenoids, limonoids, steroids, and phenolic compounds. This research aimed to assess the effect of Dysobinol, a limonoid compound from the seed of C. macrophyllus, on MCF-7 cell growth. Cell viability was evaluated using the MTS colorimetric assay, DNA fragmentation was assessed by agarose electrophoresis, apoptosis and cell cycle arrest were determined by flow cytometry, and gene expression levels were evaluated using qRT-PCR. Dysobinol was also analyzed in silico using drug-likeness, pharmacokinetic, and molecular docking analysis. Dysobinol demonstrated moderate cytotoxicity against MCF-7 cells, with an IC50 of 148.20 μg/mL. Dysobinol induced G1 phase cell cycle arrest that was not accompanied by the induction of apoptosis in MCF-7 cells. In silico studies showed that the EGFR/AKT/cyclin D1 proteins were affected by Dysobinol. Furthermore, drug-likeness and pharmacokinetics analysis showed that Dysobinol is bioavailable orally and has high gastrointestinal absorption and low penetration into the blood-brain barrier. Together, these results indicate that Dysobinol can regulate breast cancer cell proliferation through cell cycle arrest rather than apoptosis, and its pharmacological profile highlights its potential as a promising lead compound for anticancer drug development.
Co-Authors Aathirah, A Sayyidatina Albayyinah, Dyandra Hera Amalia, Riezki Anni Anggraeni, Anni Ari Hardianto Ekawardani, Savira Euis Julaeha Fajriyah, Maulida Hafiz, Ersanda Hesti Lina Wiraswati IMAN PERMANA MAKSUM KHOMAINI HASAN Lia Faridah Lubis, Rubianto A. Ma'ruf, Ilma Fauziah Masyhuri, Aga Adi Nurlelasari Nurlelasari Nurmalasari, Ratna Permadi, Nandang Pertiwi, Wulan PUTRI, RAFIKA Putri, Rafika Nanda Rima Melati Rustaman Rustaman Safri Ishmayana Savira Ekawardhani Shabrinna, Hanif Soetijoso Soemitro Supriyadi, Isma Yustifania Sutarya Enus Tambunan, Ghina Uli Felicia Tati Herlina Toto Subroto Upay, Purba Yeni Wahyuni Hartati Yenni Wahyuni Hartati, Yenni Wahyuni Yohan Yohan