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All Journal Jurnal Ilmiah Medicamento Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Language and Health EJOIN : Jurnal Pengabdian Masyarakat Manilkara: Journal of Bioscience Jurnal Farmasi Sains dan Teknologi
Joko Tri Wibowo, Joko Tri
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia. Skip Utara Yogyakarta, 55281
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Peran Telemedicine dalam Peningkatan Kepuasan Pasien: Tinjauan Literatur Anasulfalah, Hakim; Wibowo, Joko Tri; Wardani, Ratna; Widiyanto, Aris; Atmojo, Joko Tri; Hasibuan, Ustifina Hasanah
Journal of Language and Health Vol 5 No 3 (2024): Journal of Language and Health
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v5i3.5441

Abstract

Penelitian ini merupakan tinjauan literatur yang menganalisis efektivitas telemedicine dalam meningkatkan kepuasan pasien. Telemedicine, yang memanfaatkan teknologi komunikasi jarak jauh untuk layanan kesehatan, telah menjadi solusi inovatif untuk mengatasi berbagai tantangan dalam akses layanan medis, terutama selama pandemi COVID-19.Metode: Penelitian ini merupakan tinjauan literatur yang menggunakan sumber dari berbagai basis data elektronik, termasuk Clinical Key, Google Scholar, MEDLINE/PubMed, ProQuest, Science Direct, Scopus, dan Springer Link. Kata kunci yang digunakan mencakup "telemedicine" dan "kepuasan pasien". Penelitian ini menganalisis lima artikel yang relevan untuk mengevaluasi efektivitas telemedicine dalam meningkatkan kepuasan pasien. Tahun artikel yang digunakan dengan rentang 2019 – 2022. Hasil: Berdasarkan lima artikel yang dianalisis, ditemukan bahwa telemedicine memberikan manfaat signifikan dalam menurunkan biaya perjalanan dan waktu tunggu, serta meningkatkan fleksibilitas dan kenyamanan bagi pasien, terutama di wilayah terpencil atau dengan mobilitas terbatas.Pembahasan: penelitian ini menunjukkan bahwa pasien yang menggunakan layanan telemedicine umumnya merasa lebih puas dibandingkan dengan konsultasi tatap muka, yang diukur melalui pengurangan biaya dan waktu serta kemudahan akses. Namun, keberhasilan telemedicine sangat bergantung pada dukungan teknologi yang handal dan keterampilan komunikasi tenaga medis untuk memastikan interaksi yang efektif. Kendala seperti keterbatasan akses internet dan kompetensi teknologi masih menjadi tantangan dalam implementasi telemedicine di berbagai negara.Kesimpulan: telemedicine memiliki potensi besar untuk diintegrasikan dalam sistem kesehatan secara berkelanjutan, sehingga dapat mendukung perawatan konvensional dan memperluas jangkauan layanan kesehatan
Uji Aktivitas Antimikroba dari Ekstrak Metanol Teripang Asal Perairan Lampung Untari, Febriana; Rasyid, Abdullah; Murniasih, Tutik; Wibowo, Joko Tri
MANILKARA: Journal of Bioscience Vol 3 No 2 (2025): Februari
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33830/manilkara.v3i2.11162.2025

Abstract

Sea cucumbers possess various biological activities, including antihypertensive, antioxidant, anticoagulant, antimicrobial, hemolytic, cytotoxic, and immunomodulatory properties. These activities are attributed to the presence of primary and secondary metabolites in sea cucumbers, such as peptides, vitamins, minerals, fatty acids, saponins, steroids, carotenoids, collagen, gelatin, chondroitin sulfate, and amino acids. This study aims to evaluate the antimicrobial activity of methanol extracts from several sea cucumber species collected from Lampung waters. The agar disk diffusion method was used in the study. The results of methanol extracts from five sea cucumber species tested againts five microbial species showed varying outcomes. The highest yield of sea cucumber methanol extract was found in Bohadschia marmorata (3.88%), while the lowest was Metriatyla lessoni (2.68%). In the antibacterial potential test, no antibacterial activity was observed against the four tested bacteria. However, the fungus Candida albicans exhibited an inhibition zone. Four sea cucumber species demonstrated antifungal potential against C. albicans, with the following inhibition zone diameters: B. Marmorata (13.35 ± 2.76 mm), Holothuria lessoni (12.9 ± 0.71 mm), Stichopus quadrifasciatus (10.4 ± 0 mm), and Holothuria leucospilota (8.25 ± 0.07 mm).
PELATIHAN SENAM HIPERTENSI UNTUK MENGONTROL TEKANAN DARAH PADA PENDERITA HIPERTENSI DI DUSUN TANEN, KEMUNING, NGARGOYOSO, KARANGANYAR Indarto, Indarto; Yulianto, Dwi Joko; Wibowo, Joko Tri; Puspitasary, Kiki
EJOIN : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2024): EJOIN : Jurnal Pengabdian Masyarakat, Juni 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v2i6.2892

Abstract

Hypertension is a health problem that is quite dangerous throughout the world because hypertension is the main risk factor that leads to cardiovascular diseases such as heart attack, heart failure, stroke, and kidney disease. In 2016, ischemic heart disease and stroke became the two main causes of death in the world. Based on the 2018 Riskendes Central Java Province Report, data on patients suffering from hypertension in Central Java Province was 63,191, and hypertension sufferers in Karanganyar Regency were 1,651. It is important to carry out health education to control the blood pressure of hypertension sufferers through counseling activities and hypertension exercises. The methods used in this activity are lectures or delivery of material, discussions and questions and answers, checking participants' blood pressure, and hypertension exercises. 47 participants attended. After doing regular hypertension exercises for 2 weeks (twice a week for 30 minutes), the results were obtained in the form of optimal blood pressure increasing, normal high blood pressure decreasing, mild hypertension remaining, moderate hypertension decreasing, severe hypertension remaining, hypertension very severe decline, even non-existent or zero. So it can be concluded that hypertension exercise can be an effort to reduce the blood pressure of hypertension sufferers.
Bioaktivitas dan Identifikasi Molekuler Jamur yang Diisolasi dari Sedimen di Pantai Amed dan Tulamben Wulandari, Ni Made Widya; Dwijayanti, Ni Kadek; Putri, Ni Putu Ananda Eka; Putra, I Putu Yogi Astara; Leliqia, Ni Putu Eka; Wibowo, Joko Tri; Dwija, Ida Bagus Nyoman Putra; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10745

Abstract

Marine fungi have demonstrated the ability to produce promising new bioactive compounds. This study aims to isolate fungi from the marine sediments collected from Amed and Tulamben Beaches, Bali, Indonesia and investigate the bioactivity of the fungal extracts. Following fungal isolation, pure isolates were obtained and fermented on rice media containing salt and without salt. Next, secondary metabolites were extracted with ethyl acetate, then separated by liquid-liquid extraction using methanol containing 10% water and n-hexane. The resulting MeOH extracts were analyzed for their phytochemical content and tested for their antimicrobial and antioxidant activities using the disc diffusion and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. In total, three fungal isolates were obtained. Molecular identification from the Internal Transcribed Spacer (ITS) region of the isolates showed the closest relationship to Aspergillus sp., Aspergillus tamarii, and Trichoderma sp. Phytochemical analysis showed all fungal extracts contained alkaloids and polyphenols. Moreover, extract from Trichoderma sp. SED-TU (1) (NS) inhibited Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus mutans with inhibition zone diameters of 4.69±0.16; 3.51±0.01, and 3.49±0.25 mm, respectively. Extract from Aspergillus tamarii RM-S-SED-AM (S) inhibited Candida albicans with an inhibition zone of 7.04±0.22 mm and also had strong antioxidant activity with an IC50 value of 62.00±0.35 µg/mL. This study indicates that fungal isolates from marine sediments have great potential as a source of bioactive natural products.
Hubungan Tingkat Kepatuhan Pasien Geriatri pada Penggunaan Obat Antihipertensi terhadap Peningkatan Kualitas Hidup di Puskesmas Grogol Nova Rahma, Widyaningrum; Puspitasary, Kiki; Wibowo, Joko Tri; Hapsari, Fauziah Nur
Jurnal Farmasi Sains dan Teknologi Vol. 1 No. 01 (2023): Jurnal Farmasi Sains dan Teknologi
Publisher : PC Ikatan Apoteker Indonesia (IAI) Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65117/w5p9nq52

Abstract

Salah satu penyakit tidak menular, bersifat degenerative dan memerlukan terapi yang panjang adalah hipertensi. Hipertensi merupakan kondisi di mana tekanan darah sistolik >140mm/Hg dan tekanan darah diastolic >90 mm/Hg. Terapi jangka panjang ini memerlukan konsistensi dan kepatuhan tinggi dari penderita agar pengobatan optimal. Rendahnya tingkat kepatuhan penderita minum obat menjadi salah satu faktor yang dapat menghambat penurunan tekanan darah penderita kembali normal dan menurunkan kualitas hidup penderita. Tujuan penelitian adalah menganalisis hubungan tingkat kepatuhan pasien geriatri pada penggunaan obat antihipertensi terhadap peningkatan kualutas hidup. Penelitian ini dilakukan dengan pendekatan cross sectional menggunakan 17 sampel pasien geriatri sesuai kriteria inklusi dan ekslusi. Teknik pengambilan sampel dengan purposive sampling menggunakan alat ukur kuesioner. Kuesioner tingkat kepatuhan dengan MMAS-8 dan kuesioner kualitas hidup dengan WHOQOL-BREF. Sebanyak 35% responden memiliki tingkat kepatuhan tinggi, 30% responden memiliki tingkat kepatuhan sedang dan 35% responden memiliki tingkat kepatuhan rendah. Sebanyak 56% responden memiliki kualitas hidup sangat baik, sisanya memiliki kualitas baik. Berdasarkan analisis bivariat dengan uji korelasi spearman dapat disimpulkan bahwa terdapat hubungan antara tingkat kepatuhan pasien geriatri pada penggunaan obat antihipertensi dan kualitas hidup di Puskesmas Grogol (p value = 0,000 < 0,05). Penelitian ini dapat disimpulkan bahwa terdapat hubungan  bermakna antara tingkat kepatuhan penggunaan obat antihipertensi dengan peningkatan kualitas hidup pasien geriatri penderita hipertensi
Studi In Silico dari Metabolit Invertebrata Laut Indonesia terhadap Protein ACE2 dan Spike Protein SARS-CoV-2 Varian Omicron Claus, Matheus Prayoga; Putra, Masteria Yunovilsa; Wibowo, Joko Tri; Yanuar, Arry
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p128-139

Abstract

Indonesia has a diverse marine biota with bioactive substances that may provide a way to overcome COVID-19. In this research, we explored secondary metabolites isolated from marine invertebrates in Indonesia. A total of 137 compounds from different types of invertebrates were screened against ACE2 and SARS-CoV-2 Omicron spike protein. In relation, molecular docking and ADMET prediction were investigated to find the best compound. A molecular dynamics study was performed to determine the stability of the binding between the compound and ACE2 and RBD of the Omicron spike protein virus receptor. The results showed that acanthomanzamine E and cortistatin L have prominent molecular docking properties as ACE2 and SARS-CoV-2 Omicron spike protein blockers with binding energies of -12.87 and -9.96 kcal, respectively. The ADMET results also showed that both compounds have a promising drug-likeness, with only minor exceptions in partition coefficient (logP) and half-life. In conclusion, acanthomanzamine E and cortistatin L have shown significant potential as lead compounds for drug targeting ACE2 and SARS-CoV-2 blockers.
Co-Authors Abdullah Rasyid Anasulfalah, Hakim Arry Yanuar Atmojo, Joko Tri Claus, Matheus Prayoga Dwija, Ida Bagus Nyoman Putra Hapsari, Fauziah Nur Hasibuan, Ustifina Hasanah Indarto Indarto Ni Kadek Dwijayanti Ni Putu Ariantari Ni Putu Eka Leliqia Nova Rahma, Widyaningrum Ohee, Thomas Alva Edison Puspitasary, Kiki Putra, I Putu Yogi Astara Putra, Masteria Yunovilsa Putri, Ni Putu Ananda Eka Ratna Wardani Tutik Murniasih Untari, Febriana Widiyanto, Aris Wulandari, Ni Made Widya Yulianto, Dwi Joko