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All Journal bionature As-syifaa Jurnal Farmasi Borneo Journal Of Pharmascientech Jurnal Kesehatan Tambusai Journal Microbiology Science Journal of Pharmaceutical and Sciences. Jurnal Novem Medika Farmasi Jurnal Pengabdian Farmasi dan Sains MPSJ
Rachmat Kosman, Rachmat
Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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PENELUSURAN FUNGI ENDOFIT PADA DAUN KOPASANDA (Chromolaena odorata L.) YANG BERPOTENSI SEBAGAI PENGHASIL ANTIBAKTERI TERHADAP BAKTERI PENYEBAB INFEKSI KULIT Rusli, Rusli; Kosman, Rachmat; Melinda, Pina
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (45.958 KB) | DOI: 10.33096/jifa.v12i1.622

Abstract

The investigation for endophytic fungi of siam weed leaves (Chromolaena odorata L.) was conducted to obtain endophytic fungi potentially produced bioactive compound which were useful as an antibacterial. The research animed to obtain endophytic fungi isolate and determined the antibacterial activity against bacteria causing skin infection. The research was experimentally conducted including isolation of endophytic fungi, earthing, macroscopic examination, screening assay for antibacterial activity against bacteria, fermentation process for 21 days, and TLC separation and antibacterial testing by TLC-Bioautography against Staphylococcus aureus and Bacillus subtilis. The isolation results obtained 7 isolate followed by fermentation process with IFDK 03 isolate. The fermentate isolate of endophytic fungi showed Rf values of 0,2 anda 0,47 against Staphylococcus aureus and Bacillus subtilis. In conclusion, Siam weed leaves had isolate endophytic fungi with the potency as an antibacterial.
EVALUASI TINGKAT PENGETAHUAN OBAT ANTIDIABETES PADA MASYARAKAT DI DESA BONTOKASSI GOWA Putra, Bayu; Kosman, Rachmat; Kamri, Andi Maulana
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.760

Abstract

Diabetes mellitus is one of disease caused by changes individual's lifestyle and is not in accordance with a healthy lifestyle. In addition, this is also caused by factors that cannot be ignored. Knowledge of the general public in rural areas is very minimal because of their ignorance about diabetes mellitus. The method used in this study is descriptive observational prospectively by providing a questionnaire to assess the level of knowledge of respondents and the use of diabetes medication. Data collection was carried out in two stages. As a result of this service activity, respondents who were given counseling actually experienced an increase in their understanding of diabetes. The data obtained were analyzed by statistical program with t-test analysis. This can be seen from the statistical results that there is an effect of p <0.05 on knowledge about diabetes, the use of antidiabetic drugs, the effectiveness of antidiabetic drugs, the quality of antidiabetic drugs, and adherence to taking antidiabetic drugs. With these changes, the importance of information on patients by pharmacists in the area is very important.
UJI EFEK ANTIDIARE EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R Forst & G. Forst) PADA TIKUS PUTIH JANTAN (Rattus novergicus) Santi, Irma; Putra, Bayu; Kosman, Rachmat; Ramadhani, Fitrah Anggun; Hativa, Hativa
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.991

Abstract

Diarrhea is a condition where defecation with a frequency of more than 3 times a day and the consistency of liquid or semi-liquid feces with water content that exceeds normal limits. One plant that is thought to have antidiarrheal effects with tannin content in it is matoa leaves (Pometia pinnata J.R Forst &; G. Forst). This study was conducted experimentally using 25 male white rats induced castor oil (Oleum ricini) as a laxative. After being induced, experimental animals were divided into 5 groups, namely the negative control group (NaCMC), the positive control group (Loperamid), the the ethanol extract of matoa leaves group with doses of 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB. All treatments were carried out orally. Then observed the frequency of diarrhea and the consistency of feces every 30 minutes for 5 hours. Furthermore, the results of the study were analyzed statistically using the Kruskal Wallis test then continued with the Post Hoc LSD test. From the results of the study it can be concluded that the ethanol extract of matoa leaves has an antidiarrheal effect on male white rats induced castor oil with an effective dose of 800 mg/KgBB
UJI EFEK ANTIINFLAMASI DARI EKSTRAK ETANOL DAUN AWAR AWAR (Ficus septica Burm L. ) TERHADAP TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KARAGEN Rahmadani, Andi Syafirah; Asmaliani, Ira; Santi, Irma; Sukmawati, Sukmawati; Kosman, Rachmat; Herman, Hendra
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1148

Abstract

Inflammation occurs as a normal protective response to tissue damage caused by physical trauma, harmful chemicals, or microbiological substances. Awar-awar leaves contain flavonoid compounds with anti-inflammatory properties, as they can inhibit cyclooxygenase or lipoxygenase enzymes and prevent the accumulation of leukocytes, thereby reducing the inflammatory response. This study aims to determine the effect and effective dose of ethanol extract from awar-awar leaves (Ficus septica Burm L.) as an anti-inflammatory agent in white rats (Rattus norvegicus). The research involved 25 male white rats divided into five treatment groups: Group I received Na-CMC, Group II received 50 mg Diclofenac Sodium, and Groups III, IV, and V received ethanol extract of awar-awar leaves (Ficus septica Burm L.) at doses of 100, 200, and 400 mg/kgBW, respectively. The results showed that the ethanol extract of awar-awar leaves at a dose of 200 mg/kgBW had the most effective anti-inflammatory effect in reducing the volume and diameter of edema in male rats
Aktivitas Antibakteri Ekstrak Etanol Daun Bawang Dayak (Eleutherine palmifolia (L.) Merr) terhadap Bakteri Penyebab Infeksi Kulit dengan Metode Difusi Agar Sahide, Rusli; Febrilia Mahmud, Melly; Kosman, Rachmat
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.567

Abstract

Daun bawang dayak (Eleutherine palmifolia (L.) Merr) merupakan salah satu tanaman tradisional yang memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun bawang dayak (Eleutherine palmifolia (L.) Merr) dengan metode difusi agar. Simplisia daun bawang dayak (Eleutherine palmifolia (L.) Merr) diekstraksi dengan metode maserasi dengan pelarut etanol 96% kemudian diuapkan hingga diperoleh ekstrak kental. Kemudian dilakukan uji skrining antibakteri dengan konsentrasi 0,2% dan 0,5% menggunakan bakteri Propionibacterium acne, Staphylococcus aureus, dan Staphylococcus epidermidis. Setelah itu dilanjutkan uji nilai KHM, uji nilai KBM dan uji aktivitas antibakteri dengan metode difusi agar. Hasil pengujian skrining antibakteri pada konsentrasi 0,5% dapat menghambat pertumbuhan bakteri Propionibacterium acne dan Staphylococcus epidermidis. Nilai KHM yang diperoleh yaitu 0,25% pada bakteri Propionibacterium acne dan Staphylococcus epidermidis. Nilai KBM 1% untuk bakteri Propionibacterium acne dan 2% untuk Staphylococcus epidermidis. Hasil pengujian aktivitas antibakteri dengan metode difusi agar diperoleh diameter zona hambat terbesar pada konsentrasi 10% pada bakteri Propionibacterium acne dengan diameter zona hambat 15,42 mm dan Staphylococcus epidermidis dengan diameter zona hambat 16,21 mm.
Antibacterial Activity Test of Endophytic Fungi Extraction Kasumba Turate (Carthamus tinctorius L.) Leaves From Galesong against Digestive Tract Infection Amin, Muhammad; Kosman, Rachmat; Rusli, Rusli
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.1005

Abstract

Digestive tract infection is still a significant health problem in Indonesia, it caused by pathogenic bacteria. Kasumba turate (Carthamus tinctorius L.) is a medicinal plant that empirically used as measles drug with several compounds such as flavonoids, quinocalcones, polyacetylenes, alkaloids, fatty acids, steroids, proteins and polysaccharides and kasumba turate (Carthamus tinctorius L.) leaves are believed to have antimicrobial activity against several microbes pathogens such as E.coli and S.aureus. This research was conducted to determine endophytic fungi isolates from kasumba turate (Carthamus tinctorius L.) leaves that can provide activity against bacteria that cause digestive tract infections seen from the bioautography profile determination. Three endophytic fungi isolated from kasumba turate (Carthamus tinctorius L.) leaves were purified and observe macroscopically. After purification an antibacterial screening test was conducted by observing the inhibition zone of each isolate; the isolate with largest inhibition zone is IFEDKT-03. Isolates were fermented for 21 days, mycelia and supernatant were separated, and extraction was performed. The endophytic fungi extract of kasumba turate (Chartamus tinctorius L.) leaves has antibacterial activity against Escherichia coli, Salmonella typhi, Shigella dysenteriae, and Vibrio cholera as indicated by Rf values of 0.23, 0.41, 0.49, 0.56, 0.70 and 0.76
LITERATURE STUDY OF ANTIBACTERIAL ACTIVITY OF THE FAMILI RUTACEA Nurfadila, Nurfadila; Kosman, Rachmat; Herwin, Herwin
Journal Microbiology Science Vol 2, No 1 (2022)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.376 KB) | DOI: 10.56711/jms.v2i1.823

Abstract

Indonesia has one of potential plants as an herbal medicine, called Lime (Citrus aurantifolia) and Kaffir Lime (Citrus hystrix DC), both used for different purposes such as cooking, seasoning and traditional medicine. Both plants are derived from the family of Rutaceae which belongs to shrubs that have many branches and twigs. This study aimed to carry out the antibacterial assay of the Rutaceae family. This study used a literature study approach, which references were obtained through 3 Journal sources, namely Google scholar, pubmed, and thscience direct. Furthermore the selected research article which met the criteria was reviewed. Based on the search done, it obtained 7 articles and identified antibacterial activity of lime and Kaffir Lime. The result confirmed that both have antibacterial compounds against bacteria Escherichia coli, and Staphylococcus aureus because they contain secondary metabolite compounds consisting of alkaloids, flavonoids, tannins, and essential oils.
ETHNOPHARMACY STUDY OF PLANTS WITH MEDICINAL PROPERTIES IN NORTH MALUKU PROVINCE Adrias, Cici Rahmayanti; Herwin, Herwin; Jamaluddin, Jamaluddin; Kosman, Rachmat
Journal Microbiology Science Vol 1, No 1 (2021)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.61 KB) | DOI: 10.56711/jms.v1i1.819

Abstract

North Maluku Province, especially in Joubela Village, Morotai Island Regency, South Morotai District, is one of the remote areas located in the eastern part of Indonesia. The tribes that still thrive on the island are the Galela and Tobelo, these tribes are some of the largest tribes in North Maluku, recorded to still preserve many plants as traditional medicine. The research aimed to find out the ethnopharmaceutical plants in the village of Joubela. This present study was conducted through direct observation to people who were known to understand the use of traditional medicinal plants such as shamans, community leaders and the public who have used plants for treatment which were selected through purpose sampling method. The results obtained 15 orders, 20 families, 26 genera and 26 species of plants that have empirical potential as medication and the most widely used plant as traditional medicine was garden shrub (Graptophyllum pictum L.), with the efficacy as an ulcer medicine.
IDENTIFICATION OF ACTIVE CHEMICAL COMPONENTS OF ETHANOL EXTRACT OF PAINTED NETTLE LEAVES (COLEUS SCUTELLARIOIDES L. BENTH) AGAINST GASTROINTESTINAL INFECTION BACTERIA USING TLCBIOAUTOGRAPHY AND AGAR DIFFUSION METHOD Junaedi, Fhadillah; Kosman, Rachmat; Herwin, Herwin
Journal Microbiology Science Vol 3, No 1 (2023)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.004 KB) | DOI: 10.56711/jms.v3i1.869

Abstract

Infectious diseases are one of the public health problems caused by the transmission and multiplication of microorganisms. The research on the antibacterial activity of painted nettle leaves (Coleus scutellarioides L. Benth) extracts was carriedout to examine the activity and chemical components that provide inhibition against gastrointestinal infection bacteria. The extraction of painted nettles leaves performed maceration methd using a solvent of 96%. The extraction results were examined to determine the antibacterial activity at 1% concentration of the test bacteria: Escherichia coli, Salmonella thypi, and Shigella dysenteriae. The results showed that 96% ethanol extract of painted nettle leaves inhibited Escherichia coli, Salmonella thypi, and Shigella dysenteriae. The research conducted using agar diffusion indicated that painted nettleleaf extract showed activity against bacteria and had highly strong potential with diameters of 6-20 mm. The results of Thin Layer Chromatography (TLC) Bioautography test of ethanol extract of painted nettle leaves using chloroform:methanol eluent (3:1) showed inhibition of Escherichia coli, Shigella dysenteriae, and Salmonella thypi at Rf values of 0.90, 0.80, 0.56. Therefore, the identification test confirmed that the chemical componentsproviding antibacterial are from flavonoids, phenols, terpenoids, alkaloids, and steroidsKey words: Identification of chemical components, painted nettle leaves, gastrointestinal bacteria, TLC-Bioautography and Agar diffusion
Antibacterial Activity of Extra Ethanol Kopasanda Leaves (Chromolaena Odorate L.) Against Pathogenic Bacteria of Urinary Tract Infection by TLC-Bioautography and Agar Diffusion Wirawan, Alif Yusra; Kosman, Rachmat; Herwin, Herwin
Journal Microbiology Science Vol 3, No 2 (2023)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v3i2.979

Abstract

Kopasanda  (Chromolaena odorata L.) leaves are one of the plants (herbs) containing various types of secondary metabolites, including saponins, tannins, alkaloids, and flavonoids, which function as antibacterial agents used as wound medicine for the community. This study aims to determine the antibacterial activity of the ethanol extract of Kopasanda (Chromolaena odorate L.) leaves using the TLC-bioautography and diffusion methods. The results of the antibacterial activity screening test obtained the active extract at a concentration of 0.1% against Escherichia coli and Staphylococcus aureus. The results of the antibacterial activity test using the TLC-Bioautography method with the eluent N-Hexane:Ethyl Acetate (4:1) showed results from Staphylococcus aureus bacteria with Rf values = 0.90, 0.78, 0.67, 0.52, 0.38, 0.27, 0.14, 0.05, and Escherichia coli bacteria with Rf values = 0.90, 0.52, 0.38, 0.27, 0.14, 0.05. Based on the results of testing the antibacterial activity with the agar diffusion method, the largest diameter of the inhibition zone at a concentration of 10% was obtained for Escherichia coli bacteria with an inhibition zone diameter of 13.59 mm, and Staphylococcus aureus with an inhibition zone diameter of 15.52 mm.
Co-Authors Achmad Rosyadi Yusuf Hibai, Achmad Rosyadi Yusuf Adrias, Cici Rahmayanti Amalia.B, Putri Andi Maulana Kamri Aulia Wati, Aulia Azhary, Nursyahidah Basri, Putri Septiani Bayu Putra, Bayu Faradila, Aulia Febrilia Mahmud, Melly Fitriana FITRIANI, SITTI ANNISA Hamdani, Nina Hamsinah Hamsinah, Hamsinah Hativa, Hativa Herwin Herwin, Herwin Ika Indra Wijaya, Ika Indra Ira Damayanti, Ira Irma Santi, Irma Iskandar , A. Nasyrah Jamaluddin Jamaluddin Junaedi, Fhadillah Kurniati Tappang, Kurniati Melinda, Pina Muhammad Amin Muzakkir Baits, Muzakkir Nur Ismayani, Nur Nurfadila Nurfadila, Nurfadila Nurmaya Effendi Nurul Inayah Nurung, Ayyub Harly Pirman AP, Pirman Putra , Bayu R. Rusli Rabbana, Rahmawati Rahmadani, Andi Syafirah Rahman, Safriana Rahmawati, Rahmawati Ramadhani, Fitrah Anggun Riany Novianti Y., Riany Rizqi Nur Azizah Rusli Safriani Rahman, Safriani Sahide, Rusli Sari, Dewi Mustika Sari, Erwika Dwika Siska Nuryanti, Siska Sitti Amirah Sri Wahyuni Sudrianto Sudrianto, Sudrianto Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Wirawan, Alif Yusra Zainal Abidin