Article Per Year (5 Year)
p-Index From 2021 - 2026
3.283
P-Index
This Author published in this journals
All Journal bionature As-syifaa Jurnal Farmasi Borneo Journal Of Pharmascientech Jurnal Kesehatan Tambusai Journal Microbiology Science Journal of Pharmaceutical and Sciences. Jurnal Novem Medika Farmasi Jurnal Pengabdian Farmasi dan Sains MPSJ
Rachmat Kosman, Rachmat
Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Free Antiradical Activity Test of Endophytic Fungi Isolates of Kasumba Turate (Carthamus tinctorius (L) Leaves from Galesong Takalar with KLT-Autography Method Sari, Dewi Mustika; Kosman, Rachmat; Rusli, Rusli
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.1027

Abstract

The kasumba turate plant (Carthamus tinctorius (L.) has the potential as a free antiradical. Free antiradical compounds in kasumba turate plants come from secondary metabolites produced by endophytic compounds known as endophytic fungi. Kasumba turate contains phenolic compounds and carotenoids that have antioxidant activity. This study aims to obtain isolates of endophytic fungi in kasumba turate (Carthamus tinctorius (L.) plants that can act as free antiradicals by KLT-Autography method. Five isolates IFDK 01, IFDK 02, IFDK 03, IFDK 04, and IFDK 05 were obtained. After testing the antioxidant activity of endophytic fungal isolates, two isolates were obtained that gave the best antioxidant activity, namely isolates IFDK 03 and IFDK 04. The results of KLT-Autography testing by spraying DPPH isolates IFDK 03 and IFDK 04 have the potential as free antiradicals showing yellow spots on a purple background having an Rf1 value, IFDK 03 isolate 0.94 and Rf2 0.55 and Rf1 value, IFDK 04 isolate 0.76 and Rf2 0.43
ISOLATION AND ACTIVITY ANTIBACTERIAL OF ISOLATES ENDOPHYTE FUNGI OF JATROPH MULTIFIDA L. STEM Herwin, Herwin; Kosman, Rachmat; Wahyuni, Sri
Journal Microbiology Science Vol 1, No 1 (2021)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.923 KB) | DOI: 10.56711/jms.v1i1.815

Abstract

Endophytic fungi that live on plant tissue has the potential to produce secondary metabolites, same as its host. This study aims to isolation endophyte fungi and antibacterial activity of isolate endophyte fungi of Jatropha multifida L. stem to Escheriacia coli and Staphylococcus aureus bacteria. The preliminary research was performed by isolation endophyte fungi of Jatropha multifida L. stem use PDAC medium and the result of isolation endophyte fungi Jatropha multifida L. stem obtained 6 isolates. Isolates endophyte fungi done examination morphology by microskopic method obtained that islolates have different carasteristic. Based on examination of antibacterial activity by agar diffusion method showed that isolates endophyte fungi that potential as antibacterial is isolate IFJT1 code where isolate IFJT1 code active to Escheriacia coli bacteria obtained inhibitory zone diameter of 17,7 mm and to Staphylococcus aureus bacteria.obtained inhibitory zone diameter of 16,7 mm
LITERATURE STUDY OF ANTIBACTERIAL ASSAY OF AVERRHOA BILIMBI L. AGAINST GRAM POSITIVE BACTERIA Sari, Erwika Dwika; Kosman, Rachmat; Herwin, Herwin
Journal Microbiology Science Vol 2, No 1 (2022)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.392 KB) | DOI: 10.56711/jms.v2i1.822

Abstract

Averrhoa bilimbi L. is one of the traditional medicines that people empirically use as medicine to treat various diseases such as cough, diabetes, rheumatism, mumps, canker sores, toothache, bleeding gums, acne, diarrhea to high blood pressure. The research aimed to determine the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria. This research applied a literature study method in which the references were obtained from 3 data bases, namely google scholar, pubmed and mdpi, then selected journals that metthe criteria in the literature study.  From the journal exploration, 7 journals were obtained. Then the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria was observed. The results confirmed that the fruit and leaves of Averrhoa bilimbi L. had an antibacterial activity against Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, and Propionibacterium acnes due to the presence of secondary metabolites, namely saponins, tannins, alkaloids and flavonoid.
UJI EFEK EPITELISASI EKSTRAK DAUN PALA (Myristica fragrans Houtt.) PADA TIKUS JANTAN Azhary, Nursyahidah; Wati, Aulia; Herman, Hendra; Kosman, Rachmat
As-Syifaa Jurnal Farmasi Vol 16, No 2 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i2.1143

Abstract

Burns are damage or loss of tissue that occurs due to exposure to a heat source such as fire, hot liquids or fats, steam, radiation, electric current, or chemicals. Purpose of the research This is to determine the effect and effective dose of the ethanol extract of nutmeg leaves (Myristica fragrans Houtt.) in accelerating the epithelialization process in burn wounds. This study used 15 animals mice were divided into five treatment groups, namely negative control group (Na-CMC), positive control group (lanaeloid), and three test groups that received the dosed extract different: 200 mg/kgBB, 400 mg/kgBB, and 600 mg/kgBB. Burns are induced using a plate heat at 100ºC for 2 seconds on the rat's back. Therapy given topically twice a day for 21 days. Wound area measurements were carried out on days 1, 3, 5, 7, 14, and 21. The research results were statistically tested using the One Way Anova test with the Bonferroni post hoc test. Results The research showed that the positive control group was not significantly different from the test extract group. Based on the research results, it can be concluded that the ethanol extract of nutmeg leaves (Myristica fragrans Houtt.) has an epithelialization effect on mice with an effective dose of 600 mg/kgBB
EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN INFEKSI SALURAN PERNAPASAN ATAS (ISPA) DI PUSKESMAS BIMA MAROA KABUPATEN KONAWE SELATAN PADA BULAN JANUARI-SEPTEMBER TAHUN 2023 Hamsinah, Hamsinah; Kosman, Rachmat; Amalia.B, Putri
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.26992

Abstract

Puskesmas Bima Maroa angka kejadian ISPA tahun 2021 866 kasus dan tahun 2022 yaitu 242 kasus penyakit ISPA dari tahun ke tahun masuk dalam daftar 10 besar penyakit yang ada di puskesmas Bima maroa. Seiring terjadinya peningkatan resistensi antibiotik di seluruh dunia sebagian besar terkait dengan penggunaan antibiotik yang tidak tepat untuk saluran pernapasan bagian atas. Penelitian ini bertujuan untuk mengevaluasi ketepatan penggunaan antibiotik pada pasien infeksi saluran pernapasan atas di Puskesmas bima maroa kabupaten konawe selatan pada bulan januari–september tahun 2023. Penelitian ini merupakan penelitian non eksperimental, deskriptif, dengan pengumpulan data secara retrospektif terhadap pasien infeksi saluran pernapasan atas di Puskesmas bima maroa. Pasien jenis kelamin laki-laki sebanyak 48% dan perempuan 52% merupakan penderita ISPA paling banyak. Antibiotik pada ISPA 84% diberikan Amoxicillin yang merupakan lini pertama dengan evaluasi ketepatan obat yaitu tepat indikasi, tepat pasien, tepat obat dan tepat dosis dengan lama pemakaian antibiotik selama 5 hari 84% dan < 5 hari 16%.
Suplementasi Asam Folat pada Wanita Hamil Trimester Pertama untuk Pencegahan Preeklampsia: Studi Kohort Retrospektif Kamri, Andi Maulana; Putra , Bayu; Kosman, Rachmat; Basri, Putri Septiani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.901

Abstract

Preeclampsia is a disorder characterized by hypertension and proteinuria that manifests during gestation. Various vitamins can influence food consumption during pregnancy. Folic acid supplementation is known to reduce preeclampsia risk, yet adherence remains low among pregnant women. The objective of the research is to identify risk variables and dosage efficacy associated with folic acid utilization. This study employs an retrospective cohort study and utilizes retrospective data collection. Data was gathered from Cahaya Ibu Pharmacy Store in Makassar, encompassing a total of 164 patients. A chi-square statistical study indicated a substantial risk association between pregnant women and the onset of hypertension in comparison to nonpregnant individuals, with a p-value of 0.001. Pregnant women had twice the risk, as shown by an odds ratio of 1.9. The study of Fisher's test data indicates a correlation between patient age and hypertension condition. The findings indicate no substantial correlation between the two variables, with a p-value of 0.523. The findings indicate a substantial correlation between the mitigation of raised blood pressure risk and the consumption of folic acid. The early use of folic acid during pregnancy planning significantly diminishes the likelihood of preeclampsia. Risk factors for preeclampsia include insufficient folic acid consumption, the duration of folic acid supplementation, and the pregnancy status of individuals with a disease risk of up to 98%. Less at age 30 years old, the consumption of folic acid may reduce the risk.
Pengaruh Pemberian Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Terhadap Penurunan Tekanan Sistolik Diastolik Pada Tikus Putih (Rattus norvegicus) Model Hipertensi Putra, Bayu; Azizah, Rizqi Nur; Kosman, Rachmat; Iskandar , A. Nasyrah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.642

Abstract

Hypertension is a major risk factor for cardiovascular diseases and can lead to serious complications if not managed optimally. This study aims to evaluate the effects and optimal dose of ethanol extract of purslane herb (Portulaca oleracea L.) in reducing systolic and diastolic blood pressure in hypertensive male rats. The rats were divided into several groups: a negative control, a positive control (captopril), and three treatment groups receiving ethanol extract of purslane at doses of 100, 200, and 300 mg/kg body weight. Systolic and diastolic blood pressure were measured throughout the study to assess the antihypertensive activity of the extract. The results showed that purslane extract at doses of 100, 200, and 300 mg/kg body weight significantly lowered blood pressure, likely due to bioactive compounds such as flavonoids, saponins, and phenols. These compounds exhibit vasodilatory activity, ACE enzyme inhibition, and diuretic effects that contribute to blood pressure reduction in the hypertensive rat model. Ethanol extract of purslane herb (Portulaca oleracea L.) was found to have a significant effect in reducing systolic and diastolic blood pressure in hypertensive rats, with the optimal dose for significant blood pressure reduction being 300 mg/kg body weight
EDUKASI TENTANG KOLESTEROL PADA IBU PKK DESA PADDINGING KECAMATAN SANROBONE KABUPATEN TAKALAR Amirah, Sitti; Kosman, Rachmat; Fitriana; Rahman, Safriana; Rusli; Putra, Bayu; Nuryanti, Siska; Harly Nurung, Ayyub
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 1 No. 2 (2023): April 2023
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2023.v1.i2.16306

Abstract

Cholesterol is a lipid compound needed by the body as an essential component of cell membranes, hormone synthesis, energy sources and other needs. The body needs lipids in moderate amounts, the average adult's cholesterol requirement is around 1100 mg of cholesterol/day. About 25-40% of cholesterol needs are obtained from food and the rest is obtained from synthesis by the body. High cholesterol levels can trigger atherosclerosis, hardening and narrowing of the arteries which can lead to various diseases such as ischemia, stroke, heart attack. By looking at the daily life of the people in Paddinding village, kec. Sanrobone, where the majority of farmers are farmers, allows the public to ignore information about health, so education is needed to improve public health status. This activity is carried out using lecture and discucussion methods that are focused on providing understanding to the public about cholesterol, what is the role of cholesterol in the body, sources of cholesterol, how to prevent and deal with cholesterol disorders. Community service activities carried out are one of the means to increase public knowledge about how to prevent and treat cholesterol disorders.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Bakteri Penyebab Infeksi Saluran Pencernaan Dengan Metode Difusi Agar Rabbana, Rahmawati; Kosman, Rachmat; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.41

Abstract

The purpose of this research was to determine the antibacterial activity of the ethanol extract of Javanwood leaves Lannea coromandelica (Houtt.) Merr.) against bacteria that cause digestive tract infections. The research method begins with the extraction process using the maceration method with 96% ethanol solvent and evaporated using a rotary evaporator. Java wood leaf ethanol extract was subjected to screening tests with a concentration of 0.1%; 0.5%; and 1% against the test bacteria Eschericia coli, Salmonella typhi, Shigella dysenteriae and Vibrio cholerae. MIC and MBC tests were carried out and continued with antibacterial activity tests using the agar diffusion method with variations in concentrations of 0.5%; 1%; 2%; 4%; 8%; and 16%. The results of the screening test for Escherichia coli and Shigella dysenteriae bacteria at 0.5%. MIC values for Escherichia coli bacteria at 0.125% and Shigella dysenteriae bacteria at 2%. While the MBC value for Escherichia coli bacteria is at 0.5% and Shigella dysenteriae bacteria at 2%. The results of testing the antibacterial activity of the ethanol extract of Javanwood leaves against Escherichia coli and Shigella dysenteriae bacteria had the largest diameter of the inhibition zone at a concentration of 16%, respectively 17.10 mm; and 13.56 mm which is included in the criteria of having strong inhibition. Based on the results of the ethanol extract of Javanwood leaves, it has potential as an antibacterial.
AKTIVITAS ANTIBAKTERI FRAKSINASI EKSTRAK DAUN ASAM JAWA (Tamarindus indica L.) (Tamarindus indica L.) TERHADAP BAKTERI Salmonella thyphi DAN Escherichia coli DENGAN METODE KLT-BIOAUTOGRAFI Rusli, Rusli; Faradila, Aulia; Kosman, Rachmat
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.87

Abstract

Tropical infectious diseases are often caused by viruses, bacteria, fungi or even parasites. Indonesian people use medical plants to treats diseases. One of them is tamarind leaves which have the ability as an antibacterial. The purpose of this study was to determine the antibacterial activity of the fractionated extract of tamarind leaves (Tamarindus indica L.) against Salmonella thyphi and Escherichia coli. Tamarind leaf simplicial was extracted using the maceration method and evaporated with a rotary evaporator to obtain thick extract. Then fractionated using n-hexane and ethyl acetate and evaporated again with a rotary evaporator. After that, ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) was used for antibacterial screening test with a concentration of 0,1% and 0,5%. Then, the TLC-Bioautography test was carried out and followed by the identification of chemical components. The results of the screening test of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) showed antibacterial activity against Salmonella thyphi and Escherichia coli. TLC-Bioautography test result showed that it was active on Salmonella thyphi and Escherichia coli with an Rf value of 0,81. Then the results of the identification of the chemical component of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) were positive for alkaloid and taninns. Based on this study, tamarind leaves have the potential as an antibacterial.
Co-Authors Achmad Rosyadi Yusuf Hibai, Achmad Rosyadi Yusuf Adrias, Cici Rahmayanti Amalia.B, Putri Andi Maulana Kamri Aulia Wati, Aulia Azhary, Nursyahidah Basri, Putri Septiani Bayu Putra, Bayu Faradila, Aulia Febrilia Mahmud, Melly Fitriana FITRIANI, SITTI ANNISA Hamdani, Nina Hamsinah Hamsinah, Hamsinah Hativa, Hativa Herwin Herwin, Herwin Ika Indra Wijaya, Ika Indra Ira Damayanti, Ira Irma Santi, Irma Iskandar , A. Nasyrah Jamaluddin Jamaluddin Junaedi, Fhadillah Kurniati Tappang, Kurniati Melinda, Pina Muhammad Amin Muzakkir Baits, Muzakkir Nur Ismayani, Nur Nurfadila Nurfadila, Nurfadila Nurmaya Effendi Nurul Inayah Nurung, Ayyub Harly Pirman AP, Pirman Putra , Bayu R. Rusli Rabbana, Rahmawati Rahmadani, Andi Syafirah Rahman, Safriana Rahmawati, Rahmawati Ramadhani, Fitrah Anggun Riany Novianti Y., Riany Rizqi Nur Azizah Rusli Safriani Rahman, Safriani Sahide, Rusli Sari, Dewi Mustika Sari, Erwika Dwika Siska Nuryanti, Siska Sitti Amirah Sri Wahyuni Sudrianto Sudrianto, Sudrianto Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Wirawan, Alif Yusra Zainal Abidin