Article Per Year (5 Year)
p-Index From 2020 - 2025
1.789
P-Index
This Author published in this journals
All Journal Jurnal Sains dan Teknologi Farmasi AcTion: Aceh Nutrition Journal Journal SAGO Gizi dan Kesehatan Gemakes: Jurnal Pengabdian Kepada Masyarakat International Journal of Health and Pharmaceutical (IJHP) Jurnal Natural Jurnal Kedokteran Hewan Indonesian Journal of Pharmacy and Natural Product Jurnal Ilmiah Farmasi Simplisia
Noni Zakiah
Pascasarjana Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Uji Toksisitas Perkembangan Siprofloksasin dan Studi Histologi Terhadap Mencit Putih Zakiah, Noni; Almahdy, Almahdy; Muchtar, M. Husni
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A study was conducted to determine the “development toxicity” of ciprofloxacin and litters kidney. The aim of this study was to observe teratogenic effect of ciprofloxacin, and observing its effect on behaviour development and litters kidney. Twenty four pregnant mice were divided into 4 groups : control, and treatments with oral dose of ciprofloxacin of 14,3 mg, 28,5 mg, and 57,1 mg/kg body weight/day for 10 days, coincided with sixth day until fifteenth day of pregnancy for prenatal and posnatal test. Half of the animals were killed on day 18 of gestation and the others half were allowed to deliver. Fetuses were removed by caesarean section. For postnatal test, ciprofloxacin exposed at first day of lactation until weaning. Behaviour toxicity was conducted by Behavioral Test Battery, and observing its effect on litters kidney by paraffin method. Quantitative data were analyzed with Anova and Duncan’s Multiple Range Test. Results showed that teratogenic effects of ciprofloxacin were fetuses death, resorption and hemorrhage. For behaviour toxicity, delayed ability was noticed at 28,5 mg/kg BW obviously, histologically there were disturbances of kidney, which were the thickening of bowman’s capsule, constriction of glomerular capillaries and necrosis.
ARSENIC CONTAMINATION SURVEY IN WHITE RICE IN ACEH Hanum, Farida; Sudiarto, Dwi; Zakiah, Noni; Safwan, Safwan; Al Rahmad, Agus Hendra
AcTion: Aceh Nutrition Journal Vol 4, No 2 (2019): AcTion Vol 4 No 2 Tahun 2019
Publisher : Jurusan Gizi Politeknik Kesehatan Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (924.072 KB) | DOI: 10.30867/action.v4i2.177

Abstract

White rice as the major staple food for Indonesian people has the opportunity to be contaminated with chemical hazards. Research in USA shows that arsenic is contained in rice. The arsenic emissions of 75% are estimated to originate from the mining, fertilizers and pesticides. This study aims to determine qualitatively arsenic contamination of white rice consumed by Acehnese people and how to cook it. A total of 30 white rice samples were obtained with purposive technique from the Aceh Health Polytechnic employees who brought breakfast. The the consideration that they come from various regions in Aceh. Arsenic analysis contamination in samples was carried out using arsenic test kit. Data collected is in the form of interviews about white rice cooking techniques and the analysis of arsenic contamination. The results showed that white rice consumed by the employees was safe from arsenic and that the rice cooking technique on a household is feasible. Besides that the arsenic test was also carried out on white rice sold in stalls, the results were positive. This indicates that white rice is consumed by people in Aceh, there are those which are contaminated with arsenic. This study provides evidence that the contamination is still present in rice which has been processed into rice cooked.  Keywords:   ABSTRAKNasi putih sebagai salah satu sumber makanan pokok di Indonesia memiliki peluang tercemar bahan kimia yang sangat berbahaya. Penelitian di USA menunjukkan bahwa arsen terkandung di dalam beras, 75% emisi arsen diperkirakan berasal dari aktivitas penambangan, pemupukan dan pestisida. Penelitian ini bertujuan untuk mengetahui cemaran arsen secara kualitatif pada nasi putih di Aceh dan bagaimana teknik memasaknya. Penelitian ini merupakan survey deskriptif berbasis laboratorium. Populasi adalah seluruh pegawai Poltekkes Kemenkes Aceh. Sebanyak 30 sampel nasi putih dicuplik secara purposif dari 30 orang pegawai yang membawa bekal sarapannya. Pertimbangan bahwa mereka berasal dari berbagai daerah di Aceh. Analisis arsen menggunakan arsen test kit. Data primer dikumpulkan dari hasil wawancara tentang teknik memasak nasi putih dan hasil analisis arsen pada nasi putih. Hasil penelitian menunjukkan bahwa nasi putih yang dikonsumsi oleh pegawai Poltekkes Kemenkes Aceh aman dari cemaran arsen. Hasil ini menegaskan bahwa teknik memasak nasi pada skala rumah tangga dapat menghasilkan nasi putih yang bebas dari cemaran kimia arsen. Analisis arsen juga dilakukan pada nasi putih yang dijual di warung sebagai pembanding, hasilnya positif. Ini menunjukkan bahwa nasi putih yang dikonsumsi oleh masyarakat Aceh, ada yang tercemar arsen. Penelitian ini membuktikan bahwa cemaran arsen masih ada pada beras yang telah diolah menjadi nasi.
Nilai nutrisi ekstrak buah nipah dan pengaruhnya terhadap glucose transporter-2 (GLUT-2) pada tikus yang diinduksi STZ Fitri, Yulia; Wagustina, Silvia; Husna, Fauzul; Suryana, Suryana; Zakiah, Noni; Sastri, Sastri
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 2 (2024): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i2.1669

Abstract

Background: The nutritional content of nipah fruit such as zinc and fiber plays an important role in regulating blood sugar levels in diabetes patients (DM). One way to increase the concentration of nutritional value and bioactive substances in palm fruit is to extract it. Active compounds such as tannins, flavonoids, polysaccharides, saponins, and terpenoids in palm fruit extract can inhibit the activity of amylase and glucosidase enzymes, which are mediated by Glucose Transporter-2 (GLUT-2) so that they affect controlling blood sugar levels. GLUT-2 is a protein that plays a role in transporting glucose from outside to inside cells, so it plays an essential role in maintaining balanced blood sugar levels.Objective: This research aims to examine the nutrients in palm fruit extract and its effect on Glucose transporter-2 (GLUT-2) in STZ-induced  in rats.Method: This study is experimental research using experimental laboratory methods carried out in the FKH USK laboratory in June 2022. Making nipah fruit extract is carried out by maceration using 95% ethanol. Carbohydrate, protein, fat, zinc, and Fe levels were analyzed using the Luff Schoorl, Kjeldahl, Soxhletasi, and AAS test method. Testing for water content and crude fibre uses a gravimetric test. Twenty-five rat samples were divided into four groups and induced with STZ 40 mg/kg BW. Checking blood sugar levels is needed to see hyperglycemic conditions in rats. GLUT-2 measurement after administering nipah extract for one month using the ELISA technique. The data obtained were analyzed by an ANOVA test.Results: Based on the results, it was found that fruit extract contained 15,79% carbohydrates, 7,04% protein, 6,02% fat, 0,0327% zinc, water content 24,05% and crude fibre 0,36%. The average GLUT-2 level in the control group was 7,24 ± 1,35 ng/ml, the DM group was 6,75 ± 0,81 ng/ml, the DM+extract group was 6,84 ± 0,56 ng/ml, the DM+metformin group was 7,34 ± 0,86ng/ml, and the DM+extract+metformin group was 6,93± 1,01 ng/ml.Conclusion: Nipah fruit extract contains carbohydrates, protein, fat and zinc. Administration of palm fruit extract for one month did not significantly effect on GLUT-2 in various groups of rats (0,83).  
Pengaruh Lama Pemakaian Sediaan Kosmetik Bedak Padat Terhadap Cemaran Mikroba Munira, Munira; Fardilla, Cut; Zakiah, Noni; Rasidah, Rasidah; Nasir, Muhammad
Indonesian Journal of Pharmacy and Natural Product Vol. 3 No. 1 (2020)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.169 KB) | DOI: 10.35473/ijpnp.v3i1.421

Abstract

Bedak adalah salah satu sediaan kosmetik yang dipakai dalam jangka waktu yang lama. Bedak yang digunakan akan terjadi kontaminasi bahkan semakin meningkat seiring dengan lamanya pemakaian. Faktor-faktor yang mempengaruhi antara lain penyimpanan, lingkungan, dan spons bedak. Penggunaan spons bedak merupakan salah satu sumber cemaran bakteri. Di mana penggunaan spons yang sama secara berulang-ulang dan bersentuhan langsung pada kulit dapat meningkatkan jumlah mikroba. Tujuan penelitian ini adalah untuk mengetahui pengaruh lamanya penyimpanan, pemakaian suatu sediaan kosmetik bedak padat terhadap tingkat cemaran mikroba. Sampel yang diuji adalah bedak padat yang belum dipakai dan yang telah dipakai selama 2 minggu. Hasil penelitian berupa jumlah cemaran bakteri (ALT) dibandingkan dengan syarat menurut Peraturan Kepala Pengawasan Obat dan Makanan RI No.HK.03.1.23.07.11.6662 Tahun 2011 yaitu tidak boleh melebihi 103 koloni/g. Hasil uji cemaran bakteripada sediaan bedak padat sebelum pemakaian mempunyai nilai rata-rata ALT 2,6 x 101koloni/g dan sesudah pemakaian mempunyai nilai rata-rata ALT 9,2 x 101 koloni/g. Nilai ALT yang diperoleh dari masing-masing sediaan kosmetik bedak padat telah memenuhi syarat.Hasil uji t dependen menunjukkan adanya perbedaan jumlah bakteri pada bedak padat sebelum dipakai dengan setelah dipakai selama 2 minggu (t = 0.000). Kata Kunci: Kosmetik, bedak padat, Angka Lempeng Total ABSTRACTPowder is one of the cosmetic preparations used for a long time. Powder that is used will occur contamination even increasing along with the length of usage. This can be caused by several factors including storage, environment, powder sponges and others. The use of powder sponges is one source of bacterial contamination. Where the use of the same sponge repeatedly and in direct contact with the skin can increase the number of microbes. The objective of study was to determine the effect of the duration of use of a compact powder cosmetic preparation on the level of microbial contamination. The samples tested were solid powder that has not been used and that has been used for 2 weeks. The results of the study were the Total Plate Count (TPC) compared to the Regulation of the Head of the Republic of Indonesia Drug and Food Control Number HK.03.1.23.07.11.6662 of 2011 concerning the Requirements for Microbial Pollution and Heavy Metals in Cosmetics which should not exceed 103 colonies / g. The test results of bacterial contamination on solid powder preparations before use have an average value of ALT 2,6 x 101 colony / g and after use have an average ALT value of 9.2 x 101 colony / g. The ALT value obtained from each compact powder cosmetic preparation has met the requirements. The results of the dependent t test showed a difference in the number of bacteria on solid powder before use with after being used for 2 weeks (t = 0.000). Keywords: Cosmetics, Compact Powder, Total Plate Count
Anti-Inflammatory Effect Of Carica Papaya Leaves Extract In Male Wistar Rats Based On Variation Of Concentration Aulianshah, Vonna; Ratu Thaharah, Yelda; Zakiah, Noni; Handayani, Rini
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i3.279

Abstract

Treatment of inflammation is currently dominated by using synthetic drugs, which if used in cases of chronic inflammation such as hyperuricemia and rheumatoid arthritis will carry the risk of increasing side effects for the user. Papaya leaves as a potential herb in some communities are also used as a treatment for inflammatory conditions. The aim of this research was to determine the anti-inflammatory effect of papaya leaf extract in vivo based on variations in concentration in Wistar white rats. This research is an in vivo study using 25 male Wistar Rats and divided into 5 groups. Group I was given as a negative control (P0), the group used Diclofenac Sodium as a positive control (P1), the Carica papaya leaf extract test group with varying concentrations of 40% (P2), 50% (P3), and 60% concentration (P4). Carrageenan 1% is used as an inflammation inducer. The inflammation observation parameter in this study was the volume of edema in the rats' feet at 30 minute intervals for 180 minutes. The average percentage reduction in edema during 180 minutes of observation in the P2, P3 and P4 extract test groups was 81.00%, 78.33% and 81.00%, respectively. The positive control group (P1) showed a reduction of 81.66%, while the negative control was only 26%. The results of statistical tests show that there is an effect of giving the extract on reducing edema in mice compared to the negative control group. From these results it can be concluded that the ethanol extract of Carica papaya leaves with concentrations of 40%, 50% and 60% showed an anti-inflammatory effect on male Wistar rats.
Multi-drug resistance-1 (MDR-1) gene expression in MCF-7 cells after treated with doxorubicin-deoxyelephantopin combination and prediction of inhibitory activity against Pgp receptors with in silico DANIEL, DANIEL; FRENGKI, FRENGKI; JALALUDDIN, MUHAMMAD; SARI, WAHYU EKA; ROSMAIDAR, ROSMAIDAR; HASRIATI, HASRIATI; ZAKIAH, NONI
Jurnal Natural Volume 24 Number 3, October 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i3.33237

Abstract

Doxorubicin chemotherapy has been a strong focus in breast cancer research. Side effects, toxicity and resistance have been extensively studied. One proposed solution to these issues that its combination with deoxyelephantopin. Deoxyelephantopin is known to be toxic in many cancer cells but safe in normal cells. IC50 of each compound were determined by using a MTT assay, and the MDR-1 gene mRNA expression were determined by using qPCR method, while the interaction of doxorubicin in combination with deoxyelephantonin on Pgp receptor were predicted by using an in silico approach. The IC50 of deoxyelephantopin was found to be 11.2 g/mL, while IC50 of doxorubicin was 448 nM IC50 values showed a deoxyelephantopin-doxorubicin combination was able to reduce MDR-1 expression by 19% compared to doxorubicin and IC50 values indicated that the combination formula reduced the expression by 15% over doxorubicin alone. The affinity of doxorubicin and deoxyelephantopin is -12.16 kcal/mol and -9.51 kcal/mol, respectively, while the affinity of doxorubicin after combine with deoxyelephantopin decreases from -12,16 kcal/mol to -11,25 kcal/mol due to the release of one Leu 221 hydrogen bond. The combination of doxorubicin with deoxyelephantopin is able to reduce expression and suppress the function of the Pgp protein.
UJI EFEKTIVITAS EKSTRAK BIJI PEPAYA (Carica papaya L.) SEBAGAI ANTHELMINTIK TERHADAP CACING Ascaridia galli: UJI EFEKTIVITAS EKSTRAK BIJI PEPAYA (Carica papaya L.) SEBAGAI ANTHELMINTIK TERHADAP CACING Ascaridia galli Khaliza, Nur; Handayani, Rini; Aulianshah, Vonna; Zakiah, Noni; Munira, Munira; Nindia, Yuni
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 1 (2025): Juni 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i1.890

Abstract

Infeksi cacing masih menjadi masalah kesehatan yang umum di negara tropis seperti Indonesia. Salah satu tanaman yang banyak dibudidayakan di Indonesia adalah pepaya (Carica papaya L.), yang bijinya diketahui memiliki sifat anthelmintik, tetapi biji pepaya seringkali dibuang tanpa dimanfaatkan. Penelitian ini bertujuan untuk mengetahui efek ekstrak biji pepaya terhadap mortalitas cacing Ascaridia galli. Sebanyak 75 ekor cacing digunakan dalam penelitian ini, dibagi dalam tiga kali ulangan, masing-masing terdiri dari lima kelompok perlakuan: kontrol negatif (NaCl 0,9%), kontrol positif (Pirantel Pamoat 0,5%), serta ekstrak biji pepaya dengan konsentrasi 10%, 15%, dan 20%. Penilaian dilakukan berdasarkan skor gerakan cacing setelah inkubasi selama 12, 24, dan 36 jam. Skor 2 diberikan jika seluruh tubuh cacing bergerak, skor 1 diberikan jika cacing tidak bergerak namun masih hidup, dan skor 0 diberikan jika cacing mati. Hasil uji in vitro menunjukkan bahwa ekstrak biji pepaya 10% menyebabkan kelumpuhan pasca inkubasi 12 jam pertama dan kematian seluruh cacing setelah 24 jam pasca inkubasi. Konsentrasi 15% dan 20% menyebabkan kematian pada semua cacing pasca inkubasi 12 jam pertama. Hasil penelitian ini dapat disimpulkan bahwa ekstrak biji pepaya konsetrasi 10%, 15% dan 20% efektif sebagai anthelmintik terhadap Ascaridia galli.
Variasi tipe pelarut dan pengaruhnya terhadap kadar flavonoid total daun kirinyuh (Chromolaena odorata) yang tumbuh di kawasan geotermal Ie Seum Aceh Besar menggunakan spektrofotometri uv-vis Munira, Munira; Zakiah, Noni; Handayani, Rini; Nasir, Muhammad; Frengki, Frengki
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 2 (2025): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i2.2575

Abstract

Background: One plant that can be a source of natural healing for various ailments is the kirinyuh (Chromolaena odorata). This plant can grow in geothermal areas. Plants grown in geothermal areas have the potential to produce higher levels of active substances. The kirinyuh plant is rich in flavonoid compounds. Flavonoids have antioxidant, anti-inflammatory, antibacterial, antiviral properties, and have potential as anticancer agents. The level and quality of flavonoid compounds are influenced by the type of solvent.Objectives: This study was conducted to determine the total flavonoid content of kirinyuh leaf extract from the Ie Seum geothermal area of Aceh Besar based on different types of solvents.Methods: Determination of total flavonoid content using UV-Vis spectrophotometry and quercetin was used as a standard in the measurement. Each measurement was repeated three times. The results were analyzed using an independent t-test.Results: The results of the determination of total flavonoid levels obtained in kirinyuh leaves using ethanol solvent were 10,65 mg QE/g and ethyl acetate was 8,97 mg QE/g. Based on the results of the Independent T-test, a significance result of 0,000 (P<0,05) was obtained. These results indicate that there is a difference in total flavonoid levels between ethanol and ethyl acetate solvents.Conclusion: The total flavonoid content using ethanol solvent types were higher than ethyl acetate.
PENINGKATAN KAPASITAS ALUMNI DALAM IMPLEMENTASI PEMANFAATAN DAUN KELOR BAGI KESEHATAN IBU HAMIL: INCREASING ALUMNI CAPACITY IN IMPLEMENTING THE UTILIZATION OF MORINGA LEAVES FOR THE HEALTH OF PREGNANT WOMEN Halimatussakdiah, Halimatussakdiah; Abdurrahman, Abdurrahman; Ahmad, Aripin; Zakiah, Noni
GEMAKES: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2025): GEMAKES: Jurnal Pengabdian Kepada Masyarakat
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36082/gemakes.v5i3.2741

Abstract

Daun kelor merupakan bahan yang mudah didapat dan dapat dikembangkan dalam usaha  pangan berkualitas untuk pencegahan anemia ibu hamil. Data dari BPS tahun 2021, menyebutkan bahwa, usaha  di Indonesia saat ini didominasi oleh kegiatan perdagangan   besar dan eceran (37,72 %) yang berupa Industri, sedangkan usaha yang bersifat pengolahan hanya (16,28 %). Pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan wirausaha produk kelor pada alumni Poltekkes Kemenkes Aceh. Pengabmas ini menggunakan pendekatan Proses Keperawatan komunitas meliputi: 1) Pengkajian dengan melakukan pengumpulan data jumlah peserta dari Ka Prodi, 2) Membuat perencanaan dan koordinasi dengan narasumber 3) Melakukan pretest pembekalan materi dan praktik ke UMKM, 4) melakukan posttest, 5) pengolahan dan analisis data dan 6) melakukan evaluasi. Pengabmas dilakukan tanggal 1 – 2 Agustus 2024 di Poltekkes Kemenkes Aceh dan UMKM Aroma Food. Jumlah peserta 20 orang dari 5 Jurusan di Poltekkes kemenkes Aceh. Analisis data menggunakan komputer dan data disajikan dalam bentuk tabel dan dilakukan penjelasan narasi atau deskriptif.  Hasil nilai pretest didapatkan nilai dominan pada katagori baik sebanyak 13 orang (65 %) dan pada meningkat nilai posttest yaitu18 orang (90 %) pada katagori baik. Sisanya pada katagori nilai cukup. Kegiatan pengabdian bermanfaat untuk peningkatan pengetahuan dan keterampilan alumni tentang usaha dan tehnis pemasaran produk olahan daun kelor. Diharapkan setelah pengabmas ini adanya kader wirausaha dari alumni Poltekkes Kemenkes Aceh dalam bentuk UMKM makanan siap saji  untuk pencegahan anemia ibu hamil dari bahan kelor yang dipasarkan secara online.
Uji Aktivitas Analgetik Teh Daun Ciplukan (Physalis angulata L.) terhadap Mencit (Mus musculus) Betina Handayani, Rini; Aulianshah, Vonna; Zakiah, Noni; Putri, Zahrifa Adinda; Halimatussakdiah, Halimatussakdiah
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 3 No. 2 (2023): Desember 2023
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v3i2.444

Abstract

Analgetik adalah bahan atau obat yang digunakan untuk menekan atau mengurangi rasa sakit tanpa menyebabkan hilangnya kesadaran.  Nyeri merupakan suatu kejadian sensorik dan emosional yang tidak menyenangkan ditandai dengan adanya kerusakan jaringan. Penelitian ini bersifat eksperimentel yang bertujuan untuk menentukan efek analgetik teh daun ciplukan (Physalis angulata L.) terhadap Mencit (Mus musculus) Betina dan untuk mengetahui dosis teh daun ciplukan (Physalis angulata L.) yang dapat memberikan efek analgetik pada Mencit (Mus musculus) Betina. Teh daun ciplukan diseduh dengan air panas pada suhu 90⁰C sebanyak 200 mL kemudian kantong teh dicelup naik turun selama 5 menit.  Penelitian ini  dibagi atas  5 kelompok perlakuan yaitu perlakuan kontrol negatif, kontrol positif,  teh daun ciplukan 0,2 mL/20 g BB mencit (dosis I);  teh daun ciplukan 0,4 mL/20 g BB mencit (dosis II); dan teh daun ciplukan 0,6 mL/20 g BB mencit (dosis III).  Hasil uji aktivitas analgetik teh daun ciplukan terhadap mencit betina pada dosis I, dosis II dan dosis III mempunyai aktivitas sebagai analgetik. Berdasarkan uji LSD teh daun ciplukan terhadap mencit betina pada dosis I dan dosis II ada perbedaan signifikan dengan kontrol positif yaitu paracetamol (p≤0,05), sedangkan dosis III tidak ada perbedaan signifikan dengan kontrol positif yaitu paracetamol (p≥0,05).
Co-Authors Abdurahman Abdurrahman Agus Hendra Al Rahmad Almahdy A Aripin Ahmad, Aripin Aulianshah, Vonna Daniel Daniel Fardilla, Cut Farida Hanum Frengki Frengki, Frengki Frengki, F Halimatussakdiah Halimatussakdiah Hasriati Hasriati, Hasriati Husna, Fauzul Khaliza, Nur Muchtar, M. Husni Muhammad Jalaluddin, Muhammad Muhammad Nasir Munira Munira, Munira Munira, M Nindia, Yuni Putri, Zahrifa Adinda Rasidah Rasidah Rasidah, R Ratu Thaharah, Yelda Rini Handayani Rony, Zahara Tussoleha Rosmaidar Rosmaidar, Rosmaidar Safwan Safwan, Safwan Sari, Wahyu Eka Sastri Sastri Silvia Wagustina, Silvia Sudiarto, Dwi Suryana Suryana Yulia Fitri