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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy Jurnal Mandala Pengabdian Masyarakat Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) JUKESHUM: Jurnal Pengabdian Masyarakat INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Kreasi: Jurnal Inovasi dan Pengabdian Kepada Masyaraka Sinteza Jurnal Teknologi Informasi untuk Masyarakat (Jurnal Teknokrat)
Leny Ramadhan
Universitas Hamzanwadi
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Efficacy of Sodium Hypochlorite (NaOCl) Against Gram Positive and Gram Negative Bacteria: A Systematic Literature Review Jeli Marlita; Yuyun Febriani; Baiq Risma Fatmayanti; Leny Ramadhan
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12508

Abstract

Sodium hypochlorite (NaOCl) is a chemical compound that acts as a strong oxidizer commonly used as an antibacterial, antiseptic, and disinfectant in various pharmaceutical and health applications. This systematic review aims to evaluate the antibacterial activity of NaOCl against various types of bacteria based on the PICO framework. Literature searches were conducted through the PubMed, ScienceDirect, and Scopus databases for publications from 2017 to 2024. Inclusion criteria included all types of bacteria, the use of NaOCl as an antibacterial or antimicrobial agent, and articles published within that time frame. The interventions reviewed were the use of NaOCl at various concentrations, while the control group referred to conditions without treatment or a comparative antibacterial agent. The results were determined based on antimicrobial activity against the bacteria tested. Two stages of independent literature searches were conducted according to the established inclusion and exclusion criteria. This review shows that NaOCl has significant antibacterial activity against various bacteria, with effectiveness depending on the concentration and characteristics of the target microorganisms.
Co-Authors Anjani, Rizky Puji Arief Rafsanjani Baiq Maylinda Gemantari Baiq Nurul Hikmah Baiq Rahmania Maulida Azra Baiq Risma Fatmayanti Baiq Risma Fatmayanti Budi Ramdhani Erma Ewisa Oktresia Fifi Nurma Ariati Fitriwati Sovia Jeli Marlita Jeli Marlita Lalu Erpan Suryadi Lili Listiani MGS Aritonang Muhammad Anshory Muhammad hasim Muhammad Zaldi Hidayatullah Muhlisun Azim Ramadani, Lalu Khilal Sari Sukma Aulia Tri Puspita Yuliana Yusi Anggriani Yuyun Febriani Yuyun Febriani