Article Per Year (5 Year)
p-Index From 2021 - 2026
2.976
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry The Indonesian Journal of Public Health Jurnal Sport Science Jurnal SOLMA Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Ners Heart Science Journal Jurnal Mandala Pengabdian Masyarakat JOURNAL LA MEDIHEALTICO Narra J IJOHCM Cendikia: Jurnal Pendidikan dan Pengajaran EduInovasi: Journal of Basic Educational Studies Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Anditri Weningtyas
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 19 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 19 Documents
Search

 1   2 
UNVEILING THE ANTIDIABETIC POTENTIAL OF KEMUNING LEAVES (Murraya paniculata L. Jack): AN IN-SILICO EXPLORATION OF DPP-4 INHIBITORY ACTIVITY Ladika Wiratama, Arif; Aulia Nanda, Taurisma; Hidayah, Farsya; Weningtyas, Anditri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.12920

Abstract

Type 2 diabetes mellitus is a global health issue associated with insulin resistance and impaired glucose metabolism. Murraya paniculata L. Jack (kemuning) has shown antidiabetic potential, yet its role as a DPP-4 inhibitor remains underexplored. This study aimed to investigate the potential of kemuning leaf bioactive compounds as natural DPP-4 inhibitors through an in-silico approach. Compound structures were obtained from the PubChem database and analyzed using AutoDock Vina for molecular docking against the DPP-4 protein. Pharmacokinetic properties, toxicity, and drug-likeness were evaluated using pkCSM and SwissADME, while complex stability was assessed through molecular dynamics simulation (RMSF). The results showed that most compounds demonstrated favorable binding affinities (−6.8 to −7.9 kcal/mol), along with acceptable pharmacokinetic and toxicity profiles. Among the tested compounds, 1-aminoindan-1,5-dicarboxylic acid emerged as the most promising candidate for natural DPP-4 inhibition.
UNVEILING THE ANTIDIABETIC POTENTIAL OF KEMUNING LEAVES (Murraya paniculata L. Jack): AN IN-SILICO EXPLORATION OF DPP-4 INHIBITORY ACTIVITY Ladika Wiratama, Arif; Aulia Nanda, Taurisma; Hidayah, Farsya; Weningtyas, Anditri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.12920

Abstract

Type 2 diabetes mellitus is a global health issue associated with insulin resistance and impaired glucose metabolism. Murraya paniculata L. Jack (kemuning) has shown antidiabetic potential, yet its role as a DPP-4 inhibitor remains underexplored. This study aimed to investigate the potential of kemuning leaf bioactive compounds as natural DPP-4 inhibitors through an in-silico approach. Compound structures were obtained from the PubChem database and analyzed using AutoDock Vina for molecular docking against the DPP-4 protein. Pharmacokinetic properties, toxicity, and drug-likeness were evaluated using pkCSM and SwissADME, while complex stability was assessed through molecular dynamics simulation (RMSF). The results showed that most compounds demonstrated favorable binding affinities (−6.8 to −7.9 kcal/mol), along with acceptable pharmacokinetic and toxicity profiles. Among the tested compounds, 1-aminoindan-1,5-dicarboxylic acid emerged as the most promising candidate for natural DPP-4 inhibition.
Formulation and Characterization Profile of Sugarcane (Saccharum officinarum L.) Leaf Extract Emulsion Sishartami, Lintang Widya; Weningtyas, Anditri; Ariesaka, Kiky Martha; Wiratama, Arif Ladika; Wibisono, Taurisma Aulia Nanda
Jurnal Biologi Tropis Vol. 25 No. 4b (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4b.10932

Abstract

Sugarcane (Saccharum officinarum L.) leaves contain various bioactive compounds, which exhibit antioxidant and pharmacological potential. However, their application in pharmaceutical preparations faces challenges due to low solubility, stability, and bioavailability. Therefore, the development of an emulsion formulation is needed to improve its stability and absorption. This study aims to determine the phytochemical content of sugarcane leaf extract and to evaluate the physical stability of its emulsion formulation. The extraction was obtained through maceration using 96% ethanol, followed by phytochemical screening. Emulsions were prepared using sugarcane leaf extract as the active ingredient, Virgin Coconut Oil (VCO) as the oil phase, Tween 80 as a surfactant, and PEG 400 as a co-surfactant. The formulations were tested for organoleptic properties, emulsion type, percent transmittance, pH, particle size, polydispersity index, zeta potential, centrifugation, and cycling stability. The results showed that sugarcane leaf extract contained flavonoids, alkaloids, tannins, phenols, triterpenoids, and saponins. Among the four tested formulas, F1 and F2 showed the best stability, with pH 6–7, high percent transmittance, uniform particle size with polydispersity index <0.3, and absence of phase separation. These findings suggest that F1 and F2 represent optimal emulsion formulations for further pharmaceutical development.
SANTERA (Santri Sehat Terawat): Edukasi Penyakit Menular Berbasis Lingkungan dan Gaya Hidup Sehat bagi Santri Ariesaka, Kiky Martha; Sishartami, Lintang Widya; Weningtyas, Anditri; Iftitahurroza, Hilma Tsurayya; Ismaya, Matius Dimas Reza Dana; Wiratama, arif Ladika; Wibisono, Taurisma Aulia Nanda; Bakhtiar, Fannia Yosa
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.672

Abstract

Lingkungan pesantren yang padat dan komunal menyebabkan santri rentan terhadap penyakit menular serta gaya hidup tidak sehat. Berdasarkan hasil wawancara dengan guru, ditemukan masalah kesehatan yang dominan seperti skabies, diare, serta kelelahan akibat kebiasaan menahan buang air besar dan melewatkan sarapan. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan kesadaran santri mengenai pentingnya kebersihan diri dan gaya hidup sehat melalui edukasi kesehatan kontekstual. Kegiatan dilaksanakan dalam tiga tahap kunjungan dan menggunakan pendekatan model ADDIE yang mencakup analisis kebutuhan, perancangan materi, pengembangan media edukatif berupa presentasi dan flyer, pelaksanaan edukasi secara interaktif kepada santri, serta evaluasi menggunakan kuesioner kepuasan. Hasil menunjukkan bahwa seluruh indikator kepuasan memperoleh skor rerata tinggi, berkisar antara 76,5% hingga 83%, dengan kategori sangat baik. Selain itu, peserta menunjukkan antusiasme dan partisipasi aktif selama sesi edukasi, serta adanya niat untuk menerapkan dan menyebarluaskan informasi yang diperoleh. Tim pengabdian juga memberikan dukungan fasilitas kesehatan berupa alat kebersihan, alat pemeriksaan sederhana, dan obat-obatan umum yang dibutuhkan oleh Unit Kesehatan Pesantren. Kegiatan ini memberikan dampak positif jangka pendek dalam hal peningkatan pengetahuan dan kesadaran, serta memperkuat kapasitas kelembagaan dalam menjaga kesehatan santri. Oleh karena itu, program ini dinilai berhasil mencapai tujuannya dan berpotensi untuk direplikasi di lingkungan pesantren lainnya dengan penyesuaian konteks lokal.
ANALISIS KESIAPAN FASILITAS LABORATORIUM TERHADAP KEPUASAN PELAYANAN DALAM PELAKSANAAN OBJECTIVE STRUCTURED CLINICAL EXAMINATION (OSCE) DI FAKULTAS KEDOKTERAN UNIVERSITAS NEGERI MALANG Ayu Sylvianingrum, Erika; Nur Ramadhani, Dimas; Iradany, Amelia; Weningtyas, Anditri
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.261-266

Abstract

Salah satu bentuk metode pembelajaran keterampilan klinis dengan metode pembelajaran Objective Structured Clinical Examination (OSCE) yang dipengaruhi oleh sumber daya manusia, sarana dan prasarana serta pelayanan administrasi di laboratorium. Untuk mengetahui kesiapan fasilitas terhadap kepuasan pelayanan laboratorium dalam pelaksanaan Objective Structured Clinical Examination (OSCE) bagi mahasiswa Fakultas Kedokteran. Penelitian ini menggunakan desain observasional analitik dengan desain cross-sectional. Siswa mengisi angket yang telah divalidasi oleh ahli. Analisis bivariat dilakukan untuk menganalisis Kesiapan Fasilitas Laboratorium Terhadap Kepuasan Pelayanan dengan uji statistik yang digunakan adalah uji korelasi pearson. Responden penelitian berjumlah 100 sample dengan kriteria telah mmengikuti ujain OSCE. Analisis fasilitas laboratorium dengan kepuasan layanan laboratorium menunjukkan bahwa adanya hubungan yang linear antara fasilitas laboratodirum dengan kepuasan layanan p 0.05 dan r r tabel. Dimana semakin baik fasilitas yang ada maka semakin puas responden dengan layanan laboratorium. Adanya hubungan antara kesediaan fasilitas dengan kepuasan layanan terhadap responden di FKUM.
The Potential of Snake Fruit Peel Extract As A Supplement to Metformin For Antidiabetic Therapy and For Preventing Cell Apoptosis: A Systematic Review Anditri Weningtyas
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52765

Abstract

The white race, especially the adult population, has a prevalence of type 2 diabetes ranging from 3% to 6%. The diabetes frequency in Singapore has greatly escalated in the past ten years. Despite being called a tropical country, Indonesia is the world's second-largest contributor to biodiversity (following Brazil). Approximately 2,500 species of plants are classified as herbs in Indonesia, which has about 30,000 species. An example of these herbs is snake fruit that gives numerous pharmacological effects, such as immunostimulator, antioxidant, antidiabetic, and it improves lipid profile. A lot of types of snake fruit can be found in Indonesia, and their various content are likely to appear due to the different types of snake fruit's physical conditions, as indicated in the previous research. Phenolic compounds and flavonoid groups can inhibit the α-glucosidase enzymes due to being capable of neutralize free radicals, and eventually, pancreatic beta cell apoptosis can be prevented. Methods use Systematic Review by conducting literature searches using PubMed and Ebsco. The literature discusses snake fruit, antidiabetic and cell apoptosis. There are six studies, concluding that snake fruit can be antidiabetic and it prevents cell apoptosis. Snake fruit can be an antidiabetic alternative in the treatment of diabetes, particularly in preventing cell apoptosis.
Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review Weningtyas, Anditri; Rohman, Mohammad Saifur; Chomsy, Indah Nur; Hose, Victor Alvianoes Guterez; Riza, Mochamad Faishal; Purbaningroom, Dian Laila; Rudijanto, Achmad; Nugrahenny, Dian
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.2

Abstract

Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients.   Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.
Transformasi Perilaku Hidup Bersih dan Sehat Melalui Model Edukasi Berbasis Komunitas di Pondok Pesantren Nurul Ulum Putri Malang Iftitahurroza, Hilma Tsurayya; Sishartami, Lintang Widya; Ariesaka, Kiky Martha; Weningtyas, Anditri; Kurniawati, Andini; Qurrataa'yun, Ahmad Al; Aulia, Sabrina; Auliarahma, Zhafirah; Manggolono, Lintang Nirmalasari Gemalochaya
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.21347

Abstract

Pendahuluan: Pondok pesantren memiliki peran strategis dalam membentuk karakter dan perilaku santri, namun kondisi kesehatan di lingkungan pesantren masih memerlukan perhatian, terutama terkait penerapan Perilaku Hidup Bersih dan Sehat (PHBS). Di Pondok Pesantren Nurul Ulum Putri Malang, masih ditemukan rendahnya pemahaman dan praktik PHBS di kalangan santri, sehingga diperlukan upaya edukasi yang kontekstual dan partisipatif. Metode: Ceramah interaktif, diskusi, demonstrasi praktik, dan pendampingan kader santri sehat. Hasil: Nilai rata-rata pretest sebesar 78,63 meningkat menjadi 87,87 pada postest, dengan nilai p = 1,0059 × 10⁻⁵ (p < 0,001), menunjukkan peningkatan signifikan pengetahuan santri setelah edukasi. Santri menunjukkan antusiasme tinggi dan mulai menerapkan perilaku sehat seperti menjaga kebersihan diri, lingkungan, dan sanitasi. Kesimpulan: Edukasi PHBS berbasis komunitas terbukti efektif meningkatkan pengetahuan dan sikap santri terhadap perilaku hidup bersih dan sehat di pesantren.
Protective Effects of L-Carnitine on Growth and Cardiac Function in High-Glucose-Exposed Zebrafish Embryos Editya Fukata; Anditri Weningtyas; Lintang Widya Sishartami; Nuramaliah Desliani Putri; Putri Kusuma C. G. R. Asfandi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.879-885

Abstract

Diabetes mellitus is a chronic metabolic disorder, and maternal hyperglycaemia during pregnancy increases the risk of fetal developmental complications. This study aimed to evaluate the protective role of L-carnitine against glucose-induced embryotoxicity in zebrafish (Danio rerio). Fertilized embryos were exposed to 5% glucose with or without L-carnitine supplementation (50 or 100 uM). Developmental outcomes including survival, hatching, malformations, body length, and heart rate were assessed using microscopy and analyzed by ANOVA and Kaplan–Meier survival curves. High glucose significantly reduced survival (hazard ratio = 6.86; p < 0.0001), delayed hatching (median hatching time 84 vs. 60 hpf; HR = 0.17, 95% CI = 0.08–0.39; p < 0.0001), and induced growth retardation and bradycardia (p < 0.0001). L-carnitine did not rescue survival or hatching but partially ameliorated growth impairment (p < 0.05) and restored heart rate in a dose-dependent manner, with 100 uM supplementation approaching control values (p < 0.001). Morphological abnormalities such as yolk sac edema and spinal curvature remained present but less severe with co-treatment. In conclusion, L-carnitine confers partial protective effects on growth and cardiac function under hyperglycaemic stress, although it does not prevent early lethality.
Co-Authors Achmad Rudijanto Amelia, Dessy Amelia, Widya Dana Ardhiyanti Puspita Ratna Ariesaka, Kiky M. Arif Ladika Arsani, Ni LKA. Aulia Nanda, Taurisma Aulia, Sabrina Auliarahama, Zhafirah Auliarahma, Zhafirah Ayu Sylvianingrum, Erika Bakhtiar, Fannia Yosa Chomsy, Indah Nur Dian Nugrahenny Dina Fauziah Dona Sandy Yudasmara Editya Fukata Fannia Yosa Bakhtiar Faridatus Solikha Gamagita, Laras Putri Hanifah, Sukma Nur Hidayah, Farsya Hilma Tsurayya Iftitahurroza Hose, Victor Alvianoes Guterez Iftitahurroza, Hilma Tsurayya Iradany, Amelia Ismaya, Matius Dimas Reza Dana Kiky Martha Ariesaka Kinanti, Rias G. KURNIAWATI, ANDINI Ladika Wiratama, Arif Liao, Hung E. Lintang Widya Sishartami Lintang Widya Sishartami Manggolono, Lintang Nirmalasari Gemalochaya Mohammad Saifur Rohman Nur Ramadhani, Dimas Nuramaliah Desliani Putri Prasetyo, Rizal Dwi Prayoga, Wahyu Surya Puja Lina Ma'rufa Purbaningroom, Dian Laila Puspitasari, Sendhi T. Putra, Rexy Ichtiar Chesara Putri Kusuma C. G. R. Asfandi Putri, Adhiena Liany Anastasia Qurrataa'ayun, Ahmad Al Qurrataa'yun, Ahmad Al Riza, Mochamad Faishal Singgih Saptadi Sri Soenarti Wibisono, Taurisma Aulia Nanda Wibowo, Ake Budyasa Widya Sishartami, Lintang Wiratama, Arif Ladika