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All Journal Jurnal Riset Kimia Al-Kimia Jurnal Kesehatan Medika Saintika Majalah Kedokteran Andalas Indonesian Journal of Global Health research jurnal abdimas saintika Jurnal Kesehatan Saintika Meditory
eliza arman, eliza
STIKES SYEDZA SAINTIKA PADANG
Chemistry Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary Other

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Catechin-Rich Gambir (Uncaria gambir Roxb.) as a Nutraceutical Agent: Modulation of IL-10 Gene Expression and Cognitive Function in Elderly Yusuf, Rahmi Novita; Arman, Eliza; Anggresani, Lia
Jurnal Riset Kimia Vol. 17 No. 1 (2026): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v17i1.938

Abstract

Aging is associated with increased oxidative stress and chronic inflammation, which contribute to cognitive decline. Modulation of anti-inflammatory pathways, particularly through interleukin-10 (IL-10), may offer a neuroprotective strategy. Catechins, polyphenolic compounds with antioxidant and anti-inflammatory properties, are abundant in Uncaria gambir Roxb., an Indonesian plant with high catechin content. This study aimed to evaluate the effects of catechin-rich gambir supplementation on cognitive function and IL-10 gene expression in older adults. A randomized, double-blind, placebo-controlled trial was conducted involving 58 participants aged ≥60 years with mild cognitive impairment (MoCA-Ina scores 20–25). Participants received either 224 mg/day of catechin or placebo for 12 weeks. Cognitive function was assessed using the MoCA-Ina, and IL-10 gene expression was measured using quantitative real-time PCR (qRT-PCR). Catechin supplementation significantly improved cognitive function compared to placebo (p < 0.001) and increased IL-10 gene expression after 12 weeks (p < 0.001). These findings suggest that gambir-derived catechins may contribute to cognitive improvement through modulation of anti-inflammatory pathways. However, further studies are required to confirm long-term effects and clinical applicability.
Co-Authors Adewirli Putra AGELICA, INGE Almahdy A Annisa Nurul Haq, Ruqaya Arief Yandra Putra Dafiriani, Putri Dafriani, Putri Fuji Astuti Febria HANDAYANI, SRI Herayono, Febby Inelvi Yulia Lia Anggresani Mayaserli, Dyna Putri Niken Niken Novita Yusuf, Rahmi Nurhasanah Amir, Ade Pebriansyah, Randi sari, silvie permata Wiya Elsa Fitri Yanti, Etri yusuf, rahmi novita