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All Journal Jurnal Veteriner Biology, Medicine, & Natural Product Chemistry Journal of Natural Sciences and Mathematics Research Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Ilmiah Citra Bakti (JAICB) SIMBIOSA Jurnal Pijar MIPA BIO-CONS: Jurnal Biologi dan Konservasi Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Rochmad Krissanjaya
Department Of Medical Laboratory Technology, Faculty Of Health Sciences, Kadiri University, Jalan Selomangleng No. 1, Kediri, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Onychomycosis in Students: An Overview of Nail Care Practices and Personal Hygiene Savitri, Lisa; Ihsan, Kharisul; Krissanjaya, Rochmad; Kasimo, Elfred Rinaldo; Yanti, Novirma; Hilmi, Mochamad Hanif
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1015-1019

Abstract

Onychomycosis is a common nail disorder caused by dermatophytes, yeasts, and non-dermatophyte molds, with increasing prevalence among young adults. Poor nail care and personal hygiene habits are essential predisposing factors that contribute to infection. Despite its clinical relevance, data on onychomycosis in student populations remain limited. A cross-sectional study was conducted among 150 undergraduate students from the Faculty of Health Sciences, aged 18–25 years. Nail specimens were collected from individuals presenting with suspected onychomycosis. Direct microscopy was performed using a 20% potassium hydroxide (KOH) preparation, and samples were cultured on Sabouraud Dextrose Agar supplemented with chloramphenicol and cycloheximide. Fungal isolates were identified based on macroscopic and microscopic characteristics. Sociodemographic data, nail care habits, and hygiene practices were collected through structured questionnaires. Data were analyzed descriptively, and associations were assessed using chi-square tests. Onychomycosis was confirmed in 27 students (18%). Dermatophytes were the most frequent isolates, with Trichophyton rubrum (9%) and T. mentagrophytes (5%) predominating, followed by Candida albicans (3%) and Aspergillus spp. (1%). Risk factors significantly associated with infection included irregular nail trimming (p = 0.01), sharing of nail clippers (p = 0.03), and prolonged use of closed footwear (p = 0.02). No significant associations were observed with gender or age. Onychomycosis is prevalent among university students, with dermatophytes as the leading causative agents. Inadequate nail care and poor hygiene practices play a critical role in the occurrence of diseases. Health education and preventive interventions should be prioritized to reduce infection rates in young adults. Further studies employing molecular methods are recommended to refine species identification and improve epidemiological insights.
The Influence of Strain Type and Female Age on the Receptivity of Female Drosophila melanogaster in Homogamous Crosses Savitri, Lisa; Ihsan, Kharisul; Krissanjaya, Rochmad; Kasimo, Elfred Rinaldo
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.937-941

Abstract

Drosophila melanogaster is a widely used model organism in genetic research due to its short life cycle and the presence of many genes homologous to those found in humans. It plays an important role in studies related to genetic inheritance, gene interaction, sex determination, and developmental genetics. One key aspect of its reproductive biology is female receptivity—the willingness of a female to accept mating—which is influenced by various internal and external factors. External factors include environmental conditions such as temperature and humidity, as well as male courtship signals like wing vibrations and chemical cues. Internal factors are mainly related to the female's sexual maturity and mating status. Generally, female receptivity increases with age after eclosion, reaches a peak, and gradually declines. This study investigates the impact of strain type and female age on receptivity in homogamous crosses of D. melanogaster, using two mutant strains: dp (with a wing mutation) and wa (with an eye color mutation). Receptivity was measured by the presence or absence of F1 offspring following crosses between males and females of the same strain, with females tested at different ages ranging from 10 to 60 hours after eclosion. The results indicate that strain type does not have a significant effect on female receptivity. In contrast, female age plays a clear role: individuals aged 30 years and older were more receptive and more likely to produce offspring. No significant interaction was found between strain type and age. These findings suggest that female receptivity in D. melanogaster is more strongly influenced by sexual maturity (as indicated by age) than by genetic differences between strains.
Academic Stress and Blood Glucose Levels: A Correlational Study Among Medical Laboratory Technology Students Savitri, Lisa; Hilmi, Mochamad Hanif; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad; Ihsan, Kharisul
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.977-981

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, often influenced by various physiological and psychological factors. One such factor is stress, particularly academic stress among university students. This study aims to explore the potential correlation between academic stress levels and random blood glucose levels among Medical Laboratory Technology (D.IV) students at Kadiri University. A cross-sectional, quantitative approach was used in this study. A total of 28 eligible students participated. Academic stress levels were assessed using the Perceived Sources of Academic Stress (PSAS) questionnaire, while random blood glucose levels were measured using spectrophotometric methods with glucose GOD FS reagents. Data were analyzed using the Pearson correlation test to determine the relationship between the two variables. The majority of students experienced moderate academic stress (71.43%), while the rest (28.57%) experienced high stress. No students reported low stress levels. Regarding blood glucose, 53.57% of participants had normal levels, and 46.43% had elevated levels. The Pearson correlation coefficient was 0.045 with a p-value of 0.819, indicating no statistically significant relationship between academic stress levels and blood glucose levels. Regression analysis also confirmed that while there was a slight positive trend (suggesting that higher stress may slightly raise glucose levels), the effect was negligible and not statistically significant. This study found no significant correlation between academic stress and random blood glucose levels among Medical Laboratory Technology students. Although stress may contribute to changes in glucose levels through hormonal mechanisms, other factors—such as diet, physical activity, and individual coping strategies—likely play a more substantial role. Interventions focusing on stress management, healthy lifestyle habits, and regular health monitoring are recommended to maintain both psychological well-being and metabolic health in students.
ANALYSIS OF KIDNEY HISTOPATHOLOGY IN SEPSIS MODEL OF MICE (MUS MUSCULUS) WITH PREVENTIVE TREATMENT OF LEAF EXTRACT FROM 'DAUN KENTUT' PLANT (PAEDERIA FOETIDA L.) AGAINST ESCHERICHIA COLI INFECTION Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad; Sukmawati, Datin An Nisa; Juwita, Syntia Tanu; Kholis, Akbar Nur; Mosse1, Yosep
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2946

Abstract

Sepsis is a critical health concern characterized by organ dysfunction due to uncontrolled host reactions to infections. The prevalence of microorganisms causing sepsis varies, with Gram-positive bacteria and fungal sepsis gaining significance. Sepsis often leads to acute kidney injury (AKI), and its association with sepsis is known as sepsis-associated AKI (SA-AKI). The "Daun Kentut" plant, known for its diverse bioactive compounds, has shown potential in combating inflammation and oxidative stress. In this study, histopathological changes in mouse kidneys induced by Escherichia coli were investigated. Hemorrhage was the primary change observed. Dehydration caused by E. coli infection potentially led to kidney injury through hormonal responses. The plant extract's anti-inflammatory potential, attributed to compounds like saponins and flavonoids, was also explored. The study emphasizes the need for understanding sepsis-related kidney damage and suggests possible preventive strategies using natural compounds.
THE ANTI-APOPTOTIC POTENTIAL OF Paederia foetida L. LEAF EXTRACT THROUGH THE DOWNREGULATION OF CASPASE-3 EXPRESSION IN AN ESCHERICHIA COLI-INDUCED SEPSIS MICE MODEL Savitri, Lisa; Krissanjaya, Rochmad; Juwita, Syntia Tanu; Sukmawati, Datin An Nisa; Probosiwi, Neni; Laili, Nur Fahma; Ilmi, Tsamrotul; Prasetyawan, Fendy
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8235

Abstract

Sepsis is a life-threatening condition characterized by an abnormal immune response to infection, leading to high mortality rates in intensive care units (ICUs) worldwide. Caspase-3, a crucial enzyme in the apoptosis pathway, plays a significant role in sep-sis-related cellular damage. This study investigates the anti-apoptotic potential of Paederia foetida L. leaf extract by examining its effect on Caspase-3 expression in an Escherichia coli-induced sepsis mice model. Male Balb/c mice were divided into six groups, including positive control, negative control, and treatment groups receiving varying doses of the extract (100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW). Caspase-3 expression in the spleen was measured after 24 hours of treatment. The results demonstrated a significant reduction in Caspase-3 expression, particularly in the group treated with 500 mg/kgBW of the extract, indicating its anti-apoptotic effect. These findings suggest that P. foetida leaf extract may serve as a potential therapeutic agent for reducing cell apoptosis in sepsis, warranting further investigation into its mechanisms and clinical pharmacological field.
THE EFFECT OF Paederia foetida L. EXTRACT ON LIVER WEIGHT OF MICE SEPSIS MODEL INFECTED WITH Escherichia coli Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8965

Abstract

Sepsis is a critical medical condition characterized by a systemic immune response to in-fection, which can lead to severe organ dysfunction and mortality. Bacterial sepsis, par-ticularly caused by Escherichia coli, poses a significant risk due to its potential to harm tissues and organs, including the liver. The liver plays a central role in metabolic process-es and host defense during sepsis, making it a key organ of interest. This study aimed to investigate the effect of Paederia foetida leaf extract on liver weight in a mice sepsis mod-el. Mice were divided into six groups: normal control (N), negative control (K-) receiving distilled water, positive control (K+) receiving ciprofloxacin, treatment 1 (P1) receiving P. foetida extract at 100 mg/kg BW, treatment 2 (P2) receiving 300 mg/kg BW, and treat-ment 3 (P3) receiving 500 mg/kg BW. After 14 days of treatment, significant differences in liver weight were observed among the groups, with the highest mean and standard de-viation recorded in the P1 group (1.3750 ± 0.3932). Liver abnormalities, including swell-ing, lobular thickening, and weight increase, were identified, indicating the liver’s adap-tive response to toxic substances during sepsis. Interestingly, the normal control group exhibited higher liver weights compared to the treatment groups, possibly due to fatty substance accumulation within the liver tissues. These findings suggest that P. foetida ex-tract may influence liver weight changes in sepsis, potentially modulating metabolic and detoxification processes. Further studies focusing on histopathological and biochemical mechanisms are needed to clarify the therapeutic potential of P. foetida in managing liver dysfunction associated with sepsis.
Study of Sperm Utilization in Female Drosophila melanogaster of bdp and btx Strains Savitri, Lisa; Ihsan, Kharisul; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1151-1157

Abstract

This study investigates the patterns of sperm utilization in female Drosophila melanogaster of the bdp and btx strains through sequential mating with multiple males. The research was conducted as a descriptive observational study without experimental manipulation. Females of each strain were crossed with four different males in a specific order, with a two-day interval between each mating. F1 offspring phenotypes were recorded daily over a six-day period following the final mating. Data were analyzed descriptively and supported by somatic chromosome reconstruction to identify the male origin of each offspring. The results indicate that sperm utilization in D. melanogaster females occurs in both random and non-random patterns. Non-random utilization was observed when offspring were produced exclusively from the first male, with no contribution from subsequent males. For example, in the female btx × male N cross, only N female and N male offspring were produced, indicating that sperm from the first male was preferentially used. In contrast, random sperm utilization was evident in later matings, where offspring from multiple males appeared, suggesting that previously stored sperm remained viable and were used alongside or instead of sperm from later matings. These findings highlight the complexity of post-mating sexual selection in D. melanogaster, particularly the role of female sperm storage and utilization mechanisms. The ability of females to either favor the sperm of a particular male or mix sperm from several males may provide evolutionary advantages in terms of genetic diversity and offspring fitness. This study contributes to a better understanding of reproductive strategies and sperm competition in insects, with potential implications for broader studies in evolutionary biology and genetics.
Evaluation of Paederia foetida L. Extract on Liver Weight Alterations in an Escherichia coli Sepsis Mouse Model Savitri, Lisa; Elfred Rinaldo Kasimo; Rochmad Krissanjaya
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.23323

Abstract

Sepsis is a critical medical condition caused by a systemic immune response to infection and is often associated with severe organ dysfunction and high mortality. Bacterial sepsis, including cases triggered by Escherichia coli, can damage host tissues as the immune response becomes dysregulated. Infections involving E. coli in the digestive tract have become increasingly common. Among the affected organs, the liver plays a key role in metabolic regulation and host defense during sepsis. This study investigated the effect of Paederia foetida L. leaf extract on liver weight in a murine sepsis model. Introducing E. coli induces systemic infection and establishes the sepsis model, a commonly used approach in experimental studies to mimic the clinical features of sepsis. After acclimation, mice received treatments for 14 days across several groups: a normal control (N), a negative control (K–) given distilled water, a positive control (K+) given ciprofloxacin, and three treatment groups receiving P. foetida extract at 100 mg/kg BW (P1), 300 mg/kg BW (P2), and 500 mg/kg BW (P3). The analysis revealed significant differences among groups, with the highest mean liver weight recorded in P1 (1.3750 ± 0.3932). Liver abnormalities included enlargement, increased organ mass, swelling, and thickening of one liver lobe, which may reflect heightened hepatic workload during infection and toxin clearance. Interestingly, the normal group showed greater liver weight than several treatment groups, possibly due to fatty accumulation within hepatic tissue, which can influence overall organ mass.
Karakterisasi Ecoenzyme dari Limbah Buah Nenas Jenis Smooth Cayenne Kultivar Pasir Kelud (PK-1) sebagai Disinfektan dalam Pembersih Lantai Krissanjaya, Rochmad; Hermanto, Dhony; Ismillayli, Nurul; Savitri, Lisa; Muttaqin, Saiful; Kasimo, Elfred Rinaldo; Probojati, Rasyadan Taufiq; Anjarwati, Aprilia; Apriana, Dita
BIO-CONS : Jurnal Biologi dan Konservasi Vol. 7 No. 2 (2025): BIO-CONS: Jurnal Biologi dan Konservasi
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31537/biocons.v7i2.2880

Abstract

Limbah nanas Smooth Cayenne PK-1 berpotensi sebagai bahan baku ecoenzyme disinfektan alami. Penelitian ini mengkarakterisasi ecoenzyme dari tiga bagian buah (daging, kulit, batang) hasil fermentasi 90 hari, lalu memformulasikannya menjadi pembersih lantai. Hasil karakterisasi menunjukkan ecoenzyme dari kulit memiliki aktivitas antibakteri tertinggi, didukung kandungan fenolik dan pH asam (3,2–3,5). Formula pembersih lantai optimum diperoleh dengan konsentrasi 20% ecoenzyme kulit nanas. Formula ini memenuhi standar SNI 06-4085-1996: pH 7,2, viskositas 1150 cP, stabilitas emulsi baik, dan stabil selama 30 hari penyimpanan. Produk menunjukkan aktivitas antibakteri signifikan terhadap E. coli (zona hambat 12,5 mm) serta efektif menghilangkan noda minyak (90,2%). Analisis regresi mengonfirmasi 20% sebagai titik optimum. Hal ini menunjukkan bahwa ecoenzyme dari kulit nanas PK-1 merupakan disinfektan alami yang efektif dan stabil untuk pembersih lantai ramah lingkungan, sekaligus mendukung pemanfaatan limbah pertanian bernilai tambah.
Analisis Kekerabatan Populasi Drosophila di Besuki, Bangil, dan Lumajang Berdasarkan Karakter Morfologi Savitri, Lisa; Ihsan, Kharisul; Krissanjaya, Rochmad
SIMBIOSA Vol 14, No 2 (2025): SIMBIOSA
Publisher : Program Studi Pendidikan Biologi, Universitas Riau Kepulauan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33373/simbiosa.v14i2.8415

Abstract

Penelitian ini bertujuan untuk mengkaji hubungan kekerabatan populasi Drosophila dari tiga lokasi di Jawa Timur, yaitu Besuki, Bangil, dan Lumajang, berdasarkan karakter morfologi. Sampel diperoleh melalui penangkapan langsung dan diamati menggunakan parameter panjang tubuh, lebar sayap, dan intensitas pigmen. Analisis deskriptif, Principal Component Analysis (PCA), dan analisis klaster digunakan untuk menentukan pola variasi dan kedekatan morfologi antar populasi. Hasil penelitian menunjukkan adanya variasi signifikan pada ketiga parameter, di mana populasi Besuki dan Bangil menunjukkan ukuran tubuh lebih besar dibandingkan Lumajang. Pigmentasi tubuh populasi Bangil lebih gelap dibandingkan dua lokasi lainnya. Analisis PCA dan klaster menunjukkan kedekatan kekerabatan Besuki–Bangil, sedangkan Lumajang membentuk kelompok tersendiri. Variasi ini diduga dipengaruhi oleh kondisi lingkungan lokal, faktor genetik, dan aspek biotik. Hasil penelitian ini menegaskan potensi penggunaan morfologi Drosophila sebagai indikator awal hubungan kekerabatan dan adaptasi lokal.
Co-Authors Akbar Nur Kholis Alves, Silvina Sandra X. Amanda, Cornelia Anjarwati, Aprilia Antoro, Ester Lianawati Apriana, Dita Datin An Nisa Sukmawati Datin An Nisa Sukmawati Dhony Hermanto Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo, Elfred Rinaldo Ester Lianawati Antoro Fendy Prasetyawan Fitri, Devi Nor Freitas, Maria Do Carmo Da Costa Hilmi, Mochamad Hanif Hilmi, Mochammad Hanif Ida Septika Wulansari Ihsan, Kharisul Juwita, Syntia Tanu Kholis, Akbar Nur Laili, Nur Fahma Lisa Savitri Loviana, Novi Masyhuri, Aga Adi Mebung, Konradus Klala Mosse1, Yosep Muttaqin, Saiful Neni Probosiwi Nurul Ismillayli Rasyadan Taufiq Probojati Retnowati, Ana savitri, Lisa Syntia Tanu Juwita Syntia Tanu Juwita Tiyas, Eka Wahyuning Tsamrotul Ilmi Wulansari, Ida Septika Yanti, Novirma Yosep Mosse1 Yuneka Saristiana