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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM JFM (Jurnal Farmasi Malahayati) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Pengabdian Masyarakat Multidisiplin Jurnal Ilmiah Medicamento Jurnal Pengabdian Masyarakat (ABDIRA) Journal of Community Practice and Social Welfare (JaCiPS) Media Farmasi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Sains dan Kesehatan
Sawu, Sirilus Deodatus
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Literature Review: Pengaruh Penambahan Cilostazol sebagai Kombinasi Antiplatelet pada Pasien Penyakit Jantung Koroner Sawu, Sirilus Deodatus; Indriyani, Oktavia
KUNIR: JURNAL FARMASI INDONESIA Vol 2 No 1 (2024): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v2i1.619

Abstract

Antiplatelet merupakan salah satu pilihan terapi pada penatalaksanaan penyakit jantung koroner (PJK). Terapi standar antiplatelet merupakan kombinasi aspirin dan clopidogrel, namun terkadang menggunakan kombinasi 3 antiplatelet dimana salah satunya yang sering ditambahkan pada terapi standar adalah cilostazol. Cilostazol merupakan inhibitor phosphodiesterase III (PDE3) yang berperan meningkatkan siklik adenosin monofosfat dalam trombosit dan dengan demikian menyebabkan berkurangnya agregasi trombosit. Penambahan cilostazol pada terapi standar antiplatelet kemungkinan tidak dimaksudkan sebagai pencegahan agregasi platelet saja. Metode yang digunakan dalam penelitian ini adalah literatur review. Literature review ini dilakukan dengan pencarian studi pada database Google Scholar dan Pubmed. Tahun publikasi dibatasi dari tahun 2013-2023 dalam bahasa Indonesia dan bahasa Inggris. Dari hasil pencarian studi diperoleh 5 studi yang memenuhi kriteria inklusi. Berdasarkan hasil penelusuran pustaka yang sudah dilakukan diperoleh hasil penambahan cilostazol pada terapi antiplatelet standar memiliki manfaat klinis tidak hanya sebagai pencegahan agregasi platelet namum dapat memberikan efek vasodilatasi, antiproliferasi dan pencegahan restenosis. Disimpulkan bahwa penambahan cilostazol memiliki manfaat pada pasien PJK yang menjalani PCI.
PERBANDINGAN EFEKTIVITAS PENGGUNAAN ATORVASTATIN DAN SIMVASTATIN PADA PASIEN PENYAKIT JANTUNG KORONER YANG DIRAWAT INAP DI RUMAH SAKIT "X" KOTA BATU Putri, Rebeca Fransisca Prahesti; Wibowo, Wibowo; Sawu, Sirilus Deodatus
JFM (Jurnal Farmasi Malahayati) Vol 8, No 1 (2025)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v8i1.17214

Abstract

Latar Belakang: Penyakit Jantung Koroner (PJK) merupakan penyakit tidak menular yang menjadi penyebab kematian nomor satu di dunia, World Health Organization (WHO) menyebutkan bahwa PJK menyebabkan kematian sebanyak 17,7 juta di dunia, hal ini diduga akan terus berkembang setiap tahunnya. Salah satu faktor risiko PJK adalah dislipidemia, pengobatan dislipidemia yang paling banyak digunakan adalah obat golongan statin yaitu, atorvastatin dan simvastatin. Tujuan: Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas terapi dislipidemia obat atorvastatin dan simvastatin pada pasien PJK yang dirawat inap di Rumah Sakit “X” Kota Batu.Metode: Penelitian ini menggunakan desain observasional analitik dengan cross-sectional study. Pengambilan data menggunakan metode purposive sampling melalui data rekam medis pasien secara retrospektif.Hasil: Jumlah sampel yang digunakan dalam penelitian ini yaitu sampel yang telah memenuhi kriteria inklusi dan eksklusi sebanyak 60 pasien. Tidak ada perbedaan antara kelompok simvastatin 20 mg dengan atorvastatin moderate intensity dilihat dari nilai kolesterol total, LDL, HDL, dan trigliserida (P-Value = 0,756; 0,914; 0,691; 0,745 berturut-turut), simvastatin 20 mg secara signifikan lebih efektif dalam mengontrol nilai LDL dibandingkan dengan atorvastatin high intensity (P-Value: 0,019), serta tidak ada perbedaan yang signifikan terhadap nilai kolesterol total, HDL, dan trigliserida (P-Value = 0,091; 0,871; 0,168 berturut-turut), tidak ada perbedaan signifikan antara kelompok simvastatin 20 mg dengan atorvastatin moderate intensity dan atorvastatin high intensity (P-Value = 1,000 dan 0,758 berturut-turut) terhadap lama rawat inap.Kesimpulan: Pasien yang menggunakan simvastatin 20 mg memiliki profil LDL yang lebih baik dibandingkan atorvastatin high intensity (P-Value = 0,019).
Pemberdayaan pengasuh lansia dalam pemanfaatan pojok herbal sebagai upaya menigkatkan kesehatan lansia di LKS-LU Pangesti lawang Wibowo Wibowo; Sirilus Deodatus Sawu; Devanus Lahardo
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 2 (2025): March
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i2.29411

Abstract

AbstrakPerkembangan jumlah lansia di Indonesia terjadi dalam jangka waktu kurang lebih 50 tahun. Dalam periode tersebut, persentase penduduk lansia Indonesia mengalami lonjakan dua kali lipat dibanding sebelumnya. Pada tahun 2020, persentase lansia mencapai 9,92 persen atau sekitar 26,82 juta orang. Penyakit ataupun masalah- masalah kesehatan lainnya yang sering dialami oleh lansia sangat berbeda dari orang dewasa, yaitu adanya masalah gangguan tidur, imobilisasi, inkontinensia, depresi, kekurangan nutrisi, menurunnya kekebalan tubuh. Potensi yang bisa dioptimalkan LKS-LU Pangesti Lawang adalah kebun yang luas yang ditanami berbagai tanaman seperti sayuran, buah buahan dan tanaman obat yang bisa memberikan manfaat untuk peningkatan kesehatan lansia penguni LKS- LU. Tahap kegiatan pengabdian kepada masyarakat dibagi menjadi 3 tahap yang  meliputi tahap persiapan administratip, pelaksanaan dan evaluasi. Waktun yang dibutuhkan untuk kegiatan ini adalah selama 3 hari yaitu pada tanggal Edukasi ini akan dilaksanakan selama 3x pertemuan pada tanggal 19 November, 2 dan 5 Desember 2024 dengan jumlah peserta 11 orang di aula LKS LU Pangesti Lawang. pukul 12.30-15.00. Pada pertemuan hari pertama  di diawali dengan kegiatan pre test, dan didapatkan nilai rata-rata 5,4. Setelah peserta diberi penjelasan tentang pojok herbal sebagai upaya meningkatkan kesehatan lansia dilanjutkan dengan post test untuk mengetahui materi yang telah diberikan didapatkan nilai post test sebesar 8,2 penanaman tanaman herbal dilakukan pada hari ke tiga pada tempat yang sesuai dengan karakteristik tanaman. Kata kunci: kesehatan lansia; pengasuh lansi; pojok herbal; tanaman obat. AbstractThe development of the number of elderly people in Indonesia has occurred over a period of approximately 50 years. In this period, the percentage of Indonesia's elderly population has doubled compared to before. In 2020, the percentage of elderly people reached 9.92 percent or around 26.82 million people. The illnesses or other health problems often experienced by the elderly are very different from those of adults, namely problems with sleep disorders, immobilization, incontinence, depression, nutritional deficiencies, decreased immunity. The potential that can be optimized by LKS-LU Pangesti Lawang is a large garden planted with various plants such as vegetables, fruit and medicinal plants which can provide benefits for improving the health of elderly residents of LKS-LU. The community service activity stage is divided into 3 stages which include the administrative preparation, implementation and evaluation stages. The time required for this activity is 3 days, namely on the date. This education will be held during 3 meetings on 19 November, 2 and 5 December 2024 with a total of 11 participants in the LKS LU Pangesti Lawang hall. 12.30-15.00. The first day of the meeting began with pre-test activities, and an average score of 5.4 was obtained. After the participants were given an explanation about the herbal corner as an effort to improve the health of the elderly, it was continued with a post test to find out the material that had been given. The post test score was 8.2. The planting of herbal plants was carried out on the third day in a place that suited the characteristics of the plants. Keywords: elderly caregivers; elderly health; herbal corne; medical plants
Uji Aktivitas Analgesik Topikal Ekstrak Daun Mint (Mentha piperita) dengan Variasi Konsentrasi Pelarut Etanol Menggunakan Metode Tail Flick: Topical Analgesic Activity Test of Mint Leaf Extract (Mentha piperita) with Variations in Ethanol Solvent Concentration Using the Tail Flick Method Sawu, Sirilus Deodatus; Lahardo, Devanus; Wibowo, Wibowo
Jurnal Sains dan Kesehatan Vol. 8 No. 1 (2026): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v8i1.2588

Abstract

Pain is a physiological response due to tissue damage or harmful stimuli that require analgesic therapy. Long-term use of synthetic analgesics carries the risk of side effects, so natural alternatives are needed, one of which is mint leaves (Mentha piperita) which contain menthol as an analgesic compound. The concentration of ethanol in the extraction process is known to affect the content of active compounds and their pharmacological activity. This study aims to evaluate the topical analgesic effect of mint leaf extract gel extracted with 50%, 70%, and 96% ethanol using the tail flick method in white mice (Mus musculus). The gel was applied to the tail of the mice, then pain was induced with hot water at 55±0.5°C. Latency time was recorded at certain observation intervals. The results showed a significant difference in the average latency time between treatment groups compared to the negative control starting at the 30th minute (p<0.05). The 96% ethanol extract gel showed the highest analgesic effect at the 150th minute with a latency time of 9.05±0.34 seconds and analgesic activity of 53.71%. In conclusion, variations in ethanol concentration affect the optimization of the topical analgesic activity of mint leaves. Keywords:          pain, mint leaf, topical analgesic, effectiveness, tail flick   Abstrak Nyeri merupakan respons fisiologis akibat kerusakan jaringan atau rangsangan berbahaya sehingga memerlukan terapi analgesik. Penggunaan analgesik sintetis jangka panjang berisiko menimbulkan efek samping, sehingga diperlukan alternatif berbahan alam, salah satunya daun mint (Mentha piperita) yang mengandung mentol sebagai senyawa analgesik. Konsentrasi etanol dalam proses ekstraksi diketahui memengaruhi kandungan senyawa aktif dan aktivitas farmakologisnya. Penelitian ini bertujuan mengevaluasi efek analgesik topikal gel ekstrak daun mint hasil ekstraksi dengan etanol 50%, 70%, dan 96% menggunakan metode tail flick pada mencit putih (Mus musculus). Gel dioleskan pada ekor mencit, kemudian diinduksi nyeri dengan air panas 55±0,5°C. Waktu latensi dicatat pada interval pengamatan tertentu. Hasil menunjukkan adanya perbedaan signifikan rerata waktu latensi antar kelompok perlakuan dibandingkan kontrol negatif mulai menit ke-30 (p<0,05). Gel ekstrak etanol 96% menunjukkan efek analgesik tertinggi pada menit ke-150 dengan waktu latensi 9,05 ± 0,34 detik dan aktivitas analgesik 53,71%. Kesimpulannya, variasi konsentrasi etanol berpengaruh terhadap optimalisasi aktivitas analgesik topikal daun mint. Kata Kunci:         nyeri, daun mint, analgesik topikal, efektivitas, tail flick
Comparison of Topical Analgesic Activity of Mentha piperita Extract with Ethanol Variations Using Hargreaves Test in Mice Sirilus Deodatus Sawu; Wibowo; Devanus Lahardo
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.107

Abstract

Pain can sometimes significantly disrupt a person's quality of life. Pharmacological pain management, often using synthetic analgesics, remains the primary option, but long-term use can lead to serious side effects and the risk of dependency. Mint leaves (Mentha piperita) are known to contain active compounds such as alkaloids and flavonoids, which have analgesic effects, making them a potential alternative to topical analgesics. This study aims to compare the topical analgesic activity of mint leaf ethanol extract with variations in ethanol solvent concentration (50%, 70%, and 96%) as an extraction solvent using the Hargreaves test method in white mice (Mus musculus). The laboratory experimental research used a posttest-only control group. Mint leaf extract was formulated in the form of a topical gel, then tested using the Hargreaves test method which measures the latency time of pain response to heat stimulation on the soles of the feet of mice. The results showed that the maximum topical analgesic activity occurred at 150 minutes for all three groups of mint leaf ethanol extract gels. The LSD test results showed that the 96% ethanol extract solvent produced significantly higher topical analgesic activity than the 70% and 50% ethanol extracts (p-value <0.05). The concentration of 96% ethanol solvent as a solvent for mint leaf extract produces the most optimal topical analgesic activity based on testing using the Hargreaves test method.
PEMBERDAYAAN ANGGOTA PKK DALAM PENGELOLAAN OBAT DAN BEYOND USE DATE (BUD) DI KELURAHAN KAUMAN KOTA MALANG Sirilus Deodatus Sawu; Venny Kurnia Andika
Jurnal Pengabdian Masyarakat Multidisiplin Vol 7 No 2 (2024): Februari
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jpm.v7i2.4174

Abstract

Storage of medicines is an important aspect in ensuring the effectiveness of the medicine when consumed. Some medicines need to be stored in a special place such as a refrigerator. The length of time medicines are stored generally follows the expiry date (ED), which is the time limit for use of the medicine after it is produced by the pharmaceutical factory before the primary packaging is opened. If the primary packaging has been opened, it follows the beyond use date (BUD). The public sometimes pays little attention to where a drug is stored and how long it is stored. The aim of the activity is to provide knowledge for PKK members in Kauman Village, Malang City about storing medicines, especially those that require special storage and Beyond Use Date (BUD) of medicines. The method used is providing information and knowledge regarding drug management in the household, especially regarding drug storage and Beyond Use Date (BUD) with a socialization method implemented 3 (three) times. The results of the socialization activities from the first to the third stages ran smoothly. From the evaluation results, it is known that the knowledge of the 20 PKK members of Kauman Village, Malang City, who were involved, experienced an increase, where from the pre-test the average score was 6.60, while the post-test results averaged a score of 8.15. The percentage increase in knowledge based on the average post-test score was 23.4%. For this reason, when providing drug services, we are expected to always provide education regarding storage and how long the drug can be stored.
Pemberdayaan Kader Kesehatan Desa Sempalwadak Kec. Bululawang, Kab. Malang Terkait Pembuatan Minyak Gosok dengan Kandungan Utama Minyak Peppermint Sebagai Pereda Nyeri Sirilus Deodatus Sawu; Yulinda Pristi Dwi Hapysari
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 6, No 2 (2026): Abdira
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v6i2.1715

Abstract

Peppermint oil has many health benefits, including relaxation, analgesic, anti-inflammatory, and used for nausea and vomiting. One of the benefits of peppermint oil as an analgesic has the potential to be developed into products such as massage oil to relieve pain. The purpose of the Community Service Program (PKM) activity is to increase knowledge and skills through counseling and training in making massage oil as a pain reliever with peppermint oil as the main ingredient. The participants of this activity were 18 health cadres from Sempalwadak Village, Bululawang District, Malang Regency. The method used was providing socialization through PowerPoint media and training in making peppermint oil massage. Evaluation of the measurement of understanding of community service participants by comparing the average pretest and posttest scores and evaluating the abilities of activity participants through a skills assessment sheet. The results of the participant knowledge evaluation showed that there was a success of the PkM activity as indicated by an increase in knowledge based on the average pretest-posttest value of 51.91% and the average skill score of participants was 3.78 with a very good category. This demonstrates that the information presented was well understood by the participants and indicates the success of the Community Service Program (PKM) activities.
Pemberdayaan Kader Kesehatan Desa Sempalwadak Kec. Bululawang, Kab. Malang melalui Pengolahan Daun Mint Menjadi Sediaan Teh Sebagai Relaksan pada Lansia Sirilus Deodatus Sawu; Venny Kurnia Andika
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 6, No 3 (2026): Abdira
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v6i3.2186

Abstract

Mint (Mentha piperita) leaves contain menthol and volatile compounds that provide relaxing and cooling effects and may improve comfort and sleep quality. These properties offer a non-pharmacological alternative for reducing sleep disturbances, anxiety, and stress among older adults. Sempalwadak Village, Bululawang District, has abundant mint resources; however, their utilization remains limited. This community service program aimed to empower community health cadres through training on the hygienic and safe processing of mint leaves into herbal tea for older adults. Seventeen health cadres participated in educational sessions and hands-on training. Program effectiveness was evaluated using pre-test and post-test assessments to measure knowledge improvement and observational checklists to assess practical skills. Success was defined as a minimum 30% increase in knowledge scores and good practical skills. The results showed a 47.43% increase in mean knowledge scores, while the average skill score reached 3.80, categorized as very good. The program effectively improved cadres’ knowledge and skills in utilizing local herbal resources to support health promotion and disease prevention for older adults.
Co-Authors Andika, Venny Kurnia Ani Riani Hasana Antonius Adji Prayitno Devanus lahardo Indriyani, Oktavia Irawan, Fransisca Elsia One Lahardo, Devanus Lupita, Nawang Christy Muslimin, Sahrul One Irawan, Fransisca Elsia Putri, Rebeca Fransisca Prahesti SUGIYANTO Sugiyanto - Sugiyanto Sugiyanto Valina, Yushinta Elsa Venny Kurnia Andika Wibowo Wibowo Wibowo Wibowo, Wibowo Yosi Irawati Wibowo Yulinda Pristi Dwi Hapysari