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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kimia Mulawarman Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Jurnal Farmamedika (Pharmamedica Journal) Jurnal Sains Kebidanan Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Conferences of Medical Sciences Dies Natalis Kreativitas Pada Pengabdian Masyarakat (Krepa) Fajar: Media Komunikasi dan Informasi Pengabdian Kepada Masyarakat
Sadakata Sinulingga
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

 1 
Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods Mardiyanto Mardiyanto; Budi Untari; Ady Mara; Sadakata Sinulingga; Nirwan Syarif; Gustina Emilia Ningsih
Science and Technology Indonesia Vol. 7 No. 3 (2022): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1259.916 KB) | DOI: 10.26554/sti.2022.7.3.320-326

Abstract

The pandemic period has caused antibiotics highly recommended to cure infections. The use of macrolide antibiotics has greatly increased recently due to outbreaks of diseases that attack the human respiratory tract all of part of the world. One member of the macrolide group is erythromycin ethyl succinate which has low solubility in water. Therefore, this study aims to convert erythromycin ethyl succinate into lipid nanoparticles in an attempt to increase solubility. The method for the formation of nanoparticles is heating emulsification and homogenization. The results obtained in the form of formula 1 (F1) showed the percent encapsulation of 85.688±0.30641. The physical properties were that it has a size of 398.9±1.4 nm, a PDI of 0.3895±0.0015, and zeta potential of -17.45±0.15 mV respectively. The stability was determined by an accelerated test by the influence of extreme temperature and mechanics affecting the stability of the particles as an indication of decreasing the pH and particle precipitation. The solubility of erythromycin ethyl succinate in the form of lipid nanoparticles was increased in a comparison with the pure substance of erythromycin ethyl succinate.
Co-Authors Adiyatma Putra Mahardika Adma, Annes Claudia Ady Mara Anggraini, Wieke Aprilia Putri Athiah, Medina Az Zahra, Fatihah Bebbi Arisya Kesumaputri Budi Untari Cahyaputra, ariefqi Naufaldi Cahyaputra, ariefqi Naufaldi Dwi Budi Santoso Dwi Indira Setyorini Eka Febri Zulissetiana Ella Amalia, Ella Elsafani Faddiasya Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Firdaus, Mutia Muthmainnah Galuh Anggraini Gustina Emilia Ningsih Hasmeinah, Hasmeinah Intan Rahma Dewi Irfannuddin Irfannuddin Irfannudin Irfannudin Kohar, Evlin Kohar, Evlin Kusumo Hariyadi Kusumo Haryadi Liniyanti D. Oswari M Fakhri Altiyan M Kenli Kendi Tampoliu Maharani Natasya Mardiyanto Mardiyanto Mariana Mariana Masayu Farah Diba Medina Athiah Melina Indah Sari Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Monanda, M Dias Athallah Monanda, M. Dias Athallah Muhammad Hasnawi Haddani Mulawarman, Hisham Muniaty Sulam Ng Muthiah Hasnah Suri Muthiah Hasnah Suri, Muthiah Hasnah Mutiara Budi Azhar Naomi W Tioline Ng, Muniaty Sulam Nirwan Syarif Nugraha, Doni S Nursiah Nasution Nurul Windi Anggraini, Nurul Windi Nurwany, Raissa Oktharina, Eka Handayani Oswari, Liniyanti D Puji Rizki Suryani Puput Eka Sari Putra Ramadhan Algiffary Irianto Dunda Putriana Fuji Safitri Ratnaningsih Dewi Astuti Riana Sari Puspita Rini Yana Rini Yana Rini Yana Romadhon, M Fitra Sabathania, Hana Daini Safyudin Santosa, Dorothy Eunike Siti Devita Utami Siti Rusdiana Puspa Dewi Soputra, Ezra Hans Soputra, Ezra Hans Sri Wahyuni Subandrate Susilawati Susilawati Susilawati Susilawati Tri Suciati Yana, Rini