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All Journal Jurnal MIPA PHARMACON Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Jurnal Abdi Insani Jurnal Perempuan dan Anak Indonesia Indonesian Biodiversity Journal Indonesian Biodiversity Journal
Julianri Sari Lebang, Julianri Sari
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PENGARUH PEMBERIAN SUBKRONIK INFUSA ROSELLA TERHADAP GAMBARAN MAKROSKOPIK ORGAN LAMBUNG DAN HEPAR TIKUS PUTIH Lebang, Julianri Sari; Datu, Olvie Syenni; Rundengan, Gerald Edward
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.57602

Abstract

Rosella (Hibiscus sabdarifa) merupakan tanaman obat yang memiliki banyak manfaat dan perlu diteliti data keamanan penggunaannya. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian subkronik infusa kelopak bunga rosella terhadap lambung dan hepar tikus putih. Rosella diekstraksi menggunakan metode infus dengan 3 konsentrasi berbeda. Infusa selanjutnya diberikan kepada tikus selama 28 hari. Parameter pengamatan yaitu ada tidaknya kematian hewan, penurunan berat badan, nilai indeks organ dan abnormalitas organ yang diamati secara makroskopik. Hasil penelitian menunjukkan tidak ditemukan gejala toksik dan kematian hewan, peningkatan berat badan hewan pada setiap waktu pengukuran, tidak terjadi perubahan warna dan konsistensi organ lambung dan hepar pada ketiga kelompok hewan yang diberi infusa. Tetapi nilai indeks organ hepar pada pemberian infusa konsentrasi 12,5% dan 25% menunjukkan perbedaan signifikan dengan kelompok kontrol. Dapat disimpulkan bahwa Pemberian subkronik infusa rosella tidak menimbulkan abnormalitas organ lambung dan hepar tikus, tetapi pada konsentrasi 12,5% dan 25% terjadi penurunan indeks organ hepar.
Pemberdayaan Kelompok Tani Kekelor dan Pinangimbalian Desa Pinapalangkow Dalam Program Pelatihan Pembuatan Sabun Dari Daun Cengkeh Suoth, Elly; Mansauda, Karlah Lifie; Lebang, Julianri Sari
The Studies of Social Sciences Vol. 7 No. 1 (2025): The Studies of Social Sciences
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/tsss.v7i1.58385

Abstract

Kelompok tani Kekelor dan Pinangimbalian di Desa Pinapalangkow merupakan kelompok tani yang tidak terlalu aktif, dimana kelompok tani ini hanya aktif pada masa panen saja. Hal ini terjadi karena para petani hanya fokus pada buah cengkehnya saja. Padahal ada bagian lain dari pohon cengkeh yang dapat dimanfaatkan seperti daun cengkeh. Daun cengkeh yang juga hampir sama dengan buah cengkeh memiliki metabolit sekunder yang dapat bermanfaat bagi tubuh manusia dapat di oleh untuk mendapatkan minyak cengkeh ataupun dapat di manfaatkan untuk pembuatan berbagai produk kesehatan lainnya. Untuk itu pendampingan atau pelatihan pembuatan sabun dari daun cengkeh ini sangat penting bagi kelompok tani Kekelor dan Pinangimbalian untuk dapat meningkatkan aktivitas dan penghasilan dari anggota kelompok tani. Selain upaya meningkatkan penghasilan bagi kedua kelompok tani yang ada di Desa Pinapalangkow, pelatihan pembuatan sabun mandi dengan bahan aktif daun cengkeh juga akan dapat memanfaatkan daun cengkeh yang banyak berjatuhan di setiap kebun dari para petani. Pelatihan pembuatan sabun mandi dari bahan aktif daun cengkeh ini juga sangat diharapkan dapat meningkatkan ekonomi dari para anggota kelompok
ANTIOXIDANT ACTIVITY TEST OF ETHANOL EXTRACT (Polycarpa aurata) OBTAINED FROM THE WATERS OF POOPOH VILLAGE, MINAHASA REGENCY Ghanny, Ath Thariq Fadhli Adhimul Ghanny; Yudistira, Adhitya; Lebang, Julianri Sari
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49459

Abstract

One of the potential marine ingredients that are needed in the fields of food, cosmetics and health is as a source of antioxidants. Antioxidants inhibit the decay of certain substances, reduce oxidative stress, inhibit cell aging, and ward off free radicals. One marine organism that has potential as a natural antioxidant is Tunikata Polycarpa aurata. This study aims to test the antioxidant activity of Polycarpa aurata ethanol extract obtained from the coast of Poopoh Village, Minahasa Regency. The test uses the DPPH method with concentrations of 25 ppm, 50 ppm, 75 ppm, and 100 ppm to analyze antioxidant activity using a spectrophotometer. The results obtained the greatest antioxidant activity in Polycarpa aurata with a concentration of 100 ppm with an average percent inhibition of 80.744%. The results of this study showed the antioxidant activity of Polycarpa aurata from the waters of Poopoh Village, Minahasa Regency has good antioxidant activity. Keywords: Polycarpa aurata, Antioxidant, DPPH, Poopoh Village, Minahasa Regency.
Test of Anti-inflammatory Effectiveness of Ethanol Extract of Green Betel Leaves (Piper betle L.) on White Rats (Rattus norvegicus) Induced with Formaldehyde Turangan, Pricilia Dona; Bodhi, Widdhi; Lebang, Julianri Sari
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55130

Abstract

Green betel leaves are known to contain tannin and flavonoid compounds which have the potential to provide anti-inflammatory effects. This study aims to determine the effect of ethanol extract of green betel leaves with several variations as an anti-inflammatory on edema of white rat’s paw induced by 1% formaldehyde given intraplantarly. Animals that had been induced by formaldehyde were given ethanol extract of green betel leaves after 30 minute,then the diameter of the rat's paw edema was measured using a caliper. The results showed that the negative control experienced an increase in the percentage of inflammation by 77.87% which was significantly different from the positive control, while the extract test group with doses of 25 mg/200gBW, 30 mg/200gBW, and 40 mg/200gBW could provide a decrease in the percentage value of inflammation respectively. - respectively 34.07%, 21.76%, and 4.80% and all three were not significantly different from the positive control (Asymptotic significance≥0.05). Based on research results, ethanol extract of green betel leaves can provide anti-inflammatory effects at a dose of 40 mg/200gBW as the best dose in reducing the diameter of rat paw edema.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
PEMBUATAN CUKA SALAK DAN PENGARUH PEMBERIAN CUKA SALAK TERHADAP KADAR ASAM URAT TIKUS PUTIH HIPERURISEMIA Datu, Olvie Syenni; Siampa, Jainer Pasca; Lebang, Julianri Sari
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hiperurisemia adalah penyakit metabolik yang disebabkan oleh kelainan metabolisme purin, terutama karena peningkatan pembentukan atau penurunan ekskresi urat. Data Organisasi Kesehatan Dunia (WHO) menunjukkan bahwa terdapat 7,44 juta kasus hiperurisemia di seluruh dunia pada tahun 2017 dan hasil Riset Kesehatan Dasar Indonesia (Riskesdas) pada tahun 2018, prevalensi penyakit sendi di Provinsi Sulawesi Utara sebesar 8,35%, di atas rata-rata nasional sebesar 7,3%, selain faktor genetik makanan tinggi purin juga menjadi faktor risiko asam urat. Salak merupakan salah satu buah yang potensial untuk dikembangkan menjadi produk farmasi. Cuka adalah produk yang diperoleh dari fermentasi bahan yang mengandung gula atau pati melalui proses fermentasi. Tujuan penelitian ini adalah untuk memformulasikan cuka salak dan untuk menguji efek pemberian cuka salak pada tikus putih hiperurisemia yang diinduksi dengan jus hati ayam. Cuka salak diperoleh dari fermentasi buah salak dengan menggunakan bakteri Saccharomyces cereviciae dan bakteri acetobacter aceti. Data menunjukkan bahwa cuka salak memiliki aroma khas buah salak dengan pH 3,46. Aktivitas antihiperurisemia menunjukkan bahwa cuka salak memiliki potensi untuk menurunkan kadar asam urat pada tikus putih hiperurisemia.
PENINGKATAN KAPASITAS MASYARAKAT DALAM UPAYA PENCEGAHAN INFEKSI KULIT DAN PRODUKTIVITAS EKONOMI MELALUI PELATIHAN PEMBUATAN SABUN-VCO DI DESA MINAESA MINAHASA UTARA Hariyanto, Yuanita Amalia; Jayanti, Meilani; Lebang, Julianri Sari
Jurnal Abdi Insani Vol 12 No 1 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i1.2083

Abstract

Considering skin disorders can now spread through a variety of media, it is crucial for the public to understand skin health issues. Skin conditions are now among the most prevalent illnesses in coastal towns. People who live near the coast are more likely to experience skin health issues. Numerous elements, such as humidity, sun exposure, personal cleanliness, and water quality, contribute to this. The goal of this project is to teach the Minaesa Village community how to make liquid soap from VCO and to educate them about personal hygiene. On-the-job training is the approach used in the PKM. Direct field visits, identifying the partners' issues and requirements, offering solutions, conducting activities to satisfy the partners' needs, and evaluation are all part of this approach. The pH of the VCOLS soap manufactured is 7, which means that it satisfies quality criteria. According to the evaluation's findings, participants' knowledge increased by 86.5%. More than 82.2% of participants expressed pleasure with the VCOLS soap, according to the evaluation of the satisfaction questionnaire about the created soap, while 17.8% expressed no opinion. The findings of the perception survey of the VCOLS soap, on the other hand, indicate that no one itched after using it, 70% thought it was non-greasy, and 67.7% thought it was hydrating. The evaluation's findings indicate that participants' knowledge of skin care and soap-making methods has grown. According to the results of the perception questionnaire, participants have successfully produced liquid soap from VCO that satisfies quality standards. It is also envisaged that the expertise offered, particularly in the creation of liquid soap from VCO, can be further enhanced through the community service activities in Minaesa Village.
Studies of Wound Healing Activity and Irritation Test of Chili (Capsicum frutescens L.) Leaves Gel on Rats (Rattus novergicus): (Studi Aktivitas Penyembuhan Luka Dan Uji Iritasi Gel Daun Cabai Rawit (Capsicum frutescens L.) Pada Tikus (Rattus novergicus) Lebang, Julianri Sari; Siampa, Jainer Pasca; Nurmiati, Nurmiati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15430

Abstract

Chili pepper (Capsicum frutescens L.) leaves have been used empirically as wound healing caused by sharp objects. Several studies showed that it has antibacterial and wound healing activities. This study aims to formulate gel from chili leaves extract, then determine wound healing activity and irritating properties on rat’s skin. Gel was formulated by using various types and concentrations of gelling agents, consisted of Carbopol 0.5%, 0.75%, 1% and hydroxy propyl methyl cellulose at 2.5%, 5% and 7.5% respectively. Cycling test was conducted to determine the physical stabilities. The results showed that all formula has no altered on organoleptic properties and pH value. Gel of 0.5% Carbopol (F2) and 7.5% of HMPC (F5) has no change in spreadability and adhesion properties. Based on statistical analysis using paired t-test and one-way ANOVA, it concludes that F2 and F5 were physically stable and further evaluated as wound healer. Wound healer evaluation showed that the healing time (days) of Carbopol based gel (F2) was 10.2±1.26 and HPMC based gel was 8±0.82. The length of incision wound (cm) at 8th day was 0.5±0.183 for F2 and 0.06±0.071 for F5. Statistical analysis of healing time showed p<0.01 and wound length showed p<0.05 indicated that F5 (contained 5% HPMC) was significantly different compared to negative control. The results of the irritation test showed that gel formulas were not causing erythema and edema on rat’s skin. It can be concluded that gel of chili leaves extract that formulated with 5% of HPMC has wound healing activity and safety to be used.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
Co-Authors Antasionasti, Irma Ariem, Feiby Datu, Olvie Syenni Edwin de Queljoe Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Ghanny, Ath Thariq Fadhli Adhimul Ghanny Hariyanto, Yuanita Amalia Kawatu, Chelsea Khairuddin Lestari, Utami Sasmita Mansauda, Karlah Lifie Meilani Jayanti Nurmiati Nurmiati Nursamsiar Nursamsiar Paulina yamlean Rundengan, Gerald Edward Sedu, Anissa Siampa, Jainer Pasca Sri Sudewi, Sri Sukriani Kursia, Sukriani Sumual, Priskila Feicy Turangan, Pricilia Dona Widdhi Bodhi Wiyono, Weny Indayany Yudistira, Adhitya