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Aditya Putra, Aditya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Transportation

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Journal : Insight of Biology

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Perubahan Sitokin Pro-inflamasi setelah Pemberian Jahe Merah pada Mencit dengan Paparan Asap Rokok: Studi In Vivo Putra, Aditya; Pratama, Farhan
Insight of Biology Vol. 1 No. 3 (2025): Insight of Biology, December 2025
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/inbio.v1i3.342

Abstract

Exposure to cigarette smoke is known to trigger oxidative stress and inflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-6 (IL-6). Excessive inflammatory responses can disrupt cellular homeostasis and contribute to tissue damage. Red ginger contains bioactive compounds, including gingerols and shogaols, which exhibit strong antioxidant and anti-inflammatory activities. This study aims to analyze changes in TNF-α and IL-6 levels in mice following the administration of red ginger extract under cigarette smoke exposure. An in vivo design was used by dividing mice into several groups: a control group, a group exposed to cigarette smoke, and a group exposed to cigarette smoke with red ginger extract treatment. After the treatment period, TNF-α and IL-6 levels were measured through serum analysis using immunological methods. The results showed that mice receiving red ginger extract experienced a significant reduction in TNF-α and IL-6 levels compared to the smoke-exposed group without treatment. These findings indicate that red ginger has potential protective effects by modulating inflammatory responses induced by cigarette smoke exposure. Therefore, red ginger can be considered a natural anti-inflammatory agent for reducing the negative impact of oxidative stress from cigarette smoke.
Co-Authors Abdi Hayat, Toga Agung Wahyudi Biantoro Amru, Basra Ahmad Balani, Rafli Chandra, Kenly Dewi Agustini, Ni Putu Djajawiguna, Hafidz Naeriansyah Humiras Hardi Purba Iqra, Mohammad Alief Kristian, Kevin Lie Liana . Mangun, Dhea JRN Martin, Juvenius Ni Made Sukma Sanjiwani Ningtyas, Regina Aulia Oktaverina, Chiata Pratama, Farhan Putra, ⁠I Putu Wirasatya Eka R, Pahala Rahayu, Adik Duwi Rajanagara, Arya Satya S, Farida Salsabila, Anya Shafira, Syifa Suhara, Cucu Sumiartin, Sumiartin Suradnyana, I Gede Made Vebriana, Gennesia William, Ray Yuda Turana Yvonne Suzy Handajani