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All Journal Jurnal Analis Kesehatan Journal Health & Science : Gorontalo Journal Health and Science Community PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan dan Pembangunan Jurnal Kesehatan Tambusai International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Formosa Journal of Science and Technology (FJST) Pharmaqueous Duta Pharma Journal Borneo Journal of Science and Mathematics Education Sains Medisina Jurnal Ayurveda Medistra Malahayati International Journal of Nursing and Health Science
I Gede Andika Sukarya
Poltekkes Kemenkes Kalimantan Timur
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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GAMBARAN KADAR CRP PADA MENCIT ALERGI SETELAH TREATMENT INFUSA DAUN KETEPENG Firmansyah, Adi; I Gede Andika Sukarya; Suryanata Kesuma
Jurnal Kesehatan dan Pembangunan Vol 14 No 1 (2024): Jurnal Kesehatan dan Pembangunan
Publisher : LPPM STIKes Mitra Adiguna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52047/jkp.v14i27.269

Abstract

Allergy is a hypersensitivity reaction that arises due to exposure to allergens. Allergens will bind to IgE attached to mast cells and cause these cells to release various chemicals in the blood. One of them is, histamine which causes most allergic reactions. Allergic reactions can cause inflammation or inflammation. Inflammatory stimulation will later stimulate the release of C-Reactive Protein (CRP). CRP is an inflammatory maker that is produced and synthesized in the liver. Ketepeng leaf infusion has the potential to stimulate an immune response because it contains chemical compounds, namely alkaloids, saponins, flavonoids, tannins, and anthracino. Flavonoids contained in this plant function to provide anti-inflammatory, antiallergic, antioxidant and antifungal effects. The purpose of this study was to determine the effectiveness of ketepeng leaves (Cassia alata L) by examining CRP (C-Reactive Protein) levels in Ovalbumin-allergic mice (Mus musculus). This type of research is Univariate, which is a method for making an overview of the state of the object being examined through data or sampling samples. The results of this study found that in group 2 after being given ovalbumin, CRP levels increased by 181.33 mg/L and in group 3, after being given ketepeng leaf infusion, CRP levels decreased by 48 mg/L. The conclusion of this study is that ketepeng leaf infusion can reduce CRP levels in mice with ovalbumin allergy and there is an effect of increasing CRP levels in mice given ovalbumin of 181.33 mg/L and a decrease in CRP levels after the treatment of ketepeng leaf infusion of 48 mg/L .
PENGARUH PEMBERIAN BLACK GARLIC (BLACK ALLIUM SATIVUM) TERHADAP KADAR C-REACTIVE PROTEIN PADA MENCIT (MUS MUSCULUS) YANG TERINFEKSI TUBERCULOSIS Sukarya, I Gede Andika; Akbar, Thoriq; Subaeri, Abdul Holik
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.36908

Abstract

Tuberculosis (TB) termasuk dalam sepuluh penyebab utama kematian di dunia dan merupakan penyebab utama kematian akibat patogen infeksius. Pada tahun 2019, terdapat sekitar 10 juta orang yang terinfeksi TB secara global, dengan wilayah Asia Tenggara dan Pasifik Barat memiliki jumlah kasus terbanyak. Mycobacterium tuberculosis menyebabkan inflamasi dan pelepasan sitokin pro-inflamasi seperti IL-6, yang merangsang sintesis protein fase akut oleh hati untuk proses fagositosis bakteri. Penelitian ini merupakan eksperimen murni yang dilakukan dengan teknik total sampling. Sampel terdiri dari empat kelompok mencit: kelompok kontrol negatif, kelompok kontrol positif, kelompok mencit yang diberi Black Garlic, dan kelompok mencit yang diberi kombinasi Black Garlic dan obat anti-Tuberculosis (OAT). Setiap kelompok terdiri dari enam mencit yang diinduksi Tuberculosis dan diberikan perlakuan sesuai kelompoknya. Kadar CRP diukur menggunakan alat Nycocard Reader II setelah perlakuan. Hasil penelitian menunjukkan bahwa rata-rata kadar CRP pada kelompok mencit kontrol negatif, kontrol positif, Black Garlic, dan kombinasi Black Garlic dan OAT yaitu 3 mg/dL. Uji Mann-Whitney U menunjukkan nilai P sebesar 0,138 (P>0,05), yang mengindikasikan tidak adanya perbedaan signifikan antar kelompok perlakuan. Pemberian Black Garlic tidak memberikan pengaruh signifikan terhadap kadar CRP pada mencit yang terinfeksi Tuberculosis. Oleh karena itu, Black Garlic belum dapat digunakan sebagai suplemen atau berpengaruh dengan kenaikan kadar CRP sebagai pengobatan alternatif untuk tuberculosis.
Effects of Black Garlic (Black Allium sativum) on Creatinine Levels in Tuberculosis-Infected Mice (Mus Musculus) Hartini, Supri; Andika Sukarya , I Gede; Putri Wasito , Anatasya
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024): IJIERM Edition September
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.380

Abstract

There is a high prevalence of tuberculosis (TB) in Indonesia, which is the second country with the highest TB cases in the world. Tuberculosis is an infectious disease that can attack various organs of the body and is the main cause of death among other infectious diseases. Garlic (Allium sativum) contains the compound allicin which has high antibacterial activity, equivalent to penicillin and modern antibiotics such as chloramphenicol, so it can be used to prevent and treat various diseases including tuberculosis. This study aims to determine the benefits of black garlic (Black Allium sativum) in controlling creatinine levels in mice (Mus musculus) infected with TB, considering that black garlic is known to have various medical properties including antioxidant, anti-inflammatory and anticancer. The research design used is Quasi-Experimental Design, namely a non-random repeat experimental design carried out with a post-test and having a control group and an experiment determined using a non-random method. The mice used were divided into several groups, including a healthy group, a group infected with tuberculosis, a group that received black garlic treatment, and a group that was given a combination of black garlic + OAT. Mice infected with TB were given black garlic, and creatinine levels were measured to determine the effectiveness of the treatment. A statistical test was carried out using the One Way Anova test on the creatinine levels of a group of tuberculous mice given black garlic. The average creatinine levels in the four treatment groups of mice were within normal limits, with the lowest value being 0.24 mg/dL and the highest value being 0.59 mg/dL. Next, a statistical test was carried out using the One Way Anova test and the results showed a P value of 0.807. This P value>0.05 indicates that the administration of black garlic does not affect creatinine levels in mice infected with tuberculosis.
Pengaruh Pemberian Ekstrak Daun Kelakai Terhadap Kadar GGT Pada Mencit Yang Terinfeksi Tuberkulosis Sukarya, I Gede Andika; Ananda, Dwi Putri; Azahra, Sresta
Jurnal Analis Kesehatan Vol. 13 No. 2 (2024): Jurnal Analis Kesehatan
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v13i2.4559

Abstract

Data Kemenkes RI tahun 2022 menunjukkan kasus tuberkulosis sebanyak 824 ribu kasus dengan 93 ribu kematian per tahun atau setara dengan 11 kematian per jam. Pengobatan tuberkulosis biasanya terdiri dari obat anti tuberkulosis (OAT). OAT ini diketahui dapat menyebabkan hepatotoksisitas ditandai dengan peningkatan kadar GGT. Salah satu upaya terapi obat hepatoprotektor ialah daun Kelakai (Stenochlaena palustris). Kandungan alkaloid dan flavonoid yang terdapat di dalam tumbuhan ini berfungsi memberi efek antibakteri, antioksidan, dan antiinflamasi. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun Kelakai terhadap kadar GGT pada mencit terinfeksi tuberkulosis yang mengalami kerusakan hati pemberian OAT. Jenis penelitian ini adalah eksperimen murni (True Experimen Reseacrh) dengan desain Pretest and Posttest Only Control Group Design dengan menggunakan 24 ekor hewan coba berupa mencit jantan yang dibagi menjadi 4 kelompok yaitu kelompok mencit kontrol, kelompok mencit Tb, kelompok mencit Tb diberi ekstrak daun kelakai, dan kelompok Tb diberi ekstrak daun kelakai dan OAT. Analisa data menggunakan uji One Way Anova. Hasil penelitian menunjukkan tidak terdapat pengaruh pemberian daun kelakai terhadap kadar GGT pada mencit tuberkulosis dengan nilai statistik p 0,652 (p value >0,05). Tidak terdapat pengaruh pemberian ekstrak daun kelakai terhadap kadar GGT pada mencit tuberkulosis.
Impact of regular whole-blood donation on hemoglobin level Hartini, Supri; Sukarya, I Gede Andika; Fortuna, Malika Sasi Fitria
Malahayati International Journal of Nursing and Health Science Vol. 7 No. 11 (2025): Volume 7 Number 11
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v7i11.538

Abstract

Background: Blood donation is regarded as a noble, voluntary act that is done without compensation. Prior to donation, donors undergo a preliminary examination (including blood pressure, blood type, hemoglobin levels, pulse, etc.). After donating blood, it is important to recheck their hemoglobin levels to determine whether they are low or remain stable. Purpose: To determine the impact of regular whole blood donation on hemoglobin levels. Method: A descriptive study with an observational design. The variable is the hemoglobin level before and after blood donation. The research was conducted at the Indonesian Red Cross Society of Tenggarong, with 45 blood donors as respondents. Hemoglobin levels were measured using a POCT (Point of Care Testing) tool. Data analysis was performed univariately to assess the hemoglobin level changes before and after donation. Results: The study revealed gender characteristics for male and female donors, with an average Hb level of 14.5 gr/dl for men and 13.25 gr/dl for women in their last donation. For current donation, the average Hb levels were 14 gr/dl for men and 11.65 gr/dl for women. The decrease in hemoglobin levels was 0.5 gr/dl for men and 1.6 gr/dl for women. Almost all donors showed no symptoms post-donation. Conclusion: Hemoglobin levels decreased after donation, but there were no symptoms such as fainting for both men and women. Suggestion: Donors can use this information to increase their understanding of hemoglobin levels, ensure they get adequate rest the night before donation, eat iron-rich foods, and avoid strenuous activities after donating blood. It is also recommended that future researchers consider including the menstrual cycle as a factor in similar studies.
Perbedaan Hasil Kadar Hemoglobin Metode POCT Pada Posisi Duduk Dan Berbaring Sukowati, Ambar; Sukarya, I Gede Andika; Saputri, Maulida Julia
Jurnal Ayurveda Medistra Vol 5 No 2 (2024): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v5i2.99

Abstract

Hemoglobin is a complex protein that binds to the iron contained in erythrocytes, with its main function being to transport oxygen from the lungs throughout the body and exchange it with carbon dioxide from the tissues to be excreted through the lungs. In outpatient hospitals, blood samples are taken in a sitting position, while inpatients, blood samples are usually taken in a lying position. The purpose of this study was to determine differences in hemoglobin levels by taking capillary blood in the sitting and lying positions, measuring hemoglobin levels using the POCT tool and differentiating hemoglobin levels. This type of research is true experiment research with posttest only control design. The sampling technique used was random sampling, namely 20 respondents from the Poltekkes Kemenkes East Kalimantan. The location of research was carried out at the Hematology Laboratory of the Diploma 3 Technology Laboratory Medical Laboratory of the East Kalimantan Ministry of Health Polytechnic for 2 weeks in June. Data analysis using the bivariate test which was analyzed by paired t-test found that the value of Sig. (2-tailed) of 0.842 > 0.05. From these results it can be concluded that there is no significant difference in the results of hemoglobin levels using the POCT method in sitting and lying positions, so that examination of hemoglobin levels using capillary blood using the POCT method in sitting and lying positions can be used.
Gambaran Karakteristik Histopatologi dan Stadium Klinis Pada Pasien Kanker Serviks Berusia Muda Periode 2020-2022 di RSUD Abdul Wahab Sjahranie Samarinda Alvita, Nadia Nanda; Irawan, Hadi; Sukarya, I Gede Andika
Borneo Journal of Science and Mathematics Education Vol 4 No 3 (2024): Vol 4 No 3 (2024): Borneo Journal of Science and Mathematics Education, October 2
Publisher : Faculty of Education and Teacher Training of UINSI Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21093/bjsme.v4i3.9073

Abstract

Kanker serviks merupakan salah satu jenis kanker dengan prevalensi tinggi di Indonesia, khususnya di Kalimantan Timur. Tingginya angka kejadian dan kematian akibat kanker serviks menjadikan penelitian ini penting untuk dilakukan, terutama di RSUD Abdul Wahab Sjahranie Samarinda sebagai rumah sakit rujukan utama di wilayah ini. Pemilihan topik ini didasarkan pada kebutuhan untuk memahami lebih dalam tentang karakteristik histopatologi dan stadium klinis kanker serviks pada pasien usia muda, yang dapat berkontribusi pada upaya pencegahan dan pengobatan yang lebih efektif. Penelitian ini menggunakan desain deskriptif retrospektif dengan analisis data sekunder dari rekam medis pasien usia muda yang didiagnosis kanker serviks pada periode 2020-2022. Data yang dianalisis mencakup karakteristik jenis histopatologi dan stadium klinis berdasarkan klasifikasi FIGO. Hasil penelitian menunjukkan bahwa jenis histopatologi yang paling sering ditemukan adalah karsinoma sel skuamosa (67,5%), diikuti oleh adenokarsinoma (22,5%) dan adenoskuamosa (10%). Sementara itu, distribusi stadium klinis menunjukkan bahwa sebanyak 16 pasien (40%) terdiagnosis pada stadium awal (I-IIA), sedangkan 24 pasien (60%) pada stadium lanjut (IIB-IVB).
HUBUNGAN LAMA MENDERITA PADA PENDERITA DIABETES MELITUS TIPE 2 DENGAN KADAR ALBUMIN DI PUSKESMAS SIDOMULYO KOTA SAMARINDA Syavamaruah, Dhaisyfa Azriel; Prihandono, Dwi Setiyo; Sukarya, I Gede Andika
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49420

Abstract

Diabetes mellitus yaitu penyakit disfungsi metabolik yang mencerminkan peningkatan gula dalam darah yang dapat menyebabkan penurunan kadar albumin akibat gangguan fungsi hormon insulin serta ketidakseimbangan asupan energi dan protein yang dibutuhkan tubuh. Diabetes melitus berpotensi menyebabkan kondisi hipoalbuminemia akibat pembatasan asupan kalori yang ditujukan untuk mengontrol kadar glukosa darah serta parameter metabolik terkait. Selain itu, asupan protein juga kerap dibatasi guna mengurangi risiko proteinuria dan komplikasi nefropati diabetik. Tujuan dari studi ini yaitu menganalisis hubungan durasi menderita diabetes melitus tipe 2 dengan kadar albumin. Kajian ini dilaksanakan dengan pendekatan studi observasional analitik dan desain cross-sectional yang melibatkan 40 responden, terdiri atas 20 penderita dengan durasi penyakit <5 tahun dan 20 penderita ≥5 tahun. Analisis data dilakukan dengan menggunakan uji chi-square. Hasil analisis menunjukkan penderita berjenis kelamin perempuan (38,47%) dan berusia 60–75 tahun (61,1%) lebih banyak mengalami hipoalbuminemia. Sebagian besar penderita dengan durasi <5 tahun memiliki kadar albumin normal (60%), sedangkan pada durasi ≥5 tahun, hipoalbuminemia ditemukan pada 55% responden. Secara statistik, tidak ditemukan hubungan signifikan antara durasi <5 tahun terhadap kadar albumin (p=0,209), namun terdapat hubungan signifikan pada durasi ≥5 tahun (p=0,043). Penelitian ini merekomendasikan penderita diabetes melitus untuk rutin memeriksa kadar albumin, menjaga pola makan, mengontrol gula darah, menerapkan gaya hidup sehat, dan mematuhi pengobatan guna mencegah komplikasi.
Co-Authors Adi Firmansyah Akbar, Thoriq Alvita, Nadia Nanda Ananda, Dwi Putri Anggi Nuraini Anfida Anis Hudriyah Annisa Nur Rizky ARDIANSYAH ARDIANSYAH Azahra, Sresta Dini Indriaty Yusran Dwi Setyo Prihandono Fifi Mufiana Nurrahma Fortuna, Malika Sasi Fitria Hadi Irawan Kesuma, Suryanata Maulida Julia Saputri Nabila Nabila Nada Sifa Sabda Nabila Nursalinda Kusumawati Prihandono, Dwi Setiyo Putri Wasito , Anatasya Saputri, Maulida Julia Subaeri, Abdul Holik Sukowati, Ambar Supri Hartini Supri Hartini Supri Hartini Supri Hartini, Supri Suryani, Maria Eka Syavamaruah, Dhaisyfa Azriel Tasya Choirifah Parwanti Tiara Dini Harlita Wiyadi Wiyadi