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All Journal E-Journal Widya Kesehatan dan Lingkungan Majalah Kedokteran BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Anakes: Jurnal Ilmiah Analis Kesehatan International Islamic Medical Journal Indonesian Journal of Medical Chemistry and Bioinformatics
Rawina Winita
Departemen Parasitologi Fakultas Kedokteran Universitas Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Potensi Propolis dan Kombinasi Dengan Klorokuin Sebagai Antimalaria Pada Mencit (Mus Musculus) yang Terinfeksi Plasmodium berghei Astuty, Hendri; Farhan, Muhamad; Winita, Rawina
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 11 No. 1 (2025): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v11i1.2610

Abstract

Malaria is still a public health problem both in Southeast Asia and other regions of the world. The emergence of resistance to several malaria drugs, including chloroquine. With the increase in malaria resistance, including chloroquine. With the increase in malaria drug resistance, many studies have been conducted to find new antimalarial compounds. One of them is propolis which contains luteolin 7-O glucoside which can inhibit the biosynthesis of parasitic type 2 fatty acids and chalcone can inhibit the hemolysis process. This study aims to examine the therapeutic potential of propolis single and combination with chloroquine in male Mus musculus infected with Plasmodium berghei. The single propolis tested were 30 mg/kgBW, 60 mg/kgBW and a combination of propolis.  This study is an experimental laboratory study with a post-test control group-only design. Comparison of parasitemia density with the 4-day suppression test method in all treatment groups with the Kruskal-Wallis test found a p-value <0.001. The results study showed that single propolis at a dose of 30 mg/kg BW was better than a dose of 60 mg/kg BW. Combination therapy between propolis and chloroquine at doses of  30 mg/kg BB and 60 mg/kg BB had significant results. The conclusion of this study shows that combination therapy of propolis at a dose of 30 mg/kg WB or a dose of 60 mg/kg BB with chloroquine has better antimalarial potential, so propolis is synergistic with chloroquine as an antimalarial.  Keywords: Propolis , Chloroquine, Plasmodium berghei, Parasitemia
Co-Authors - Natalia Agus Aulung Anita Astuti Istiqomah Arie Prasetyawan Bany Faris Amin Dwira, Surya El Bayani, Gulshan Fahmi Faruqi, Azzam Firmansyah, Nurhadi Eko Geni, Lenggo Geraldi, Iskandar Purba Haekal Ariq Hendri Astuty Hendri Astuty Hendry Astuti Heri Wibowo Irfan Kresnadi Keumala Dewi, Intan Lenggo Geni Lenggo Geni Lestiani, Budi Lisawati Susanto Madonia Fakum Silitonga Muhamad Farhan Muhammad K. Huda Muhammad Tola, Sakura Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati, - Nishfa Ayu Novita Novita, Nishfa Ayu Nurhadi Eko Firmansyah Reqgi First Trasia Ridhawati Syam Rizal Subahar Saleha Sungkar Silitonga, Madonia Fakum Viharsyah Aulia Akbar Vita Amalia Zamziar, Hanny Zuraida Zuraida Zuraida Zuraida