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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian BIO-EDU: Jurnal Pendidikan Biologi Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Bangsa Journal of Nutraceuticals and Herbal Medicine
Eko Mugiyanto, Eko
Fakultas Farmasi, Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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AKTIVITAS ANTIOKSIDAN, TOTAL FENOL DAN TOTAL FLAVONOID TANAMAN KEDONDONG (Spondias dulcis Soland ex Park) Najihah, Veni Haqiqotun; Mugiyanto, Eko; Permadi, Yulian Wahyu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 5 No 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.52 KB) | DOI: 10.22236/farmasains.v5i2.2375

Abstract

Upaya peningkatan dalam pemanfaatan antioksidan alami telah dilakukan melalui uji aktivitas antioksidan serta penentuan total fenolik dan flavonoid dari tanaman kedondong (Spondias dulcis Soland ex Park). Tujuan dari penelitian ini adalah untuk menentukan aktivitas antioksidan, total fenolik dan flavonoid dari ekstrak daun, kulit batang dan daging buah kedondong. Ekstraksi telah dilakukan menggunakan pelarut etanol 96% dengan metode maserasi. Analisis spektrofotometri UV-VIS menunjukkan kandungan total fenolik dan flavonoid daun, kulit batang, dan daging buah kedondong sebesar: (37,400 mg GAE/g ekstrak; 9,145 mg QE/g ekstrak), (85,067 mg GAE/g ekstrak; 6,829 mg QE/g ekstrak) dan (4,067 mg GAE/g ekstrak; 4,597 mg QE/g ekstrak). Hasil menunjukkan bahwa ekstrak daun memiliki aktivitas antioksidan tertinggi dengan nilai IC50 13,687 µg/mL..
Nano antioxidant serum ethanol extract lime peel (Citrus aurantifolia S.) Fortuna, Putri Asabella; Mugiyanto, Eko; Waznah, Urmatul; Rahmasari, Khusna Santika
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 7 No. 2 (2022)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v7i2.35928

Abstract

Serum is a cosmetic that has received great attention from the industry, but the main challenges are appearance, transparency and public acceptance of herbal active ingredients. On the other hand, herbal cosmetics, such as those using lime peel, are also growing. This study aims to determine the antioxidant activity of lime peel made in a nano extract serum preparation. The method for making nano extracts uses ionic gelation with PSA (Particle Size Analyzer) and Zeta Potential characterization. The concentration of nano serum of lime peel ethanol extract used was 0.5%; 1%; and 3%. Meanwhile, the antioxidant activity testing method uses DPPH and data analysis applied one-way ANOVA then by Tukey test. The results of the nano extract serum formulation using organoleptic testing are transparent, thick and liquid, odorless, and feel moist on the skin. The results of nanoparticle characterization using PSA measurements with three replications were 295.1; 320.3; 385.4 nm and the results of testing the zeta potential of nanoparticles with three replications, namely 3.2; 3.4; 6.0mV. Furthermore, the results of the antioxidant activity test on the basis of the preparation formula are classified as weak (IC50 value of 156.22 μg/mL); Meanwhile, preparation formula with a concentration of 0.5%; 1%; 3% are considered very strong (IC50 value of 46.39 μg/mL; 41.06 μg/mL; 36.27 μg/mL). The results of data analysis consider significance of p value below 0.05. The conclusion is nano lime peel extract meets the requirements and the serum preparation meets the requirements and has antioxidant activity.
Comparison of activity test of ethanol extract and palm root infusion (Arenga pinnata) as an aphrodisiac Rochmat, M. Idhar Khoirul; Mugiyanto, Eko; Waznah, Urmatul; Nur, Achmad Vandian
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 2 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i2.36346

Abstract

The palm tree (Arenga pinnata) contains secondary metabolites such as saponins, phenols, triterpenoids, alkaloids, and flavonoids that can be used as medicine, particularly as an aphrodisiac. Aphrodisiacs are natural substances, medications, or herbal supplements that have the potential to increase sexual arousal. The use of herbal aphrodisiac drugs has been increasing year by year in Indonesia. This study aims to determine the aphrodisiac activity of palm root water extract (Arenga pinnata) in test animals (Web Wiester mice). The preparation of the extract begins with the processing of palm roots, which are then made into an infusion of palm root water (Arenga pinnata). The method of making the palm extract uses infusion and maceration techniques. The aphrodisiac potential test was conducted in vivo using 32 Web Wiester mice, which were divided into 5 groups; the dosage was determined by dividing the mice into five groups (positive control, negative control, 0.5 ml infusion, 1 ml infusion, and extract). The characterization of aphrodisiac properties in the extract included testing the libido of mice (Mus musculus). The results showed that the extract test group with a dose of 250 Mg/KgBW had the highest mating retention among the other test groups.
Evaluation of the mucolytic activity of ethanol extract of Temu Ireng (Curcuma aeruginosa Roxb.) Waznah, Urmatul; Mufrodah, Nely; Wirasti, Wirasti; Mugiyanto, Eko
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 2 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i2.34760

Abstract

Curcuma aeruginosa Roxb., known as Temu Ireng, is a species within the Zingiberaceae family that has been empirically noted for its potential as a cough remedy. Temu Ireng contains alkaloids, flavonoids, and saponins, which play crucial roles in mucus liquefaction. This study aims to investigate the mucolytic activity of the ethanol extract of Curcuma aeruginosa Roxb. In this study, we used an experimental method. The extract was obtained via maceration and analyzed in vitro for its ability to reduce the viscosity of bovine intestinal mucus using a digital viscometer. Bovine intestinal mucus was utilized due to its compositional similarity to human mucus. Test sample concentrations of the Temu Ireng extract were 1.0%, 1.5%, and 2.0%, with acetylcysteine serving as the positive control. Mucolytic activity was indicated by a decrease in mucus solution viscosity. The data were analyzed using one-way ANOVA. The results demonstrated a decrease in mucus viscosity for the Temu Ireng extract test solutions, with statistical analysis indicating a significant difference between the negative control and both the positive control and the Temu Ireng extract samples at concentrations of 1.5% and 2.0%, with p-values of 0.032 and 0.030 respectively (p<0.05). The study concludes that the ethanol extract of Curcuma aeruginosa Roxb. exhibits mucolytic activity at concentrations of 1.0%, 1.5%, and 2.0%.
White Mangrove Pidada (Sonneratia Alba) Leaves Extract in Handbody Lotions: A Qualitative Evaluation and Alignment With Indonesian National Standards Nisa, Husna Idza Auziadzatun; Pambudi, Dwi Bagus; Mugiyanto, Eko
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.4409

Abstract

The White Mangrove Pidada Leaves (Sonneratia alba) serve as a source of secondary metabolites, including phenols, tannins, steroids, and flavonoids, known for their high antioxidant content, making them effective in countering free radicals. The choice of a handbody lotion formulation is based on its easy skin absorption, non-sticky nature, and absence of residue upon application. The focus of this study is to evaluate the handbody lotion formulation enriched with White Mangrove Pidada Leaves extract. Utilizing a qualitative approach, this study employed a cycling test conducted over three cycles for the evaluation of handbody lotion formulations. After three cycles, Formula A demonstrated a semi-solid consistency, light green color with a grape scent, pH 6, and homogeneity. Notably, it showcased a spreadability of 4.925 cm, adhesiveness of 1.76 seconds, and viscosity of 6.791 mPa.S. In the case of Formula B, a semi-solid with a light green color and grape scent, despite having pH 6, exhibited a lack of homogeneity, with a spreadability of 5.175 cm, adhesiveness of 1.37 seconds, and viscosity of 6.592 mPa.S. Formula C, characterized as a semi-solid with a dark green color and grape scent, displayed homogeneity, pH 6, a spreadability of 5.25 cm, adhesiveness of 2 seconds, and viscosity of 7.568 mPa.S. The findings lead to the conclusion that, following three cycles, the handbody lotion formulations align with the criteria established by the Indonesian National Standard (SNI).
Analisis Antibakteri Ekstrak Pacar Kuku (Lawsonia Inermis L.) Sthaphylococcus Aureus Dengan Metode Turbidimetri Nurul Janah, Fatimah; Nur, Achmad Vandian; Rahmasari, Khusna Santika; Mugiyanto, Eko
BIO-EDU: Jurnal Pendidikan Biologi Vol. 9 No. 3 (2024): BIO-EDU: Jurnal Pendidikan Biologi - December 2024
Publisher : Jurusan Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Timor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32938/jbe.v9i3.7925

Abstract

The leaves of henna are commonly used by local communities to treat burns, inflammation, and skin diseases. This plant contains lawsone (2–hydroxy-1,4-naphthoquinone) and various phenolic glycosides, flavonoids, tannins, alkaloids, and quinones, which are believed to contain antibacterial activity. This study aims to determine whether ethanol extracts from the leaves and stems of henna exhibit antibacterial activity and to assess their inhibitory effects against Staphylococcus aureus. The methods employed in this study include maceration and turbidimetric analysis. The extraction method was maceration with 96% ethanol as the solvent. The antibacterial activity was tested using the turbidimetric method with extract concentrations of 15%, 25%, and 30%. Chloramphenicol was used as a positive control, and NaCl served as a negative control. The results revealed that the leaf extracts of henna exhibited antibacterial activity in the leaves and stems of henna nails by comparing the average absorbance values before and after incubation. At concentrations of 15%, 25% and 30% of the leaves of henna na na experienced shedding after incubation which showed that the growth of bacteria had been inhibited. Meanwhile, in the henna nail stem extract, the concentration of 15% decreased after incubation and the concentration of 25%, 30% showed an increase in absorbance value after the incubation process.
A Design and Evaluation of a SNEDDS-Based System for Temu Ireng (Curcuma aeruginosa Roxb.) Extract: Enhancing Antioxidant Efficacy Using the SLD Technique Waznah , Urmatul; Oktaviani, Riska Kurnia Oktaviani; Ainin, Shabrina; Khafid, M. Iskandar; Mugiyanto, Eko
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30268

Abstract

Temu Ireng (Curcuma aeruginosa Roxb.) is known for its strong antioxidant properties, primarily due to its bioactive compounds such as curcumin. However, these chemicals' lipophilia and instability in traditional formulations frequently limit their bioavailability. To address these challenges, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) was developed using the Simple Lattice Design (SLD) method to improve the chemical and physical properties of Temu Ireng extract by forming a stable nanoemulsion that is uniformly distributed in the digestive system. This study aimed to formulate and evaluate a SNEDDS of Temu Ireng extract using the SLD approach, with a focus on enhancing its antioxidant activity. The formulation involved selecting suitable oils, surfactants, and cosurfactants, followed by optimization based on solubility studies, phase diagrams, and thermodynamic stability tests. The SNEDDS was characterized for physical properties such as emulsification time, transmittance, particle size, zeta potential, and polydispersity index. The optimized SNEDDS formulation exhibited excellent characteristics, including an emulsification time of less than 1 minute, near 100% transmittance, a particle size of 9.77 ± 1.33 nm, zeta potential of 0.9 ± 0.1 mV, and a polydispersity index of 0.302 ± 0.033. Antioxidant testing using the DPPH method showed that the 0.1% SNEDDS formulation of Temu Ireng extract had an inhibition concentration (IC50) value of 58.482 mg/L, indicating strong antioxidant activity. The results suggest that the SNEDDS formulation using the SLD method could be an effective strategy to enhance the bioavailability and therapeutic efficacy of Temu Ireng extract as an antioxidant agent.
Pelatihan Pembuatan Sabun Cuci Piring dari Limbah Kulit Lemon untuk Meningkatkan Keterampilan dan Kemandirian Ibu-Ibu PKK di Kelurahan Krapyak Kota Pekalongan Waznah, Urmatul; Rahmasari, Khusna Santika; Ningrum, Wulan Agustin; Oktaviani, Riska Kurnia; Slamet, Slamet; Mugiyanto, Eko; Fadhilah, Isna; Ulhaq, M Daffa’ Dhiya’
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 6 (2025): Agustus
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i6.2832

Abstract

Pelatihan pembuatan sabun cuci piring dari limbah kulit lemon di Kelurahan Krapyak, Kota Pekalongan, bertujuan meningkatkan keterampilan dan kemandirian ekonomi ibu-ibu PKK serta mendukung pengelolaan limbah organik berbasis komunitas. Metode pengabdian meliputi persiapan,pelatihan  dan kuesioner untuk mengukur pengetahuan dan keterampilan peserta sebelum dan sesudah pelatihan. Hasil menunjukkan adanya peningkatan signifikan pada pengetahuan peserta, yang tercermin dari kenaikan rata-rata nilai pre-test ke post-test. Kegiatan ini membekali ibu-ibu PKK dengan keahlian baru dalam pengolahan limbah menjadi produk bernilai ekonomi, sekaligus mendorong peran aktif perempuan dan penguatan ekonomi keluarga. Inisiatif ini juga mendukung pencapaian Sustainable Development Goals pada aspek pengelolaan limbah dan pemberdayaan perempuan. Hasil evaluasi menggunakan kuesioner menunjukkan peningkatan pengetahuan rata-rata peserta sebesar 75%. Program ini selaras dengan tujuan pembangunan berkelanjutan, terutama pada aspek pengurangan limbah (SDG 12) dan pemberdayaan perempuan (SDG 5), serta berpotensi menjadi model replikasi di masyarakat lain.
Analisis Ayat-Ayat Al-Qur’an tentang Jahe untuk Kesehatan dalam Perspektif Al-Quran dan Sains Fuad, Asfal; Mugiyanto, Eko
Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora Vol. 10 No. 2 (2024): Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora
Publisher : Institut Agama Islam Sultan Muhammad Syafiuddin Sambas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37567/alwatzikhoebillah.v10i2.3433

Abstract

This study aims to analyze Quranic verses that mention ginger (Zingiber officinale), particularly in Surah Al-Insan [76:17], and to examine its benefits from both a modern scientific and Islamic spiritual perspective. The study employs a qualitative method with a descriptive-analytical approach and thematic tafsir (maudhu'i). The primary data sources include the Qur'an and tafsir literature, while secondary sources consist of scientific research on the bioactive compounds in ginger, such as gingerol, shogaol, and zingerone. The results indicate that ginger has significant health benefits, including antioxidant and anti-inflammatory effects, immune system enhancement, and prevention of degenerative diseases such as cancer and cardiovascular diseases. From a spiritual perspective, the mention of ginger in the Qur'an as a drink for the inhabitants of paradise symbolizes the balance between physical and spiritual blessings. The integration of Quranic teachings and modern science affirms that ginger is a blessed plant, reminding humans of the importance of maintaining health as an expression of gratitude to Allah SWT. This study contributes to a deeper understanding of the relationship between scientific knowledge and revelation, while encouraging the use of herbal plants to improve quality of life.
Uji Toksisitas Daun Ketepeng (Cassia Alata L.), Kulit Buah Pisang Ambon (Musa Paradisiaca L. Var Sapientum) dan Kulit Rimpang Kencur (Kaempferia Galanga Linn.) dengan Metode Brine Shrimp Lethality Test (BSLT) Ratu, Antonius Padua; Mugiyanto, Eko
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Senyawa antikanker dapat dilakukan skrining dengan metode BSLT.Metodei ini merupakan metode awal dan salah satu cara yang cepatserta murah untuk penapisan toksisitas dari ekstrak tanaman denganmenggunakan hewan laut yaitu larva udang Artemia salina Leach.Berdasarkan alasan tersebut, maka uji ini sangat tepat digunakandalam mengawali penelitian bahan alam. Penelitian ini dilakukanuntuk skrining toksisitas daun ketepeng, kulit buah pisang ambon dankulit rimpang kencur dengan metode BSLT sebagai uji awal untukmengetahui bioaktivitas. Selain BSLT, juga dilakukan penapisanfitokimia. Hasil penelitian dengan metode BSLT dari ekstrak etilasetat daun ketepeng, kulit buah pisang ambon, dan kulit rimpangkencur menunjukkan LC50 masing-masing sebesar 59,14 ppm,146,78 ppm, dan kurang dari 10 ppm. Hasil penapisan fitokimiamenunjukkan bahwa ekstrak etil asetat daun ketepeng hanya terdapatflavonoid, ekstrak etil asetat kulit buah pisang ambon terdapatflavonid dan terpenoid; dan kulit rimpang kencur terdapat alkaloiddan terpenoid. Ekstrak etil asetat kulit rimpang kencur menunjukanaktivitas tertinggi dan pontesial sebagai antikanker, maka perludilakukan isolasi dan identifikasi sehingga diperoleh senyawa aktif.Anticancer compounds can be screened by the BSLT method. Thismethod is an early method and one of the quickest and cheapest waysto screen the toxicity of plant extract using marine animals shrimplarvae Artemia salina Leach. Based on these reasons, this researchwas very appropriate to use in initiating the research of naturalmaterials. This research was conducted for toxicity screening ofketepeng leaf, banana peel and kencur rhizome skin by BSLT methodas preliminary test to know bioactivity. Besides BSLT, phytochemicalscreening is also performed. The result of BSLT method from theextract of ethyl acetate of ketepeng leaf, banana peel, and kencurrhizome skin showed LC50 of 59.14 ppm, 146,78 ppm and less than10 ppm, respectively. The results of phytochemical screening showedthat the extract of ethyl acetate of ketepeng leaf contained onlyflavonoid, ethyl acetate extract of banana peel contained flavonoidand terpenoid; and kencur rhizome skin kencur contain alkaloid andterpenoid. The ethyl acetate extract of the skin of kencur rhizome skinshows the highest activity and pontesial as anticancer, it is necessaryto isolate and identify so that the active compound is obtained.
Co-Authors Achmad Vandian Nur, Achmad Vandian Ainin, Shabrina Antonius Padua Ratu Fadhilah, Isna Fatmala, Rizki Fortuna, Putri Asabella Fuad, Asfal Khafid, M. Iskandar Khusna Santika Rahmasari Mufrodah, Nely Najihah, Veni Haqiqotun Ningrum, Wulan Agustin Nisa, Husna Idza Auziadzatun Nuniek Nizmah Fajriyah Nurul Aktifah, Nurul Nurul Janah, Fatimah Oktaviani, Riska Kurnia Oktaviani, Riska Kurnia Oktaviani Pambudi, Dwi Bagus Permadi, Yulian Wahyu Qulub, Muhammad Syifaul Raharjo, Setyo Tri Rochmat, M. Idhar Khoirul S Slamet, S Slamet . Syarifah, Dewi Ulhaq, M Daffa’ Dhiya’ Urmatul Waznah Vandian, Achmad Waznah , Urmatul Waznah, Urmatul Wirasti, W Wirasti, Wirasti Yulian Wahyu Permadi