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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian BIO-EDU: Jurnal Pendidikan Biologi Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Bangsa Journal of Nutraceuticals and Herbal Medicine
Eko Mugiyanto, Eko
Fakultas Farmasi, Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Karakterisasi Simplisia dan Ekstrak Anti Piretik Daun Dadap Serep (Erythrina Lithosperma Miq) dari Kabupaten Pekalongan Mugiyanto, Eko; Slamet, S; Fatmala, Rizki
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Quality of compound content in the plant could be influenced bymany factor, it could be the origin of the plant, the body part of theplant being tested, and the character of the extract. Erythrinalithosperma Miq locally known as dadap serep, is a plant thatcommonly spread in the area Pekalongan. The purpose of thisresearch is to identify the character of simplicia and extract fromdadap serep. Characterization using the standardization procedureextract issued by Indonesia National Agency of Drug and FoodControl (BPOM). Characterization was performed on simplicia andethanol 96% extract of leaves. Characterization of simplicia includeorganoleptis, drying shrinkage, water soluble extract, and solubleethanol content. Characterization of ethanol extracts include nonspecificcharacteristics i.e. moisture content, total ash content, andacid soluble ash content. The result of characterization is obtainedappropriate with specification by the range value of each type ofsimplicia parameter and ethanol extract of leaves dadap serepobtained from Pekalongan area.
PENGARUH PENAMBAHAN EKSTRAK DAUN SIRSAK (Annona muricata L.)TERHADAP PROFIL FARMAKOKINETIKA PIROKSIKAM Raharjo, Setyo Tri; Pambudi, Dwi Bagus; Mugiyanto, Eko
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Piroxicam is one of the NSAID drug that common used in inflammation. Utilizing of herbal medicine along with synthetic drugs can lead to certain interactions, especially the occurrence of pharmacokinetic drug profile changes. The aim of this study is to determine the effect of addition of soursop leaf extract againt pharmacokinetic piroxicam profile. The method used was cross sectional using 6 rabbits, the data were analyzed statistically with t-test using SPSS version 21 program. The results showed that the piroxicam treatment had Cmax = 0.650 ?g / ml, tmax = 3 hours, t ½ = 0.693 hours, and AUC = 0.597 hours.?g / ml, while on treatment of combination of piroksikam with soursop leaf extract have value of Cmax = 0,683 ?g / ml, tmax = 1 hour, t ½ = 0,693 hours, and AUC = 0,652 jam.?g / ml. The result of data analysis using T test showed that there was significant difference in AUC value (p <0,05). These results suggest that the addition of soursop leaf extract may affect the piroxicam pharmacokinetic profile.
SINTESIS PREKURSOR SENYAWA 2-AMINOBUTYRIC ACID (ABA) DENGAN STARTING MATERIAL MONOSODIUM GLUTAMATE (MSG) Syarifah, Dewi; Slamet, Slamet; Wirasti, Wirasti; Mugiyanto, Eko
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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The aim of the research is to synthesize the compound of Precursor of ABA from MSG the starting material by structural modification as well as to determine the characteristics and physical properties of the synthesis compound. It was done by modification of chemical structure starting with glutamic acid isolation from MSG. Then it isolate reacted with AlCl3 to obtain the ABA compound precursor. The rendemen was 18.5%, of synthesis identification obtained of white powder, odorless, dissolves in hot water and melt at a temperature of 187-189 0C. The UV-Vis spectrophotometry showed that the synthesis process formed a new compound. Confirm with HPLC analysis.
PERBEDAAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN, DAGING BUAH, DAN BIJI MENGKUDU (Morinda citrifolia L.) DENGAN METODE DPPH (1,1–DIPHENYL-2-PICRYLHYDRAZYL) Qulub, Muhammad Syifaul; Wirasti, W; Mugiyanto, Eko
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Antioksidan adalah senyawa yang menghambat efek negatif dari radikal bebas, Noni (Morinda citrifolia L) memiliki senyawa fenolik seperti itu. Tujuan dari penelitian ini adalah untuk mengevaluasi perbedaan aktivitas antioksidan daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. dengan metode pembilasan radikal bebas DPPH. Uji aktivitas antioksidan diukur dengan spektrofotometri UV-Vis dan data dianalisis dengan ANOVA. Hasil penelitian menunjukkan bahwa daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. memiliki total fenolik 47.10 ± 1.73, 18.10 ± 0.00 dan 108.43 ± 1.52 mg GAE / g ekstrak, flavonoid total 15.97 ± 0.03, 3.83 ± 0.15 dan 6.18 ± 0,21 mgQE / g ekstrak., Sementara nilai IC50 374,29 ± 4,14, 442,40 ± 5,78, dan 59,22 ± 0,68 ?g / mL, masing-masing. Analisis ANOVA memiliki perbedaan dengan nilai signifikansi (p-value) <0,05.
Comparative Study of FT-IR Profiles Preparation of Nano-Hydrogel Combination of Soursop Extract and Zinc Waznah, Urmatul; Vandian, Achmad; Mugiyanto, Eko; Fajriyah, Nuniek Nizmah
Prosiding University Research Colloquium Proceeding of The 15th University Research Colloquium 2022: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Nanoparticles delivery system of of herbal preparations and their combinations has received more attention from scientists recently. This combination might lead to chemical reactions among the added constituents. This study aims to compare the FT-IR profile of Carbopol-940 base before and after the addition of soursop extract and zinc oxide nanoparticle. The preparation is made by mixing the base with Annona muricata nano-extracts and nano-zinc. Extraction was carried out by cold maceration of A. muricata leaves in ethanol and then convert into nanoparticles with the assisting of Chitosan biopolymer by ionic gelation method. Nano-zinc is formulated by precipitating zinc acetate by sodium hydroxide. The two nano-formulas were then mixed up into the Carbopol-940 gel matrix. The results show a shift in the profile of Carbopol-940 at a wavelength of 1500 nm to 1700 nm. From the results, it can be seen that there is no difference in the physical characteristics of the base with the addition of the two nano active ingredients. Further research needs to be done to confirm this finding.
AKTIVITAS ANTIOKSIDAN, TOTAL FENOL DAN TOTAL FLAVONOID TANAMAN KEDONDONG (Spondias dulcis Soland ex Park) Najihah, Veni Haqiqotun; Mugiyanto, Eko; Permadi, Yulian Wahyu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 5 No. 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v5i2.2375

Abstract

Upaya peningkatan dalam pemanfaatan antioksidan alami telah dilakukan melalui uji aktivitas antioksidan serta penentuan total fenolik dan flavonoid dari tanaman kedondong (Spondias dulcis Soland ex Park). Tujuan dari penelitian ini adalah untuk menentukan aktivitas antioksidan, total fenolik dan flavonoid dari ekstrak daun, kulit batang dan daging buah kedondong. Ekstraksi telah dilakukan menggunakan pelarut etanol 96% dengan metode maserasi. Analisis spektrofotometri UV-VIS menunjukkan kandungan total fenolik dan flavonoid daun, kulit batang, dan daging buah kedondong sebesar: (37,400 mg GAE/g ekstrak; 9,145 mg QE/g ekstrak), (85,067 mg GAE/g ekstrak; 6,829 mg QE/g ekstrak) dan (4,067 mg GAE/g ekstrak; 4,597 mg QE/g ekstrak). Hasil menunjukkan bahwa ekstrak daun memiliki aktivitas antioksidan tertinggi dengan nilai IC50 13,687 µg/mL..
Co-Authors Achmad Vandian Nur, Achmad Vandian Ainin, Shabrina Antonius Padua Ratu Fadhilah, Isna Fatmala, Rizki Fortuna, Putri Asabella Fuad, Asfal Khafid, M. Iskandar Khusna Santika Rahmasari Mufrodah, Nely Najihah, Veni Haqiqotun Ningrum, Wulan Agustin Nisa, Husna Idza Auziadzatun Nuniek Nizmah Fajriyah Nurul Aktifah, Nurul Nurul Janah, Fatimah Oktaviani, Riska Kurnia Oktaviani, Riska Kurnia Oktaviani Pambudi, Dwi Bagus Permadi, Yulian Wahyu Qulub, Muhammad Syifaul Raharjo, Setyo Tri Rochmat, M. Idhar Khoirul S Slamet, S Slamet . Syarifah, Dewi Ulhaq, M Daffa’ Dhiya’ Urmatul Waznah Vandian, Achmad Waznah , Urmatul Waznah, Urmatul Wirasti, W Wirasti, Wirasti Yulian Wahyu Permadi