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All Journal Jurnal Kesehatan ODONTO Dental Journal Jurnal Kesehatan Gigi Jurnal Kedokteran Gigi Universitas Padjadjaran Journal Of Vocational Health Studies Meditory : The Journal of Medical Laboratory Medika Kartika : Jurnal Kedokteran dan Kesehatan JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH
Sari Setyaningsih
Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Efek Ekstrak Daun Sirih Merah (Piper crocatum) terhadap Perubahan Jumlah Osteoklas Area Tekanan Pergerakan Ortodonti pada Gigi Tikus Sari Setyaningsih; Latifa Eksa Salsabila; Happy Harmono; Herniyati
Jurnal Skala Husada : The Journal of Health Vol 23 No 1 (2026): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

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Abstract

Gaya mekanis ortodonti menghasilkan area tekanan dan tarikan sebagai proses remodeling tulang alveolar untuk keberhasilan dalam perawatan ortodonti. Area tekanan tersebut untuk menyiapkan ruang sebagai arah pergerakan gigi dan ruang tersebut akan terbentuk sebagai akibat aktifitas osteoklas. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun sirih merah (Piper crocatum) terhadap perubahan jumlah osteoklas pada area tekanan pergerakan gigi ortodonti tikus. Desain penelitian adalah eksperimental laboratoris dengan rancangan post-test only control group design. Sampel berupa 36 ekor tikus Wistar jantan yang dibagi menjadi 9 kelompok: kontrol negatif (tanpa gaya, tanpa ekstrak), kontrol positif (diberi gaya mekanis), dan perlakuan (diberi gaya mekanis + ekstrak sirih merah 20 mg/kgBB) dengan waktu pengamatan 1, 3, dan 7 hari. Gaya mekanis diberikan pada gigi molar 1 rahang atas menggunakan Nickel-Titanium Closed Coil Spring dengan gaya sebesar 2,116 oz. Hasil penelitian menunjukkan jumlah osteoklas rata-rata tertinggi terdapat pada kelompok perlakuan 1 hari (36,25), 3 hari (33,5), dan 7 hari (34,75) yang meningkat secara signifikan dibandingkan kelompok kontrol. Aktivitas antioksidan ekstrak sangat kuat dengan nilai IC50 sebesar 40,2977 µg/ml. Berdasarkan pengamatan terjadi perubahan peningkatan jumlah osteoklas pada area tekanan dibandingkan kelompok kontrol, terutama pada pengamatan hari ke-7, yang berpotensi mempercepat pergerakan gigi ortodonti. Kata kunci: daun sirih merah, gaya mekanis ortodonti, osteoklas, area tekanan, remodeling tulang.
Matrix Metalloproteinase‑8 Expression and Collagen Density Alterations in Male and Female Rat Models of Porphyromonas gingivalis‑Induced Periodontitis Agustin Wulan Suci Dharmayanti; Zahara Meilawaty; Amandia Dewi Permana Shita; Sari Setyaningsih; Pudji Astuti; Dwi Warna Aju Fatmawati; Benni Benyamin; Suhartini; Tantin Ermawati; Endah Aryati Eko Ningtyas; Ani Subekti
Jurnal Kesehatan Gigi Vol. 13 No. 1 (2026): June 2026
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v13i1.15071

Abstract

Periodontitis is periodontal tissue inflammation caused by periodontal pathogens, including Porphyromonas gingivalis (P.gingivalis). The incidence of periodontitis in men and women differs significantly, especially in the severity of periodontal tissue destruction, if it overrules smoking habits and poor oral hygiene. However, the information was inadequate and debatable. This study aimed to compare the effect of P. gingivalis on periodontal tissue destruction in female and male rat models, showing increased MMP-8 expression and decreased collagen density. This study was a laboratory experiment using male and female Wistar rats. Each gender of animal models was divided into two groups: control and periodontitis. The periodontitis group induced P. gingivalis every three days for 19 days in the distopalatal and distobuccal gingival sulcus of the mandibular first molar. After the final induction, they were euthanized, and their mandibles were removed for histological observation by immunohistochemistry to determine the expression of MMP-8 in periodontal tissue and Picrosirius Red to determine collagen density. Expression of MMP-8 was observed at 400x magnification using a light microscope, whereas collagen density was observed at 400x magnification; the images were analyzed using the ImageJ application. The data were analyzed using ANOVA and a multiple-comparison test (p<95%). The results revealed that male and female periodontitis models showed significant differences in MMP-8 expression and collagen density (p<0.05). Briefly, P. gingivalis caused periodontal tissue damage in female and male periodontitis models, whereas the female periodontitis model experienced more periodontal tissue damage than the male.
Co-Authors Agustin Wulan Suci Dharmayanti Amandia Dewi Permana Shita Ani Subekti Arina, Yuliana Mahdiyah Daat Atik Kurniawati Benni Benyamin Burhannuddin Dessy Rachmawati Dwi Prijatmoko Dwi Warna Aju Fatmawati Endah Aryati Eko Ningtyas Erawati Wulandari Ernie Maduratna Setiawatie Galau, Argha Sirna Happy Harmono Hendy Hendarto Herniyati Herniyati I Gede Sudarmanto Indriyani Chusnadia, Shafira Latifa Eksa Salsabila Ni Putu Eka Agustini Permata, Dea Permatasari, Sabania Dinar Prihatiningrum, Berlian Pudji Astuti Pudji Astuti PUDJI ASTUTI Rahmah, Tanzilal Azizir Ratna Dewanti, I Dewa Ayu Rendra Chriestedy Prasetya Suhartini Suhartini Suhartini Tantin Ermawati Widodo, Alaya Dwi Salvahira Yunianti, Ervisya Nandya Zahara Meilawaty Zahara Meilawaty Zahara Meylawaty Zahreni Hamzah