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All Journal Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA The Journal of Society Medicine (JSOCMED) Neurona Sanus Medical Journal Jurnal Pengabdian Masyarakat Trimedika
Yudhisman Imran, Yudhisman
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High blood pressure tends to increase carotid intima-media thickness in adult females Imran, Yudhisman; Prawiroharjo, Pukovisa; Mawi, Martiem
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.135-142

Abstract

BackgroundAtherosclerosis is initiated by endothelial dysfunction, as a result of increasing degradation of nitrit oxide by reactive oxygen species, thereby increasing oxydative stress. Dyslipidemia is one of the risk factors of endothelial dysfunction. The aim of this study was to evaluate the relationship of blood pressure and serum lipid level with carotid intima-media thickness (CIMT) in subjects aged between 55-65 years.MethodsA cross sectional study was carried out in 52 male and female subjects aged between 55-65 years. Age, gender, body mass index (BMI), blood pressure, lipid profile, and CIMT were assessed in all subjects. The independent t-test was used to to analyze the relationship between all variables and CIMT. The level of statistical significance was set at p<0.05ResultsMean age was 59.19 ± 3.68 years, prevalence of thickened CIMT was 66.5%, and plaques were found in 9 subjects. There wwre no significant differences in age, BMI, systolic and diastolic blood pressure, and lipid profile between normal and thickened CIMT (p>0.05). However, there was a significant difference in gender between the two groups (p=0.011). In females, mean systolic and diastolic blood pressure were higher in the thickened CIMT group than in the normal CIMT group, but the difference was not significant (p>0.05). ConclusionsOur findings suggest that high blood pressure tends to increase CIMT in female adults. An increasing value of CIMT should be considered as a sign of cerebrovascular disease.
Later age at menopause was associated with higher cognitive function in post-menopausal women Rachmiyani, Irmiya; Surjadi, Lily Marliany; Nirmalasari, Rully Ayu; Imran, Yudhisman
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (736.075 KB) | DOI: 10.18051/UnivMed.2018.v37.203-208

Abstract

BACKGROUND Menopause is a condition in which the menstrual periods have stopped for the last 12 months due to cessation of ovarial functions causing estrogen hormones to decrease. Various studies find that many factors affect cognitive function at post-menopausal age among others the decrease in estrogens, age at menopause, duration of menopause, and education. However, the effects have been subject to controversy. The aim of this study was to determine the relationship of age, age at menopause, estradiol level, and education with cognitive function among healthy post-menopausal women. METHODS A cross-sectional study was conducted involving 31 post-menopausal women between 50 to 75 years old. Data on age, age at menopause, and education were collected using a questionnaire. The estradiol levels were measured using an electrochemiluminescent immunoassay (ECLIA). The Indonesian version of the Montreal Cognitive Assessment (MoCA INA) was used to assess the cognitive function. Multiple linear regression was used to analyze the data. A p<0.05 was considered statistically significant.RESULTS Age (b=-0.086; 95% C.I.=-0.263-0.090; p=324) and estradiol levels (b=0.106; 95% C.I.=-0.018 -0.230; p=0.092) were not significantly associated with cognitive function. However, education (b=1.537; 95% C.I.=0.176-2.898; p=0.028) and age at menopause (b=0.364;0.056-0.671; p=0.022) were significantly associated with cognitive function. Age at menopause was the most influential factor of cognitive function (Beta=0.402) compared to education (Beta=0.394).CONCLUSION Later age at menopause could increase cognitive function in post-menopausal women. Our findings are that modifiable factors that delay age at menopause should receive attention, in order to promote cognitive function. Keywords: Age at menopause, estrogens, cognitive function, post-menopausal women
Low 25-hydroxyvitamin D level increases carotid intima-media thickness in elderly women Imran, Yudhisman; Aswar, Andini; Rachmiyani, Irmiya; Adriani, Donna
Universa Medicina Vol 38, No 2 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2019.v38.114-120

Abstract

BackgroundCerebrovascular disease occurs due to atherosclerosis of the carotid artery triggered by endothelial dysfunction, which can be assessed by measuring the carotid intima-media thickness (CIMT). There are several risk factors contributing to endothelial dysfunction, such as 25-hydroxyvitamin D [25(OH)D] deficiency. A number of research studies have shown variable results on the relationship between 25(OH)D deficiency and endothelial dysfunction. The objective of the present study was to determine the relationship between 25(OH)D and CIMT in elderly women.METHODS A cross-sectional study was conducted involving 45 elderly women aged ≥60 years. The inclusion criteria were: able to communicate well and able to walk actively without any help. The exclusion criteria were: not having diabetes mellitus, stroke, heart disease, kidney disease, not consuming vitamin D or medicines containing corticosteroids, and not using hormone replacement therapy. Laboratory examination was conducted for fasting blood sugar, lipid profile, and 25(OH)D. CIMT was measured using carotid Doppler ultrasonography at the left carotid artery. Simple linear regression analysis was used to analyze the data.RESULTSMean 25(OH)D level was 11.753 ± 4.027 ng/mL, and mean CIMT 0.61 ± 0.10 mm. Simple regression analysis showed a significant relationship between 25(OH)D level and CIMT (β=-0.001; 95% C.I.=-0.020-0.003; p=0.009).CONCLUSION Our data suggest an inverse association between 25(OH)D level and CIMT in elderly women. This study supports the protective role of vitamin D against subclinical atherosclerosis in elderly women.
Effect of Brain Gym ® exercises on cognitive function and brain-derived neurotrophic factor plasma level in elderly: a randomized controlled trial Adriani, Donna; Imran, Yudhisman; Mawi, Martiem; Amani, Patwa; Ilyas, Ermita I.I.
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.732 KB) | DOI: 10.18051/UnivMed.2020.v39.34-41

Abstract

BackgroundCognitive impairment and dementia are some of the major health concerns in the aging population. Many studies showed positive effects of physical exercise in delaying or preventing these conditions. Brain Gym ® exercises is a structured aerobic exercise involving head, eyes and crossing movements of the extremities in order to stimulate both brain hemispheres. This study was conducted to evaluate the effect of Brain Gym ® exercises sessions on cognitive function and plasma brain-derived neurotrophic factor (BDNF) in the elderly.MethodsA non-blinded randomized controlled study involving 64 healthy women aged >60 years who were randomized into Brain Gym ® exercises treatment group (n=32) and control group (n=32). Treatment group joined 60 minutes of brain gym exercises sessions twice a week for 12 weeks. The measured outcomes were cognitive function (assessed by mini-mental state examination [MMSE] questionnaire) and plasma BDNF levels. The outcomes were measured at base-line and after the intervention. An independent t-test was used to analyze the data.ResultsThe BDNF levels were increased in both groups after 12 weeks, and there was a significant difference between treatment group (41.26 ± 6,82 ng/mL) and control group (37.10 ± 8.11 ng/mL)(p=0.040). However, the MMSE score was not significantly different between the two groups (p=0.200).ConclusionBrain Gym ® exercises sessions significantly increase plasma BDNF level in the elderly population. In practical terms, we may suggest evaluation of the effects of Brain Gym ® exercises as a strategy in the treatment of disorders associated with central degenerative changes.
Case Report of Management of Increased Intracranial Pressure in Epidural Hematoma Putra, Rikki Oktrian; Imran, Yudhisman; Rahmansyah, Mulia; Khusfiani, Triasti; Putri, Mustika Anggiane; Az zahra, Ainaya
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.123

Abstract

Epidural haematoma (EDH) is an abnormal collection of blood between the bone and the dura mater. A 26-year-old male was brought by his family to the Hospital Emergency Department with complaints of headache after a traffic accident. The patient was unconscious for 5 minutes and had one seizure. After the seizure, the patient regained consciousness and complained of headache and vomiting. Neurological status examination was within normal limits.  CT-Scan examination of the head found a linear fracture accompanied by a picture of epidural haemorrhage (EDH) 59.34 cc in the right parietal, and midline shift to the left. The patient received conservative management in the form of mannitol. The patient also underwent operative management in the form of decompressive craniotomy for haematoma evacuation. This case describes a patient with EDH with symptoms of increased intracranial pressure and received medical and operative management.
The Use of NIHSS as an Assessment of Acute Stroke Severity Imran, Yudhisman; Zahra, Ainaya Az
Journal of Society Medicine Vol. 3 No. 2 (2024): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i2.128

Abstract

Stroke is a neurological emergency that is characterized by sudden neurological deficits caused by vascular injury (infarction, hemorrhage) in the brain. In Indonesia, stroke is the main cause of disability and mortality. The mortality rate of stroke patients is closely related to the severity of the stroke experienced by the patient. Therefore, a scoring system is needed to assess the severity of acute stroke. The National Institutes of Health Stroke Scale (NIHSS) is used as the gold standard for assessing stroke severity. NIHSS also helps the treatment plan of stroke patients and determine the patient’s prognosis. The use of NIHSS in assessing the severity of acute stroke deserves further attention because it has a significant impact on the outcome of stroke patients during the treatment period.
MASSA MULTIPEL SEREBRI DISERTAI HIDROSEFALUS PADA DUGAAN MENINGITIS TUBERKULOSIS Kartika, Merry; Ramadhan, Mochamad Iskandarsyah Agung; Pratiwi, Sujie; Imran, Yudhisman
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 6, Nomor 2, Juli 2021
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v6i2.9522

Abstract

Objektif: Mendiagnosis gambaran masa multipel pada Computerized Tomography (CT) scan non-kontras pasien dengan dugaan meningitis tuberkulosis (MTB).Ilustrasi Kasus: Laki-laki, 34 tahun, dibawa keluarganya ke Unit Gawat Darurat (UGD) dengan keluhan kelemahan tubuh pada sisi kanan sejak 2 hari yang lalu. Keluhan nyeri kepala, demam, penurunan berat badan, batuk lama dan keringat malam dikeluhkan pasien sejak 2 bulan. Pemeriksaan neurologi ditemukan Glasgow Coma Scale (GCS) E4M5Vafasia global. Rangsang meningeal (+). Kekuatan motorik kesan hemiparese dekstra, Laboratorium darah: leukositosis, anti Human Immunodeficiency Virus (HIV) rapid (-). Rontgen thorax didapatkan bronkopneumonia bilateral dan efusi pleura et causa TB. CT scan kepala non-kontras didapatkan lesi heterogen hipo-hiperdens pada white matter lobus frontal dan temporal kiri, hidrosefalus komunikans ringan disertai tanda-tanda edema hemisfer serebri sinistra.Hasil Diskusi: Pasien ini didapatkan tanda infeksi TB disertai kaku kuduk dan adanya gambaran hidrosefalus pada CT scan kepala non-kontras sehingga diduga sebagai MTB. Hemiparesis dextra dan afasia global dapat disebabkan oleh massa multipel di frontal dan temporal sinistra yang pada CT scan kepala non-kontras dapat difikirkan sebagai tuberkuloma. Tuberkuloma biasanya soliter namun dapat multipel pada 15-34% kasus.1 Gambaran tuberkuloma pada CT scan kepala non-kontras tidak spesifik, dapat berupa massa hipodens, isodens, hiperdens, atau campuran. Apabila dilakukan CT scan kepala dengan pemberian kontras didapatkan penyengatan berbentuk cincin inhomogen, disertai adanya gambaran ventrikulitis.Kesimpulan: Penegakan diagnosis Tuberkuloma pada METB dilakukan dengan berdasarkan manifestasi klinis dan gambaran radiologis CT scan atau Magnetic Resonance Imaging (MRI) kepala yang sebaiknya dilakukan dengan kontras.
KADAR KOLESTEROL LDL SEBAGAI PREDIKTOR LAMA PERAWATAN PADA PASIEN STROKE ISKEMIK AKUT Ayudia, Putri; Imran, Yudhisman
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 2, Juli 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i2.15710

Abstract

LATAR BELAKANG Stroke adalah kondisi abnormalitas pada peredaran darah otak yang onsetnya berlangsung mendadak dengan manifestasi klinis gangguan neurologis fokal sampai global, yang terjadi lebih dari 24 jam dan dapat menimbulkan kematian. Kadar LDL (Low Density Lipoprotein) merupakan kolesterol yang dapat menyebabkan aterosklerosis yang kemudian dapat berkembang menjadi stroke iskemik. Penelitian ini bertujuan untuk menilai hubungan kolesterol LDL dengan lama perawatan pada pasien stroke iskemik akut. METODE Penelitian ini menggunakan disain cross-sectional. Penelitian dilakukan pada Agustus 2021 sampai dengan Desember 2021 menggunakan data sekunder dari rekam medik. Subjek penelitian ini adalah 34 pasien stroke iskemik akut yang di rawat di RS Juanda Kuningan Jawa Barat periode Februari 2019 – Februari 2020. Analisis data yang digunakan adalah bivariat dengan uji Chi-square kemaknaan p<0,05 dan analisis multivariat. HASIL Jenis kelamin paling banyak adalah laki-laki (61,8%), kadar kolesterol LDL tidak normal (85,3%), tekanan darah tidak normal (73,5%), kada glukosa darah normal (52,9%), dan lama perawatan ≥ 7 hari Terdapat hubungan bermakna antara kadar kolesterol LDL dengan lama perawatan pada pasien stroke iskemik akut (p=0,042) dan merupakan variabel paling berperngaruh (OR=35,212). KESIMPULAN Terdapat hubungan bermakna antara kadar kolesterol LDL dengan lama perawatan pada pasien stroke iskemik akut. Kadar kolesterol LDL merupakan variabel paling berperngaruh.
MENGHAFAL AL-QURAN: TINJAUAN FUNGSI KOGNITIF Adriani, Donna; Amani, Patwa; Putri, Mustika Anggiane; Imran, Yudhisman; Fauzi, Ahmad
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 9, Nomor 1, Januari 2024
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v9i1.17487

Abstract

Cognitive function is a mental process consisting of knowledge, information processing, and reasoning. Cognitive functions include the domains of perception, memory, learning, attention, decision-making, and language skills. Assessment of cognitive functions consists of attention and concentration, executive function, memory, language, visuoconstruction skills, conceptual thinking, calculation, and orientation. Cognitive disorder is a maladaptive response characterized by impaired memory, disorientation, incoherence and difficulty thinking logically. Memorization involves various complex processes called basic cognitive processes which include encoding, storing, and recalling memories, because these processes occur in many memory systems that function differently but are interconnected with one another. Al-Quran is the holy book of Muslims that comes from Allah SWT and was revealed through the Prophet Muhammad SAW. Memorizing the Al-Quran can stimulate the neurotrophin factor. In adulthood, there is a decrease in cognitive function of 6.7%. Cognitive function can be assessed from the serum levels of Brain Derived Neurotrophic Factor (BDNF) and serum Nerve Growth Factor (NGF). Brain Derived Neurotrophic Factor is a protein that increases the survival of neurons and synapses that play a role in learning and memory processes. Nerve Growth Factor is a protein that plays a role in the growth, development and maintenance of nerve cells. The purpose of this study is to explain physiologically the effect of memorizing the Al-Quran on cognitive function in terms of serum BDNF and NGF levels. Based on the results of several studies, it was found that memorizing the Al-Quran continuously can improve cognitive function.
PENYULUHAN DAN PELATIHAN BRAIN GYM PADA MAHASISWA DI LEBAK BULUS DAN PARUNG Adriani, Donna; Amani, Patwa; Putri, Mustika Anggiane; Imran, Yudhisman; Rachmiyani, Irmiya
JUARA: Jurnal Wahana Abdimas Sejahtera Volume 5, Nomor 2, Juli 2024
Publisher : Jurusan Teknik Lingkungan Fakultas Arsitektur Lanskap dan Teknologi Lingkungan, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/rh01pz91

Abstract

Tujuan kegiatan penyuluhan dan pelatihan Brain Gym ini adalah meningkatkan pengetahuan, sikap, dan perilaku tentang manfaat Brain Gym dalam meningkatkan fungsi kognitif, serta meningkatkan kesehatan masyarakat. Kemampuan ini meliputi orientasi, proses mengingat, menilai, persepsi serta memperhatikan. Brain gym adalah suatu bentuk olahraga dengan gerakan yang memiliki keseimbangan, menyilang, yang dapat mengaktifkan kedua hemisfer otak dan menstimulasi neuron sensoris dan motorik. Brain Gym dapat meningkatkan fungsi kognitif salah satunya dinilai melalui kadar BDNF serum, jika dilakukan secara teratur, berulang- ulang, dan terstruktur. Brain gym dapat meningkatkan konsentrasi pada penderita Diabetes Melitus grup Prolanis Putewa Jakarta Timur. Metode PkM adalah penyuluhan tentang manfaat Brain Gym terhadap fungsi kognitif, pelatihan Brain Gym, diskusi tanya jawab, serta pengisian kuesioner. Program Pengabdian kepada Masyarakat ini dilaksanakan dengan sasaran mahasiswa Perguruan Tinggi di Lebak Bulus, Jakarta dan Parung, Bogor, Jawa Barat. Berdasarkan kuesioner didapatkan hasil pengetahuan peserta: sangat baik 8,11 %, baik 56,76 %, kurang 35,13 %; sikap: sangat baik 33,78 %, baik 40,54 %, kurang 25,68 %; perilaku: sangat baik 31,08 %, baik 64,87 %, kurang 4,05 %. Kesimpulan: Sebagian besar peserta memiliki pengetahuan, sikap, dan perilaku yang baik.  
Co-Authors Adriani, Donna Ainum, Vanessa Amry, Carissa Maharani Arvasabell, Raissya Keikazita Aswar, Andini Aurora, Malicca Nayya Ayudia, Putri Az zahra, Ainaya Az Zahra, Fatimah Az-Zahra, Athaya Ulima Azahra, Aurelia Fatima Diyan, Ikrimah Djamal, Syifa Kamila Ermita I.I. Ilyas Fadhil, Rafly Afif Fahreza Arraisyi Fauzi Ahmad Muda Jordhi, Dimas Kartika, Merry Khusfiani, Triasti Lestari, Ikrimah Diyan Maharani, Astrid Winesti Maharani, Ni Putu Radela Maizura, Fanny Izzati Martiem Mawi Nasution, Dina Putri Nurkumala, Kaila Patwa Amani, Patwa Pratiwi, Sujie Pukovisa Prawiroharjo Putra, Rikki Oktrian Putri, Audria Assyfa Salsabila Putri, Dian Maharani Putri, Mustika Anggiane Rachmiyani, Irmiya Rahmansyah, Mulia Ramadhan, Mochamad Iskandarsyah Agung Resky Annisa Damayanti, Resky Annisa Rezlin, Madury Rully Ayu Nirmalasari, Rully Ayu Salma, Nabila Maudy Saroso, Ade Firman Sugiri, Nabil Lokeswar Surjadi, Lily Marliany Susy Irma Adisurya Sutanto, Hans Utama Syafitri, Julia Aina Tamarifa, Zhaqina Azizah Wiludjeng, Arinka Ghita Wongso, Agnes Zenyka Wulandari, Ainurrahmi Zahra, Ainaya Az Zulkarnain, Salwa Fildzah