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All Journal WARTA Jurnal Teknologi Laboratorium Journal of Health (JoH) Jurnal Wiyata : Penelitian Sains dan Kesehatan Indonesian Journal of Chemistry Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Biomedika Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Community Development Journal: Jurnal Pengabdian Masyarakat Journal Of Human And Education (JAHE) Conference on Innovation in Health, Accounting, and Management Sciences Proceeding Jurnal Pengabdian Masyarakat dan Riset Pendidikan

Dian Kresnadipayana

Analisis Kesehatan, Fakultas Ilmu Kesehatan, Universitas Setia Budi Jl Letjen, Sutoyo, Mojosongo, Surakarta

Author-ID : 621077

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Uji Aktivitas Antibakteri Pada Ekstrak Kaki Seribu terhadap Lactobacillus Acidophilus Devi Novitasari; Dian Kresnadipayana; Soebiyanto
Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS) Vol. 1 (2020): Proceeding 1st Setia Budi Conference on Innovation in Health, Accounting, and Managem
Publisher : Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS)

Lactobacillus acidophilus merupakan salah satu bakteri yang menyebabkan karies gigi. Ekstrak kaki seribu mempunyai aktivitas dalam menghambat pertumbuhan bakteri. Penelitian ini dilakukan untuk mengetahui ada tidaknya efek antibakteri ekstrak kaki seribu terhadap Lactobacillus acidophilus dan untuk mengetahui senyawa turunan kuinon dapat digunakan sebagai antibakteri terhadap Lactobacillus acidophilus. Metode yang digunakan adalah analisis literature review, pencarian literatur dilakukan dengan mengumpulkan data dari berbagai jurnal baik internasional maupun nasional secara online melalui database "Google Scholar" dan "Science Direct". Berdasarkan hasil review jurnal menunjukkan bahwa ekstrak kaki seribu memiliki kandungan senyawa aktif yang bersifat toksik diantaranya benzokuinon, hidrokuinon, fenol, HCN, benzaldehyde, alkohol dan turunan anthranilate. Ekstrak kaki seribu dapat digunakan sebagai antibakteri terhadap Lactobacillus acidophilus. Senyawa turunan kuinon juga dapat digunakan sebagai antibakteri terhadap Lactobacillus acidophilus.

Uji Toksisitas Ekstrak Biji Jarak Pagar (Jatropha curcas) terhadap Organ Ginjal Tikus Galur Wistar Dengan Parameter Histopatologi Noor Halimah M. Sanad; Soebiyanto; Dian Kresnadipayana
Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS) Vol. 1 (2020): Proceeding 1st Setia Budi Conference on Innovation in Health, Accounting, and Managem
Publisher : Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS)

Jarak pagar (Jatropha curcas) salah satu tanaman yang banyak dikembangkan sebagai pestisida alami. Tanaman jarak pagar mengandung senyawa-senyawa aktif seperti sitosterol, stigmasterol curcin, lectin, flavonoid, viteksin, isoviteksin, alkaloid, terpenoid, dan phorbol ester. Senyawa aktif ini yang berperan dalam pemanfatan tanaman jarak sebagai obat tradisional dan pestisida atau insektisida terutama senyawa phorbol ester yang memiliki sifat toksik yang tinggi dan sering digunakan untuk pestisida alami. Uji toksisitas subkronis oral adalah salah satu dari serangkaian uji toksisitas yang dapat dilakukan untuk mengetahui resiko pemaparan suatu zat terhadap manusia. Parameter yang diamati dalam uji toksisitas subkronis salah satunya yaitu gambaran histopatologi organ ginjal. Metode yang digunakan adalah studi literature review, pencarian literatur dilakukan dengan mengumpulkan data dari berbagai jurnal penelitian secara online pada internet melalui situs Science Direct, Google Scholar, serta SINTA yang mencakup variable yang akan diteliti yaitu senyawa toksik yang dapat merusak organ ginjal. Berdasarkan hasil dari literatur review ekstrak tanaman biji jarak pagar memiliki pengaruh pada organ ginjal dengan kandungan toksik yang di hasilkannya seperti phorbol ester dimana senyawa ini dapat berpotensi merusak organ ginjal seperti terjadinya perubahan mikroskopis berupa sklerosis glomerulus pada ginjal tikus galur wistar.

Effects of Carbamate Insecticides using Carbofuran Active Ingredients on Blood Glucose Levels of Wistar White Rats (Rattus norvegicus) Nurul Tri Isnaini; Soebiyanto Soebiyanto; Dian Kresnadipayana
Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS) Vol. 2 (2022): Proceeding 2nd Setia Budi Conference on Innovation in Health, Accounting, and Managem
Publisher : Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS)

Carbofuran is carbamate pesticides that kills insects, mites, and nematodes on contact or after consumption. The use of pesticides according to the rules is beneficial for farmers unless it can cause poison, health problems, environmental pollution, and residues in food products. If exposed, it causes health problems characterized by an increase in blood glucose levels. This study aims to identify the effect of carbamate insecticides using active ingredients of carbofuran on blood glucose levels of white Wistar (Rattus norvegicus) rats.This study used male Wistar strain rats. It included 3 treatment groups and 1 negative control group. Treatment group 1 used a dose of 0.5mg/kgBW rats; treatment group 2 used a dose of 1.0mg/kgBW rats; treatment group 3 used a dose of 1.5mg/kgBW rats; and control group used distilled water. The treatment was for 28 days. The blood glucose levels were checked using the Konelab 20 Clinical Chemistry Analyzer per week. Data were presented in tables, figures, and statistical analysis with SPSS 26.The results of showed the average blood glucose levels from week 0 to week 4 in group K1 (76.00; 71.00; 74.60; 75.60; 76.80 mg/dL), P1 (90.40; 91.60; 89.80; 84.80; 67.20 mg/dL), P2 (72.75; 85.00; 88.50; 58.50; 68.25 mg/dL), and P3 (82.75; 93.00; 100.25; 106.50; 117.75 mg/dL). Data analysis used the One Way ANOVA test with p-values of 0.035 (p <0.05) indicating significant differences in blood glucose levels in treatment group 3. It can be concluded that carbofuran affects blood glucose levels of rats in treatment group 3.

Minuman Fungsional Fermentasi Berbasis Limbah Kulit Kopi Arabica dengan Symbiotic Colony of Bacteria and Yeast (SCOBY) Saccharomyces cerevisiae Dian Kresnadipayana; D. Andang Arif Wibawa; Mardhiva Indra Saputra; Mei Kresnawati; Levina Levina Nur Andini; Istiqomah Dwi Mayawati
Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS) Vol. 2 (2022): Proceeding 2nd Setia Budi Conference on Innovation in Health, Accounting, and Managem
Publisher : Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS)

Anggrasmanis Arabica Coffee, Jenawi District, Karanganyar Regency is a variety of arabica coffee which is one of the leading commodities originating from the Jenawi highlands, Karanganyar. In the coffee trade, an important part of trading is the beans obtained by going through several stages of processing. During such processing, considerable waste is produced both in solid and liquid form. The largest coffee processing solid waste is pulp (coffee cherry peel). The dried coffee fruit skin (cascara) can be used as fertilizer and animal feed. This study aims to utilize and maximize the antioxidant potential of raw materials for arabica dry coffee fruit peel waste (cascara) in Anggrasmanis Village, with the use of active dry yeast microbes, namely Saccharomyces cerevisiae, into fermented functional drinks that are of selling value and beneficial to health. . In this study, cascara was processed into fruit juice in a ratio of 1% : 5% : 10% ( cascara : sugar : water ), the addition of yeast was carried out according to the dosage indicated on the yeast packaging (2 grams for 10 liters of the basic solution). and in the fermentation process for 7 days . The results of this study are in the form of fermented functional drinks from cascara arabica with the product name "Cascha" with an ethanol / methanol content of 0.142% so that functional drinks from casacara meet the Indonesian National Standard (SNI).

PENGELOLAAN WISATA KULINER TRADISIONAL BERBASIS GOOGLE MY BUSINESS DAN KEUANGAN PADA KOMUNITAS TINTHIR DEMPING Faiz Rahman Siddiq; Yunus Harjito; Agus Endrianto Suseno; Muhammad Firnanda Syaibani; Sugiyarmasto Sugiyarmasto; Berkah Cahyo Mujiono; Dian Kresnadipayana; Mardhiva Indra Saputra
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 5 (2023): Volume 4 Nomor 5 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i5.21636

Pengabdian masyarakat ini bertujuan untuk membangun wisata kuliner tradisional di Kelompok Tinthir Institute di Dusun Demping, dengan memanfaatkan platform Google My Business dan pembukuan akuntansi. Pengabdian ini dilaksanakan karena pentingnya meningkatkan pemahaman masyarakat tentang bisnis kuliner tradisional di era modern. Metode penelitian mencakup memberikan instruksi praktis tentang cara menggunakan Google My Business dan menerapkan sistem pembukuan sederhana. Hasilnya menunjukkan peningkatan yang signifikan dalam pengetahuan tentang manajemen keuangan dan peningkatan yang signifikan dalam aksesibilitas online untuk bisnis wisata kuliner tradisional. Keberhasilan pengabdian ini menunjukkan betapa pentingnya teknologi untuk mendukung bisnis tradisional dan seberapa penting pengelolaan keuangan dalam membangun ekonomi suatu kelompok/komunitas. Ini berdampak pada peningkatan pendapatan serta keberlanjutan wisata kuliner tradisional. Secara keseluruhan, pengembangan wisata kuliner tradisional dan peningkatan pengelolaan keuangan lokal sangat dibantu oleh strategi berbasis Google My Business dan pembukuan akuntansi. Hal ini tidak hanya membantu secara finansial, tetapi juga menunjukkan contoh upaya serupa di tempat lain untuk meningkatkan ekonomi lokal secara keseluruhan.

PENERAPAN IPTEK KELOMPOK TERNAK KAMBING “NGREMBOKO” BERBASIS PAKAN ORGANIK DAN MANAJEMEN PRODUKTIF Kresnadipayana, Dian; Setyawan, Didik; Wibawa, Dionysius Andang Arif; Siddiq, Faiz Rahman
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.21235

Salah satu potensi di Desa Anggrasmanis, Kecamatan Jenawi, Kabupaten Karanganyar, Provinsi Jawa Tengah adalah bidang pertanian, peternakan dan perkebunan yang belum digarap maksimal oleh masyarakat. Salah satunya adalah Kelompok Ternak Kambing “Ngremboko” yang mempunyai program dalam kegiatan ternak kambing. Tujuan dalam dalam hal ini untuk menciptakan produktivitas kelompok produktif dan non produkti di Desa Anggrasmanis.. Permasalahan Mitra (1) Mitra melakukan pemotongan rumput dan pakan secara manual. Hal ini akan membutuhkan waktu yang lama untuk proses pakan sehingga banyak waktu yang terbuang hanya untuk pemotongan rumput dan pakan. (2) Belum adanya inovasi pakan ternak inovasi berbasis probiotik maka produksi kambing juga tidak optimal ini terlihat kambing-kambing yang kurus yang hanya mengandalkan pakan alami. (3) Belum optimal tata kelola organisasi dan keuangan mitra, dengan adanya masalah tersebut maka suasana organisasi belum kondusif, beberapa anggota belum aktif dalam usaha ini. Solusi yang ditawarkan adalah perlunya pengadaan mesin pemotong rumput, perlunya pelatihan pembuatan pakan berbasis pakan organik dengan probiotik, perlunya penyuluhan tentang manajemen organisasi dan keuangan menuju usaha produktif. Pengadaan alat produksi merupakan pendukung kuantitas akan pemotongan rumput dan pakan. Hasil dari pemotongan rumput tersebut dapat diaplikasi ke tahap pembuatan pakan ternak organik berbasis probiotik. Pelatihan-pelatihan dalam pembuatan starter probiotik sehingga mitra dapat membuat sendiri pakan ternak organik tersebut. Kegiatan ini akan dilaksanakan pada hari pertama. Penyuluhan mitra merupakan langkah kegiatan untuk menambah pengetahuan mitra dilaksanakan pada hari kedua.

A Cytotoxic Activity of Ethanol Extract of Yellow Root Stem (Arcangelisia flava (L.) Merr.) and Its Effect on Expression of Bcl-2 and Bcl-xL Genes in MCF-7 Cells Safitri, Devita; Frihani, Assyifa Adelia; Nisa, Sabila Alfa; Kresnadipayana, Dian; Herdwiani, Wiwin
Biomedika Vol 15 No 2 (2022): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v15i2.1309

Breast cancer was the main cause of death in women on the world, the percentage of breast cancer deaths in Indonesia reaching 9.6% with a prevalence of 201,143 cases of total cancer cases in 2020. The increasing incidence of breast cancer caused the use of breast cancer drugs to increase, especially natural ingredients that could be used as an alternative treatment for breast cancer with minimal side effects. Yellow root (Arcangelisia flava (L.) Merr.) contained berberine compounds which was known to have cytotoxic activity. he aim of this study was to determine the cytotoxic activity of the yellow root stem extract (Arcangelisia flava (L.) Merr.) and its effect on the expression of Bcl-2 and Bcl-xL in MCF-7 breast cancer cells. Extraction was obtained by maceration method with 70% ethanol as solvent. The method of testing cytotoxic activity using the MTT method assay at the concentration series (2800; 1400; 700; 350; 175; 87.5; 43.75) μg/ml then calculated the IC50 value using linear regression. The narrative review was conducted by collecting data from various online research journals using the keywords cytotoxicity of extracts of yellow root (Arcangelisia flava (L.) Merr.) AND the effect on the expression of Bcl-2 and Bcl-xL genes in MCF-7 cells. The results of the cytotoxic test showed that the extract had cytotoxic activity against MCF-7 breast cancer cells with an IC50 of 838.67 μg/ml so that the cytotoxic effect was moderate (100-1000 μg/ml) and the results of the study of the effect of protein expression on cancer cells showed that berberine contained in yellow root can reduce the expression of Bcl-2 and Bcl-xL through the mitochondrial intrinsic pathway in MCF-7 breast cancer cells so that it can induce apoptosis induction.

UJI TOKSISITAS MERKURI (Hg) TERHADAP ORGAN GINJAL PADA TIKUS GALUR WISTAR (Rattus norvegicus) DENGAN PEMERIKSAAN UREUM DAN KREATININ SERTA HISTOPATOLOGI GINJAL Karsanto, Narindro -; Kresnadipayana, Dian; Narang, Yemima Adelia
Klinikal Sains : Jurnal Analis Kesehatan Vol 12 No 1 (2024): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v12i1.4144

Heavy metals have a bad effect for the body of animals and humans. The heavy metal that has the highest toxicity is mercury. Mercury (Hydrargyrum) is a chemical compound that is toxic to the body. Exposure to mercury that enters the body can cause acute and chronic poisoning effects as well as disturbances in various organ systems of the body. This study aims to determine the effect of subchronic toxicity on the kidneys by examining levels of urea, creatinine and histopathology of rat’s kidney organs. In this preclinical study, the toxic compound used was mercury sulfate in powder form, then dissolved in aquabidest. This study used 12 male rats divided into 4 groups. The first group, the control group was given aquabidest solution, the 3 treatment groups were given mercury sulfate preparations at a dose of 10 mg/Kg BW, 20 mg/Kg BW, 30 mg/Kg BW. This research lasted for 4 weeks. Urea levels were checked three times, namely at week 0, week 2, and week 4 during the treatment period. At the end of the examination, the test animals were sacrificed for histopathological examination. Administration of mercury sulfate with varying doses had an effect on the kidneys of rats as seen from the results of examination of unstable urea and creatinine levels, namely decreased and increased from normal limits, as well as histopathological examination of the kidneys which showed damage to the parts of the kidney. The conclusion of this study was that there was a toxic effect on the kidneys of white rats when exposed to mercury sulfate orally with graded doses for 4 weeks.

Pengabdian Masyarakat Internasional Penguatan Ecowisata Potensi Desa Segorogunung, Kab. Karanganyar Setyawan, Didik; Herawati, Dewi Astuti; Siddiq, Faiz Rahman; Hariyanti, Widi; Pujiastuti, Peni; Suseno, Suseno; Wibowo, Yari Mukti; Anita Indrasari; Kresnadipayana, Dian; Rahmadina, Nadia; Muftiyanto, R. Taufiq Nur
Journal Of Human And Education (JAHE) Vol. 5 No. 1 (2025): Journal of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v5i1.2221

Potensi Desa Segorogunung ini baik hasil pertanian maupun wisata yang berbasis alam diharapkan memberikan kontribusi pada pendapatan desa maupun masyarakatnya. Wisata yang mengembangkan ekowisata pada hakikatnya merupakan bentuk wisata yang bertanggungjawab terhadap keberlanjutan area wisata yang alami, memberi manfaat ekonomi kepada masyarakat sekitar dan mempertahankan kelestarian budava bagi masyarakat setempat. Potensi ekowisata Desa Segorogunung diperlukan integrasi yang dapat memberikan keuntungan kepada masyarakat. Terdapat 3 area kegiatan pengabdian masyarakat yang dilakukan, yaitu pengembangan potensi kebun teh untuk wisata, pemanfaatan pemasaran digital dalam menyampaikan informasi dan kegiatan di Bumi Perkemahan Desa Segorogunung, dan perlunya standarisasi proses bisnis pengelolaan UMKM Teh Mbok Murti. Hasil yang didapatkan dari kegiatan tersebut masyarakat mendapat kemanfaatan yang semakin berkembangnya pemanfaatan kebun teh, terinformasinya keberadaan Bumi Perkemahan Desa Segorogunung melalui berbagai media digital, dan terimplementasinya standarisasi proses bisnis UMKM Teh Mbok Murti.

Pengembangan Kampung Wisata Sewu Kembang Berbasis Ekonomi Hijau di Nglurah, Kelurahan Tawangmangu, Kabupaten Karanganyar Setyawan, Didik; Kresnadipayana, Dian; Arifwibawa, Dionysius Andang; Siddiq, Faiz Rahman; Wicaksana, Bagus Ismail Adhi
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 3 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 3 (Januari 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i3.4478

The development of tourism villages based on local wisdom is an important community empowerment strategy to promote green economic self-reliance. Tourism villages serve not only as tourist destinations but also as platforms for sustainable rural economic empowerment. Sewu Kembang Tourism Village in Nglurah Hamlet possesses significant natural and cultural potential; however, this potential has not been optimally managed in terms of production systems, institutional management, and marketing. This community service program aims to enhance compost fertilizer production capacity, strengthen institutional management, and develop digital-based marketing strategies for the Joint Business Group (KUBE) “Dwi Tunggal” and the Tourism Awareness Group (Pokdarwis) of Nglurah Hamlet. The program employed a participatory approach through workshops, technical assistance, and operational document facilitation. The results indicate improvements in production capacity, the establishment of structured management systems, and the implementation of marketing media and strategies. These findings demonstrate that empowerment based on local wisdom and green economy principles can enhance institutional capacity and support the sustainable economic development of tourism villages.

Co-Authors Alfian Fendy Setiawan Anita Indrasari Ariefah Yulandari Arifwibawa, Dionysius Andang Bagus Ismail Berkah Cahyo Mujiono D. Andang Arif Wibawa Desi Ristiyanasari Devi Novitasari Dewi Astuti Herawati Diah Anggraheni Setianingsih Dian Indriana Hapsari Dwi Lestari Faiz Rahman Siddiq Frihani, Assyifa Adelia Gregorius Indra Budianto Gregorius Indra Budianto, Gregorius Indra GURUH SRI PAMUNGKAS Guruh Sri Pamungkas, Guruh Sri Hariyanti, Widi Harjito, Yunus Holyness Nurdin Singadimedja Inge Wiratna Istiqomah Dwi Mayawati Karsanto, Narindro - Leni Marbetha Levina Levina Nur Andini Mardhiva Indra Saputra Mardhiva Indra Saputra Mardiyono Mardiyono Maria Fransiska Utami Bugis Mei Kresnawati Mohammad Masykuri Mudasir Mudasir Muftiyanto, R. Taufiq Nur Muhammad Firnanda Syaibani Narang, Yemima Adelia Nisa, Sabila Alfa Noor Halimah M. Sanad Nur Hidayati Nur Hidayati Nurul Tri Isnaini Peni Pujiastuti Rahmadina, Nadia Rahmat Budi Nugroho, Rahmat Budi Rebeca Ester Nauli Sinaga Reny Pratiwi Rinda Binugraheni, Rinda Ristiyanasari, Desi Safitri, Devita Setiawan, Alfian Fendy Setyawan, Didik Siddiq, Faiz Rahman Sinaga, Rebeca Ester Nauli Soebiyanto Soebiyanto Sri Hastuti Sugiyarmasto Sugiyarmasto Susan Primadevi Susan Primadevi Susan Primadevi, Susan Suseno Suseno Suseno Suseno Sutarno Sutarno Tri Mulyowati Tri Mulyowati, Tri Tutik Dwi Wahyuningsih Venty Suryanti Waty, Helmy Indra Wibawa, Dionysius Andang Arif Wiwin Herdwiani Yari Mukti Wibowo Yulandari, Ariefah

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