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All Journal Jurnal Riset Kimia KOVALEN: Jurnal Riset Kimia Indonesian Journal of Chemistry AL-HAYAT: Journal of Biology and Applied Biology Jurnal Biosilampari: Jurnal Biologi Stannum : Jurnal Sains dan Terapan Kimia Jurnal Pustaka Mitra : Pusat Akses Kajian Mengabdi Terhadap Masyarakat Indonesian Journal of Community Empowerment and Service Jurnal Pengabdian Masyarakat Pinang Masak
Munifilia Ekasari
Program Studi S1-Kimia, F. Saintek Universitas Jambi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Education Electrical & Electronics Engineering Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Physics Public Health Social Sciences Other

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Formulation and Characterization of Soursop Leaf extract (Annona muricata L.) Nanoemulsion Using VCO and Tween 80 Puspitasari, Ratih Dyah; Sarani, Desfira; Erliana, Dina; Ekasari, Munifilia
KOVALEN: Jurnal Riset Kimia Vol. 11 No. 2 (2025): December Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2025.v11.i2.17827

Abstract

Methanol extract of soursop leaves contains various bioactive compounds such as alkaloids, saponins, tannins, and flavonoids. To increase the absorption of these compounds, a nanoemulsion formulation of soursop leaf extract was carried out. Extraction was carried out using the maceration method using 96% methanol, followed by a thickening process using a rotary evaporator and freeze drying to obtain the dry extract. The nanoemulsion preparation was made from methanol extract of soursop leaves (Annona muricata L.) using Virgin Coconut Oil (VCO) as the oil phase and Tween 80 as a surfactant. The nanoemulsion was formulated using a high-energy method using an ultrasonicator. Two formulas were tested (F1 and F2) and evaluated through organoleptic tests, clarity (transmittance), physical stability (centrifugation), solubility, emulsion type, storage test (freeze-thaw), and measurement of droplet size and polydispersity index with a Particle Size Analyzer (PSA). The results showed that formula F1 had the most optimal characteristics, with a clarity of 80% indicating better droplet dispersion with an average droplet size of 13.96 nm and a polydispersity index of 0.216 indicating the successful formation of a stable and uniform nanoemulsion. Nanoemulsions showed good physical stability, were soluble in polar and semi-polar solvents, and were oil-in-water (O/W) type supporting increased solubility and availability of active compounds in air-based systems. These results indicate that F1 is the most potential formula to increase the bioavailability of active compounds in soursop leaves and can be further developed as a carrier system candidate in pharmaceutical preparations.
Co-Authors Adelia, Ayu Al Faruqi, Fiqri Anita Dwi Puspitasari Arif, M. Ridwan Avidlyandi, Avidlyandi Azizah Khusnul Charles Banon Denny Prabawa, Aditya Devi Nurhasana Dhian Eka Wijaya Dina Erliana Edwin Permana Endarwati Wiwik Endarwati Faris Hermawan, Faris Fatkhurrachman Fatkhurrachman Fikranzha, Rahul Firdaus, Widani Firdaus, Widani Indah Hartati Indrian, Okta Intan Lestari Khafit Wiradimafan Kodarta, Wahyu Maria Ulfah Marlina, Lala Adetia Morina Adfa Morina Adfa Mudyanto, Andre Muhammad Damris Nur Hikmah Nurhasana, Devi Nurjamil, Dimas Setya Pane, Reza Hotna Uli Pasaribu, Martali Uli Puspitasari, Ratih Dyah Ramdhan, Furkon Risky Hadi Wibowo SALPRIMA YUDHA S Sarani, Desfira Setiyaningrum, Dewi A Setiyaningrum, Dewi A Shari Winda Supriati, Rochmah Triawan Deni Agus Uni Baroroh Husnudin vifta, rissa laila Wibowo Risky Hadi Yudha S Yudha S Yunita Chaya, Helen