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All Journal Medical Journal of Indonesia Jurnal Penyakit Dalam Indonesia
Alvina Widhani, Alvina
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia - RSUPN Dr. Cipto Mangunkusumo, Jakarta
Medicine & Pharmacology

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Association between immune system parameter and clinical characteristics among patients with solid cancer Cahyanur, Rahmat; Widhani, Alvina; Pantoro, Nico Iswanto; Madadika, Annisa Tsana
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247272

Abstract

BACKGROUND Lymphopenia has been reported to be a major predictor of chemotherapy-related toxicity. This study aimed to investigate the correlation between neutrophils, lymphocytes, CD4, and CD8 in solid cancer patients and cancer clinical characteristics. METHODS This was a cross-sectional study of patients who will undergo chemotherapy at the Hematology and Medical Oncology Clinic, Cipto Mangunkusumo Hospital, from June to September 2023. Clinical characteristics, CD4 and CD8 levels, and neutrophil and lymphocyte counts were assessed at the first visit. A comparative test was carried out on the patients’ average CD4, CD8, neutrophil, and lymphocyte counts. RESULTS Types of cancer were associated with CD4 levels. Patients with head and neck cancer had lower CD4 levels (411.3 [119.3–1,427.5] cells/mm³) compared with colorectal (514.7 [129.2–861.3] cells/mm³), breast and gynecological (567.5 [180.1–939 cells/mm³), and other cancers (681.4 [175.1–2,056.9] cells/mm³), with p = 0.009. Patients aged ≥40 years had higher CD8 levels than those aged <40 years (376.4 [142.8–1,293.1] cells/mm³ versus 565.3 [185.9–1,944] cells/mm³, p = 0.01). Additionally, lymphocyte count was associated with cancer type, with the lowest number in head and neck cancer (1,380 [280–2,660] μl, p = 0.044). CONCLUSIONS CD4 levels and lymphocyte counts were associated with the cancer type, whereas CD8 levels were influenced by age.
Co-Authors Adeputri Tanesha Idayu Adeputri Tanesha Idayu, Adeputri Tanesha Adityo Susilo, Adityo Aida Lydia Aida Lydia, Aida Andhika Rachman Andru, Gestana Angga Pramudita Anggoro, RM Suryo Annisa, Firda Arif Mansjoer Aulia Rizka, Aulia Bramantya Wicaksana C. Martin Rumende, C. Martin Ceva W. Pitoyo Cleopas Martin Rumende Cynthia Olivia Maurine Jasirwan Desi Salwani, Desi Dono Antono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edwin Wijaya Edwin Wijaya, Edwin Erni J Nelwan, Erni J Erni Juwita Nelwan, Erni Juwita Evy Yunihastuti Findy Prasetyawaty, Findy Firda Annisa Gurmeet Singh Gurmeet Singh Hamdan, Muhammad Afriadi Hasudungan, Wicensius Parulian Herikurniawan Herikurniawan Herikurniawan, Herikurniawan Ika Prasetya Wijaya Jasirwan, Chyntia OM Josephine, Jennifer Khie Chen Laras Budiyani Laras Budiyani, Laras Leonard Nainggolan Madadika, Annisa Tsana Maksum, Maradewi Maradewi Maksum Mira Yulianti Mira Yulianti, Mira Mondrowinduro, Prionggo Muhammad Yamin Nababan, Saut Horas Noto Dwimartutie Nur Imami, Ghefira Pantoro, Nico Iswanto Praptini, Mirna Nurasri Rahmat Cahyanur Rino A Gani Rino A Gani Robert Sinto Robert Sinto Rudi Putranto Satrio, Trian Siti Setiati Siti Setiati Teguh Harjono Karjadi, Teguh Harjono Wicaksana, Bramantya Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko