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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal Sari Pediatri Biomedical Journal of Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Health Information : Jurnal Penelitian Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Penyakit Dalam Indonesia
Eddy Mart Salim, Eddy Mart
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Epigenetik pada Alergi Susu Sapi Vera, Risa; Irfannuddin, Irfannuddin; Salim, Eddy Mart; Karmila, Ariesti
Sari Pediatri Vol 26, No 6 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.6.2025.399-404

Abstract

Alergi susu sapi dipengaruhi oleh dua faktor utama, yaitu predisposisi genetik dan faktor lingkungan. Interaksi antara faktor genetik dan faktor lingkungan mencetuskan terjadinya alergi susu sapi diperantarai oleh mekanisme epigenetik. Faktor lingkungan selama masa prenatal  maupun postnatal dapat memengaruhi program epigenetik pada masa awal perkembangan sistem imun. Faktor lingkungan, seperti paparan terhadap mikroba, faktor diet pada  ibu dan anak serta  mikrobiota pada saluran cerna memengaruhi  proses imunitas di masa yang akan datang dan berperan penting dalam perkembangan penyakit alergi.
Correlation of TNF-α with Systemic Lupus Erythematosus Activity in Mohammad Hoesin Hospital Palembang Ismed, Yonis; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025 (Issue In Progress)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.349

Abstract

Systemic lupus erythematosus (SLE) is a persistent autoimmune disorder marked by immunological dysregulation and widespread inflammation.  Tumor necrosis factor-α (TNF-α), a pivotal pro-inflammatory cytokine, has been associated with the pathophysiology of systemic lupus erythematosus (SLE), although its clinical relevance is still debated.  This study aims to assess the connection between serum TNF-α levels and disease activity, as quantified by the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI), in Indonesian patients with systemic lupus erythematosus (SLE).  A cross-sectional study was performed including 34 patients exhibiting mild-to-moderate systemic lupus erythematosus activity (MEX-SLEDAI ≤12) at Dr. Mohammad Hoesin General Hospital in Palembang, Indonesia.  Individuals with significant active disease were excluded.  Serum TNF-α concentrations were quantified via a commercial ELISA kit, while disease activity was evaluated through MEX-SLEDAI.  Correlation analysis was conducted using Spearman’s rank test, with p < 0.05 being statistically significant.  The average age of participants was 33.6 ± 11.0 years, with 94.1% identifying as female.  The median MEX-SLEDAI score was 3 (range 2–7), and the median TNF-α level was 1.834 pg/mL (range 0.99–8.62).  No substantial connection was detected between serum TNF-α levels and disease activity (r = 0.111, p = 0.533).  This suggests that serum TNF-α levels did not correlate with or forecast clinical disease activity in this investigation.  The results indicate that the efficacy of TNF-α as a biomarker in SLE may be contingent upon contextual factors, especially illness severity.  Additional multicenter and longitudinal studies involving individuals with a broader spectrum of disease activity are necessary to elucidate its clinical significance.
Correlation Between Serum Malondialdehyde Levels and Disease Activity in Patients with Mild to Moderate Systemic Lupus Erythematosus Hartanto, Kristian; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025 (Issue In Progress)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.350

Abstract

Systemic lupus erythematosus (SLE) is characterized by persistent inflammation and oxidative stress, which contribute to the progression of the disease.   Lipid peroxidation is indicated by malondialdehyde (MDA).   The objective of this investigation was to evaluate the correlation between serum MDA levels and disease activity in patients with mild to moderate systemic lupus erythematosus (SLE).   This investigation was a cross-sectional correlation analysis that employed baseline data from adult patients with systemic lupus erythematosus who were receiving conventional treatment.   Spearman's correlation was employed to determine the relationship between serum MDA levels and disease activity, which was evaluated using the MEX-SLEDAI score.   The study encompassed 38 patients with mild to moderate SLE.   The MEX-SLEDAI score was 3 (range 2–7), and the median serum MDA concentration was 1.42 µmol/L (range 0.90–1.99).   Spearman's correlation analysis demonstrated a moderately positive correlation between serum MDA levels and MEX-SLEDAI scores (r = 0.415, p = 0.010), indicating that elevated oxidative stress is associated with increased disease activity in SLE patients.   A considerable positive correlation between serum malondialdehyde levels and disease activity is statistically significant in patients with mild to moderate systemic lupus erythematosus (SLE).   These results support the existence of oxidative stress in the pathophysiology of lupus and suggest that MDA may serve as a potential biomarker for disease monitoring.
Co-Authors Adinata, Triawan Bastian Bastian Dian Wahyuni E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Hartanto, Kristian Hermansyah Hermansyah Irfannuddin Irfannuddin Ismed, Yonis Jusak Nugraha K, Trisnawaty Karmila, Ariesti Kodrati, Adika Kriswiastiny, Rina kurniati, nova Legiran Legiran Mikhael, Rodry Muhammad Ali Apriansyah, Muhammad Ali Muhammad Irsan Saleh Muhammad Reagan Muthia, Putri Prihantika S., Sabrina Radiyati Umi Partan, Radiyati Umi Rahadiyanto, Kemas Ya'Kub Risa Vera, Risa Rudi Putranto Saleh, M Irsan Silitonga, Aira Priamas Surya Darma Tanoehardjo, Francisca Srioetami Tanoehardjo, Francisca Srioetami Tanoerahardjo, Francisca Srioetami Theodorus Yakub, Kemas Yulianto kusnadi Yuniza Yuniza, Yuniza Zen Hafy