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All Journal Indonesian Journal of Cancer Radioterapi & Onkologi Indonesia Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Nommensen Journal of Medicine Cermin Dunia Kedokteran Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Vito Filbert Jayalie, Vito Filbert
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Other

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Journal : Radioterapi

 1 
Xerostomia Severity and Quality of Life After Nasopharyngeal Cancer Radiotherapy: Intensity Modulated vs Two-dimensional Radiation Therapy in Indonesia Soehartati Argadikoesoema Gondhowiardjo; Nikrial Dewin; Andreas Ronald; Vito Filbert Jayalie; Handoko Handoko; Sri Mutya Sekarutami; Zanil Musa
Radioterapi & Onkologi Indonesia Vol 11, No 2 (2020): VOLUME 11 NO.2 JULY 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i2.116

Abstract

Introduction: Two-dimensional technique (2DRT) is most commonly used in Indonesia. This technique causes severe late toxicity particularly in nasopharyngeal cancer (NPC). Radiation techniques such as Intensity-Modulated Radiation Therapy (IMRT) and Three-Dimensional Conformal Radiation Therapy (3DCRT) provide larger doses at the site of NPC while preserving normal tissue. This study aims to compare late side effects and quality of life (QoL) between IMRT and 2DRT groups.Method: This was a cross-sectional study with consecutive sampling. Salivae samples were collected at least 6 months after last radiation date. Xerostomia severity were determined by measuring whole saliva flow rate which then categorized based on Common Terminology Criteria for Adverse Events (CTCAE). European Organization for Research and Treatment of Cancer (EORTC) core questionnaire and EORTC head and neck module (QLQ-H&N35) wereused to assess QoL.Result: The IMRT group had higher saliva flow rate than 2DRT group (1,085 ±0,409 vs  0,188 ± 0,219 stimulated, 0,500±0,254 vs 0,196 ±0,156 unstimulated, p<0.001). According to CTCAE, IMRT group experienced less  grades 2 and 3 of xerostomia compared to 2DRT group (p<0.05). Moderate correlation between recovery time and saliva flow rate (p<0.05) was found in IMRT group at least 6 months after last radiation date. QLO-C30 scores were higher in IMRT group than those in 2DRT group, particularly in global health status, physical functioning, emotional functioning, pain and insomnia (p<0.05). IMRT group scored better in several QLQ-H&N35 subscales namely head and neck pain, swallowing, speech problems, trouble with social eating, trouble with social contact, dry mouth (p<0.05) and sticky saliva (p<0.001).Conclusion: IMRT was significantly superior to 2DRT in preserving and sparing the salivary gland especially parotid and improving quality of life .Thus, we recommend to treat NPC cases in Indonesia with IMRT to reduce toxicity of the treatment and improve quality of life, as it commonly affects people at productive age.
The Applicability of Neutrophil-Lymphocyte Ratio in Predicting The Survival of Nasopharyngeal Cancer: An Evidence Based Case Report Vito Filbert Jayalie; Nadiyya Faza Zhafirah; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.132

Abstract

Background: Having high prevalence and mortality with a distinctive geographical distribution, nasopharyngeal cancer (NPC) has caused a huge burden in the world. There are several prognostic factors in NPC, however additional marker is needed to give a better picture on disease outcome. Innate and adaptive immunity play a great role in disease progression, however, the role of neutrophil-lymphocyte ratio (NLR) is still controversial. This study aims to investigate the role of NLR status as a prognostic factor in NPC. Methods: Literature searching was conducted through Pubmed, Cochrane, Proquest, EBSCO and Science Direct under specific keywords. Further filtering double and screening for eligibility criteria were performed before critical appraisal and measurement of level of evidence by The Centre for Evidence-Based Medicine (CEBM) University of Oxford. Review for the best available evidence was done by two-independent reviewer.Results: 130 records were retrieved and 6 final articles were finally appraised. All studies were published after 2017 with sample sizes of 140-5973 subjects. NLR cut-off were varied across studies (2.21-3.6) and the overall survival (OS) ranging from 51-82.5%. Moreover, 5-year disease specific survival (DSS) and progression free survival (PFS) for low and high NLR were 76-90.5% vs 53-82.1% and 68-86.2% vs 52-76.5%, respectively. Conclusion: NLR status can be used to predict OS in NPC patients. A careful approach should be taken in determining treatment options. Further research is needed to know the role of NLR in combination with other biomarker in predicting the survival of patients.
Combination of Adoptive Cell Therapy and Radiotherapy in Cancer Management Vito Filbert Jayalie; Endang Nuryadi
Radioterapi & Onkologi Indonesia Vol 13, No 1 (2022): Volume 13 No.1 January 2022
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i1.137

Abstract

Cancer remains a healthcare burden in the world, with the increasing cases and deaths. Adoptive cell therapy (ACT) is one of the immunotherapies which modifies immune system to recognize cancer cells, which is then transfused to induce antitumoral responses in the human body. ACT works by using cancer-specific immune cells, especially Natural Killer and T cells in the form of tumor-infiltrating lymphocytes, T-cell receptor or chimeric antigen receptor. As the combination therapy with radiotherapy, radiation is able to induce tumor-associated antigen (TAA) and major histocompatibility complex (MHC) class I expression, which leads to increased immune cells around the tumor. As the result, transferred ACT to the body may be able to proliferate and perform its function well. Moreover, radiotherapy is able to downregulate regulatory T cells and myeloid-derived suppressor cells which can inhibit the role of the immune system in attacking cancer. Clinically, studies combining radiation and ACT in cancer care are limited to several types of cancer, such as metastatic melanoma, nasopharyngeal cancer, lymphoma and non-small cell lung cancer. Radiotherapy is able to increase therapeutic efficacy, especially as a bridging therapy before ACT. Nevertheless, further trials to know the potency of combining ACT and radiotherapy in other types of cancer, especially in earlier stages are needed.
Epidemiology of 10 Cancer Types in Indonesia: A Multicenter Study Jayalie, Vito Filbert; Gondhowiardjo, Soehartati; Kotambunan, Charity; Apriantoni, Riyan; Manuain, Donald Arinanda; Hawariy, Salik; Prajogi, Gregorius Ben; Permata, Tiara Bunga Mayang; Handoko, Handoko; Munandar, Arie; Sekarutami, Sri Mutya
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.161

Abstract

Cancer remains one of the largest contributors to the burden of health and mortality around the world. A study estimated 19.3 million new cases of cancer in the year 2020. GLOBOCAN 2020 provides a list of the most common cancers in the world which are prostate, lung, and colorectal cancers in men and breast, colorectal, and lung cancer in women. Naturally, different sociodemographic and geographic characteristics will cause disparities in these estimates. Since valid epidemiological data on cancer types in Indonesia remains unavailable, this study intended to provide data on the pattern of distribution of the 10 most common cancer types amongst various hospitals in Indonesia. This was achieved through the collection of registries and/or medical records that were obtained from March to September 2022. The data were then sorted and analyzed using SPSS 20.0. The resulting epidemiological data in multi-centers in Indonesia yielded a similar top 10 most common cancers trend with the GLOBOCAN 2020 worldwide incidence, although some differences were seen. A universal similarity that is found amongst different databases seems to be the prevalence of breast cancers, which always ‘champions’ all databases as the most common cancers among women. This provides a reflection for policy and decision makers for their prompt action to promote the prevention, diagnosis, and treatment of cancers in Indonesia, especially breast cancers.
Co-Authors -, Shelly Adrian Reynaldo Sudirman Andreas Ronald Andy William Andy William Anisa, Beryliana Maya Apriantoni, Riyan Arie Munandar Beryliana Maya Anisa Caren Andika Surbakti Cosphiadi Irawan Dahlan, M. Sopiyudin Dimas Priantono Dimas Priantono, Dimas Endang Nuryadi Evert D.C. Poetiray Firdaus, Riyadh Fushen, Fushen Handoko Handoko Handoko Handoko Hanifah, Rizka Hasna Ibadurrahmi Hasna Ibadurrahmi, Hasna Hawariy, Salik Indah Nur Rachmah Indonesia Emergency Knowledge and Attitude Evaluator Team Kotambunan, Charity Lintang Sekar Sari Lutfiana, Nela Luther Holan Parasian M. Sopiyudin Dahlan Manuain, Donald Arinanda Marlinda Adham Matthew Billy Melitina Tecoalu Nadiyya Faza Zhafirah Nela Lutfiana Nikrial Dewin Nurjati Chairani Siregar Oliver Emmanuel Yausep Parasian, Luther Holan Permata, Tiara Bunga Mayang Prajogi, Gregorius Ben Rachmah, Indah Nur Radhian Amandito Raksheeth Agarwal Rania Zahra Ratnawati Soediro Rino Alvani Gani Riyadh Firdaus Sari, Lintang Sekar Sebastian, Andreas Ronald Barata Sekarutami, Sri Mutya Shelly - Soegeng Wahyoedi Soehartati Argadikoesoema Gondhowiardjo Soehartati Gondhowiardjo Soehartati Gondhowiardjo Sri Mutya Sekarutami Sri Mutya Sekarutami Sudirman, Adrian Reynaldo Surbakti, Caren Andika Wulyo Rajabto Zahra, Rania Zanil Musa Zubairi Djoerban Zulkifli Amin Zulkifli Amin