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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana Journal of Marine Research Bioedukasi: Jurnal Pendidikan Biologi BIOMA : Jurnal Biologi Makassar Jurnal Akuakultur Sungai dan Danau BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains JURNAL PENDIDIKAN TAMBUSAI AL-HAYAT: Journal of Biology and Applied Biology EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Biopendix: Jurnal Biologi, Pendidikan dan Terapan Best Journal (Biology Education, Sains and Technology) Jurnal Biogenerasi Jurnal Riset Biologi dan Aplikasinya Jurnal Ilmiah Biologi UMA (JIBIOMA) Bioscientist : Jurnal Ilmiah Biologi Mimbar Kampus Islamic Journal of Integrated Science Education BIO-CONS: Jurnal Biologi dan Konservasi Mimbar Kampus: Jurnal Pendidikan dan Agama Islam Bionature
Husnarika Febriani, Husnarika
Universitas Islam Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Pengaruh Ekstrak Daun Kenikir (Cosmos caudatus Kunth.) pada Histopatologi Hepar Tikus Putih (Rattus norvegicus L.) Induksi Aspirin Ayunda, Sapna; Febriani, Husnarika; Syukriah, Syukriah
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 6, No 2 (2024): November
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v6i2.5185

Abstract

Aspirin is one of the most commonly used nonsteroidal anti-inflammatory drugs (NSAIDs); however, long-term use and high doses can damage liver function and structure. To reduce aspirin’s side effects, kenikir leaves (Cosmos caudatus K.) are used as an alternative treatment. This study aims to evaluate the effects of kenikir leaf extract on liver damage caused by aspirin, both morphologically and histopathologically. A total of 25 male white rats were divided into 5 groups: KN (control), KP (aspirin 200 mg/kg BW for 10 days), P1 (aspirin + kenikir extract 700 mg/kg BW for 14 days), P2 (aspirin + kenikir extract 800 mg/kg BW for 14 days), and P3 (aspirin + kenikir extract 900 mg/kg BW for 14 days). Liver cell damage was analyzed using scoring and histomorphometry methods, followed by one-way ANOVA and Duncan’s test. The results showed that kenikir leaf extract significantly improved the morphology and histopathology of rat livers induced by aspirin, including parenchymal degeneration, hydropic degeneration, and necrosis. The most effective dose was 800 mg/kg BW, which also improved the diameter of the central vein and the width of the liver sinusoids.
Teams Games Tournament Learning Model on Students Activities and Learning Outcomes at Modern Islamic Boarding School Febriani, Husnarika; Tambunan, Efrida Pima Sari; Hasibuan, Turlan Rumaito
Islamic Journal of Integrated Science Education (IJISE) Vol. 1 No. 3 (2022): November
Publisher : Program Studi Tadris IPA, Fakultas Tarbiyah (IAIN) Kediri, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/ijise.v1i3.368

Abstract

This research aims to find out the influence of the Teams Games Tournament (TGT) learning model  on students activities and learning outcomes of class XI at Nurul Hakim Modern Islamic Boarding School. The type of this research is a Quasy Experiment. The population in this study was all students of class XI IPA of Nurul Hakim Modern Boarding School which amounted to 60  students. The sample used was class XI IPA 1 as an experimental class of 30 students and class XI IPA 2 as a control class of 30 students. Research instruments used to find out student learning activities are using a student learning activity questionnaire and for student learning outcomes was use multiple choices test of 25 questions. Data analysis was done using hypothesis tests. The percentage of students' learning activities in the experimental class was 83.70% which was higher than the learning activities of the control class students, which was 51.50%. The average learning outcome in the experimental class model was 82.00  and in the control class was 78.00. Based on the results of the analysis of thitung > ttabel which is 3.06 > 2.00, which means that Ha is accepted, and Ho is rejected. So, it could be concluded that there is an influence of student learning activities and outcomes using the Teams Games Tournament (TGT) learning  model.
Morpho-histological Study of the Rat Spleen Post-Induction of Sodium Nitrite and Acorus calamus L. Rhizome Ethanolic Extract Amira, Siti; Febriani, Husnarika; Syukriah, Syukriah; Nur Faizah, Ulinnuha
Jurnal Riset Biologi dan Aplikasinya Vol. 5 No. 2 (2023)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jrba.v5n2.p89-97

Abstract

Sodium nitrite (NaNO2) is one of the most inorganic salts and is often used in processed meat products. Long-term consumption of sodium nitrite has been reported to cause of oxidative stress and spleen histological changes. Therefore, anti-oxidative effects are needed from natural ingredients such as Acorus calamus L. The study aims to determine the effect of A.calamus L. rhizome extract on anatomical structure and histological changes in the rat spleen induced with NaNO2. We used a completely randomized design with twenty-five male rats divided into 5 groups. Negative control (NC) was given 0.5% CMC for 40 days; positive control (PC) on days 1-15 was given NaNO2 (50 mg/kg BW); on days 16-30 given (50 mg/kg BW) NaNO2 + 0.5% CMC and on days 31-40 given 0,5% carboxy methyl cellulose (CMC). Treatment 1 (T1), Treatment 2 (T2), and Treatment 3 (T3) on days 1-15 were given NaNO2 doses of 50 mg; and; on days 16-30, groups T1, T2, and T3 were given NaNO2 + extract with each predetermined dose (250 mg/kg BW for T1, 500 mg/kg BW for T2, and 750 mg/kg BW for T3). For days 31-40 groups T1, T2, and T3 were given extracts with each predetermined dose. Results revealed that the extract of the A. calamus L. rhizome affects weight, length, and width of the spleen (P<0.05); and bleeding lesions; while having no noticeable effect (P<0.05) and having a noticeable effect on the area of the white pulp (P<0.05). Administration of ethanol extract of A. calamus L. at a dose of 250 mg/kg BW has an impact on improving spleen length; a dose of 500 mg/kg BW has an impact on the weight and length of the spleen; and a dose of 750 mg / kg BW has an impact on improving spleen length, but the size variation is still in the normal category. While extracts at doses of 250 and 500 mg/kg BW have a repair impact on tissue shrinkage in damaged white pulp. 
Pengaruh Pemberian Ekstrak Etanol Daun Sambiloto Andrographis paniculata (Burm. fil) Ness Terhadap Histologi dan Faal Ginjal Tikus Putih (Rattus novergicus L.) yang Diinduksi Timbal Asetat (Pb(C2H3O2)2) Cutami, Ledia Fristia; Tambunan, Efrida Pima Sari; Febriani, Husnarika
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 7 No 2 (2024): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/bioedusains.v7i2.12567

Abstract

This study aims to examine the impact of ethanol extract from bitter leaf (Andrographis paniculata) on the morphology, histology, and physiology of the kidneys of white rats (Rattus novergicus) induced by lead acetate. The method used was a completely randomized experimental design, consisting of five treatment groups with five repetitions. The control group was only given food and drink, while the experimental group received lead acetate for 28 days at a dose of 40 mg, followed by administration of bitter extract at varying doses (250, 500, and 750 mg/kg body weight) for 14 days. The results showed that administration of lead acetate caused histological damage to the kidneys, such as necrosis, tubular degeneration, and tubular dilatation, and increased blood urea and creatinine levels, which are indicators of kidney function. These findings indicate that an ethanol extract of bitter leaf at a dose of 750 mg/kg body weight can mitigate this histological damage and has the potential to reduce urea and creatinine levels. Thus, bitter leaf extract shows potential as a kidney protective agent against damage induced by lead acetate. Keywords: Kidney, Creatinine, Lead Acetate, Ureum
PENGARUH PAKAN TAMBAHAN AMPAS TAHU DAN TEPUNG KACANG HIJAU (Vigna radiata, L.) TERHADAP MORFOMETRIK DAN BOBOT AYAM BROILER (Gallus domesticus) Aldyan, M Ardhi; Febriani, Husnarika
BEST Journal (Biology Education, Sains and Technology) Vol 7, No 1 (2024): Juni 2024
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v7i1.8447

Abstract

Limbah industri produksi tahu sudah tidak dimanfaatkan kecuali digunakan sebagai pakan ternak. Masyarakat sering menyebut limbah tahu sebagai ampas tahu. Limbah ini digunakan sebagai pakan ternak karena mengandung lemak dan protein yang tinggi. Selain ampas tahu, tepung kacang hijau juga dimanfaatkan sebagai makan ternak karena mengandung protein tinggi. Tepung kacang hijau merupakan hasil produk setengah jadi kacang hijau. Tujuan penelitian ini untuk mengetahui pengaruh pakan tambahan ampas tahu dan tepung kacang hijau (Vigna radiata) terhadap morfometrik dan bobot ayam broiler (Gallus domesticus). Penelitian ini menggunakan rancangan acak lengkap dengan 20 ayam broiler dibagi menjadi 4 kelompok perlakuan. P0= 100% pakan komersil. P1= 90% pakan komersil, 5% ampas tahu, dan 5% tepung kacang hijau. P2= 80% pakan komersil, 10% ampas tahu, dan 10% tepung kacang hijau. P3= 70% pakan komersil, 15% ampas tahu, dan 15% tepung kacang hijau. Parameter yang diukur penimbangan bobot dan pengukuran morfometrik yaitu panjang kaki, paha, dada, sayap, dan maksilla. Analisis data menggunakan one way ANOVA dan dilanjutkan dengan uji Duncan. Hasil yang didapatkan dalam penambahan pakan tambahan ampas tahu dan tepung kacang hijau berpengaruh terhadap morfometrik dengan nilai p=0.000. Hasil yang didapatkan dalam penambahan pakan tambahan ampas tahu dan tepung kacang hijau berpengaruh terhadap bobot badan dengan nilai p=0.000. Pakan yang paling optimal dalam pertumbuhan morfometrik dan bobot badan adalah pada kelompok P2.
PENGARUH EKSTRAK DAUN SALAM (Syzygium polyanthum) TERHADAP HATI TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KADMIUM KLORIDA Syahfitri, Fazira Rahma; Syukriah, Syukriah; Febriani, Husnarika
BIOMA : JURNAL BIOLOGI MAKASSAR Vol. 10 No. 1 (2025): Bioma : Januari - Juni 2025
Publisher : Department of Biology, Faculty of Mathematics and Natural Sciences, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kadmium klorida (CdCl2) berasal dari pembentukan radikal bebas yang dapat menimbulkan stress oksidatif dan dapat merusak organ pada hati serta meningkatkan kadar SGPT dan SGOT. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak daun salam (Syzygium polyanthum) terhadap kadar SGOT, SGPT, Indeks hepatosomatik dan morfologi hati tikus putih yang diinduksi kadmium klorida (CdCl2). Penelitian ini menggunakan RAL dengan 20 tikus yaitu kelompok kontrol negatif, kelompok kontrol positif, kelompok perlakuan (P1), kelompok perlakuan (P2), kelompok perlakuan (P3) yang diberi ekstrak daun salam (Syzygium polyanthum) dengan dosis 200 mg/kg BB (P1), 300 mg/kg BB (P2), 400 mg/kg BB (P3). Pemberian ekstrak daun salam (Syzygium polyanthum) dan penginduksian kadmium klorida (CdCl2) dilakukan selama 14 hari. Pengambilan darah dilakukan pada hari ke 15 melalui sinus orbitalis. Hasil uji Duncan dapat dilihat bahwa kadar SGPT pada P1 (73,50 U/L), P2 (66,75 U/L), P3 (62,00 U/L). Pada kadar SGOT kelompok positif berbeda nyata terhadap kelompok perlakuan dengan nilai sebesar P1 (166,00 U/L), P2 (156,25 U/L), P3 (152,75 U/L). Hasil pengamatan morfologi hati tikus putih berbeda nyata antara kelompok kontrol positif terjadi perubahan warna menjadi coklat pucat terhadap kelompok perlakuan P1, P2, dan P3 yang masih berwarna coklat kemerahan. Rata-rata indeks hepatosomatik P1 (4,1725), P2 (4,3275), P3 (3,9770). Berdasarkan data yang diperoleh bahwa ekstrak daun salam (Syzygium polyanthum) mampu dalam menurunkan kadar SGPT, SGOT serta menurunkan rata-rata indeks hepatosomatik tikus putih yang diinduksi kadmium klorida (CdCl2) pada dosis 400 mg/kg BB. Kata kunci : CdCl2, Indeks hepatosomatik, Morofologi hati, SGPT, SGOT, Syzygium polyanthum
PENGARUH PEMBERIAN EKSTRAK ETANOL BUAH AREN (Arenga pinnata Merr.) TERHADAP PROFIL DARAH TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Triyudha, Garibaldi; Febriani, Husnarika; Aisyah Hutasuhut, Melfa
Jurnal Biogenerasi Vol. 10 No. 2 (2025): Volume 10 no 2 periode februari - september 2025 ( continues)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i2.5636

Abstract

Carbon tetrachloride (CCl4) is a common sanitizer and decomposer that can be harmful if eaten, inhaled, or absorbed through the skin. Herbal plants can be used as therapeutic treatment to counteract the effects of these dangerous drugs. Palm fruit (Arenga pinata Merr) is one of them. The aim of this research was to determine the effect of administering palm fruit extract on the number of erythrocytes, leukocytes, hemoglobin and platelets in white rats induced by carbon tetrachloride.This study used a completely randomized design with 20 mice divided into 5 treatment groups. Negative controls were given food, drink and 1 ml/kg BW olive oil, positive controls were given 1 ml/kg BW carbon tetrachloride and olive oil with a ratio of 1:3. Treatments 1, 2 and 3 were given carbon tetrachloride 1ml/kg BW and olive oil with a ratio of 1:3 and given ethanol extract of palm fruit at different doses (P1= 90 mg/kg BB, P2= 180 mg/kg BB, P3= 360 mg/kg BB) for 15 days. The results obtained include that the ethanol extract of palm fruit has a very significant effect on erythrocytes, hemoglobin, leukocytes and platelets with a P value = 0.000 and the average value of erythrocytes (7.66 µl), hemoglobin (13.45 g/dl), leukocytes (15 .34 µl), platelets (895.25 mm²). The optimal dose of palm fruit extract to counteract and improve the number of erythrocytes, hemoglobin, leukocytes and platelets is a dose of 360 mg/kg BB.
PENGARUH PEMBERIAN EKSTRAK ETANOL BUAH AREN (Arenga pinnata Merr.) TERHADAP KADAR KREATININ, UREUM DAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Awaliah Sifa, Nurharija; Febriani, Husnarika; Widiarti, Leni
Jurnal Biogenerasi Vol. 10 No. 2 (2025): Volume 10 no 2 periode februari - september 2025 ( continues)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i2.5637

Abstract

One substance that produces radical compounds is carbon tetrachloride (CCl4). As a solvent, insecticide, coolant, stain remover, and soap, carbon tetrachloride is widely used. Direct skin contact, ingestion, inhalation, and eye contact are ways this material enters the body. The antioxidants found in palm fruit (Arenga pinnata Merr.) can help protect against damage caused by free radicals. This study aims to determine how giving ethanol extract of palm fruit (Arenga pinnata Merr.) to white rats (Rattus norvegicus L.) affects creatinine, urea levels and kidney histology when exposed to carbon tetrachloride (CCl4).This study used a completely randomized design with 20 mice divided into 5 treatment groups. Negative controls were given food, drink and 1 ml/kg BW olive oil, positive controls were given 1 ml/kg BW carbon tetrachloride and olive oil with a ratio of 1:3. Treatments 1, 2 and 3 were given carbon tetrachloride 1ml/kg BW and olive oil with a ratio of 1:3 and given ethanol extract of palm fruit at different doses (P1= 90 mg/kg BW, P2= 180 mg/kg BW, P3= 360 mg/kg BW) for 16 days. The results obtained include that ethanol extract of palm fruit has a very significant effect on creatinine, urea and kidney histology. The optimal dose of palm fruit ethanol extract to improve kidney is a 360 mg/kg BW.
Effect of Giving Ethanol Extract of Palm Fruit (Arenga pinnata Merr.) on The Lipid Profile of White Rats (Rattus norvegicus L.) Induced by Carbon Tetrachloride (CCl4) Rambe, Rendi Ardiansyah; Febriani, Husnarika; Syukriah, Syukriah
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 1 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue1page1-6

Abstract

Carbon tetrachloride (CCl4) is a chemical substance in the form of a clear liquid, volatile and toxic with a sweet odor. Palm fruit (Arenga pinnata Merr.) is a plant that has high antioxidants and is able to reduce the effects of free radicals in the body. The purpose of this study was to evaluate the impact of ethanol administration of palm fruit (Arenga pinnata Merr.) on total cholesterol, triglyceride, HDL and LDL levels of white rats (Rattus norvegicus L.) which were induced by carbon tetrachloride (CCl4). This study used a completely randomized design with 20 mice divided into 5 treatments and 4 replications. Negative controls were given food and drink, positive controls were given carbon tetrachloride 1 mL/kg BW + olive oil ratio 1:3, Treatments 1,2, and 3 were given carbon tetrachloride 1 mL/kg BW + olive oil with a ratio 1:3 + palm fruit ethanol extract in graded doses (P1=90, P2=180, and P3=360 mg/kg BW) for 15 days. Data analysis used one way ANOVA and continued with the Duncan test. The results showed that 1 mL/kg BW of carbon tetrachloride could damage the lipid profile of white rats. Giving ethanol extract of palm fruit (Arenga pinnata Merr.) to P1 and P2 at a dose of 90 mg/kg BW and 180 mg/kg BW had no significant effect. Meanwhile, P3 with a dose of 360 mg/kg BW had a significant effect on reducing total cholesterol, triglyceride and LDL levels and could significantly increase HDL levels at a significant level (p<0.05).
The Effects of Andrographis Paniculata (Burm. f.) Nees Extract on the Liver White Rats (Rattus norvegicus L.) induced by Lead Acetate Andrian, Luthfiyah; Febriani, Husnarika; Tambunan, Efrida Pima
Bionature Vol. 25 No. 1 (2024): April-Juni 2024
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i1.2061

Abstract

Lead acetate is classified as a heavy metal compound that has the ability to stimulate the overproduction of free radicals, sometimes referred to as Reactive Oxygen Species (ROS), leading to oxidative stress at the cellular level. When lead acetate is introduced into the body, it undergoes systemic circulation and distributes to several organs, including the liver. Prolonged exposure of the liver to high levels of lead can result in hepatic damage. The leaves of Andrographis paniculata (Burm. fil.) Ness are known to possess antioxidant properties, rendering them suitable for medicinal use in combating free radicals. The objective of this study is to investigate the impact of ethanol extract derived from Andrographis paniculata (Burm. fil.) Ness on the morphological characteristics and hepatic functionality of white rats (Rattus norvegicus L.) that have been treated with lead acetate. The present study employed a completely randomized design, consisting of five treatment groups and five repetitions. The control group received only food and drink, while the experimental group was administered lead acetate for a duration of 28 days at a dosage of 40 mg. The treatment groups, on the other hand, were each administered ethanol extract of Sambiloto leaves at dosages of 250, 500, and 750 mg/kg BW for a period of 14 days. The findings indicated that the treatment of lead acetate resulted in liver histological damage, specifically parenchymatous degeneration, hydropic degeneration, and necrosis. Additionally, it led to elevated levels of SGPT and SGOT. The study's findings indicate that the administration of a 750 mg/kg BW dose of ethanol extract derived from Sambiloto leaves can effectively mitigate liver histological damage and lower levels of SGPT and SGOT.
Co-Authors Aisyah Hutasuhut, Melfa Aldyan, M Ardhi Amira, Siti Andrian, Luthfiyah Awaliah Sifa, Nurharija Ayunda, Sapna Azhari, Mhd Bayu Cutami, Ledia Fristia Damanik, Novita Fadillah, Nurul Maurito Gita Anggraini, Gita Harahap, Nurbaiti Hasibuan, Turlan Rumaito JS, Nurri Yusriyyah Khairuddin - Khairuna Khairuna Leni Widiarti, Leni Lestari, Sri Murni Ayu Mashitah, Ulfa Matondang, Indah Dinamayanti Mayasari, Ulfayani Nabila, Jihan Nasution, Nur Ainun Nasution, Putri Aminah Nur Faizah, Ulinnuha Nurjannah, Suci Nurjannah Parinduri, Ayu Nurhabibah Pima Sari Tambunan, Efrida Puspita Sari Putri, Nesya Destika Rahmadina, Rahmadina Rambe, Rendi Ardiansyah Riskiyah, Ainur Rohani Rohani Sahputra, Bagus Septiandi, Rigi Solin, Raslina Surbakti, Nur Anisah Br Syahfitri, Fazira Rahma Syahputra, Akbar Syukriah Syukriah, Syukriah Tambunan, Efrida Pima Tambunan, Efrida Pima Sari Triyudha, Garibaldi Zahratul Idami