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In-Silico Studies of Musa balbisiana Colla with Proteins Promoting Antibiotic Resistance in Bacterial and Fungal Pathogens Ramdhani, Danni; Kusuma, Sri Agung Fitri; Kusmiati, Meti
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.54464

Abstract

Fruit of klutuk banana (Musa balbisiana Colla) has been used by Indonesian people to stop the diarrhea caused by the effect of dysentery and also fungal infections of the skin. In this study, we used molecular docking methods to investigate the mechanism of inhibition of their main bioactive compounds cholesta-5,7-dien-3beta-ol, cycloartenol, cyclomusalenone and were compared with the native ligand (the control drugs: amphotericin B, erythromycin and fluconazole) against the proteins responsible for antibiotic resistance in bacterial and fungal pathogens. The target receptor that plays a role were cytochrome P450 14-alpha-sterol demethylase (CYP51), N-myristoyl transferase (NMT), and penicillin-binding protein 3 (PBP3). Swiss ADME servers were used for the determination of Lipinski rule of 5, and drug-likeness prediction respectively, whereas, admetSAR and Protox-II tools were used for toxicity prediction. Cyclomusalenone performed the best binding affinity value -6.0, -8.5, and -6,1 (kcal.mol-1) compared than the control drugs (amphotericin B, erythromycin, and fluconazole). All the bioactive compounds are non-carcinogenic and non-cytotoxic by nature, and they all conform to the Lipinski rule. Based on these data, we recommend predicting the targets of bioactive compound for testing antifungal activity in vitro and in vivo.
DETEKSI DINI HIPERTENSI: PEMBERDAYAAN GURU DAN ORANG TUA SISWA UNTUK HIDUP SEHAT Syafariah, Yayah; Ferdiani, Dina; Nurhasanah, Annisa; Nurpalah, Rianti; Kusmiati, Meti; Kasmanto, Hendro; Meri, Meri
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 5 (2024): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i5.26587

Abstract

Abstrak: Hipertensi, atau tekanan darah tinggi, merupakan salah satu penyakit tidak menular yang menjadi perhatian global dalam bidang kesehatan masyarakat. Penyakit ini sering kali tidak menunjukkan gejala yang jelas, sehingga banyak penderita tidak menyadari kondisinya hingga terjadi komplikasi serius seperti stroke atau serangan jantung. Diperkirakan, hipertensi menyebabkan sekitar 9,4 juta kematian setiap tahun secara global dan akan mempengaruhi lebih dari 1,56 miliar orang pada tahun 2025. Di Indonesia, prevalensi hipertensi tercatat mencapai 34,1% pada tahun 2018, dengan kota Tasikmalaya melaporkan 38.466 kasus pada tahun 2021. Namun, kesadaran dan pengobatan terhadap hipertensi masih rendah, termasuk di lingkungan SDN Mancogeh, Tasikmalaya, yang menjadi lokasi kegiatan pengabdian masyarakat ini. Kegiatan deteksi dini hipertensi melalui pemberdayaan guru dan orang tua siswa merupakan langkah penting dalam menciptakan lingkungan sekolah yang sehat dan mendukung kesehatan jangka panjang. Program ini bertujuan untuk meningkatkan hardskill dan softkill guru, orang tua, dan masyarakat sekitar tentang hipertensi melalui pemeriksaan tekanan darah dan edukasi terkait pencegahan. Metode berupa penyuluhan dan praktek pemeriksaan. Peserta adalah guru SD dan Masyarakat sekitar sebanyak 50 orang. Proses evaluasi secara observasi dibantu pada daftar absen dan analisis deskripisi. Hasil sebesar 82% mengalami peningaktan hardskill dan softskill. Sedangkan hasil pemeriksaan dini, mayoritas peserta (65,9%) memiliki tekanan darah normal, sementara 34,1% peserta mengalami hipertensi Diharapkan, dengan keterlibatan aktif masyarakat, program ini dapat mendorong kesadaran akan pentingnya deteksi dini dan pengelolaan hipertensi untuk mencegah komplikasi serius.Abstract: Hypertension, or high blood pressure, is one of the non-communicable diseases that has become a global public health concern. This condition often presents without clear symptoms, leading many sufferers to be unaware of their condition until serious complications, such as stroke or heart attack, occur. It is estimated that hypertension causes around 9.4 million deaths globally each year and is projected to affect more than 1.56 billion people by 2025. In Indonesia, the prevalence of hypertension was recorded at 34.1% in 2018, with the city of Tasikmalaya reporting 38,466 cases in 2021. However, awareness and treatment of hypertension remain low, including at SDN Mancogeh in Tasikmalaya, the location of this community service activity. Early detection of hypertension through the empowerment of teachers and parents is an important step in creating a healthy school environment that supports long-term health. This program aims to improve the hard and soft skills of teachers, parents, and the surrounding community on hypertension through blood pressure checks and educational activities related to prevention. The methods include counseling and practical blood pressure examinations. Participants consist of 50 elementary school teachers and local community members. The evaluation process was conducted through observation, assisted by attendance records and descriptive analysis. The results showed that 82% of participants experienced an improvement in both hard and soft skills. Regarding early hypertension screening, the majority of participants (65.9%) had normal blood pressure, while 34.1% were found to have hypertension. It is hoped that with the active involvement of the community, this program can raise awareness of the importance of early detection and management of hypertension to prevent serious complications.
OPTIMALISASI POSYANDU; MEMBANGUN KESADARAN IBU UNTUK TUMBUH KEMBANG BALITA DI CILENDEK BARAT Kusmiati, Meti; Fasha, Amanda; Serliana Maulida, Efril; Widya Sari, Indri; Anggrayni, Mutiara; Azka Salsabila, Naila; Agisni, Riska
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 4 No 4 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v4i4.1628

Abstract

Posyandu merupakan ujung tombak penanggulangan masalah gizi di masyarakat , diduga sekitar 40% posyandu tidak lagi aktif dikarenakan  berbagai penyebab. Manfaat Posyandu  bagi masyarakat dapat memperoleh kemudahan untuk mendapatkan informasi dan pelayanan kesehatan bagi anak balita dan ibu.  Tujuan kegiatan ini yaitu untuk memberikan edukasi pentingnya  membawa balita ke posyandu untuk memantau tumbuh kembangnya. Metode kegiatan dilakukan melalui penyuluhan memberikan materi langsung menggunakan media power point, poster  dan leaflet serta pre test dan post test untuk mengukur pengetahuan ibu tentang pentingnya posyandu untuk memantau tumbuh kembang.. Hasil kegiatan pengabdian masyarakat ini didapatkan adanya pengaruh yang signifikan terhadap peningkatan pengetahuan ibu yang memiliki balita tentang pentingnya posyandu untuk memantau tumbuh kembang dibuktikan dengan dibuktikan dengan nilai pretest yang  menampakkan jumlah masyarakat memiliki pengetahuan kurang baik sebanyak 15 orang (50,0%), dan hasil post test menampakkan jumlah orang yang memiliki pengetahuan baik sebanyak 30 orang (100,0%). Nilai t untuk pengaruh ini ialah 5,385 dan p value = 0,000. Kesimpulannya, terdapat dampak terhadap peningkatan pengetahuan ibu yang memiliki balita tentang pentingnya posyandu untuk memantau tumbuh kembang. Kata kunci : Ibu , balita, pengetahuan, posyandu, tumbuh kembang
Skrining Hipotiroid Kongenital (SHK) Pada Ibu Hamil di Puskesmas Tajurhalang Kabupaten Bogor Munir, Rindasari; Kusmiati, Meti; Fauziah, Nurul Azmi; Ningrum, Anggun Setia
JURNAL PENGABDIAN KEPADA MASYARAKAT Spesial Issue
Publisher : LPPM UNINUS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

According to WHO, in several developed countries such as America, Japan, Australia and Europe, since 197-, neonatal screening programs for hypothyroidism have been implemented so as to reduce the occurrence of mental retardation in children (Apriliani et al., 2021). Symptoms of hypothyroidism in newborns are usually not very obvious and congenital hypothyroidism can cause severe mental retardation unless therapy is received early, so a congenital hypothyroid (HK) screening examination is very important to do(Apriliani et al., 2021). Congenital Hypothyroidism Screening is effective 48-72 hours after birth(Ida Bagus Eka Utama Wija, 2020). Based on the pre and post test scores from 30 participants, it was found that there was an increase in the good category in knowledge with an average score of 1.7 to 3.00, meaning that the counseling was successfully implemented.There needs to be awareness of pregnant women, where the task of building awareness is held by health workers, so it is hoped that health agencies which are already required to run the SHK program will be more aggressive and package their invitations to pregnant women well.
FAKTOR – FAKTOR YANG MEMPENGARUHI PEMILIHAN ALAT KONTRASEPSI PADA WANITA USIA SUBUR DI PRAKTEK MANDIRI BIDAN Kusmiati, Meti
Sinar : Jurnal Kebidanan Vol 6 No 2 (2024): SINAR Jurnal Kebidanan
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/sinar.v6i2.23780

Abstract

Kontrasepsi adalah menghindari atau mencegah terjadinya kehamilan sebagai akibat pertemuan antara sel telur yang matang dengan sel sperma. Cara kerja kontrasepsi mengusahakan agar tidak terjadi ovulasi, melumpuhkan sel sperma, menghalangi pertemuan sel telur dengan sel sperma. Program KB tentunya memiliki dampak baik itu dampak positif maupun negatif. Dampak positif, yaitu penurunan angka kepadatan penduduk, penanggulangan kesehatan reproduksi, peningkatan kesejahteraan keluarga. Tujuan dari penelitian ini adalah mengetahui faktor yang mempengaruhi pemilihan alat kotrasepsi pada wanita usia subur ( WUS). Jenis penelitian yang digunakan adalah survey analitik dengan pendekatan cross sectional. Pada penelitian ini sampel yang diambil menggunakan metode Random (Probability) Sampling. Dalam pengumpukan data pada uji statistik dalam penelitian ini dengan kuesioner. Hasil Uji statistik chi square diperoleh tidak adanya hubungan antara usia, paritas, pendidikan, pekerjaan, kesejahteraan, dukungan suami, dan sumber informasi dengan pemilihan alat kontrasepsi dan terhubungan antara pengetahuan dengan pemilihan alat kontrasepsi. Wanita dengan pengetahuan baik cenderung memilih alat kontrasepsi implan.
Urgensi Sikap Profesional Dalam Meningkatkan Kepercayaan Konseli terhadap Konselor Kusmiati, Meti; Rohmatullah, Niam
At-Tadris: Journal of Islamic Education Vol. 1 No. 2 (2022): At-Tadris: Journal of Islamic Education
Publisher : Ikatan Dai Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56672/re4s3k79

Abstract

As a service worker, a counselor is required to be a professional. Where a professional is someone who is an expert in their field, easy to adapt to their environment, easy to manage their time and attitude. Becoming a professional counselor is regulated in a counseling code of ethics that must be maintained and carries counseling principles that can facilitate counseling services. The performance of a counselor is spread across various fields, because basically every field requires guidance and the counselor is an expert in terms of guidance and development. The professionalism of a counselor is not only in terms of work, there are several criteria for a counselor to be considered a professional. This professionalism can create a positive influence for counselors and counselees. The counselee will put his trust in a professional counselor.