Article Per Year (5 Year)
p-Index From 2021 - 2026
0.92
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Acta Pharmaceutica Indonesia ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Farmako Bahari
Permana, Benny
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Pengembangan Dan Validasi Metode Analisis Amlodipin Besilat Dan Cemarannya Dalam Sediaan Tablet Muhammad Haqqi Hidayatullah; Slamet Ibrahim; Benny Permana
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.20210

Abstract

Amlodipine besylate belongs to the class of oral dihydropyridine calcium channel blockers that can be used to hypertension and angina therapy. Amlodipine as a pharmaceutical preparation must meet the criteria for a good pharmaceutical preparation, namely safe, efficacious and quality. In terms of safety, the presence of organic impurity in pharmaceutical products can affect the safety of medicinal products. Because the difficultness to obtain a standard of impurity, it is necessary to develop an analytical method to analyze the presence of contamination by stress testing. The analytical method was developed using a High Performance Liquid Chromatography (HPLC) instrument with Eclipse Plus C18 column 5 m (150 x 4.6 mm), mobile phase triethylamine (TEA): methanol in a ratio of 40:60 with isocratic elution and a flow rate of 1 mL/minutes and a wavelength of 237 nm with an injection volume of 10 µL. The results of the method validation showed good linearity with R2 of 0.9996, detection limit of 18.46 µg/mL and quantization limit value of 61.54 µg/mL. The value of the coefficient of variation on the precision parameter is 1.18-1.26%. The percent recovery accuracy value is 93.07-105.44% and the range value for proportional samples is in the concentration range of 24-84 µg/ml with R2 = 0.9993. The HPLC system meets all requirements for acceptance of the system conformity test. The results of this experiment showed that there were 2 out of 5 peaks of degradation products whose chemical structure was known. The application of the analytical method on commercial samples showed levels between 90.79-95.68% and there was no impurity in the product samples.
Studi In Silico Metabolit Sekunder Kapang Monascus sp. sebagai Kandidat Obat Antikolesterol dan Antikanker Marlia Singgih; Benny Permana; Selvira Anandia Intan Maulidya; Anna Yuliana
ALCHEMY Jurnal Penelitian Kimia Vol 15, No 1 (2019): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (83.745 KB) | DOI: 10.20961/alchemy.15.1.25294.104-123

Abstract

Kapang Monascus sp. secara tradisional telah digunakan dalam fermentasi beras merah (angkak) yang bermanfaat sebagai pewarna makanan, pengawet makanan maupun obat-obatan. Saat ini, beras angkak telah menjadi suplemen makanan yang terkenal karena banyaknya senyawa bioaktif yang terkandung seperti monakolin, pigmen, asam dimerumat dan lain-lain. Tujuan penelitian ini adalah untuk menemukan metabolit sekunder kapang Monascus sp. yang meliputi senyawa monakolin dengan efek antikolesterol, pigmen dengan efek antikanker pada kanker payudara serta memprediksi toksisitas senyawa melalui studi in silico. Senyawa uji terdiri dari 14 senyawa monakolin dan 33 pigmen Monascus sp. Protein HMG KoA (3-hidroksi-3-metilglutaril koenzim A) reduktase digunakan sebagai reseptor antikolesterol sementara estrogen alfa, estrogen beta, dan aromatase digunakan sebagai reseptor antikanker. Perangkat lunak AutoDock digunakan untuk menganalisis kompleks struktural reseptor dengan senyawa uji. Prediksi toksisitas dilakukan menggunakan perangkat lunak ADMET predictor dan QSAR Toolbox. Prediksi toksisitas dan hasil docking menunjukkan bahwa asam monakolin L menunjukkan aktivitas antikolesterol yang baik terhadap HMG KoA reduktase; pigmen monaskin menunjukkan aktivitas antikanker yang selektif terhadap reseptor estrogen beta; dan keduanya diprediksi aman. Prediksi toksisitas senyawa monakolin dan pigmen Monascus sp. menunjukkan terdapat 7 senyawa monakolin yaitu 3-hidroksi-3,5-dihidromonakolin L, asam dihidromonakolin L, monakolin L, asam monakolin J, monakolin J, asam monakolin L , monakolin M, dan 5 pigmen Monascus sp. yaitu ankaflavin, monaskin, monaskopiridin A, monaskopiridin B dan monascuspiloin yang dinyatakan tidak toksik. Tujuh pigmen Monascus sp. yang terdiri dari monankarin A, monankarin B, monankarin C, monankarin D, monankarin E, monankarin F, dan monasfluol A bersifat positif mutagen, karsinogen dan toksik terhadap reproduksi. Hasil penelitian ini berpotensi dapat diaplikasikan untuk desain dan pengembangan obat antikolesterol dan antikanker.In Silico Study of Secondary Metabolites of Monascus sp. as A Candidate for Anticholesterol and Anticancer Drugs. The fungus Monascus sp. has traditionally been used to prepare red fermented rice (angkak) as a natural food colorant, food preservative or medicinal agent. Recently, it has become a popular dietary supplement due to many of its bioactive constituents such as monacolin compounds, pigments, and dimerumic acid, etc. These functional constituents also had been deemed to be provided with various health benefits. This research aims to find secondary metabolites of monacolin compounds with antihypercholesterolemic effect, Monascus sp. pigment with anticancer effect on breast cancer, and predict their toxicity through in silico study. The studied compounds consist of 14 monacolin compounds and 33 Monascus sp. pigments. HMG CoA (3-hydroxy-3-methylglutaryl Coenzyme A) reductase protein was used as antihypercholesterolemic receptor in which estrogen alfa, estrogen beta, and aromatase were used as anticancer receptors. AutoDock docking software was used to analyze structural complexes of the receptors with studied compounds. Toxicity prediction was done using ADMET predictor and QSAR Toolbox softwares. Toxicity prediction and docking results revealed that monacolin L acid exhibits good anticholesterol activity towards HMG CoA reductase; monascin pigment exhibits selective anticancer activity towards estrogen beta receptor; and both of them were predicted to be safe. Toxicity prediction of studied compounds showed that 7 monacolin compounds which are 3-hydroxy-3,5-dihydromonakolin L, dihydromonacolin L acid, monacolin L, monacolin J acid, monacolin J, monacolin L acid, monacolin M and 5 Monascus sp. pigments which are ankaflavin, monascin, monascopyridine A, monascopyridine B dan monascuspiloin are not toxic. Seven Monascus sp. pigments which are monankarin A, monankarin B, monankarin C, monankarin D, monankarin E, monankarin F and monasfluol A are mutagenic, carcinogenic and also reprotoxic. The research results could be useful for the design and development of the anticholesterol and anticancer drugs.
Co-Authors Adi Suwandi Anna Yuliana, Anna Asman Sadino Choong Chie Weng Debora Ronauli Dian Ayu Eka Pitaloka Elin Julianti Faridhatul Khairiyah Fuji Ayu Noviartika Ilma Nugrahani Indra Wibowo Indra Wibowo Marlia Singgih Marlia Singgih Wibowo Meilia Suherman Muhammad Haqqi Hidayatullah Nadiyah Athifah Salim Martak Nurani Istiqomah Rahmawati Rahmawati Rika Hartati Riska Prasetiawati Sakti Nunggal Agung Samuel Gunadi Tanusondjaja Selvira Anandia Intan Maulidya Slamet Ibrahim Soni, Dang Sophi Damayanti Tedjo Narko Titah Yudistira Tri Suciati Weng, Choong Chie Yani Triyani