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All Journal Medical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Journal Orthopaedi and Traumatology Surabaya (JOINTS) Journal of Global Pharma Technology The Hip and Knee Journal
Ismail Hadisoebroto Dilogo
Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Neuroscience

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Adhesive Plastic Drapes Did Not Prove to Prevent Surgical Site Infection in Total Knee Arthroplasty: A Randomized Controlled Trial Pontoh, Ludwig Andretia Powantia; Dilogo, Ismail Hadisoebroto; Putra, Anggaditya; Widodo, Wahyu; Oesman, Ihsan; Fiolin, Jessica; Herdiman, Joshua Alward
The Hip and Knee Journal Vol 5, No 2 (2024): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46355/hipknee.v5i2.159

Abstract

Surgical site infection (SSI) prevention is crucial in total knee arthroplasty (TKA) procedures. One controllable factor is preventing foreign substances from contaminating the surgical field, for which adhesive draping over surgical drapes is commonly used. To determine whether using adhesive transparent film dressing has any effect on the occurrence of SSI in TKA. We conducted a study comparing 100 TKA, divided into two groups (each with 50 participants). The first group received adhesive plastic draping during TKA, while the second group was the control. Bacterial aerobic culture swabs were taken before applying the plastic draping and after surgery following skin closure. Follow-up evaluations were conducted within one month to detect signs of SSI. The results none of the 100 TKAs included in the study yielded positive bacterial culture results. One-month post-operative evaluations revealed no signs of SSI in any of the groups.The conclusion use of adhesive plastic drapes does not provide any benefit in preventing SSI in TKA. Skin preparation, prophylaxis, and surgeon preparation protocols are more crucial for SSI prevention than adhesive plastic drapes.
Adipose-derived mesenchymal stem cells enhance regeneration in a chronic peripheral sciatic nerve injury Sprague-Dawley rat model Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257780

Abstract

BACKGROUND Obtaining optimal functional outcomes in patients with chronic peripheral nerve injuries (PNIs) remains challenging due to the limited regeneration of the neuromuscular junction (NMJ). Adipose-derived mesenchymal stem cells (AD-MSCs) can differentiate into Schwann-like cells, secrete neurotrophic factors, and recruit native Schwann cells. This study aimed to analyze the effects of AD-MSCs on functional outcomes in a chronic PNI model. METHODS An in vivo study was performed using 20 male Sprague-Dawley rats with chronic PNI of the right sciatic nerve. Rats were divided into two groups: the AD-MSC group (n = 10), receiving human AD-MSC injections in the NMJ; and the control group (n = 10), receiving normal saline injections. Walking track analysis and electrophysiological assessments were performed 8 weeks after the nerve repair. Postmortem gastrocnemius muscle weights and immunohistochemical examinations were also performed. RESULTS The AD-MSCs showed significantly larger fiber diameters than the control group (45.54 [13.1] versus 35.46 [6.64]; p = 0.011). While clinical, electrophysiological, and gastrocnemius muscle weight data suggested a trend toward improved outcomes in the AD-MSCs group, the differences were not statistically significant. CONCLUSIONS AD-MSC implantation may enhance nerve regeneration, as demonstrated by a better outcome profile in the AD-MSCs group.
Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Effect of umbilical cord-mesenchymal stem cells on skin tensile strength in pressure ulcers: a rat model study Aulia, Indri; Dilogo, Ismail Hadisoebroto; Prasetyono, Theddeus Octavianus Hari; Pawitan, Jeanne Adiwinata; Kekalih, Aria; Siregar, Nurjati Chairani; Whulanza, Yudan; Hasibuan, Lisa
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.268222

Abstract

BACKGROUND Stem cell therapy has emerged as a promising alternative for the management of chronic wounds, including pressure ulcers. Tensile strength, which reflects the biomechanical integrity of the skin, serves as an objective measure of wound healing. This study aimed to evaluate the effect of locally administered umbilical cord-mesenchymal stem cells (UC-MSCs) on the tensile strength of healing 3rd-degree pressure ulcers in a Sprague Dawley rat model. METHODS 21 adult male Sprague Dawley rats were divided into 3 groups: normal rats without ulcers, untreated pressure ulcer as control, and pressure ulcers treated with UC-MSCs. The treatment group received locally injected 4 × 10⁶ UC-MSCs at the ulcer site. On day-21, the tensile strength parameters (rupture point, elongation at break, and elastic modulus) of the dorsal skin were assessed using the Universal Testing System. RESULTS When expressed relative to normal skin tensile strength, the UC-MSC group exhibited higher tensile parameters that were higher than the controls by 2.08% for rupture point, 3.29% for elongation at break, and 8.42% for elastic modulus. Although these differences between the UC-MSCs and control groups across all tensile strength parameters were not statistically significant, a clear trend toward improved tensile strength parameters were observed in the UC-MSCs group. CONCLUSIONS Local UC-MSCs administration showed a consistent trend toward improved tensile strength in healing 3rd-degree pressure ulcers, albeit without statistically significant differences compared to controls. These findings support the further exploration of UC-MSCs as a potential treatment for promoting biomechanical restoration in healing pressure ulcers.
Co-Authors Achmad A. Yusuf Achmad F. Kamal Achmad Fauzi Kamal Adang Bachtiar Ahmad A. Jusuf Ahmadin Yusuf Rizal Susatyo Andri M.T. Lubis Aprilya, Dina Aria Kekalih Bernadus Riyan Hartanto Canintika, Anissa Feby DIAH ISKANDRIATI Eko Prasetyo Adi Wibowo Endrotomo Sumargono Erica Kholinne Errol U. Hutagalung Farhan Haidar Fazlur Rahman Fiolin, Jessica Fitri Octaviana Giarso, Peter Harahap, Alida R. Herdiman, Joshua Alward Heri Suroto Immanuel P. Sitorus, Immanuel P. Immanuel Panca Sitorus Indri Aulia Jeanne Adiwinata Pawitan Jessica Fiolin Jessica Fiolin Kousar, Iqra Lisa Hasibuan Ludwig A. Pontoh Mahmood, Amer Milton Lee Chip Routt Mohammad Hidayat Mohammad Zaim Chilmi Muhammad Budimansyah Nizar Al Rhaazi Nurjati C. Siregar Nurjati Chairani Siregar Oesman Ihsan Pandelaki, Jacub Phedy Phedy Puspita Eka Wuyung Putra, Anggaditya R. Susworo Radiana Dhewayani Antarianto Rahyussalim Rahyussalim, Rahyussalim Ria Anggraeni Saptawati Bardosono Sholahuddin Rhatomy Starifulkani Arif Theddeus O. H. Prasetyono Wahyu Widodo Wahyu Widodo William Chandra Yogi Ismail Gani Yudan Whulanza Zuhri Efendi