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All Journal HAYATI Journal of Biosciences Bioscience Vektora : Jurnal Vektor dan Reservoir Penyakit Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Tropical and Infectious Disease BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati YARSI Medical Journal Jurnal Pembelajaran dan Biologi Nukleus Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Gunung Djati Conference Series SERVIRISMA: Jurnal Pengabdian kepada Masyarakat Jurnal MedScientiae Jurnal MedScientiae Jurnal Kedokteran Meditek
Susilowati, Rina Priastini
Universitas Kristen Krida Wacana
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Journal : Jurnal MedScientiae

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Pengaruh Aktivitas Fisik Dan Kualitas Tidur Terhadap Prestasi Akademik Peserta Didik Fakultas Kedokteran UKRIDA Angkatan 2019 maria caecaelia botoor; Rina Priastini Susilowati; Jodie Josephine
Jurnal MedScientiae Vol. 1 No. 1 (2022): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscie.v1i1.2439

Abstract

Background: Sleep is an active behavior that is carried out by humans continuously where the quality of sleep is a benchmark for a person to be able to enjoy sleep and maintain the stability of his body. Physical activity that is carried out consistently and regularly can have a great influence on a person's physical condition. Academic achievement is the result of a student's learning which is the most important part of education. This study used a quantitative descriptive study method, cross-sectional by taking data through a questionnaire. The study showed that the Class of 2019 students had good sleep quality and did sufficient physical activity. Where physical activity has a significant effect on the level of academic achievement of the students of the Faculty of Medicine Ukrida Batch 2019. Based on a partial test with a significance value of 0.406 (> 0.05) which shows that there is an influence between physical activity on academic achievement. . Based the partial test with a significance value of 0.220 (> 0.05) which indicates the influence of sleep quality on academic achievement. The F test is a joint test of the regression coefficients by comparing the p-value with a certain level of significance.
Perubahan Histopatologis Sel Epitel Midgut Larva Nyamuk Aedes aegypti Akibat Paparan Insektisida Nabati Dwi Anggraini; Monica Puspa; Rina Priastini Susilowati
Jurnal MedScientiae Vol. 1 No. 1 (2022): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscie.v1i1.2440

Abstract

Aedes aegypti mosquitoes are the main vector of Dengue Hemorrhagic Fever (DHF). Various prevention efforts were carried out to reduce their population. One of them is the use of synthetic or bioinsecticides. Bioinsecticides are safer for humans, animals and the environment so they had been used widely as an alternative nowadays. Larvicide is one of the insecticides product that attacks mosquito breeding sites in the water. Larvicide has various mechanisms that can attack some target organs including larvae’s midgut. Based on several trial results, plant insecticides have been cause epithelial cells in larvae’s midgut to lyses, change shape, vacuolize and detach from the basal membrane. Peritrophic membrane, microvilli and brush border are partially or completely damage. Histopathological changes in the midgut epithelial cells of Ae. aegypti larvae were caused by metabolite compounds, either singly or in combination that contained in plant extracts
Literature Review: Pengaruh Kebiasaan Jajan dan Higienitas Jajanan terhadap Kejadian Diare pada Anak SD Rina Priastini Susilowati; Budiman Hartono; Bryan Reyes Stephen
Jurnal MedScientiae Vol. 1 No. 1 (2022): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscie.v1i1.2447

Abstract

Consuming street food is a habit common among elementary school students. Snacking habits can be influenced by parents and friends, and various other factors. The hygiene of the snacks in school environment is also a consideration. This study aims to determine the effect of snacking habits and snacks hygiene on incidence of diarrhea among elementary school students. The study was conducted by comparing available data from six journals. The results showed conflicting data on the effect of snacking habits on incidence of diarrhea with two sources showing significant (p < 0.05) and insignificant (p > 0.05) impact. Hand washing habits (p < 0.05), carrying meals (p < 0.05), and knowledge (p < 0.05) had a significant influence on snacking habits and incidence of diarrhea. For snack hygiene, food quality (p < 0.05); storage (p < 0.05); and processing (p < 0.05); sanitation facilities (p < 0.05); and food handlers’ hygiene (p < 0.05) had a significant effect on E.coli contamination. Apart from hygiene, some snacks were found to contain harmful food additives. In conclusion, it is necessary to conduct an educational program for healthy snacks as well as monitor and maintain canteen hygiene on a regular basis.
Hubungan Kebiasaan Mengonsumsi Kopi Susu dan Kopi Hitam dengan Tekanan Darah Dewajanti, Anna Maria; Pratiwi, Indah; Susilowati, Rina Priastini; Rumiati, Flora
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2879

Abstract

The habit of people who consume coffee will have an impact on increasing blood pressure, where if you drink 4 or more cups of coffee in one day, the systolic pressure will increase by approximately 10 mmHg and around 8 mmHg in diastolic blood pressure. The purpose of this study was to see the relationship between the habit of consuming milk coffee and black coffee with blood pressure in students of the Faculty of Medicine at Krida Wacana Christian University. This research used a cross-sectional approach with a population of 2020 Ukrida Faculty of Medicine students. The sample in this study was 102 people with a simple random sampling technique. It was found that the average 2020 Ukrida Faculty of Medicine student consumed coffee 1-2 times a day at a rate of 1-2 cups per day, but there were also some who consumed 3-4 cups of coffee a day. Data analysis used the Person Chi-Square and obtained the p-value for milk coffee: 0.126 and the p-value for black coffee: 0.656. So this shows that both milk coffee and black coffee have no significant relationship with an increase in blood pressure.
analisis respon imunitas terhadap infeksi sars-cov-2 pada manusia Nainggolan, Edward Anderson; Tamba, Ernawaty; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2998

Abstract

Understanding the immune response to COVID-19 is critical to help develop appropriate management. Understand the description and response of the immune system that is formed in humans through COVID-19 infection. Conduct a critical review of research journals on the immune response to SARS-CoV-19. Search for articles in research journal databases using the keywords COVID-19, SARS-CoV-2, and Immunity. COVID-19 patients have increased serum cytokine levels (TNFα, IL-2, IL-6, IL-10, IFNγ) compared with healthy patients. IL-6, IL-10, and CRP increased significantly with disease severity. The number of T cells decreases in COVID-19 patients, especially those who are more severe. There were no significant differences in antibody titers based on gender, age, or BMI in post-vaccine individuals. Smokers had significantly lower antibody titers after the second dose of vaccination. COVID-19 patients experience a decrease in the number of lymphocytes and an increase in CRP and cytokines such as TNFα, IL-2, IL-6, IL-10, and IFNγ, especially in severe cases. A positive correlation exists between CRP and IL-10. The number of T cells such as CD4+T and CD8+T also decreases in COVID-19 patients, especially those who are more severe. This could be a diagnostic and prognostic marker for COVID-19.
Ginger Rhizome Extract (Zingiber officinale) as an Alternative Bioinsecticide Against The Mortality of German Cockroach (Blattella germanica): Indonesia Susanto, Inneke Kusumawati; Susilowati, Rina Priastini; Hidajat, Joshua Jean Michael
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3053

Abstract

Cockroach is one of the types of insects that exists everywhere. Cockroach can live in a lot of places, such as the gutter, the trash, and even in the bathroom. Cockroach is one of the agents that is responsible for the spreading of diseases such as diarrhea, dysentery and cholera in children. In Indonesia, there exists a lot of different types of cockroach, one of it is the German Cockroach or Blattella germanica L., and the cockroach problem in Indonesia is mainly handled by using chemicals insecticides, this happens because there’s a lot and its commonly found in a lot of places. Pyrethroid based chemicals insecticides are one of the most common chemical insecticides used by the public. These chemical insecticides have various kinds of adverse effects because they leave residues that can be inhaled by humans and also consumed by humans through food products. Some of the effects of chemical insecticides are diseases of the liver, kidneys, and also problems with the central nervous system. Therefore, an alternative solution is needed in dealing with the cockroach problems in Indonesia, namely Bioinsecticides. Bioinsecticides are insecticides made using natural ingredients without the addition of chemical substances. Ginger is one of the spices that can be found anywhere, in ginger there are compounds called flavonoids, and these compounds can be used as bioinsecticides. Bioinsecticides are made by taking the ginger extract then putting the extract into a spray bottle according to the dose using a pasteur pipette.  
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.
The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Co-Authors Adit Widodo Santoso Alexander Anna Maria Dewajanti Beatrix Clarissa Gunarta Bryan Reyes Stephen Budiman Hartono Budiman Hartono Budiman Hartono Dwi Anggraini Ernawaty Tamba Flora Rumiati Flora Rumiati Flora Rumiati Henricho Himawan Hidajat, Joshua Jean Michael Indah Pratiwi Inggrid Osya Farfar Inneke Kusumawati Susanto Jasmine Harumi Sabini Jodie Josephine Kris Herawan Timotius Liauw Djai Yen Marcel Antoni maria caecaelia botoor Monica Puspa Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Nainggolan, Edward Anderson Nanik Siti Aminah Pratanu, Lydia Puspa Sari, Monica Putri, Dyah Ayu Adella Sabini, Jasmine Harumi Sancia Nathania Legenie Banuang Santoso, Adit Widodo Tanian, Michelle Amelia Win Darmanto Yanto Hindrawan