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All Journal CERATA Jurnal Ilmu Farmasi Journal of Fundamental and Applied Pharmaceutical Science Prosiding University Research Colloquium WASATHON MOTORIK CERATA
Arrosyid, Muchson
Universitas Muhammadiyah Klaten
Humanities Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Optimization of FDT Turmeric Rhizome Extract (Curcuma domestica Val.) Using a Combination of Crospovidone and Croscarmellose Sodium Hidayati, Nurul; Sari, Anna's Alisya; Hana Mustofa, Choiril; Nurhaini, Rahmi; Wahyuningsih, Astri; Arrosyid, Muchson
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.24483

Abstract

Turmeric rhizome (Curcuma domestica Val.) is a plant that has anti-diarrheal activity. To get an immediate effect and action in the treatment of diarrhea, turmeric rhizome is formulated into a fast-disintegrating tablet (FDT) dosage form. FDT is strongly influenced by super disintegrant (crushing material). Crospovidone is used as a super disintegrant, as it has a wicking effect (capillary action), while croscarmellose sodium has a swelling effect. The study aims to determine the effect of variations in the concentration of crospovidone and croscarmellose sodium on the physical properties of FDT and determine the optimal concentration of crospovidone and croscarmellose sodium. The sample used was a dry extract of turmeric rhizome. The dried extract of turmeric rhizome was made 5 runs with variations of crospovidone 2–5% and croscarmellose sodium 2–5%. Run 1 (2.75%: 4.25%), run 2 (3.5%: 3.5%), run 3 (5%: 2%), run 4 (2%: 5%), and run 5 (4.25%: 2.75%). The responses used included disintegration time, hardness, and restriction tests. The results utilized to determine the optimum formula were derived from the simplex lattice design (SLD) method. The outcomes of the optimal formula testing experiment were based on the findings from 13.0.5 predictive software experts, employing a one-sample t-test analysis at a 95% confidence level. The results of this study indicate that the combination of crospovidone and croscramellose sodium can reduce the response time of disintegration, hardness, and FDT. The optimum formula was obtained with the variation of crospovidone 3.5% and croscarmellose sodium 3.5%.
ANALYSIS OF THE EFFECT OF EXTRACTION METHODS ON TOTAL PHENOLIC CONTENT OF BANGLE RHIZOMES (Zingiber purpureum Roxb.) Styawan, Anita Agustina; Narasia, Narasia; Nurhaini, Rahmi; Arrosyid, Muchson
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.29242

Abstract

Bangle (Zingiber purpureum Roxb.) is a medicinal plant from the Zingiberaceae family widely used in traditional medicine due to its bioactive compounds, particularly phenolic compounds with anti-inflammatory, antibacterial, and antioxidant properties. The phenolic content of plant materials is strongly influenced by the extraction method; however, comparative studies on Bangle rhizomes using different extraction techniques remain limited. This experimental analytical study aimed to compare the total phenolic content of Bangle rhizomes extracted using maceration and steam distillation methods. Powdered dried rhizomes were extracted by maceration using 96% ethanol, while fresh rhizomes were subjected to steam distillation to obtain essential oil. Total phenolic content was determined by UV–Vis spectrophotometry with Folin–Ciocalteu reagent at a maximum wavelength of 743 nm and an operating time of 60 minutes, expressed as mg gallic acid equivalent (GAE)/g extract. The results showed that the ethanol extract obtained by maceration exhibited a significantly higher total phenolic content (105.03 mg GAE/g) than the distillation product (83.57 mg GAE/g). Statistical analysis using an independent t-test revealed a significant difference between the two extraction methods (p < 0.05). In conclusion, the maceration method using 96% ethanol is more effective than steam distillation in extracting phenolic compounds from Bangle rhizomes.
Co-Authors Andasari, Sholikhah Deti anggun klarisaputri anita agustina setyawan Anita Agustina Styawan Anna Latifah Aristhasari Putri Astri Wahyuningsih - Avanilla Fany Septyasari Avanillla Fany Septyasari Chairil Hana Mustofa Choiril H.M. Choiril Hana Mustofa Frendi Aviv Setiawan Hana Mustofa Hanif Putri Hanna Nikma Fatin Hardhani, Salsabila Nur Hardiyanto, Totok Hendra Budiman I Indriyastuti Ima Rohmawati Indriyastuti, I Mustofa, Hana Narasia, Narasia Nur Romandhoni, Azzi Nurul Hidayati Putri, Hanif Rahmi Nurhaini Refi Refi Resia Muliana Rini Puspitasari, Rini Rosi Nur Indahsari Salsabila Salsabila Sari, Anna's Alisya Selvi Candra Dewi Septi Septi Setiawan, Frendi Aviv Shifangi Shifangi Sholikhah Deti Andasari Sri Subekti Sri Wahyuni Sunyoto Sunyoto Sutaryono Sutaryono - Sutaryono, S Syahputri, Rezyana Budi Titik Susanti Titik Susanti Vemas Vemas Wahyu Anasari Wahyu Wahyu Wahyu Wulanndari Wati, Fitriana