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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika The Indonesian Biomedical Journal Universa Medicina Communications in Science and Technology Indonesian Journal of Biomedicine and Clinical Sciences Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Cermin Dunia Kedokteran
Adika Zhulhi Arjana
Faculty Of Medicine, Universitas Negeri Yogyakarta, Yogyakarta
Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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High Expression of FcγII (CD32) Receptor on Monocytes in Dengue Infected Patients Umi Solekhah Intansari; Harina Salim; Usi Sukorini; Adika Zhulhi Arjana; Muhammad Juffrie
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.434

Abstract

BACKGROUND: Pathogenesis of severe dengue infection has not been elucidated. Immune complex of pre-existing antibodies and heterotypic dengue virus bind to FcγII (cluster of differentiation (CD32)) receptor (FcγIIR) on monocyte facilitates entry and replication of dengue virus. Aim of this study was to evaluate the expression of FcγIIR on monocytes in patients infected with dengue and in healthy subjects.METHODS: This study used a cross-sectional design that included patients infected with dengue who were hospitalized in Dr. Sardjito General Hospital, Panembahan Senopati Hospital, and Sleman Hospital, who met the inclusion criteria and selected consecutively. Examinations were completed using a lyse, no-wash method of flow cytometry. Computerized statistical analysis was conducted and was considered to be significant if p<0.05.RESULTS: Sixty-five study subjects were divided into healthy subjects (24 subjects) and patients with dengue infection (41 subjects). There were no significant differences in hemoglobin (Hb) and hematocrit (Hct) values between the groups, but differences were found in the number of leukocytes, absolute number of monocytes and platelet count (p<0.001, 0.002 and <0.001, respectively). The mean expression of FcγIIR monocytes in patients with dengue infection (208.77±32.06 median fluorescent intensity (MFI)) and the healthy subjects (124.03±47.76 MFI) with p<0.0001.CONCLUSION: The mean expression of FcγIIR monocytes in patients with dengue infection was higher than in healthy subjects.KEYWORDS: dengue infection, FcγII (CD32) receptor monocyte, flow cytometry
Platelet Profile in Patients with Status Asmaticus in Kebumen Juwariyah, Juwariyah; Arjana, Adika Zhulhi; Rahayu, Ester Tri; Rosita, Linda; Irfan, Mohammad Rozan
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.712 KB) | DOI: 10.30659/sainsmed.v8i2.1003

Abstract

BACKGROUND: Asthma has been considered as type 1 hypersensitivity disease, but actually asthma involves a variety of inf lammatory factors.Based on pro-inf lammatory cells, asthma is classified into eosinophilic, non-eosinophilic, neutrophilic, and non-neutrophilic. Platelet plays a role in  pathophysiology of asthma through inf lammation. However, platelet profile in patients with asthma have not been established.OBJECTIVE: to determine the platelet indices of patients with status asmaticus of different phenotypes.METHODS: a cross-sectional study was conducted among a minimum sample size of 67 patients. Data were collected from medical records of patients in RSUD Kebumen. Platelet indices included mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).RESULTS: There was no significant difference in the value of MPV and PDW in patients with eosinophilic and neutrophilic asthma (p> 0.05). But,there was a significant difference in PCT between the two groups (P <0.05)CONCLUSION: There was difference only in plateletcrit (PCT) between patients with eosinophilic and netrophilic asthma.
Normal Value of Thrombocytes Indices in Indonesian Adults: Focus on Gender and Ages Usi Sukorini; Adika Zhulhi Arjana; Tri Ratnaningsih; Rahmat Dani Satria
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3205

Abstract

BACKGROUND: Monitoring platelet count and related indices is crucial for managing hematological disorders. No studies are reporting normal platelet indices in the adult Indonesian population. Therefore, this study was conducted to establish normal reference values for platelet count and indices in a healthy population in Indonesia and investigate their association with platelet count and each parameter.METHODS: This cross-sectional study included healthy adults from both sexes who underwent hematological testing in our laboratory. Two mL of venous blood was drawn and analyzed using an automated machine ADVIA 2120 to identify platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), mean platelet component (MPC), platelet component distribution width (PCDW), mean platelet mass (MPM), platelet mass distribution width (PMDW), and large platelet count.RESULTS: This study included 1037 subjects with median of 27 (18–58) years old. Normal reference range values for platelet indices in adult Indonesians was established, which was significantly different between males and females (p<0.05) in following parameters: platelet count (191.77–400.37 vs. 203.00–433.00 ×109/L), MPV (7.30–9.91 vs. 7.20–10.00 fL), PDW (38.09–59.83 vs. 37.10–58.50%), PCT (0.17–0.33 vs. 0.17–0.35%), PMDW (0.68–1.06 vs. 0.67–1.04 pg) for males vs. females, respectively. However, other parameters such as MPC, PCDW, MPM, and large platelet, did not show any significant differences.CONCLUSION: The reference intervals of platelet indices in the adult Indonesian population were different from previously established reference values, indicating the importance of dedicated reference interval determination with gender consideration.KEYWORDS: thrombocyte indices, platelet count, hematology reference values, blood platelet analysis 
Number of natural killer cells and cytokine levels in peripheral blood at various degrees of severity Devita, Ninda; Arjana, Adika Zhulhi; Intansari, Umi Solekhah; Susilowati, Rina
Communications in Science and Technology Vol 8 No 1 (2023)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.8.1.2023.1106

Abstract

This study aims to investigate NK cell number and cytokines level in various degrees of severity in COVID-19 cases. A total of 63 COVID-19 patient aged >18 y were divided into mild-moderate and severe-critical groups. Patient characteristics and peripheral blood count were obtained from medical records. NK cells number, levels of IFN-?, IL-10, and IL-12 in peripheral blood were examined by means of flow cytometry. The severe-critical group had leukocytosis, neutrophilia, lymphopenia, higher Neutrophil Lymphocyte Ratio, lower NK cell number and higher level of IL-10. In severe-critical group, those aged >60 years had higher IL-10. In both groups, patients with diabetes comorbidities had a higher number of NK cells (p<0.05). NK cell number and IL-10 in peripheral blood have potential as a predictor of severe COVID-19 patients.
Correlation between type of surgery and incidence of postoperative venous thromboembolism (VTE) Supomo; Budi Mulyono; Usi Sukorini; Adika Zhulhi Arjana; Tandean Tommy Novenanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11888

Abstract

Venous thromboembolism (VTE) is a significant complication in patients after undergoing major surgery. The type of surgery is believed correlated with the incidence of VTE. This study aimed to evaluate the correlation between type of surgery and incidence of VTE among patients who underwent major surgery. It was a retrospective study conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of patients who underwent major surgery and were diagnosed with VTE between 2016 and 2020. Patients were grouped by surgery type, and length of stay (LoS). All caused deaths were also analyzed. Among 29,120 patients who underwent major surgery, 76 (0.26%) experienced VTE with females patients accounting for 75%. The mean age of the patients was 55 yr. All VTE cases had the mean LoS of 25 d. The highest proportion of patients who experienced VTE were patients who underwent tumor removal (67.0%) followed by trauma patients (18.4%). A significant difference in the incidence of mortality between the surgical groups was reported (p = 0.02). Post-cardiology had the highest risk of mortality (OR=7.46; 95% CI: 0.322 - 172.61) while age had the lowest risk of mortality (OR=1.01; 95% CI: 0.953 - 1.071). In conclusion, surgery type is correlated with the incidence of VTE. Surgery due to cancer and trauma has a higher risk of VTE compared to the others.
Laboratory findings of postoperative venous thromboembolism (VTE) in Dr. Sardjito General Hospital, Yogyakarta Supomo; Mulyono, Budi; Sukorini, Usi; Arjana, Adika Zhulhi; Novenanto, Tandean Tommy
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13627

Abstract

Venous thromboembolism (VTE) is a significant risk, especially for older individuals. Indonesian studies found 37.1% VTE incidence in bedridden patients over 40 and 2.1% in major surgeries. Surgery, like hip fractures, raises the risk temporarily. Diagnosis relies on tests like ultrasound with Doppler, Wells score, and neutrophil-to-lymphocyte ratio (NLR). This study aimed to evaluate the laboratory findings of postoperative VTE. A retrospective analysis was conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of VTE patients who underwent major surgery. The laboratory data, including complete blood count characteristics for every month for three months after postsurgery and DVT presentation when it occurred on the diagnostic day were collected. In total of 27 patients involved in this study, VTE cases were more common in digestive (41.2%) and obstetric gynecology surgeries (29.4%) for females, and nervous (44.4%) and cardiovascular surgeries (22.2%) for males. Females had a higher prevalence of Well Score ≥3 (82.4% vs 40%; p=0.058) and longer VTE therapy durations (65.50 ± 46.51 vs 39.60 ± 41.04 d; p=0.172). Males had more unilateral VTE occurrences (90.9 vs 56.3%; p=0.070) and a higher proportion of total occlusion cases (60 vs 37.5%; p=0.422). NLR exhibited a significant decrease from the 1st to the 2nd month (10.52 vs 3.64; p=0.009), followed by an insignificant increase in the 3rd month (3.64 vs 3.98; p=0.878). Notably, NLR trended downward in the 2nd month examination. In conclusion, VTE occurs in 0.21% of postoperative patients, with the highest incidence observed in post-gynecological surgery patients. The NLR can serve as a diagnostic tool for VTE in extremities, as an elevated NLR indicates the presence of a more proximal thrombus.
Potensi miRNA sebagai Biomarker Diagnosis Dini Penyakit Hati Kronis Pasca Infeksi Hepatitis B : Sebuah Tinjauan Pustaka Devita, Ninda; Habibah, Ulil Albab; Arjana, Adika Zhulhi
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss2.art10

Abstract

Inflamasi kronis pasca infeksi virus hepatitis B menyebabkan kondisi infeksi kronis, fibrosis hingga keganasan. Modalitas diagnosis non invasif yang ada saat ini masih terbatas. Pemeriksaan non invasif dengan kemampuan diagnosis yang tinggi dibutuhkan untuk deteksi dini kondisi ini. miRNA berperan dalam patomekanisme inflamasi kronis pasca infeksi virus hepatitis B. Bebagai data menunjukkan kadar miRNA serum ditemukan berbeda signifikan pada pasien hepatitis B kronis, sirosis hati dan kanker hati. Walaupun data yang ada saat ini hasilnya masih bervariasi, bukti ilmiah menunjukkan korelasinya dengan proses imunologis, virologis, tumorgenesis, dan perubahan fibrosis pasca infeksi Hepatitis B. Pemeriksaan miRNA baik secara tunggal, kombinasi beberapa miRNA atau dengan modalitas diagnosis lain memiliki kemampuan diagnosis yang tinggi. miRNA potensial sebagai marker diagnosis dini berbagai kondisi pasca infeksi virus Hepatitis B. Kata Kunci: miRNA; hepatitis B; deteksi dini; biomarker
Tinjauan Imunologi pada Fenomena Non-Responder terhadap Vaksinasi Hepatitis B: Analisis Arjana, Adika Zhulhi; Devita, Ninda
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.1437

Abstract

Hepatitis B vaccine has been highly effective in preventing HBV infection. However, a subset of individuals fails to develop adequate protective antibodies after complete vaccination series (anti-HBs ≥ 10 mIU/mL), termed as non-responders. Non-responder phenomenon is influenced by a complex interplay of genetic, immunological, and environmental factors. This narrative review aims to delve into the immunological aspects of the non-responder phenomenon, exploring the factors influencing vaccine response, the immunological mechanisms involved, and potential approaches to managing and overcoming non-responders.
Co-Authors Anak Agung Gede Sugianthara Budi Mulyono Budi Mulyono Ester Tri Rahayu Ester Tri Rahayu Habibah, Ulil Albab Harina Salim Ika Fidianingsih Irfan, Mohammad Rozan Irfan, Rozan Muhammad Irfan, Rozan Muhammad Juwariyah Juwariyah Juwariyah Juwariyah Khoiriyah, Umatul Linda Rosita Marsetyawan HNE Soesatyo Mohammad Juffrie, Mohammad Muhammad Juffrie Mulyaningrum, Utami Mulyono, Budi Ninda Devita Ninda Devita, Ninda Novenanto, Tandean Tommy Nurmasitoh, Titis Rahayu, Ester Tri Rahayu, Ester Tri Rahmat Dani Satria Rina Susilowati Rozan Muhammad Irfan Rozan Muhammad Irfan Rozan Muhammad Irfan Supomo Tandean Tommy Novenanto Tri Ratnaningsih Umi S. Intansari Ida Savitri Laksanawati Usi Sukorini Utami Mulyaningrum Yanri W Subronto Yuantari, Rahma Yunika Puspa Dewi