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All Journal Biofaal Journal Munggai: Jurnal Ilmu Perikanan dan Masyarakat Pesisir Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Innovative: Journal Of Social Science Research Jurnal Pengabdian Masyarakat Bangsa Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Journal of Health Science and Medical Therapy INSANTA: JURNAL PENGABDIAN KEPADA MASYARAKAT WASATHON Tolis Mengabdi : Jurnal Pengabdian Kepada Masyarakat BATOBO: Jurnal Pengabdian Kepada Masyarakat Pasapua Health Journal Jurnal Sains, Teknologi dan Kesehatan Medicor : Journal of Health Informatics and Health Policy BAKTI : Jurnal Pengabdian Kepada Masyarakat JHN: Journal of Health and Nursing
Ukratalo, Abdul M
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Journal : Biofaal Journal

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POTENSI KULIT BATANG Cinnamomum burmannii Bl. DALAM MENCEGAH INFERTILITAS; KAJIAN TERHADAP BERAT TESTIS DAN JUMLAH SPERMATOZOA MENCIT (Mus musculus) MODEL DIABETES MELLITUS TIPE-1 Moniharapon, Mechiavel; Ukratalo, Abdul M; Pattimura, Nadira; Samson, Efraim; Pangemanan, Victory O
Biofaal Journal Vol 4 No 2 (2023): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v4i2pp108-117

Abstract

In individuals with diabetes mellitus, the increase in Reactive Oxygen Species (ROS) can damage the mitochondrial membrane, leading to the loss of potential mitochondrial membrane function in inducing apoptosis of sperm cells. Cinnamomum burmannii is a type of spice that contains antioxidants, thus capable of neutralizing free radicals and reducing oxidative stress caused by diabetes mellitus. Flavonoids also have an effect on increasing spermatogenesis. The aim of this research is to examine the role of methanol extract from Cinnamomum burmannii bark in increasing testis weight and spermatozoa count in type-1 diabetes mellitus mice (Mus musculus). The study employs a Completely Randomized Design (CRD) with five treatments and three replications. Twenty mice are divided into groups: K- (control), K+ mice injected with STZ without medication), P1 (dose of 200 mg/kg BW), P2 (dose of 400 mg/kg BW), and P3 (dose of 800 mg/kg BW). Before administering the Cinnamomum burmannii bark extract, blood sugar levels are measured in the K+, P1, P2, and P3 groups. If blood sugar levels have increased (>128 mg/dL), the P1, P2, and P3 groups are given the Cinnamomum burmannii bark extract according to the predetermined dosage. The treatment is carried out for 14 days. On the last day, surgery is performed to extract the testes and observe the spermatozoa count. The observation data on testis weight and spermatozoa count will be analyzed using ANOVA with SPSS 24.0. The results indicate that the administration of methanol extract from Cinnamomum burmannii bark significantly affects the increase in testis weight and spermatozoa count in type-1 diabetes mellitus mice. The increase in testis weight and spermatozoa count is proportional to the dosage given
DAUN KAYU PUTIH (Melaleuca leucadendra L) SEBAGAI PENGENDALI LARVA Aedes aegypti DALAM UPAYA PENCEGAHAN DEMAM BERDARAH DENGUE (DBD) DI KOTA AMBON Kaihena, Martha; Ukratalo, Abdul M
Biofaal Journal Vol 2 No 1 (2021): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.082 KB) | DOI: 10.30598/biofaal.v2i1pp28-34

Abstract

Demam Berdarah Dengue merupakan penyakit yang sampai saat ini belum ditemukan obat atau vaksinnya sehingga dilakukan upaya pencegahannya adalah dengan memutus rantai penularan penyakit yaitu dengan mengeradikasi vektornya. Masyarakat Pulau Buru, Provinsi Maluku menggunakan daun kayu putih untuk menghusir nyamuk. Dalam penggunaannya, daun kayu putih dibakar dan khasiatnya dapat mematikan nyamuk. Daun kayu putih mengandung minyak atsiri yang potensial dikembangkan sebagai larvasida alami pencegah berkembangbiaknya nyamuk A. aegypti. Tujuan dari penelitian ini adalah mengetahui potensi ekstrak etanol daun kayu putih (Melaleuca leucadendron L) dalam membunuh larva nyamuk A. aegypti. Penelitian ini dilaksanakan menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 3 kali ulangan. Tiga ratus larva nyamuk instar III dimasukan pada masing-masing wadah yang berisi ekstrak etanol herba meniran (EEHM) dengan konsentrasi yang sudah ditentukan. Tiap wadah diisi 20 larva. Pengamatan aktivitas larvasida ekstrak etanol herba meniran dilakukan setiap 2 jam sekali selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kayu putih mampu membunuh larva nyamuk Aedes aegypti dengan dosis efektif ekstrak etanol kulit batang kedondong dalam membunuh larva nyamuk Aedes aegypti adalah 20 g/mL.Nilai LC50 ekstrak etanol daun kayu putih sebesar 5,091 dengan batas bawah 1,904 dan batas atas 7,007. Sedangkan nilai LC90 ekstrak etanol daun kayu putih sebesar 12,599% dengan batas bawah 9,980 dan batas atas 20,091.
AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN Calophyllum inophyllum Linn TERHADAP KADAR GULA DARAH MENCIT (Mus musculus) MODEL DIABATES MELLITUS Ukratalo, Abdul M; Kaihena, Martha; Ramadhany, Muhammad Reza
Biofaal Journal Vol 3 No 2 (2022): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v3i2pp89-95

Abstract

The use of herbal remedies in treating diabetes mellitus has been used for generations because in addition to the relatively small side effects, the price is more economical. Bintangur (Calophyllum inophyllum Linn) is a plant that has multiple benefits. Bintangur contains compounds derived from xantona, coumarins, flavonoids, benzodipiranones, triterpenoids and steroids. Flavonoid compounds in star leaves are thought to be able to capture free radicals that cause damage to cells β the pancreas that causes diabetes mellitus. The purpose of this study was to determine the potential of ethanol extract of Calophyllum inophyllum Linn leaves against decreasing blood sugar levels of diabetes mellitus mice. Mice of 20 heads divided into 5 groups KN, K (-), K (+), P1 = dose 0.2 ml / head / day and P2 = dose 0.4 ml / head / day. In the K(-), K(+), P1 and P2 groups STZ induction and blood sugar levels were observed. After an increase in blood sugar levels in the K (+) group, metformin drugs were given, P1 and P2 were given stargur leaf extract according to a predetermined dosage. Observation of post-induction blood sugar levels was observed on days 7 and 14. The research data were then analyzed using the ANOVA test. The results of the ANOVA test showed that the calculated F value was 177.503 with an F probility of 0.000 (sig<0.05) which means that the administration of stargur leaf ethanol extract had an effect on kgd mice.
Co-Authors Amos Killay Assagaf, Abdur Rahman Barcinta, Muhammad Fahrul Basyarewan, Eko Saputra N Buranga, Edwin Ciputra, Dmytrick Efraim Samson, Efraim Embisa, Yushar A Handy Erwin Pier Leimena Ichsan, Muh. Nurhidayat Kaliky, Arief Rahman S La Eddy Loilatu, Muhammad Fitrah Mainassy, Meilissa C Manery, Dodikrisno E Martha Kaihena Moniharapon, Mechiavel Muhammad, Alfaro Nadira Pattimura Nanere, Bill E Pagaya, Joseph Palembang, Citra Fathia Pangemanan, Victory O Pieter Kakisina Ramadhany, Muhammad R Ramadhany, Muhammad Reza Seumahu, Cecelia Anna Syuaib, Achmad Tuhumuri, Evelin Tuhumury, Fiyogi D A Wakanno, Ferros Rozik