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All Journal Heca Journal of Applied Sciences Malacca Pharmaceutics Journal of Educational Management and Learning
Abas, Abdul Hawil
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Other

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A Review on Mitochondrial Genome of Ants (Hymenoptera: Formicidae) Kolondam, Beivy Jonathan; Tallei, Trina Ekawati; Koneri, Roni; Abas, Abdul Hawil; Mamahit, Juliet Merry Eva
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.74

Abstract

Ants, which are members of the Formicidae family, have been the subject of considerable scientific scrutiny due to their remarkable diversity and ecological importance. Extensive research endeavors have been directed towards understanding the complex behaviors and ecological responsibilities exhibited by these organisms. The advent of cutting-edge sequencing technology in recent times has sparked a significant breakthrough in the deciphering of mitochondrial genomes in many animals, including ants. The objective of this review paper is to provide an informative summary of the mitochondrial DNA of ants. Exploring the intricate structural aspects, we investigate the genetic diversity that exists in the mitochondrial genomes of ants. The investigation of evolutionary processes provides insight into the complex alterations that have shaped genomes throughout time. The broader ramifications of these genetic differences for the fields of ant biology and conservation are thoroughly considered. An examination is conducted on the structural characteristics, genetic variations, and evolutionary features of ant mitochondrial genomes, along with an investigation into their physiological impacts. As the molecular complexities of ant mitochondrial genomes are revealed, there is an opportunity to further explore their realm, leading to a more comprehensive comprehension of these extraordinary organisms.
Student Perspectives on the Role of Artificial Intelligence in Education: A Survey-Based Analysis Idroes, Ghazi Mauer; Noviandy, Teuku Rizky; Maulana, Aga; Irvanizam, Irvanizam; Jalil, Zulkarnain; Lensoni, Lensoni; Lala, Andi; Abas, Abdul Hawil; Tallei, Trina Ekawati; Idroes, Rinaldi
Journal of Educational Management and Learning Vol. 1 No. 1 (2023): August 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/jeml.v1i1.58

Abstract

Artificial intelligence (AI) has emerged as a powerful technology that has the potential to transform education. This study aims to comprehensively understand students' perspectives on using AI within educational settings to gain insights about the role of AI in education and investigate their perceptions regarding the advantages, challenges, and expectations associated with integrating AI into the learning process. We analyzed the student responses from a survey that targeted students from diverse academic backgrounds and educational levels. The results show that, in general, students have a positive perception of AI and believe AI is beneficial for education. However, they are still concerned about some of the drawbacks of using AI. Therefore, it is necessary to take steps to minimize the negative impact while continuing to take advantage of the advantages of AI in education.
Ficus minahassae (Teijsm. & de Vriese) Miq.: A Fig Full of Health Benefits from North Sulawesi, Indonesia: A Mini Review Abas, Abdul Hawil; Tallei, Trina Ekawati; Idroes, Rinaldi; Fatimawali, Fatimawali
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.24

Abstract

Plants have been widely utilized as traditional medicine for an extended period of time. Numerous traditional remedies have demonstrated inherent anti-disease properties. Among the countries that extensively rely on traditional medicine, Indonesia stands out. Within the region of North Sulawesi, Indonesia, Ficus minahassae, an indigenous plant possessing several health benefits, is utilized by the local community as a traditional medicinal resource. This plant is employed for the treatment of various ailments such as rheumatism, physical discomfort, stimulation of lactation in breastfeeding women, bruises, relapse, fever, fatigue, migraines, bodily pain, headaches, convulsions, colds, coughs, influenza, and fractures. Typically, the leaves, roots, and stems of F. minahassae are boiled and consumed. Additionally, this plant has been reported to possess antibacterial and antioxidant properties. However, scientific investigations exploring the health advantages of F. minahassae are significantly limited in comparison to other traditional medicines. Consequently, it is highly recommended to conduct further research on the health benefits associated with this plant.
A Review of the Ethno-dentistry Activities of Calotropis gigantea Ningsih, Diana Setya; Celik, Ismail; Abas, Abdul Hawil; Bachtiar, Boy Muhclis; Kemala, Pati; Idroes, Ghazi Mauer; Maulydia, Nur Balqis
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.31

Abstract

Calotropis gigantea is a medicinal herb that thrives in arid climates. All parts of this plant are rich in secondary metabolites, which are very beneficial for health. Phytochemicals of this plant include flavonoid, alkaloids, steroids, cardiac glycosides, and terpenoids, which have a wide range of pharmacological effects. The potential of metabolit compound from C. gigantea can be used in dental treatment. This review describes the potential use of C. gigantea in ethno-dentistry, specifically as anti-caries, soft tissue inflammation (periodontitis and gingivitis), degenerative diseases (tumor/cancer), and wound healing. This review provides general perspectives and basic literature on the use of C. gigantea in the field of etno-dentistry.
Integrative Network Pharmacology Study of Cordyceps militaris Compounds for Prostate Cancer Treatment Laihad, Sarah Cecilia Astrid; Tallei , Trina Ekawati; Tendean , Lydia Estelina Naomi; Turalaki, Grace Lendawati Amelia; Marunduh, Sylvia Ritta; Purwanto , Diana Shintawati; Kepel, Billy Johnson; Abas, Abdul Hawil
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.382

Abstract

Prostate cancer remains one of the leading causes of cancer-related mortality in men, while adverse effects and the development of drug resistance often limit current therapeutic strategies. Natural products have gained increasing attention as potential sources of novel anticancer agents due to their multitarget properties and relatively low toxicity. Cordyceps militaris, a medicinal fungus rich in bioactive compounds, has been reported to exhibit anticancer activity; however, its compound-target interactions in prostate cancer have not been comprehensively elucidated. This study aimed to explore the interactions between C. militaris bioactive compounds and prostate cancer-associated targets using a pharmacology network-based in silico approach. A total of 50 bioactive compounds were collected from metabolite profiling studies, of which 19 compounds were selected based on high predicted TP53 expression enhancer activity (Pa ≥ 0.7) using WAY2DRUG PASS analysis. Protein targets were predicted using SwissTargetPrediction and the Similarity Ensemble Approach, and then intersected with prostate cancer-associated proteins retrieved from GEPIA2, GeneCards, and OMIM, yielding 499 overlapping targets. Protein interaction network analysis was performed using STRING and visualized in Cytoscape, enabling the identification of key hub proteins based on the applied parameters, highlighting ten key proteins, including SRC, ESR1, MAPK1, AKT1, HSP90AA1, MAPK3, HSP90AB1, EGFR, GRB2, and PRKACA, within the interaction network. Pathway enrichment analysis indicated that these targets were predominantly involved in cancer-associated signaling pathways, such as the EGFR tyrosine kinase inhibitor resistance pathway. Furthermore, the results revealed that the selected compounds interact with these key prostate cancer-associated proteins. Pharmacokinetic and toxicity evaluation predicted favorable drug-likeness and acceptable safety profiles for selected compounds. Overall, this study highlights the potential of C. militaris bioactive compounds as promising alternative for prostate cancer through multitarget modulation of clinically relevant signaling pathways. Further experimental validation is still required to confirm these findings.
Co-Authors Bachtiar, Boy Muhclis BEIVY JONATHAN KOLONDAM Celik, Ismail Diana Setya Ningsih, Diana Setya Fatimawali . Ghazi Mauer Idroes Irvanizam, Irvanizam Kemala, Pati Kepel, Billy Johnson Laihad, Sarah Cecilia Astrid Lala, Andi Mamahit, Juliet Merry Eva Marunduh, Sylvia Ritta Maulana, Aga Maulydia, Nur Balqis Purwanto , Diana Shintawati Rinaldi Idroes Roni Koneri Tallei , Trina Ekawati Tendean , Lydia Estelina Naomi Teuku Rizky Noviandy TRINA EKAWATI TALLEI Turalaki, Grace Lendawati Amelia Zulkarnain Jalil