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All Journal Biota JMM (Jurnal Masyarakat Mandiri) Rumphius Pattimura Biological Journal
Sofyantoro, Fajar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Journal : Biota

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Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Co-Authors Adelfiani, Adelfiani Akbar, Ananda Malik Amadeus, Sovann Ardaning Nuriliani Ariesti, Wiwin Bambang Retnoaji Dafa, Maula Haqul Dyanita, Anissa Cahyadevi Eka Putri Empra, Desi Endar Pertiwi, Anggita Ganies Riza Aristya Illiyin, Sirayya Mayani, Olvita Moli Podhi, Felisitas Nastiti Wijayanti Oktaviana, Shintia Primahesa, Alfian Prissandi, Anthera Al Firdaus Rahayu, Sekar Risydah, Fiqiha Rohmah, Zuliyati Sadewo, Imran Salsabila, Sophia Samparisna Rumansara, Papuani Saragih, Hendry T. S. S. G. Septriani, Nur Indah Simanungkalit, Eben Ezer Slamet Widiyanto Sularsah, Sais T.S.S.G. Saragih, Hendry Tasyarofa, Alya Yuda, Khalid Abdillah Abdurahman