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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding IDJP (Indonesian Journal of Pharmaceutics) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Ilmu Kefarmasian Indonesia Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Journal of Agropharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ameliana, Lidya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : e-Journal Pustaka Kesehatan

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Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro (Optimization of Hydroxypropyl Methylcellulose and Carbopol for Moisture Content and Release Rate of Ibuprofen Patch In Vitro) Kristine Dwi Puspitasari; Dwi Nurahmanto; Lidya Ameliana
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Ibuprofen is non steroidal antiinflammatory drug (NSAID) of the propionic acid class which is widely used for the treatment of rheumatoid arthritis. Ibuprofen patch is an effective approach evading ibuprofen's adverse effect in the GI tract and first pass effect. The function of polymer is to control the drug release from the patch. The aims of this study were to determine the effect of hydroxypropyl methylcellulose (HPMC) K4M and carbopol 934 combination on the moisture content (MC), in-vitro drug release, and to obtain the optimum formula of those polymers. Ibuprofen patch were prepared into three formulas based on simplex lattice design with the ratio of HPMC K4M : carbopol 934, that were 1 : 0, 0.5 : 0.5, and 0 : 1. Design expert software was used to obtain the optimum formula of both polymers. The results of this study showed that patch with HPMC K4M : carbopol 934 (0.5 : 0.5) gave the best MC and the in-vitro drug release. The optimum formula was HPMC K4M and carbopol 934 with the ratio of 0.5 : 0.5. Keywords: ibuprofen, patch, HPMC, carbopol
Pengaruh Komposisi Polivinilpirolidon (PVP K-30) dan Etil Selulosa (EC N-22) terhadap Prosentase Kelembapan Air dan Laju Pelepasan Meloksikam dalam Sediaan Plester Selly Rio Wardhani; Lidya Ameliana; Budipratiwi Wisudyaningsih
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The object of this study was to prepare and evaluated a matrix type transdermal patch of meloxicam using blend of polyvinylpyrolidone (PVP K-30) and ethylcellulose (EC N-22) were 1:9 (Formula I); 2:8 (Formula II); and 3:7 (Formula III). Evaluation of patch is organoleptic, percentage moisture content, and the release of the drug. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% ( = 0.05). The results of organoleptic evaluation of patch dosage, transdermal patches were found yellow, odorless, and dry. Results test percentage moisture content (Formula I) 1.501 ± 0.022 %; (Formula II) 2.206 ± 0.010 %; dan (Formula III) 3.725 ± 0.033 %. Results test flux (Formula I) 455.078 ± 0.835 μg/cm2/menit1/2; (Formula II) 539.08 ± 0.835 μg/cm2/menit1/2; dan (Formula III) 677.851 ± 0.799 μg/cm2/menit1/2. It can be concluded that the combination of polyvinylpyrolidone (PVP K-30) and ethylcellulose (EC N-22) at ratio 3:7 was the best choice for manufacturing transdermal patch based on release profile.
Optimasi Gom Xanthan dan Natrium Karboksimetilselulosa terhadap Mutu Fisik dan Laju Pelepasan Gel Meloksikam In Vitro (Optimization of xanthan gum and Carboxymethylcellulose Sodium on Physical Characteristic and In Vitro Release of Meloxicam from Gel) Rizka Kurnia Cetika; Lidya Ameliana; Lina Winarni
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The aims of this study was to develop and optimize the composition of xanthan gum, carboxymethylcellulose sodium and combination of both that fulfilled the desired requirements in the preparation of meloxicam gel. The prepared gels were evaluated in term of appearance, pH, spreadibilty, viscosity, rheological properties, homogenity and in vitro drug release of meloxicam. The gel was optimized using simplex lattice design method. Influence of gelling agent xanthan gum and carboxymethylcellulose sodium were also investigated. The data was analyzed by statistic program of design expert software trial version 9.0.3.1. All of the evaluation that has been done has fulfilled the optimum requirements desired. The optimal formulation was found the number of xanthan gum is 0.060 – 3 grams and CMC Na is 0.144 – 3 grams in every 100 grams of gels. Keywords: gel, meloxicam, xanthan gum, carboxymethylcellulose sodium
Optimasi Konsentrasi Hidroksipropil Selulosa dan Polivinilpirolidon dalam Sediaan Buccal Film Simvastatin (Optimization Of Hydroxypropyl Cellulose and Polyvynylpyrolidone Concentration in Simvastatin Buccal Film) Nurul Qomariyah; Lidya Ameliana; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3951

Abstract

Simvastatin, an antihyperlipidemia drug belongs to HMG-CoA reductase inhibitor, has extend first-pass metabolism and low bioavailability (5%) with 95-98% protein bond and short half-life (2 hours). The problem of low bioavailability can be solved by buccal delivery systems with producing simvastatin mucoadhesive buccal film. Concentration of HPC and PVP can affect the value of simvastatin release and mucoadhesive strength of film. Optimization using factorial design method determine the optimum concentration of HPC and PVP with highest simvastatin release and mucoadhesive strength. Solvent casting method used for preparation of 4 formula according to factorial design. The result was formula A (FA) with HPC and PVP concentration ratio (50: 10) gave the highest simvastatin release at 95.41% and the highest mucoadhesive strength at 73.37 grams. FTIR analysis results of FA indicated that there were no change in the functional groups on simvastatin as an active ingredient, and the mucoadhesive residence time showed that FA buccal films can be attached to the goat buccal tissues for 186 minutes. Keywords: Buccal film, mucoadhesive, simvastatin, HPC, PVP, factorial design. 
Pengaruh Trietanolamin terhadap Karakteristik Fisika Kimia dan Laju Pelepasan Ibuprofen dalam Sediaan Gel Dispersi Padat Ibuprofen-PEG 6000 (Effect of Triethanolamine on Physicochemical Characteristic and Dissolution Rate of Ibuprofen in Ibuprofen-PEG 600 Tanfidz Alishlah; Budipratiwi Wisudyaningsih; Lidya Ameliana
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The present research has been undertaken with the aim to develop a topical gel formulation of ibuprofen which would avoid side effects of ibuprofen in oral administration. In this study, ibuprofen was made in solid dispersion form with PEG 6000 polymer composition 1 : 1.5 by fusion method. Solid dispersions aims to improve the solubility of ibuprofen. Triethanolamine as an alkalizing agent was added with different concentration in each gel formula which are 1 %, 2 %, and 4 %. They were evaluated for physicochemical properties such as organoleptic, pH, viscosity and in vitro drug release. Based on this research, it can be concluded that the different concentration of triethanolamine doesn’t give the significant effect on viscosity, nonetheless there is a significant effect on pH and dissolution rate of ibuprofen. It is obtained that the highest dissolution rate is F3 with a flux as 216.93 μg/cm2.minutes. Keywords: gel, ibuprofen, solid dispersion, PEG 6000, triethanolamine
Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating (Optimization Temperature and Heating Time Formation of Inclusion Complexes Glibenclamide-β-Cyclodextrin by Sealed-Heating Metho Aslyni Putri Suranina Barus; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Glibenclamide is a second-generation sulfonylurea that used for type II diabetes mellitus. Glibenclamide is included in the biopharmaceutical classification system (BCS) class II, which has a low solubility and high permeability. One effort that can be done to improve the solubility of drug is inclusion complexation. The aims of the study was to determine temperature and heating time on inclusion complexation of glibenclamide-β-cyclodextrin using sealed-heating method. Optimization done using a factorial design for two factors with 22 number of experiments. Inclusion complexes were determined its miosture content, solubility and in vitro dissolution. Moisture content study showed that F1> FB > FA > FAB. The results of solubility study were analyzed statistically using One-Way ANOVA and least significantly different (LSD). Statistical analysis showed that each formula had a significant difference solubility with FAB > FB > FA > F1>Control. Optimization on in vitro dissolution showed that FAB was an optimum formula with drug release of 87.24% within 180 min. This formula was characterized by DSC to observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. DSC analysis was indicated that inclusion complexation between glibenclamide and β-cyclodextrin was formed. Keywords: glibenclamide, β-cyclodextrin, inclusion complexe, sealed-heating
Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch) Indarto Adikusumo; Lidya Ameliana; Dwi Nurrahmanto
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Meloxicam is non steroidal antiinflammatory drug (NSAID) of the enolic acid class which is widely used in treatment of rheumatoid arthritis. Its adverse effects of oral route, which are nausea dan diarrhea could be evaded by using transdermal patch. Meloxicam is practically insoluble in water, therefore it should be made into solid dispersion.The aims of this research was to determine the effect of combination of hydroxypropyl methylcellulose (HPMC) K-4M and carbopol 940 on the in-vitro drug release and moisture content (MC) and to obtain the optimum formula of those polymers using design experts software. Meloxicam patches were prepared into three formulas based on simplex lattice design with the ratio of HPMC K-4M : carbopol 940 that were 1: 0 ; 0.5 : 0.5 and 0 : 1. The results of this research showed that the patch with HMPC K-4M : carbopol 940 of 0:1 gave the best in-vitro drug release and MC. The optimum formula was HPMC K-4M and carbopol 940 with the ratio of 0 : 1 Keywords: meloxicam, solid dispersion, patch, HPMC, carbopol.
Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate desy diana sari; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.12266

Abstract

Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.
Pengaruh Propilen Glikol dalam Patch Dispersi Padat Ketoprofen terhadap Karakteristik Fisika Kimia dan Laju Penetrasinya Lidya Ameliana; Haris Raudhatuzakinah Dwiputri; Dwi Nurahmanto
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7572

Abstract

Ketoprofen is a non steroid anti-inflammatory drug (NSAID) used as analgesic and anti-inflammation. This research had been done by ketoprofen patch preparation and evaluations aiming to enhance its penetration through the skin using propylene glycol as penetration enhancer. Evaluations included homogenity testing and FTIR for ketoprofen solid dispersion and organoleptic, weight uniformity, thickness, folding endurance, surface pH, moisture content, and penetration rate assay of ketoprofen patch. Penetration rate was determined by paddle type dissolution and the sample was analyzed by spectrophotometry UV-Vis. The value of moisture content and penetration rate were analyzed by One Way ANOVA with confidence level of 95 %. The value of moisture contents were F0 1.17 ± 0.0551 %; F1 1.27 ± 0.0208 %; F2 1.33 ± 0.08 %; and F3 1.43 ± 0.0208 %. The penetration rates of ketoprofen were F0 0.5258 ± 0.0191 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; and F3 1.1260 ± 0.0850 µg/cm2.minute. It can be concluded that the formula with propylene glycol 150 mg/patch can deliver the best penetration rate and moisture content that were fullfill the requirements. Keywords: ketoprofen, patch, propilen glikol, penetratio enhancer, solid dispersion
Pengaruh Komposisi Hidroksi Propil Metil Selulosa K-15 dan Etil Selulosa N-22 terhadap Prosentase Kelembapan Air dan Pelepasan Meloksikam dari Sediaan Plester (The Influence of Hidroxy Propyl Methyl Cellulose K-15 and Ethyl Cellulose N-22 Ratio on Procent Monica Iwud Rully Pramesthie; Lidya Ameliana; Budipratiwi Wisudyaningsih
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The present research has been undertaken with the aim to develop a transdermal patch of meloxicam with ratio of hydroxy propyl methyl cellulose (HPMC) K-15 and ethylcellulose (EC)N-22 as a matrix were 1:9 (Formula 1), 2:8 (Formula 2), 3:7 (Formula 3).The physicochemical parameters like organoleptic and % moisture content were evaluated. Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05).The results of evaluation of patch dosage, transdermal patches were found yellow, odorless and dry. Result of moisture content F(1) 1.168 ± 0.009 %; F(2) 1.841 ± 0.019 % and F(3) 2.584 ± 0.025 %. Result of in vitro drug release F(1) 364.865 ± 0.701 µg/cm2.menit1/2; F(2) 397.212 ± 0.441 µg/cm2.menit1/2 and F(3) 439.277 ± 0.559 µg/cm2.menit1/2. It can be concluded that the combination ofHPMC K-15 and EC N-22 at ratio 7:3 was the best choice for manufacturing transdermal patch based on physicochemical and the release profile.   Keywords: transdermal patch, meloxicam, hydroxypropylmethyl celulosa, ethylcellulosa
Co-Authors Alik Almawadah Arafika, Whendy Waliya Aslyni Putri Suranina Barus Budipratiwi Wisudyaningsih desy diana sari Devi Dwi N Devi Dwi N, Devi Dwi Nurahmanto Dwi Nurahmanto Dwi Nurrahmanto Eka Deddy Irawan Elok Rimadani Esti Hendradi Evi Umayah Ulfa Evi Umayah Ulfa Farkha, Fara Sukma Firdatus Sholehah Fitri Wazni Friska Wira Sabrina Gazzali, Amirah Mohd Haris Raudhatuzakinah Dwiputri Indarto Adikusumo Kristine Dwi Puspitasari Kuni Zu’aimah Barikah Lestyo Wulandari Lina Winarni Lina Winarti Lina Winarti Lita Putri Ayu Lestari Lusia Oktora RKS Lusia Oktora RKS, Lusia Lusia Oktora Ruma Kumala Sari maarif, safirul Mochammad Yuwono Monica Iwud Rully Pramesthie Nurahmanto, Dwi Nurul Qomariyah Nurul Shalikha Paramayuda, Farukh Putri Mustika Nandani Rizka Kurnia Cetika Roja, Talidah Alqibtiyah Sabrina, Friska Wira Sabrina, Friska Wira Selly Rio Wardhani Shalikha, Nurul Tanfidz Alishlah, Tanfidz Viddy Agustian Rosyidi Wirawan Deni Yenika Ayu Mega Dianatri Yudi Wicaksono