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All Journal Journal of Food and Pharmaceutical Science Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Indonesian Journal of Chemistry Pharmaceutical Sciences and Research (PSR) Journal of Food and Pharmaceutical Sciences
Abdul Karim Zulkarnain
Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakarta. Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Optimization of HPMC and Na-CMC as Gelling Agents on Physical Properties and Stability in Sunflower Seed Oil Gel Formulation Putri Rahmani , Sanubari Indah; Zulkarnain, Abdul Karim
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.8227

Abstract

Abstract: In recent years, skincare with natural ingredients is being developed for it has fewer side effects and is relatively suitable for all skin types. One of the potential ingredients from the natural ingredients is sunflower seed oil, which has proven to have potential as a skin moisturizer and fight acne bacteria. The purpose of this study was to make a gel formulation of sunflower seed oil by optimizing the combination of the gelling agent of HPMC and Na-CMC. The Simplex Lattice Design method was used to optimize the gel base with Design Expert software version 13. There were 8 gel formulas made and evaluated including organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. The independent variables in SLD were the amount of HPMC and Na-CMC, while the responses included pH, viscosity, and spreadability. The optimal formula suggested by SLD is a combination of 1.451% HPMC and 1.549% Na-CMC. The optimal formula has a pH of 6.813 ± 0.041, a viscosity of 194.8 ± 2.94 dPas, an adhesion of 6.29 ± 0.50 seconds, and a spreadability of 21.5 ± 10.05 cm2. The optimum prediction formula from the software has no significant difference from the test results which show that the method can be used to predict the physical properties of sunflower seed oil gel preparations. The results of the physical stability test also stated that its physical properties were stable in terms of pH, viscosity, spreadability, and adhesion.
Optimization of Carbopol, CMN-Na, Gelatin, and In Vitro Activity Test of 4-Hydroxy Chalcone Gel as Sunscreen Zulkarnain, Abdul Karim; Jumina, Jumina
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.8237

Abstract

Abstract: The 4-hydroxychalcone compound is a flavonoid derivative that has benzene rings with unsaturated chains and a chromophore group, which can absorb UV rays and reduce the intensity of radiation exposure to the skin. This study aims to examine the effect of gelling agents on the physical properties of gel preparations, optimum formula stability, and activity of 4-hydroxychalcone gel as a sunscreen in vitro. Base optimization was carried out using Design Expert software version 10 with the simplex lattice design method and variations in gelling agent concentrations, namely carbopol, sodium carboxymethylcellulose (CMC-Na), and gelatin. The activity of 4-hydroxychalcone sunscreen gel was determined spectrophotometrically by determining the Sun Protecting Factor (SPF) value, the percentage of erythema transmission (%TE), and the percentage of pigmentation transmission (%TP). Data were analyzed statistically with SPSS software. The results showed that the optimum formula composition was obtained at a concentration of 0.67% carbopol, 2% CMC-Na, and 1.83% gelatin. The optimum formula of 0.5% 4-hydroxychalcone gel was stable during storage at room temperature and did not experience syneresis during 72 hours of storage at ± 10°C. The 0.5% 4-hydroxychalcone gel gave an SPF value of 27.37 % TE was 1.76% and % TP was 10.21%, therefore it is categorized as a sunblock.
Optimasi Gelling Agent Karbopol Dan Na-CMC Serta Uji Aktivitas Gel Heksagamavunon-5 Sebagai Tabir Surya Secara In Vitro Muhlida, Vinilia Ihramatul; Zulkarnain, Abdul Karim; Ritmaleni, Ritmaleni
Majalah Farmaseutik Vol 21, No 4 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.110976

Abstract

Heksagamavunon-5 (HGV-5) merupakan senyawa analog kurkumin yang diketahui memiliki aktivitas antioksidan sehingga berpotensi untuk dikembangkan sebagai sediaan tabir surya. Untuk memudahkan penggunaannya pada kulit, senyawa tersebut dapat diformulasikan dalam bentuk sediaan gel. Penelitian ini bertujuan untuk menentukan formula optimum basis gel, mengevaluasi stabilitas fisik basis dan gel HGV-5, serta mengevaluasi aktivitas tabir surya gel HGV-5 secara in vitro. Metode Simplex Lattice Design dengan software Design Expert digunakan untuk mengoptimasi kadar gelling agent karbopol (0,5-1,5%) dan Na-CMC (2,0-3,0%). Delapan run formula gel dievaluasi sifat fisiknya untuk menentukan formula optimum. Stabilitas gel diuji dengan metode cycling test selama tiga siklus. Aktivitas gel HGV-5 sebagai tabir surya diuji dengan metode spektrofotometri dengan menentukan nilai Sun Protection Factor (SPF), persen transmisi eritema, dan persen transmisi pigmentasi. Hasil penelitian menunjukkan bahwa gel HGV-5 dengan konsentrasi karbopol 0,5% dan Na-CMC 3,0% memiliki pH sebesar 5,71; viskositas 290,51 dPa.s; daya sebar 10,64 cm2; serta daya lekat 10,20 detik. Gel HGV-5 memiliki nilai SPF sebesar 37,14; %TE 0,133; dan %TP 0,002. Basis gel dan gel HGV-5 stabil terhadap respons viskositas, daya sebar, dan daya lekat selama penyimpanan 3 siklus. Gel HGV-5 stabil terhadap respons pH, sedangkan pH basis gel bergeser namun masih dalam ring aman pada kulit selama penyimpanan 3 siklus.
Co-Authors ., Jumina ., Jumina Agustinus Winarno Aliva Nur Lathifa Aliva Nur Lathifa, Aliva Nur Amira Fawwaz Tsabitah Arundita Kusumawida Bambang Purwono Dwi Aris Agung Nugrahaningsih Dwi Siswanta Dwi Siswanta Emmy Yuanita Fatimi, Hana Anisa Feela Faridhotu Ifthary Naqsya PR Ikhsan Nursalim Indri Dwi Rahasasti Iqbal Tahir Jeriko Sinurat Johan Syafri Mahathir Ahmad Joko Waluyo Jumina . Jumina Jumina Jumina Jumina Khairul Ikhsan Kinuyo Matsumoto Kurniawan, Yehezkiel Steven Luky Oktaviasari Lusty Grace Toding Mae Sri Hartati Wahyuningsih Marchaban Marchaban Marchaban, Marchaban Marlyn Dian Laksitorini, Marlyn Dian Meiroza Susanti Meiroza Susanti, Meiroza MM Woro Endah Tyashapsari Muhlida, Vinilia Ihramatul Naemi Kajiwara Nela Fatmasari Oktaviasari, Luky Panut Mulyono Priatmoko Priatmoko Putri Rahmani , Sanubari Indah Ratna Asmah Susidarti Ratna Asmah Susidarti Ribka Elcistia Ritmaleni, Ritmaleni Sari, Silvia Lila Septina Virgonita Shanendra Ulfa F Subagus Wahyuono Sugeng Triono Syach, Muhammad Ferdian Triani Kurniawati Triani Kurniawati Wahyuono, Subagus Wiweka Adi Pratama