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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ilmiah Medicamento Pharmaceutical Sciences and Research (PSR) Sciences of Pharmacy Jurnal Kefarmasian Indonesia
Arief, Thendi Abdul
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Public Health

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Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy Widyaningrum, Naniek; Dhea, Alda Rasni; Rofi, Alina Nur; Arief, Thendi Abdul; Timur, Willi Wahyu
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502542

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that affects more than 80% of adolescents and young adults. Conventional therapies such as antibiotics and topical retinoids have limitations in the form of resistance and irritation. Epigallocatechin gallate (EGCG) from green tea leaves (Camellia sinensis L.) has antibacterial, anti-inflammatory, and antioxidant activities that make it a safe natural anti-acne candidate. The aim of this study was to assess the clinical efficacy and safety of topical EGCG cream on the improvement of inflammatory and non-inflammatory acne lesions. A pre-post clinical trial was conducted on ten participants aged 17–50 years with active acne. Respondents applied 6% EGCG cream twice daily for six months. The number of lesions (papules, pustules, and blackheads) was evaluated monthly and analyzed using a paired t-test (p<0.05). There was a significant decrease in the number of papules (9.4 ± 5.97 to 3.0 ± 3.13), pustules (1.7 ± 1.57 to 0), and comedones (21.5 ± 10.76 to 4.2 ± 3.05) in five months (p<0.05), with the onset of improvement since the first month without side effects. Topical EGCG cream is effective and safe in reducing acne lesions quickly and sustainably. With its multi-target mechanism, EGCG has the potential to be developed as a phytocosmetic active ingredient for acne vulgaris therapy.
Co-Authors Agung Endro Nugroho Amalia Safitri Ambarsari, Paulina amelia rumi, amelia Andriani, Ainul Anggoro Bhakti, Agung Dwi Aprilia, Laela Arief Nurrochmad Budiarti, Niky Da Costa, Yohanna Lawanda Dhea, Alda Rasni Evan Maulana, Alghafiqy Harya Fahriah, Hanum Hasifah FEBRIANI, ANISA Hadi, Paulina Ambarsari Mawar Ning Hanafi, Anggit Naufal Maula, Ajni Minhatul Naniek Widyaningrum Ningrum, Yuyun Darma Ayu Oktasari, Masita Permata, Amaliyah Pertiwi, Luthfiah Putri, Chintiana Nindya Rachmadi, Nabila Risti Ramadhani, Adinda Fajrah Ririen Hardani Rofi, Alina Nur Saputri, Novitasari Adi Sofa, Nada Aini Tianingsih, Anis Virdaus, Monica Willi Wahyu Timur