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All Journal Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA The Indonesian Biomedical Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Molekul: Jurnal Ilmiah Kimia
Arief Nurrochmad
Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy University of Gadjah Mada, Yogyakarta Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Efek Penghambatan Terhadap Pertumbuhan Tumor Paru dan Uji Ketoksikan Akut Ekstrak Kapsul Chang Sheuw Tian Ran Ling Yao Pada Mencit (Mus musculus) dan Tikus (Ratus tanezumi) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.692 KB) | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It’s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
PENGARUH EKSTRAK RIMPANG TEMU PUTIH (Curcuma zedoaria Rosc.) TERHADAP KARSINOGENESIS PARU YANG DIINDUKSI OLEH BENZO[]PIREN Murwanti, Retno; Meiyanto, Edy; Nurrochmad, Arief; Alexxander, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 2 (2006)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This experiment was aimed to investigate the influence of Curcuma zedoaria Rosc. ethanol extract on the growth of benzo[a]pyrene-induced lung tumor in male Balb/c mice. New born miced were induced with 0,2 mmol, 0,4 mmol, and 0,8 mmol benzo[a]pyrene intraperitoneally at day 1, 8, and 15 after born. On day 25 after born, the male mice were distributed into 5 groups. Group 1, 2 and 3 were treated with Curcuma zedoaria Rosc. ethanol extract consecutively 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. Group 4 was treated with DMSO (solvent) and group 5 was B[a]P induced tumor positive control.  Mice were sacrificed at 4 month age, and lung were collected for examination of tumor nodules macroscopic and microscopically. Intensity of carcinogenicity was expressed as number of  tumor bearing mice in each group, and number of of tumor nodules per mouse lung. From the result it was concluded that  Curcuma zedoaria Rosc. ethanol extract dose 250-750 mg/kgBW can inhibit the growth of lung tumor in male mice up to 18,75%. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol rimpang temu putih terhadap pertumbuhan  tumor paru pada mencit jantan galur Balb/c yang diinduksi benzo[a]piren. Anak mencit yang baru lahir diinduksi secara intraperitoneal dengan benzo[a]piren pada hari ke-1, ke-8, dan ke-15 setelah kelahiran dengan dosis masing-masing sebesar 0,2 mmol, o,4 mmol, dan 0,8 mmol. Pada hari ke-25 setelah kelahiran, mencit jantan dibagi menjadi 5 kelompok, kelompok pertama sampai ke-3 diberi ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB, kelompok  ke-4 diberi pelarut DMSO dan kelompok ke-5 sebagai kelompok kontrol positif kanker B[a]P. Mencit dikorbanan pada umur 4 bulan dan diambil organ paru, untuk diamati adanya nodul tumor secara makroskopis dan mokroskopis. Intensitas karsinogenesitas dinyatakan sebagai jumlah mencit yang terkena tumor paru dalam setiap kelompok, dan jumlah tumor per mencit dalam setiap organ paru. Analisis statistik yang digunakan adalah analisis Non parametrik Test (Kruskal-Wallis Test) dan diteruskan dengan Mann-Whitney Test. Dari penelitian ini diambil kesimpulan bahwa ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan dosis 750 mg/kgBB mampu menghambat pertumbuhan tumor paru pada mencit jantan pada fase post inisiasi dengan prosentase penghambatan berturut-turut 28,5%, 83,5%, dan 18,75%.
Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory. Nurrochmad, Arief; Wirasti, Wirasti; Dirman, Arifin; Lukitaningsih, Endang; Rahmawati, Adillah; Fakhrudin, Nanang
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1362.529 KB) | DOI: 10.14499/indonesianjpharm29iss4pp188

Abstract

Brown macroalgae (BM) which contain fucoxanthin exhibited high antioxidant activity. This study was performed to examine antioxidant, anti-collagenase, anti-elastase, anti-tyrosinase activities, and effect on cell viability of Human Dermal Fibroblast adult (HDFa) of BM, Turbinaria decurrens Bory. T. decurrens dried powder were macerated by ethanol to obtain extract (ETD) and was fractination by column chromatography to obtain fraction (FTD). Fucoxanthin content was determined using HPLC. The antioxidant activities, anti-collagenase, anti-elastase, and tyrosinase inhibitory assay were performed. The effect of ETD and fucoxanthin standard on cell viability were conducted on HDFa cell-induced by hydrogen peroxide (H2O2). The HPLC analysis showed that ETD and FTD contain fucoxanthin of 284.9±3.3µg/g and of 653.4±30.6µg/g dry-weight, respectively. The antioxidant assay showed that ETD and FTD produced high antioxidant activity by ferric reducing antioxidant power (FRAP) and b-carotene bleaching (BCB) methods that were comparable to fucoxanthin. ETD exhibited significantly higher tyrosinase inhibitory than kojic acid (p<0.01), while FTD had a comparable effect to kojic acid. The result also revealed that ETD and FTD produced anti-elastase and anti-collagenase (matrix metalloproteinase-1 (MMP-1). Fucoxanthin and ETD were able to maintain cell viability on HDFa cell-induced H2O2. This study suggests that T. decurrens may be effective to prevent skin aging and wrinkle formation, possibly through the antioxidant activity and maintain cell viability of fibroblast. 
UJI IN-VITRO PENGHAMBATAN ENZIM ASETILKOLINESTERASE DAN IDENTIFIKASI FITOKIMIA FRAKSI AKTIF EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) Dina, Shela Puzi; Herowati, Rina; Nurrochmad, Arief
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 6 No 1 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.129 KB) | DOI: 10.22236/farmasains.v6i1.2994

Abstract

Asetilkolin adalah neurotransmitter yang berperan dalam pengaturan fungsi kognitif terutama pembentukan memori baru. Hidrolisis berlebihan asetilkolin oleh enzim asetilkolinesterase dapat menyebabkan gangguan pada pembentukan memori. Mengkudu merupakan tanaman yang banyak terdapat di Indonesia dan telah teruji memiliki kemampuan penghambatan enzim asetilkolinesterase. Penelitian ini bertujuan untuk mengetahui kemampuan penghambatan aktivtas enzim acetylcholinesterase fraksi-fraksi dari ekstrak etanol buah mengkudu dan identifikasi senyawa yang terkandung dalam fraksi aktif dari ekstrak etanol buah mengkudu melalui analisis liquid chromathography-mass spectrometry. Pemisahan senyawa dilakukan melalui dua tahap yaitu ekstraksi menggunakan metode maserasi dan fraksinasi menggunakan kromatografi cair vakum. Pengujian penghambatan enzim asetilkolinesterase dilakukan dengan menggunakan metode Ellman (kolorimetri) pada konsentrasi 1000, 500, 250, 125 µg/mL. Identifikasi senyawa kimia fraksi teraktif dilakukan dengan analisis liquid chromathography-mass spectrometry. Nilai IC50 ekstrak etanol, fraksi 1, fraksi 2 dan fraksi 3 buah mengkudu secara berturut-turut sebesar 4882,29, 947,99, 1726,99, 18673,82 µg/mL. Fraksi teraktif diduga mengandung asam linolenat, asam linoleat, pinoresinol, metil linoleat dan metil oleat.
PENGARUH EKSTRAK RIMPANG TEMU PUTIH (Curcuma zedoaria Rosc.) TERHADAP KARSINOGENESIS PARU YANG DIINDUKSI OLEH BENZO[]PIREN Murwanti, Retno; Meiyanto, Edy; Nurrochmad, Arief; Alexxander, .
Jurnal Farmasi Indonesia Vol 3, No 2 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i2.71

Abstract

This experiment was aimed to investigate the influence of Curcuma zedoaria Rosc. ethanol extract on the growth of benzo[a]pyrene-induced lung tumor in male Balb/c mice. New born miced were induced with 0,2 mmol, 0,4 mmol, and 0,8 mmol benzo[a]pyrene intraperitoneally at day 1, 8, and 15 after born. On day 25 after born, the male mice were distributed into 5 groups. Group 1, 2 and 3 were treated with Curcuma zedoaria Rosc. ethanol extract consecutively 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. Group 4 was treated with DMSO (solvent) and group 5 was B[a]P induced tumor positive control.  Mice were sacrificed at 4 month age, and lung were collected for examination of tumor nodules macroscopic and microscopically. Intensity of carcinogenicity was expressed as number of  tumor bearing mice in each group, and number of of tumor nodules per mouse lung. From the result it was concluded that  Curcuma zedoaria Rosc. ethanol extract dose 250-750 mg/kgBW can inhibit the growth of lung tumor in male mice up to 18,75%. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol rimpang temu putih terhadap pertumbuhan  tumor paru pada mencit jantan galur Balb/c yang diinduksi benzo[a]piren. Anak mencit yang baru lahir diinduksi secara intraperitoneal dengan benzo[a]piren pada hari ke-1, ke-8, dan ke-15 setelah kelahiran dengan dosis masing-masing sebesar 0,2 mmol, o,4 mmol, dan 0,8 mmol. Pada hari ke-25 setelah kelahiran, mencit jantan dibagi menjadi 5 kelompok, kelompok pertama sampai ke-3 diberi ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB dan 750 mg/kgBB, kelompok  ke-4 diberi pelarut DMSO dan kelompok ke-5 sebagai kelompok kontrol positif kanker B[a]P. Mencit dikorbanan pada umur 4 bulan dan diambil organ paru, untuk diamati adanya nodul tumor secara makroskopis dan mokroskopis. Intensitas karsinogenesitas dinyatakan sebagai jumlah mencit yang terkena tumor paru dalam setiap kelompok, dan jumlah tumor per mencit dalam setiap organ paru. Analisis statistik yang digunakan adalah analisis Non parametrik Test (Kruskal-Wallis Test) dan diteruskan dengan Mann-Whitney Test. Dari penelitian ini diambil kesimpulan bahwa ekstrak etanol rimpang temu putih dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan dosis 750 mg/kgBB mampu menghambat pertumbuhan tumor paru pada mencit jantan pada fase post inisiasi dengan prosentase penghambatan berturut-turut 28,5%, 83,5%, dan 18,75%.
EFEK PENGHAMBATAN TERHADAP PERTUMBUHAN TUMOR PARU DAN UJI KETOKSIKAN AKUT EKSTRAK KAPSUL CHANG SHEUW TIAN RAN LING YAO PADA MENCIT (MUS MUSCULUS) DAN TIKUS (RATUS TANEZUMI) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It?s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
Evaluation of the Antithrombotic Activity of Acmella oleracea L. Flower Ethanol Extract Tiaravista, Amanda Gita; Putri, Laras Widawaty; Nurrochmad, Arief; Widyarini, Sitarina; Fakhrudin, Nanang
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19055

Abstract

Acmella oleracea L. (hereinafter abbreviated as AOE) is one of the plants with the potential for antithrombosis, one of the deadliest cardiovascular diseases in Indonesia. The antithrombotic activity test on AOE leaf extract revealed that it could lyse blood clots. However, no information regarding the AOE flower as an antithrombosis is provided. This study, thus, aims to determine the chromatography profile and the antithrombotic activity of the AOE flower ethanol extract. To identify the AOE chemical profile, thin-layer chromatography was carried out. Antithrombotic testing was performed on male rats of the Sprague-Dawley strain. Then, the antithrombotic activity was tested using the FeCl3-induced rat method, with the observed parameter being total occlusion time. The test animals were also divided into six groups: normal, solvent (CMC-Na 0.9%), comparator drug (clopidogrel 8.67 mg/kg), and AOE (doses 125, 250, and 375 mg/kg). The data obtained were then analyzed statistically using Kruskal-Wallis, followed by Tukey's. The TLC profile results confirmed the presence of the alkaloid compound in AOE. The authors also found that AOE at doses of 125, 250, and 375 mg/kg significantly prolonged the occlusion time comparable to that of clopidogrel at 8.67 mg/kg (p 0.05). This finding indicates that AOE has antithrombotic activity in FeCl3-induced rats.
Molecular Docking of Nigella Sativa L. with PXR Receptors and the Effect of Thymoquinone on PXR Expression in HepG2 Cells Megawati, Annik; Nurrochmad, Arief; Nugroho, Agung Endro; Lukitaningsih, Endang; Marbun, Prajona
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.11003

Abstract

ABSTRACT. The interaction between herbal remedies and drugs is a fascinating phenomenon that might cause therapeutic complications in patients. Warfarin is an anticoagulant drug that provides anti-blood-clotting effects by inhibiting the formation of vitamin K-dependent coagulation factors, and warfarin interacts with the nuclear receptor PXR, subsequently modulating cytochrome P450 during the metabolism process. St. John's wort, an herbal medicine with antidepressant effects, can alter the pharmacokinetics of warfarin. Thymoquinone is one of the active compounds in N. sativa and has pharmacological activities such as anticoagulant, antidiabetic, diuretic, antidepressant, and anti-inflammatory effects. In this study, we investigated the compounds in Nigella sativa (N. sativa) against pregnane X receptor (PXR) and evaluated the impact of thymoquinone (TQ) administration on PXR expression in HepG2 cells. The molecular docking analysis was conducted utilizing the Molecular Operating Environment (MOE) with the PXR (PDB ID: 7AXJ). At the same time, the PXR gene expression was measured using RT-PCR instruments. The RMSD value in docking represents the deviation criteria between the native ligand position and the redocking position result, indicating the capability of MOE and PDB qualification for performing molecular docking. The docking analysis showed that warfarin had the strongest binding energy (7AXJ -6.0507) by forming hydrogen binding type on Arg410. Despite TQ being the major component, it also displayed a high affinity for the two PDB IDs (7AXJ -4.5962). Furthermore, the concurrent administration of warfarin and TQ (19.27 μM) in HepG2 cells showed a significant reduction in the relative mRNA expression of the PXR gene. Given the above-mentioned findings, our study adequately enables us to predict the mechanism behind herb-drug interactions (HDIs) implicating N. sativa, specifically the TQ compound to warfarin metabolism via the activation of the PXR receptor. Keywords: Thymoquinone, expression mRNA, PXR, molecular docking, HepG2 cells.
Dampak Penundaan Jadwal Kemoterapi Terhadap Rekurensi Pada Pasien Kanker payudara Mukrinin, Walit Uhkri; Nurrochmad, Arief; Rahmawati, Fita
Majalah Farmaseutik Vol 20, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i1.75491

Abstract

Kemoterapi merupakan modalitas pengobatan utama pada kanker payudara bersama dengan operasi dan radioterapi. Kemoterapi memberikan manfaat dalam peningkatan ketahanan hidup pasien, namun manfaat tersebut dipengaruhi oleh kepatuhan terhadap jadwal kemoterapi. Dampak prognostik negatif dari keterlambatan dosis kemoterapi ini dapat berpengaruh pada hasil ketahanan hidup. Tujuan dari penelitian ini adalah untuk mengetahui gambaran penundaan jadwal kemoterapi (alasan dan durasi penundaan) serta dampaknya terhadap rekurensi. Penelitian ini menggunakan desain kohort retrospektif, melibatkan 138 pasien wanita kanker payudara stadium awal (stadium I-IIB) yang mendapatkan kemoterapi. Ekposur dalam penelitian adalah penundaan jadwal kemoterapi dan durasi penundaan, sedangkan luaran penelitian adalah rekurensi kanker payudara. Data penelitian diperoleh dari rekam medik pasien di RSUP Dr. Sardjito Yogyakarta. Analisis penelitian menggunakan metode Chi-square, Kaplan-Meier serta Cox-regression untuk mengetahui Hazard Ratio dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa penundaan jadwal kemoterapi pada pasien kanker payudara berhubungan dengan meningkatkan resiko rekurensi (HR 4,718; 95% Cl: 1,533-14,520, log rank tes p=0,003). Sementara durasi penundaan jadwal kemoterapi ≤7 hari dan >7 hari tidak berhubungan dengan peningkatan resiko rekurensi (HR 1,001; 95% Cl: 0.307-3,260, log rank tes p=0,999). Keterlibatan farmasi klinis sangat diperlukan untuk mencegah dan menyelesaikan masalah terkait efek samping obat serta monitoring pengobatan sehingga luaran pengobatan menjadi optimal.
Gambaran Pengobatan Terapi Obat Antituberkulosis (OAT) Pada Pasien TB Koinfeksi HIV Di RSUD Abepura Jayapura Papua Anggraeni, Nuniek; Nuryastuti, Titik; Nurrochmad, Arief
Majalah Farmaseutik Vol 20, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i1.82706

Abstract

Tuberkulosis (TB) merupakan infeksi oportunistik yang banyak terjadi pada orang dengan HIV/AIDS, dan menjadi penyebab kematian utama. Pasien TB memerlukan terapi pemberian obat secara bersamaan dengan 4 macam obat Antituberkulosis (OAT), yang bila disertai dengan adanya koinfeksi HIV akan menambah jumlah pengobatan dengan ARV sehingga berisiko menyebabkan kegagalan terapi karena semakin banyak obat yang dikonsumsi dan dalam jangka waktu yang panjang. Tujuan penelitian ini untuk mengetahui gambaran terapi dan luaran klinik pada pasien TB koinfeksi HIV di RSUD Abepura Jayapura Papua. Analisis data dilakukan secara deskriptif menggunakan metode univariat meliputi data karakteristik subjek, gambaran penggunaan obat dan luaran klinik TB. Sampel terdiri dari 32 pasien TB koinfeksi HIV selama periode 1 Januari 2019 sampai dengan 31 Desember 2021 yang baru terdiagnosis TB dan HIV secara bersamaan, mendapat terapi OAT dan belum pernah mendapat terapi ARV sebelumnya. Kelompok pasien TB koinfeksi HIV lebih banyak ditemukan pada kelompok usia muda dan produktif 18-40 tahun (93,75%), laki-laki (68,75%), pasien yang bersekolah pada tingkat menengah atas (68,75%), pasien yang belum menikah (62,50%), tidak bekerja (56,25%), dan banyak terjadi pada suku papua (90,63%). Lokasi anatomi yang paling banyak terjadi pada paru (75%), sediaan OAT yang paling banyak digunakan dalam bentuk kombipak (84,38%), paduan OAT yang banyak digunakan RHZE (93,75%) dengan durasi 6-8 bulan (50%). Tingkat keberhasilan terapi mencapai 62,5% (pasien sembuh 21,88% dan pengobatan lengkap 40,62%), dengan pasien putus pengobatan 37,5%.
Co-Authors Agil Novianto, Agil Agung Endro Nugroho Alexxander, . Alexxander, . Anggraeni, Nuniek Annik Megawati, Annik Arief Rahman Hakim Baiq Maylinda Gemantari Dina, Shela Puzi Dirman, Arifin Edy Meiyanto Endang Lukitaningsih Fita Rahmawati Harjaningsih, Woro Ida Ayu Putu Sri Widnyani Ika Puspitaningrum Ika Puspitasari Imono Argo Donatus, Imono Argo Laras Widawaty Putri Marbun, Prajona Mukrinin, Walit Uhkri Muthi Ikawati Nanang Fakhrudin, Nanang Puji Astuti Rahma, Nazulanita Rahmawati, Adillah Rahmawati, Desty Restia Retno Murwanti Riris Istighfari Jenie Romadhonsyah, Fitra Sitarina Widyarini Subagus Wahyuono Tiaravista, Amanda Gita Titik Nuryastuti Tri Murti Andayani Wahyuddin, Munifah Wirasti, Wirasti Wisnu Kusuma, Eka Yundari, Yundari