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All Journal Jurnal Akuatiklestari SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pengabdian Magister Pendidikan IPA Narra J Journal of Patchouli and Essential Oil Products Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan
Isnaini, Nadia
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Hybrid function of light fraction patchouli oil in hair care formulations for effective hair and anti-dandruff treatment Isnaini, Nadia; Muhammad, Syaifullah; Prajaputra, Vicky; Indra, Indra; Sufriadi, Elly; Ernawati, Ernawati; Riski, Cantika D.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1622

Abstract

Hair issues, such as hair loss and dandruff, pose significant challenges in hair care. Patchouli oil, rich in bioactive components, has emerged as a promising candidate for addressing these concerns. The aim of this study was to investigate the hybrid functionality of fractionated patchouli oil in hair care formulations designed to promote hair growth and control dandruff caused by Malassezia globosa. Crude patchouli oil (CPO) was fractionated to enhance its efficacy, producing light fraction patchouli oil (LFPO), which was then characterized using gas chromatography-mass spectrometry (GC-MS) analysis. Hair tonic formulations containing three different LFPO concentrations (0.5%, 1.0%, and 1.5%) were developed and evaluated for stability, pH, viscosity, and antifungal activity against M. globosa. The results showed that LFPO contained 2.51% acid number, 0.70% ester number, 0.71 mg/kg iron content, and 25.88% patchoulol. The formulations exhibited stable physicochemical properties, with pH levels of 5.36–5.51 and viscosity ranging from 3.94 to 4.08 centipoise (cP), suitable for hair tonic applications. Formulation of 1.5% LFPO demonstrated the strongest antifungal activity, producing a 31.18±1.37 mm inhibition zone against M. globosa, surpassing ketoconazole (21.72±0.28 mm), suggesting potential as a natural antifungal agent. Histological analysis in rabbits revealed that 1.5% LFPO formulation reduced epidermal cell shedding, increased hair length by 41.6±0.35 mm after six weeks, and promoted dense hair follicle growth. This research provides a foundation for developing natural, effective, and stable hair care formulations. Despite these promising results, the efficacy and safety of LFPO formulations in humans remain unexplored. Therefore, a clinical human trial is necessary to assess skin tolerance, irritation risks, and long-term effects under real-world conditions.
Co-Authors Apriani, Sahra El-Shazly, Mohamed Ernawati Ernawati Essy Harnelly Faradhila, Jihan Gani, Fadli A. Idroes, Ghifari Maulana Indra Indra Kemala, Pati Khairan Khairan Lydia Septa Desiyana, Lydia Septa Maqfirah, Siti Margolang, Hikma Kasih Maulydia, Nur Balqis Maysarah, Hilda Miraza, Adithya Zulfadli Misrahanum Misrahanum Nabila, Agillia Nafissa, Naja Oktaviana, Nurul Panggabean, Dara Meutia Prajaputra, Vicky Raihanylkhairi Rezkina, Cutwan Annura Rinaldi Idroes Riski, Cantika D. Salsabila, Indah Sari, Febia SITI MARYAM Sri Agustina, Sri Sufriadi, Elly Syaharani, Cut Puspita Salsabila Syaifullah Muhammad Ulfa, Safra Yudi Haditiar Zulkarnain Zulkarnain