Article Per Year (5 Year)
p-Index From 2020 - 2025
0.947
P-Index
This Author published in this journals
All Journal VALENSI Communications in Science and Technology Greensphere: Journal of Environmental Chemistry JOURNAL OF BIOMEDICAL SCINECES AND HEALTH
Huda, Muhammad Badrul
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
One pot two-step borylation/fluorination reaction of dysobinin from Chisocheton macrophyllus and its cytotoxicity against cancer cell Huda, Muhammad Badrul; Nurlelasari; Safriansyah, Wahyu; Fajar, Mohamad; Widiyowati, Iis Intan; Supratman, Unang; Permana, Yessi; Budiman, Yudha P.
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1514

Abstract

Dysobinin is a naturally occurred limonoid, which is a specific form of triterpenoid, mostly found in certain plants, particularly the Meliaceae family. Overall, it has been found that limonoids have a wide range of biological functions. Typically, the compound comprises anticancer, antimicrobial, and anti-inflammatory properties. Even though dysobinin has shown some effectiveness, its potential in pharmacology, so far, is found limited. This study, therefore, aims to enhance the pharmacological properties of dysobinin through the addition of fluorine. To do this, a one-pot, two-step reaction comprising C-H borylation and selectfluor was used to turn dysobinin into two new compounds: 1,2-dihydro-6?-acetoxyazadirone (5) and 1?-fluorodysobinin (6). After the transformation, various spectroscopic methods, including UV (Ultraviolet), IR (infrared), MS (mass spectra), as well as NMR (1D and 2D) were applied to figure out the structures of the new compounds. Accordingly, of the derived compounds, 1?-fluorodysobinin showed significantly higher cytotoxicity against A549 lung cancer cells when compared to dysobinin.
Perbandingan Metode Soxhletasi dan Perebusan untuk Isolasi Kafein dari Daun Teh Huda, Muhammad Badrul; Prayogo, Fitra Adi
Journal of Biomedical Sciences and Health Volume 2 Nomor 1 Bulan Februari 2025
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/z33a0j76

Abstract

Penelitian ini bertujuan untuk mengisolasi dan memurnikan kafein dari daun teh (Camellia sinensis) menggunakan dua metode ekstraksi: soxhletasi dan perebusan. Prinsip "like dissolves like" diterapkan dalam pemilihan pelarut untuk ekstraksi kafein. Kedua metode diikuti dengan kristalisasi dan rekristalisasi untuk meningkatkan kemurnian kafein yang diisolasi. Hasil penelitian menunjukkan perbedaan signifikan dalam rendemen dan kemurnian kafein yang diperoleh. Metode perebusan menghasilkan rendemen kafein sebesar 0,38% dengan titik leleh 235°C, mendekati nilai literatur untuk kafein murni (235-238°C). Sebaliknya, metode soxhletasi menghasilkan rendemen lebih rendah sebesar 0,008% dengan titik leleh 210°C, mengindikasikan kemurnian yang lebih rendah. Analisis visual kristal kafein juga menunjukkan perbedaan, dengan metode perebusan menghasilkan kristal putih-hijau dan metode soxhletasi menghasilkan kristal oranye-coklat. Penelitian ini menyoroti pentingnya pemilihan metode ekstraksi yang tepat untuk optimalisasi hasil dan kemurnian kafein dari daun teh, dengan implikasi signifikan untuk aplikasi dalam industri makanan, minuman, dan farmasi. Kata kunci: Caffeine, Tea Leaves, Soxhlet Extraction, Boiling Method, Crystallization   ABSTRACT This study aimed to isolate and purify caffeine from tea leaves (Camellia sinensis) using two extraction methods: soxhletation and boiling. The principle of "like dissolves like" was applied in selecting solvents for the extraction of caffeine, a nonpolar compound that is more soluble in organic solvents. Both methods were followed by crystallization and recrystallization to improve the purity of the isolated caffeine. The results showed significant differences in the yield and purity of the caffeine obtained. The boiling method produced a caffeine yield of 0.38% with a melting point of 235°C, close to the literature value for pure caffeine (235-238°C). In contrast, the soxhletation method produced a lower yield of 0.008% with a melting point of 210°C, indicating lower purity. Visual analysis of the caffeine crystals also showed differences, with the boiling method producing white-green crystals and the soxhletation method producing orange-brown crystals. This study highlights the importance of selecting an appropriate extraction method to optimize the yield and purity of caffeine from tea leaves, with significant implications for applications in the food, beverage and pharmaceutical industries. Keywords: Caffeine, Tea Leaves, Soxhlet Extraction, Boiling Method, Crystallization
Fabrikasi, Karakterisasi, dan Uji Antibakteri Nanopartikel Triterpenoid dari Daun Sambung Nyawa (Gynura procumbens) Huda, Muhammad Badrul; Fachriyah, Enny; Wibawa, Pratama Jujur
Greensphere: Journal of Environmental Chemistry Vol 5, No 1 (2025): Volume 5 Nomor 1 Tahun 2025
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/gjec.2025.27478

Abstract

Gynura procumbens (sambung nyawa) tergolong dalam famili Compositae atau Asteraceae, merupakan salah satu tanaman obat yang secara tradisional digunakan di beberapa negara di Asia Tenggara terutama Indonesia, Malaysia dan Thailand. Kajian fitokimia ekstrak etanol G. procumbens menunjukkan adanya flavonoid kuersetin, tanin, saponin, steroid, triterpenoid, asam kafeat, asam vanilat, asam parakumarat, asam klorogenat dan asam parahidroksi benzoat. Dalam hal ini senyawa triterpenoid secara khusus mempunyai nilai ekologi karena senyawa ini bekerja sebagai antifungi, insektisida, antibakteri dan antivirus. Fakta ini mendorong perlunya peningkatan sifat bioaktif triterpenoid agar dapat digunakan dalam bidang-bidang tersebut secara lebih efektif dan efesien. Salah satu cara untuk meningkatkan bioaktifitas suatu senyawa adalah dengan membuat nanopartikel. Oleh karena itu, penelitian ini betujuan untuk memperoleh isolat triterpenoid dari ekstrak n-heksana daun sambung nyawa dan memperoleh nanopartikel triterpenoid untuk meningkatkan sifat bioaktifitasnya. Secara garis besar penelitian ini dilakukan melalui dua tahap, pertama adalah isolasi dan karakterisasi triterpenoid dari ekstrak n-heksana daun sambung nyawa. Kedua adalah sintesis dan karakterisasi nanopartikel triterpenoid. Ketiga adalah uji aktivitas antibakteri. Hasil penelitian menunjukkan bahwa serbuk daun sambung nyawa memiliki komponen aktif triterpenoid. Ekstrak kental n-heksana diperoleh sebanyak 9.75 gram dengan rendeman sebesar 3.58%. Uji triterpenoid pada ekstrak kental n-heksana menunjukkan hasil positif dengan terbentuknya warna hijau-biru. Hasil kromatografi kolom diperoleh 10 fraksi (A-J), dimana fraksi I positif triterpenoid. Hasil pemisahan fraksi I dengan KLT preparatif menghasilkan 5 pita pada lampu uv 365, dengan pita I4 positif triterpenoid sehingga dilakukan analisis dengan GC-MS. Hasil data analisis GC-MS menunjukkan isolat belum murni karena terdapat 2 peak yang menunjukkan senyawa triterpenoid. Puncak kedua diduga merupakan  senyawa Lup-20(29)-en-3-ol.  Berdasarkan analisa PSA triterpenoid telah berukuran 216.3 nm. Hasil uji  aktivitas antibakteri menunjukkan nanopartikel bersifat selektif terhadap bakteri S.aureus dengan daya hambat yang lebih baik jika dibandingkan dengan isolat tanpa sonikasi.
Synthesis and Antibacterial Activity of Chitosan-Cinamaldehyde/AgNp Schiff Base Composite Huda, Muhammad Badrul; Rinaryadi, Kemilau Permata Hati; Ngadiwiyana, Ngadiwiyana; Christwardana, Marcelinus; Sarjono, Purbowatiningrum Ria; Ismiyarto, Ismiyarto
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.45121

Abstract

Chitosan is a material that has antibacterial properties. Chitosan was modified with cinnamaldehyde to form chitosan Schiff base, which acts as a capping agent in the synthesis of silver nanoparticles. The Schiff base product was modified again into a silver nanoparticle Schiff base composite to improve its ability as a capping agent and improve its antibacterial properties. This study aims to synthesize a chitosan-cinnamaldehyde/AgNP Schiff base composite (CCSB/AgNP) as an active ingredient with excellent antibacterial properties. The first stage was the synthesis of a chitosan-cinnamaldehyde Schiff base. In the second stage, the synthesis of the chitosan/AgNP composite was carried out by adding STPP with sonication and a water bath. The third stage involved synthesizing of the CCSB/AgNP composite using the same method as the second stage employing both heating and non-heating as well as sonication and non-sonication. The product was characterized using a UV-Vis spectrophotometer, FT-IR, SEM-EDX, mapping, and AAS. Antibacterial tests were performed on the synthesized product using the Total Plate Count (TPC) method. Chitosan has a molecular weight of 338080 g/mol and a degree of deacetylation of 65.09%. The Schiff base product of chitosan-cinnamaldehyde is a brownish-yellow solid with a yield of 76.9% (w/w) and a degree of substitution of 87.02%. The presence of Ag was confirmed by EDX mapping, which revealed mass percentages of 0.26%, 1.00%, and 3.97% for C/AgNP-1, C/AgNP-2, and CCSB/AgNP-2, respectively. The chitosan/AgNP product has a yield of 97% (w/w) and an SPR effect at 439 nm. The synthesis of CCSB/AgNP obtained a dark green solid with a yield of 87% (w/w) and an SPR effect at 433 nm. The antibacterial activity test yielded the highest percentage reduction in the number of bacteria in CCSB/AgNP at 3 days of observation at 95.1%, and 7 days at 94.1%. 
Co-Authors Budiman, Yudha P. Enny Fachriyah Fajar, Mohamad Ibrahim, Mohd Hairy Iis Intan Widiyowati Ismiyarto Ismitarto Jumadi Marcelinus Christwardana Ngadiwiyana M.Si. S.Si. Nurlelasari Pratama Jujur Wibawa Prayogo, Fitra Adi Purbowatiningrum Ria Sarjono Rinaryadi, Kemilau Permata Hati Safriansyah, Wahyu Unang Supratman Yessi Permana