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All Journal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmiah Farmako Bahari Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) Berkala Ilmiah Kimia Farmasi Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Innovation Research and Knowledge SWARNA Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Kunir: Jurnal Farmasi Indonesia (KJFI) Journal of Chemistry Sciences and Education Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal)
Istriningsih, Endang
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Journal : BIOCITY: Journal of Pharmacy Bioscience and Clinical Community

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Uji Analgetik Kombinasi Ekstrak Daun Pepaya (Carica papaya L.) dan Daun Kelor (Moringa oleifera L.) pada Mencit Putih (Mus musculus) dengan Uji Geliat Fahamsya, Arifina; Istriningsih, Endang; Karang, Ananda Kukuh Adi
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 4 No 1 (2025): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v4i1.5194

Abstract

Ethnomedicinal plants that have been proven as analgesics are moringa leaves (Moringa oleifera L.) and papaya leaves (Carica papaya L.). The purpose of this study is to determine the analgesic activity of a combination of papaya and moringa leaf extracts. Analgesic testing used the writhing method. A total of 25 mice were grouped into 5 treatment groups, namely negative control (CMC Na 1%), positive control (mefenamic acid 500mg/70kgBW), group I (moringa leaf extract 400mg/kgBW), group II (papaya leaf extract 600mg/kgBW), and group III (combination of moringa leaf extract 200mg/kgBW and papaya leaf extract 300mg/kgBW). The results of the study were obtained using the formula for calculating the percentage of analgesic power and tested using the Post Hoc test and the Least Significant Difference (LSD) test. Based on the analysis, a significant difference was obtained between the treatment group and the negative control. The highest percentage of analgesic effect was obtained from group III, the combination of moringa leaf extract and papaya leaf extract at 56.4%. This result is equivalent to the positive control, with the administration of mefenamic acid.
Co-Authors Afina, Afina Agung Nur Cahyanta Agung Nur Cahyanta, Agung Nur Alfiraza, Ery Nourika Alquraisi, Rima Harsa Atqiya Anggraeni, Lusy Anggraeni, Silvi Arifina Fahamsya Atqiya, Himayatul Darsini Desi Sri Rejeki Devi Ika Kurnianingtyas Devi Ika Kurnianingtyas Solikhati Devi Ika Kurnianingtyas Solikhati Dewi, Amaria Dinar Anggia Zen Fahamsya, Arifina Fatimatuzzahroh, Fany Fiqih Kartika Murti, Fiqih Kartika Firsty, Girly Risma Fisrty, Girly Risma Fitria, Nisa Sifa Hidayah, Aan Amanatul Hidayah, Nuriatul Hidayat, Sidiq Nur Karang, Ananda Kukuh Adi Khoirunnisa Khoirunnisa Khorunnida, Shofa Kurnianingtyas, Devi Ika Kusuma, Ibnu Nizar Nadiyya Rizka Maulana Nisa, Khafidatun Novita, Salsa Adinda Nurfauziah, Afina Pramesti, Indah Pramiastuti, Oktariani Rizqiyana, Fika RR. Ella Evrita Hestiandari Setyo Wulandari, Prihastini Tomy Sugiarto Gautama Utiya Nurul Amni Wulandari, Prihastini Setyo