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Journal : Science and Community Pharmacy Journal

LITERATURE REVIEW : Cost Effective Analysis of Sitagliptin for the Treatment of Diabetes Mellitus Type 2 Vidiani, Anak Agung Pradnya Paramitha; Puspitaningrum, Anisa Nova; Girsang, Valentina; Adrianto, Madyo
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.546

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by increased glucose levels in the blood. The prevalence of type 2 DM is currently increasing. In pharmacological treatment, metformin is the first-line oral therapy for most patients with type 2 diabetes. Therapy with targeted incretin has been shown to stimulate glucose-dependent insulin secretion, reduce glucagon secretion, improve beta cell function, slow gastric emptying, increase satiety, reduce appetite, and provide general benefits beyond the pancreas. Search for scientific articles by utilizing internet searches through Google Scholar and PubMed. Using keywords related to "Cost Effective Analysis", "Diabetes Mellitus type 2", "Sitagliptine" with Boolean operator "AND". Sitagliptin is less cost-effective when compared to liraglutide. Sitagliptin is the first agent of the DPP-4 inhibitor with other substances following soon after. The evaluation shows that the prevention of complications in patients with type 2 diabetes and cardiovascular disease (CVD) in the SGLT2 inhibitor group is more recommended, namely empaglifozin as the second line compared to sitagliptin.
A Literature Review: Effectiveness of NSAIDs in Osteoarthritis Patients Adrianto, Madyo; Anak Agung Pradnya Paramitha Vidiani; Puspitaningrum, Anisa Nova; Girsang, Valentina
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.582

Abstract

Pain, stiffness, swelling, and decreased joint function are some of the clinical signs of osteoarthritis, a disease that affects numerous anatomical and physiological aspects of joint tissue, cartilage degradation, bone remodeling, and osteophyte development. This literature review's objective is to ascertain the efficacy of NSAIDs in osteoarthritis by searching for journals from PubMed.. The method used was to search for articles through pubmed using the keywords "NSAID", "osteoarthritis", "Therapy" with a filter added for the last 5 years (2019-2024) obtained 103 articles. Then with the keywords "NSAID", "osteoarthritis", "therapy", "efficacy" obtained 71 articles. After analysis, there are 13 journals that can be include into inclusion requirement. NSAIDs preparations are particularly helpful for osteoarthritis therapy, both in knee and hip osteoarthritis. NSAIDs medications in a variety of dose forms, including oral, topical, spray, injection and plaster, are useful in relieving pain in osteoarthritis patients