Article Per Year (5 Year)
p-Index From 2021 - 2026
2.036
P-Index
This Author published in this journals
All Journal Jurnal Respirologi Indonesia Jurnal Buana Farma Eduvest - Journal of Universal Studies PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Jurnal Penelitian Sains dan Kesehatan Avicenna
Harahap, Daimah Wirdatus Sanaun
Unknown Affiliation
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search
Journal : jurnal buana farma

 1 
UJI AKTIVITAS ANTIOKSIDAN TERHADAP EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. var. arum manis) MENGGUNAKAN METODE DPPH Mahzura, Siti; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1624

Abstract

Radikal bebas dapat memicu stres oksidatif yang berperan dalam berbagai penyakit degeneratif, sehingga diperlukan sumber antioksidan alami yang aman dan efektif. Daun mangga arum manis mengandung berbagai senyawa bioaktif seperti flavonoid, alkaloid, tanin, saponin, dan triterpenoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah mengetahui aktivitas antioksidan ekstrak etanol daun mangga arum manis (Mangifera indica L. var. arum manis) menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Metode penelitian yang digunakan adalah eksperimen laboratorium. Daun mangga dikumpulkan dari Kecamatan Secanggang, Kabupaten Langkat, kemudian dideterminasi di Herbarium Medanense. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan metabolit sekunder. Uji aktivitas antioksidan dilakukan menggunakan variasi konsentrasi ekstrak 20, 40, 60, 80, dan 100 ppm serta vitamin C sebagai kontrol positif. Sampel direaksikan dengan larutan DPPH 50 ppm dan absorbansi diukur pada panjang gelombang 517 nm setelah inkubasi 30 menit. Hasil penelitian menunjukkan bahwa persentase inhibisi meningkat seiring peningkatan konsentrasi ekstrak, dengan nilai inhibisi tertinggi sebesar 50,2% pada konsentrasi 100 ppm. Analisis regresi linear menghasilkan nilai IC₅₀ sebesar 98,73 ppm yang termasuk kategori aktivitas antioksidan kuat. Sebagai pembanding, vitamin C menunjukkan nilai IC₅₀ sebesar 6,07 ppm yang mengindikasikan aktivitas antioksidan sangat kuat. Kesimpulan penelitian ini adalah bahwa ekstrak etanol daun mangga arum manis memiliki aktivitas antioksidan kuat berdasarkan nilai IC₅₀. Meskipun potensinya lebih rendah dibandingkan vitamin C, ekstrak ini tetap menunjukkan kemampuan signifikan sebagai sumber antioksidan alami. Penelitian lanjutan disarankan menggunakan metode FRAP atau ABTS untuk memperkuat hasil.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. ‘Arumanis’) TERHADAP Staphylococcus aureus Alya, Cinta; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1625

Abstract

The increasing prevalence of bacterial resistance to antibiotics has encouraged the exploration of natural products as alternative antimicrobial agents. This study aimed to evaluate the inhibitory potential of the ethanolic extract of ‘Arumanis’ mango leaves (Mangifera indica L. ‘Arumanis’) against Staphylococcus aureus ATCC 25923. The research was conducted using a laboratory experimental design including plant identification, preparation of simplicia, extraction by maceration with 96% ethanol, phytochemical screening, and antibacterial activity testing using the disk diffusion method. The extract was tested at concentrations of 5%, 10%, and 15% (50–150 mg/mL), with three replications (n=3) for each treatment and control group. The inhibition zones were measured including the 6 mm disk diameter and analyzed descriptively as mean ± standard deviation. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. The antibacterial assay showed inhibition zone diameters of 3.00 ± 2.12 mm (5%), 4.38 ± 2.51 mm (10%), and 6.13 ± 2.63 mm (15%), while the positive control chloramphenicol (30 µg/disk) produced a 21.43 ± 0.06 mm inhibition zone and the negative control (10% DMSO) showed no inhibitory effect. Although inhibition zones were observed at all concentrations, the diameters were relatively small compared to the standard antibiotic. Therefore, the ethanolic extract of M. indica ‘Arumanis’ leaves demonstrates concentration-dependent inhibitory potential against S. aureus, but with limited antibacterial activity, indicating the need for further evaluation using dilution methods to determine the Minimum Inhibitory Concentration (MIC).
ANALISIS BIAYA TERAPI ASPIRIN DAN CLOPIDOGREL PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 – 2025 Nasution, Nursaima Putri; Harahap, Daimah Wirdatus Sanaun; Br Ginting, Astriani Natalia
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1647

Abstract

Ischemic stroke is one of the leading causes of mortality and long-term disability, imposing a substantial economic burden due to high treatment and rehabilitation costs. Antiplatelet therapies such as aspirin and clopidogrel are commonly used for secondary prevention to reduce the risk of recurrent stroke; however, differences in treatment costs require evaluation to support efficient use of healthcare resources. This study aimed to analyze and compare the total cost and cost-effectiveness of aspirin and clopidogrel therapy in patients with ischemic stroke at Royal Prima General Hospital during the period 2022-2025. This study was an observational analytic study with a retrospective design using patients’ medical record data. The analysis was conducted from the hospital perspective by calculating direct medical costs, including drug costs, hospitalization, diagnostic examinations, and medical procedures. Pharmacoeconomic evaluation was performed using the Cost-Effectiveness Analysis (CEA) approach, with cost-effectiveness assessed through the calculation of the Cost-Effectiveness Ratio (CER) based on patients’ clinical outcomes. The results demonstrated differences in total treatment costs between aspirin and clopidogrel therapy, influenced by variations in cost components and patients’ clinical characteristics. In conclusion, cost-effectiveness analysis using CEA and CER can provide a scientific basis for selecting antiplatelet therapy that is rational and cost-efficient in the management of patients with ischemic stroke.
EFEKTIVITAS DAN BIAYA SEFALOSPORIN PADA PASIEN SIROSIS HEPATIS DENGAN RISIKO SPONTANEOUS BACTERIAL PERITONITIS DI RUMAH SAKIT ROYAL PRIMA PADA TAHUN 2022-2025 Dakhi, Grace Kristin Sonayania; Harahap, Daimah Wirdatus Sanaun; Br Ginting, Astriani Natalia
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1694

Abstract

Hepatic cirrhosis is a chronic liver disease often accompanied by serious complications, one of which is spontaneous bacterial peritonitis (SBP), which plays a significant role in increasing morbidity and mortality. Third-generation cephalosporin antibiotics, such as cefotaxime and ceftriaxone, are widely used as first-line therapy in patients with hepatic cirrhosis at risk of SBP. However, the increasing incidence of bacterial resistance and the high cost of treatment require an evaluation of the clinical effectiveness and cost-efficiency of the therapy provided. This study aims to assess the effectiveness and cost of using cephalosporin antibiotics in patients with hepatic cirrhosis at risk of SBP at Royal Prima Hospital Medan during the period 2022–2025. This study uses a pharmacoeconomic approach in the form of Cost-Effectiveness Analysis (CEA) to assess the cost-effectiveness of cephalosporins based on the relationship between treatment costs and patient clinical outcomes. Cost-effectiveness is assessed through the calculation of the Cost-Effectiveness Ratio (CER). The results show that the characteristics of patients are predominantly male and in the adult to elderly age group. This finding is in line with the epidemiological characteristics of liver cirrhosis which is more common in men, especially due to long-term risk factors such as chronic liver disease and alcohol consumption. The study shows that the analysis of the Cost-Effectiveness Ratio (CER) and Cost-Effectiveness Analysis (CEA) values has a positive and significant effect on total medical costs, which indicates that increasing costs per unit of clinical outcomes will have a direct impact on increasing total treatment costs.
EVALUASI PENGGUNAAN OBAT PADA PASIEN DISPEPSIA MENGGUNAKAN METODE ATC/DDD DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 Hutabarat, Rachel Epifanes; Harahap, Daimah Wirdatus Sanaun; Ginting, Astriani Natalia Br
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1677

Abstract

Dyspepsia is a common non-communicable disease that requires pharmacotherapy management according to clinical guidelines. Evaluation of drug use can be conducted using the ATC/DDD (Anatomical Therapeutic Chemical/Defined Daily Dose) and DU90% (Drug Utilization 90%) methods to describe prescribing patterns in healthcare facilities. This study aimed to evaluate drug use in dyspepsia patients at Royal Prima Hospital Medan in 2022 using a retrospective descriptive design using medical records of 180 patients from January–December 2022. Drugs were classified based on the WHO 2023 ATC system and analyzed using DDD calculations and the DU90% method. The results showed that four drugs included in the DU90% segment were omeprazole (tablets and injections) and ranitidine (tablets and injections), with a total contribution of 90.4% of the total DDD. The pattern of drug use is dominated by proton pump inhibitors and H₂ receptor antagonists, which are the main therapies in the management of dyspepsia based on the 2022 National Consensus on the Management of Dyspepsia and Helicobacter pylori Infection, so that the distribution of drug use obtained in this study shows compliance with national therapy recommendations.
Co-Authors Alya, Cinta Aulia, Sri Cinta Bangar, Roy Indrianto Br Ginting, Astriani Natalia Br Sembiring, Novitaria Dakhi, Grace Kristin Sonayania Diah Handayani Ginting, Astriani Natalia Br Hutabarat, Rachel Epifanes Iksen, Iksen Kasta Gurning Lumban Gaol, Irma Yohana Mahzura, Siti Nasution, Nursaima Putri Ningsih, Wulan Seppia Retnosari Andrajati Santi Purna Sari Sihotang, Nurhanifah Syahputra, Hariyadi Dharmawan Vera Estefania Kaban