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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Science and Technology Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) JMM (Jurnal Masyarakat Mandiri) Pharmaceutical Journal of Indonesia JSMARTech : Journal of Smart Bioprospecting and Technology Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Oktavia Rahayu Adianingsih
Departemen Farmasi Fakultas Kedokteran Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Enhanced Anti-Inflammatory Activity of Kaempferia galanga Extract by Solid Self-Nanoemulsifying Drug Delivery System and Its Development in Fast Disintegrating Tablet Latifani, Salma; Fitriani, Annisa nur; Paniroy; Maesayani, Kadek Sanitha; Freddy, Juan; Adianingsih, Oktavia Rahayu
Science and Technology Indonesia Vol. 9 No. 4 (2024): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.4.840-850

Abstract

The increasing global incidence of osteoarthritis (OA) emphasizes the need for effective treatments, particularly for the elderly. Conventional OA treatments pose administration challenges, leading to patient discomfort due to difficulties in administration. Herbal formulations offer an alternative to mitigate these issues. Kaempferia galanga (KG) contains ethyl p-methoxycinnamate, a compound displaying anti-inflammatory properties that hold promise for OA treatment. This study explores the formulation of a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Kaempferia galanga extract (KGE) and evaluates its anti inflammatory efficacy, subsequently developing it into a fast disintegrating tablet (FDT) dosage form. Initially, a liquid SNEDDS (L-SNEDDS) was prepared with varying surfactant and co surfactant concentrations. The optimal formula of L-SNEDDS (FL2) using tween 80: cremophor RH 40: PEG 400 in a ratio of 1:1:2 demonstrated favorable characteristics, including transmittance of 86.93 ± 1.16%, emulsification time of 28 ± 2.65 s, particle size of 27.79 ± 2.00 nm, PDI of 0.21 ± 0.014, and zeta potential of -12.57 mV. FL2 was solidified using aerosil 200 to produce S-SNEDDS and tested for anti-inflammatory efficacy in vivo using a carrageenan induced rat model. Results showed enhanced anti-inflammatory efficacy of KGE via S-SNEDDS, marked by reduced edema volume. Afterward, FDT S-SNEDDS were prepared using the direct compression method by comparing different types of superdisintegrants. The formulation using the combination of crospovidone and croscarmellose sodium (FT2) demonstrated excellent flow properties, tablet disintegration time of 63 s, wetting time of 34.01 ± 7.87 s, friability of 0.19%, and hardness of 3.53 ± 6.16 kg/cm2. The dissolution test indicated a better dissolution profile for FT2 compared to other formulations. In conclusion, this research presents the potential of FDT S-SNEDDS as a promising drug delivery system for enhancing the therapeutic effects of Kaempferia galanga extract in treating inflammatory conditions such as osteoarthritis.
Pengembangan dan Optimasi Kapsul Mikrosfer Ekstrak Licorice sebagai Bentuk Sediaan Oral Extended Release Kanker Payudara Cahyani, Farmasita Nabilla; Ardiana, Rachmawati; Khasanah, Dewi Uswatun; Dewi, Adinda Sukma; Adianingsih, Oktavia Rahayu
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.10

Abstract

Kanker payudara adalah kanker dengan angka kejadian tertinggi pada wanita. Protein yang terlibat dalam proses metastasis pada kanker adalah high mobility group box 1 (HMGB1). Licorice (Glycyrrhiza glabra) dilaporkan memiliki efek farmakologi antikanker dan ekstrak etanol roasted licorice dapat mengurangi viabilitas metastasis sel kanker. Sistem penghantaran mikrosfer merupakan serbuk padat terdiri dari polimer, crosslinked, dan bahan aktif yang dapat memberikan efek terapeutik diperpanjang. Penelitian ini bertujuan untuk memprediksi kemampuan licorice menghambat protein HMGB1 melalui molecular docking study dan mengetahui konsentrasi crosslinked natrium tripolifosfat yang paling optimal dalam formula kapsul mikrosfer ekstrak licorice. Metode penelitian dilakukan dengan uji in silico  berupa molecular docking dan uji ADMET, formulasi kapsul mikrosfer ekstrak licorice dengan variasi konsentrasi natrium tripolifosfat 3%, 6%, dan 9%, dan uji evaluasi mutu sediaan meliputi morfologi dan ukuran, sifat alir, penetapan kandungan, organoleptik, kadar air, waktu hancur, dan keseragaman bobot. Data hasil uji evaluasi dianalisis secara statistik menggunakan uji Kruskal Wallis melalui IBM SPSS 28.0. Hasil yang diperoleh yakni senyawa glycyrrhetic acid, liquiritin apioside, dan liquiritin berpotensi menghambat protein HMGB1, glycyrrhetic acid dan licochalcone A merupakan substrat CYP450 3A4, dan delapan senyawa merupakan substrat P-gp dengan kelas toksisitas rendah. Kemudian tidak ada perbedaan yang signifikan pada hasil uji ketiga formula namun konsentrasi crosslinked natrium tripolifosfat yang paling optimum dapat terlihat melalui uji evaluasi mutu sediaan. Kesimpulan penelitian ini adalah senyawa glycyrrhetic acid, liquiritin apioside, dan liquiritin dalam licorice berpotensi menghambat HMGB1 dan formula mikrosfer yang memenuhi uji evaluasi paling baik adalah formula dengan konsentrasi natrium tripolifosfat 3%.
Pengaruh Induksi Cathepsin K terhadap Pembetukan Imunoglobulin (IgG) Anti-Cathepsin K, Osteosit, dan Kadar Alkaline Phosphatase (ALP) pada Tikus Putih (Rattus norvegicus L. Betina Galur Wistar Pascaovariektomi Fransisco Wahyu Santoso; Arif Ismail; Oktavia Rahayu Adianingsih; Yurike Mandrasari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

ABSTRACT Osteoporosis is a "silent disease" that can weaken bones and cause fractures. Two from five of Indonesia's population at risk of osteoporosis and it is estimated in 2025 that number will become tripled. It has been found a kind of drug, that serves as cathepsin K inhibitors, that shows great potential in reducing osteoporosis. Cathepsin K has an important role in tissue destruction, bone remodeling, and cartilage destruction, This study is aimed to verify the effect of the cathepsin K vaccine candidate to the decrease of bone resorption in Rattusnorvegicus strain wistar post-ovariectomy. Female Rattusnorvegicas Strain Wistar (age: 10-12 weeks) are divided into 5 groups: control (-), control (+) with ovariectomy, the treatment groups are ovariectomized and given cathepsin K 50 ng/200 µL, 100 ng/200 µL, and 200 ng/200 µL.. Surgery perform on the 30th day and then IgG titers of anti-cathepsin K and ALP serum level are measured and the number of osteocytes is counted. ANOVA test shows that the administration of the vaccine candidate, cathepsin K that are added with CFA-IFA, is significantly increase the titers of IgG anti-cathepsin K in the serum (p = 0.00). The administration of cathepsin K 50 ng/200 µL, 100 ng /200 µL, and 200 ng/200 µL do not significantly reduce the number of osteocytes. The administration of cathepsin K 50 ng/200 µL, 100 rig / 200 µL, and 200 ng/200 µL do not increase the ALP serum levels (p> 0.05) significantly. The conclusion of the study is that the administration of the cathepsin K vaccine candidate can increase the IgG anti-cathepsin K titers in Female Rattusnorvegicus Strain Wistar Rats Post-ovariectomy, but do not significantly affect the number of osteocytes and ALP serum levels. Therefore, the osteoporosis vaccine candidate with cathepsin K as a basic material still need to be researched and develop
Design, Construction and Expression of Spike Highly Conserved Region (HCR) SARS-CoV-2 and Cholera Toxin Subunit B Fusion Protein in Lactococcus lactis NZ3900: Construction of recombinant plasmid in Lactococcus lactis Kesuma, Suryanata; Adianingsih, Oktavia Rahayu; Winarsih, Sri; Widodo, Nashi; Yurina, Valentina
Journal of Tropical Life Science Vol. 15 No. 2 (2025): In Press
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/2xf1qp96

Abstract

Prevention of SARS-CoV-2 transmission has primarily been achieved through vaccination, which is generally administered via injection and may cause discomfort. No commercially available SARS-CoV-2 vaccines can be administered via the mucosal route. However, recent advancements have demonstrated that vaccination with Lactococcus lactis enables vaccine delivery through the mucosa. A promising target for SARS-CoV-2 vaccine materials is the highly conserved region (HCR) of the SARS-CoV-2 spike (SARS-CoV-2 HCR Spike). Vaccine efficacy is enhanced by adding Cholera Toxin Subunit B (CTB) as an adjuvant. HCR and CTB proteins were recombinantly fused using a synthetic gene with optimized codons. This study aimed to construct a fusion protein of the SARS-CoV-2 spike protein and CTB in L. lactis strain NZ3900. The construction and expression of fusion proteins were analyzed using sequencing and protein electrophoresis. Codon optimization resulted in a Codon Adaptation Index value of 0.93 and a GC content of 27.06%. The cloning results revealed the formation of L. lactis colonies expressing the Fusion protein of the SARS-CoV-2 HCR Spike and CTB, which formed yellow colonies on the selection Elicker medium. PCR and sequencing confirmed the presence of the hcr-ctb gene, with a length of 981 bp and 100% sequence similarity. The Fusion protein of the SARS-CoV-2 HCR Spike and CTB was successfully expressed with a molecular weight of >35 kDa. In conclusion, we successfully constructed a Fusion protein of the SARS-CoV-2 HCR Spike and CTB in L. lactis NZ3900 as a potential vaccine candidate for oral administration to prevent SARS-CoV-2 infection.
Penguatan Kelompok Kader dan Produksi Produk Sabun dan Hand sanitizer Homemade di Dusun Gondang, Singosari Puspita, Oktavia Eka; Adianingsih, Oktavia Rahayu; Ihsan, Bachtiar Rifai Pratita; Yurina, Valentina; Ebtavanny, Tamara Gusti
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 2 No 1 (2022)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.01.30

Abstract

Kegiatan mencuci tangan dengan air mengalir dan sabun atau menggunakan hand sanitizer berbasis alkohol merupakan bagian dari protokol kesehatan sebagai upaya yang dilakukan untuk mencegah penyebaran virus penyebab COVID-19. Untuk menanggapi kebutuhan masyarakat mengenai ketersediaan sabun dan hand sanitizer, maka dilakukan kegiatan pengabdian kepada masyarakat yang bertujuan untuk meningkatkan kemampuan masyarakat dalam memproduksi sabun dan hand sanitizer secara mandiri. Kegiatan ini dilakukan selama bulan Juni hingga Oktober 2021 dengan target sasaran yaitu kelompok Karang Taruna Ketup4t dan PKK di Dusun Gondang, Desa Randuagung, Kecamatan Singosari, Kabupaten Malang, Jawa Timur. Metode pelaksanaan kegiatan adalah participation action research dengan cara pemberian edukasi pembuatan produk dan pendampingan anggota kelompok kader dalam proses pembuatan produk. Hasil utama kegiatan ini adalah kader mampu memproduksi sabun dan hand sanitizer homemade. Kesimpulan dari kegiatan ini adalah Kelompok Kader di Dusun Gondang mampu memproduksi sabun dan hand sanitizer homemade.
Co-Authors Alif Fariz Jazmi Ardiana, Rachmawati Arif Ismail Arsy Arundina Ayuk Lawuningtyas Hariadini Bachtiar Rifai Pratita Ihsan Cahyani, Farmasita Nabilla Christopher Kuncoro Johan Christopher Kuncoro Johan Daffa Rizky Dewi, Adinda Sukma Diah Permatasari, Diah Diana Lyrawati Diana Lyrawati Ema Pristi Yunita Fifi Farida Fajrin Fitriani, Annisa Nur Fransisco Wahyu Santoso Freddy, Juan Ihsan, Bachtiar Rifai Pratita Juan Freddy Kesuma, Suryanata Khasanah, Dewi Uswatun Latifani, Salma Maesayani, Kadek Sanitha Nashi Widodo Nur Samsu Nur Samsu Oktavia Eka Puspita Oktavia Eka Puspita, Oktavia Eka Paniroy Putri Fitri Alfiantya Samuel Aryo Wicaksono Shafira Gita Eka Pritayanti Sitti Ayu Hemas N. Sri Winarsih Tamara Gusti Ebtavanny VALENTINA YURINA Valentina Yurina VALENTINA YURINA Wibi Riawan Yurike Mandrasari Zulkarnaen Zulkarnaen